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Hee Jin Lee 5 Articles
Standardized pathology report for breast cancer
Soo Youn Cho, So Yeon Park, Young Kyung Bae, Jee Yeon Kim, Eun Kyung Kim, Woo Gyeong Kim, Youngmee Kwon, Ahwon Lee, Hee Jin Lee, Ji Shin Lee, Jee Young Park, Gyungyub Gong, Hye Kyoung Yoon
J Pathol Transl Med. 2021;55(1):1-15.   Published online January 11, 2021
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  • 459 Download
  • 1 Citations
AbstractAbstract PDFSupplementary Material
Given the recent advances in management and understanding of breast cancer, a standardized pathology report reflecting these changes is critical. To meet this need, the Breast Pathology Study Group of the Korean Society of Pathologists has developed a standardized pathology reporting format for breast cancer, consisting of ‘standard data elements,’ ‘conditional data elements,’ and a biomarker report form. The ‘standard data elements’ consist of the basic pathologic features used for prognostication, while other factors related to prognosis or diagnosis are described in the ‘conditional data elements.’ In addition to standard data elements, all recommended issues are also presented. We expect that this standardized pathology report for breast cancer will improve diagnostic concordance and communication between pathologists and clinicians, as well as between pathologists inter-institutionally.


Citations to this article as recorded by  
  • Sentinel lymph node biopsy in patients with ductal carcinomain situ: systematic review and meta-analysis
    Matthew G. Davey, Colm O’Flaherty, Eoin F. Cleere, Aoife Nohilly, James Phelan, Evan Ronane, Aoife J. Lowery, Michael J. Kerin
    BJS Open.2022;[Epub]     CrossRef
Association between p53 Expression and Amount of Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer
Miseon Lee, In Ah Park, Sun-Hee Heo, Young-Ae Kim, Gyungyub Gong, Hee Jin Lee
J Pathol Transl Med. 2019;53(3):180-187.   Published online March 11, 2019
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  • 184 Download
  • 13 Citations
AbstractAbstract PDF
Most triple-negative breast cancers (TNBCs) have a high histologic grade, are associated with high endoplasmic stress, and possess a high frequency of TP53 mutations. TP53 missense mutations lead to the production of mutant p53 protein and usually show high levels of p53 protein expression. Tumor-infiltrating lymphocytes (TILs) accumulate as part of the anti-tumor immune response and have a strong prognostic and predictive significance in TNBC. We aimed to elucidate the association between p53 expression and the amount of TILs in TNBC.
In 678 TNBC patients, we evaluated TIL levels and expression of endoplasmic stress molecules. Immunohistochemical examination of p53 protein expression was categorized into three groups: no, low, and high expression.
No, low, and high p53 expression was identified in 44.1% (n = 299), 20.1% (n = 136), and 35.8% (n = 243) of patients, respectively. Patients with high p53 expression showed high histologic grade (p < .001), high TIL levels (p = .009), and high expression of endoplasmic reticulum stress-associated molecules (p-eIF2a, p = .013; XBP1, p = .007), compared to patients with low p53 expression. There was no significant difference in disease-free (p = .406) or overall survival rates (p = .444) among the three p53 expression groups.
High p53 expression is associated with increased expression of endoplasmic reticulum stress molecules and TIL influx.


Citations to this article as recorded by  
  • Triple negative breast cancer: Immunogenicity, tumor microenvironment, and immunotherapy
    Sotiris Loizides, Anastasia Constantinidou
    Frontiers in Genetics.2023;[Epub]     CrossRef
  • Dihydroartemisinin-Transferrin Adducts Enhance TRAIL-Induced Apoptosis in Triple-Negative Breast Cancer in a P53-Independent and ROS-Dependent Manner
    Xinyu Zhou, Abel Soto-Gamez, Fleur Nijdam, Rita Setroikromo, Wim J. Quax
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • New Challenges in the Differential Diagnosis of High-Grade Triple-Negative Breast Cancer and Serous Carcinoma
    Andrii Puzyrenko, Chandler S Cortina, Julie M Jorns
    International Journal of Surgical Pathology.2022; 30(7): 728.     CrossRef
  • Prognostic analysis of cuproptosis-related gene in triple-negative breast cancer
    Shengnan Sha, Luyi Si, Xinrui Wu, Yuanbiao Chen, Hui Xiong, Ying Xu, Wangrui Liu, Haijun Mei, Tao Wang, Mei Li
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • p53 Missense Mutation is Associated with Immune Cell PD-L1 Expression in Triple-Negative Breast Cancer
    Ai-Yan Xing, Long Liu, Ke Liang, Bin Wang
    Cancer Investigation.2022; 40(10): 879.     CrossRef
  • Crosstalk between Immune Checkpoint Modulators, Metabolic Reprogramming and Cellular Plasticity in Triple-Negative Breast Cancer
    Arpita Poddar, Sushma R. Rao, Prashanth Prithviraj, George Kannourakis, Aparna Jayachandran
    Current Oncology.2022; 29(10): 6847.     CrossRef
  • The tumor microenvironment and triple-negative breast cancer aggressiveness: shedding light on mechanisms and targeting
    Natsuki Furukawa, Vered Stearns, Cesar A. Santa-Maria, Aleksander S. Popel
    Expert Opinion on Therapeutic Targets.2022; 26(12): 1041.     CrossRef
  • Intracellular partners of fibroblast growth factors 1 and 2 - implications for functions
    Katarzyna Dominika Sluzalska, Jakub Slawski, Martyna Sochacka, Agata Lampart, Jacek Otlewski, Malgorzata Zakrzewska
    Cytokine & Growth Factor Reviews.2021; 57: 93.     CrossRef
  • Targeted Chinese Medicine Delivery by A New Family of Biodegradable Pseudo-Protein Nanoparticles for Treating Triple-Negative Breast Cancer: In Vitro and In Vivo Study
    Hiu Yee Kwan, Qinghua Xu, Ruihong Gong, Zhaoxiang Bian, Chih-Chang Chu
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Transcriptomic Properties of HER2+ Ductal Carcinoma In Situ of the Breast Associate with Absence of Immune Cells
    Marie Colombe Agahozo, Marcel Smid, Ronald van Marion, Dora Hammerl, Thierry P. P. van den Bosch, Mieke A. M. Timmermans, Chayenne J. Heijerman, Pieter J. Westenend, Reno Debets, John W. M. Martens, Carolien H. M. van Deurzen
    Biology.2021; 10(8): 768.     CrossRef
  • With Our Powers Combined
    Lawrence Kasherman, Katherine Karakasis, Amit M. Oza
    The Cancer Journal.2021; 27(6): 511.     CrossRef
  • The Research Progress on the Prognostic Value of the Common Hematological Parameters in Peripheral Venous Blood in Breast Cancer

    Li Chen, Xiangyi Kong, Chengrui Yan, Yi Fang, Jing Wang
    OncoTargets and Therapy.2020; Volume 13: 1397.     CrossRef
  • Biomolecular Factors Represented by Bcl-2, p53, and Tumor-Infiltrating Lymphocytes Predict Response for Adjuvant Anthracycline Chemotherapy in Patients with Early Triple-Negative Breast Cancer

    Xenia Elena Bacinschi, Anca Zgura, Inga Safta, Rodica Anghel
    Cancer Management and Research.2020; Volume 12: 11965.     CrossRef
Rosai-Dorfman Disease: Report of a Case Associated with IgG4-Related Sclerotic Lesions
Bong-Hee Park, Da Hye Son, Myung-Hwan Kim, Tae Sun Shim, Hee Jin Lee, Jooryung Huh
Korean J Pathol. 2012;46(6):583-586.   Published online December 26, 2012
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  • 49 Download
  • 5 Citations
AbstractAbstract PDF

We describe a rare case of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) associated with a six-year history of autoimmune pancreatitis, which was controlled by steroid treatment. The patient presented with multiple, cervical and thoracic lymphadenopathy and abnormal, nodular opacities in the lung. Histologically, Rosai-Dorfman disease with numerous IgG4-positive cells was identified in a subcutaneous lymph node in the patient's left forearm. The patient recovered uneventfully with steroid treatment.


Citations to this article as recorded by  
  • Lung Involvement in Destombes-Rosai-Dorfman Disease
    Quentin Moyon, Samia Boussouar, Philippe Maksud, Jean-François Emile, Frédéric Charlotte, Nathalie Aladjidi, Grégoire Prévot, Jean Donadieu, Zahir Amoura, Philippe Grenier, Julien Haroche, Fleur Cohen Aubart
    Chest.2020; 157(2): 323.     CrossRef
  • Rosai-Dorfman Disease: Rare Pulmonary Involvement Mimicking Pulmonary Langerhans Cell Histiocytosis and Review of the Literature
    Rashid AL Umairi, Danielle Blunt, Wedad Hana, Matthew Cheung, Anastasia Oikonomou
    Case Reports in Radiology.2018; 2018: 1.     CrossRef
  • IgG4-related skin disease may have distinct systemic manifestations: a systematic review
    Adam E. Bennett, Neil A. Fenske, Paul Rodriguez-Waitkus, Jane L. Messina
    International Journal of Dermatology.2016; 55(11): 1184.     CrossRef
  • Nosology and Pathology of Langerhans Cell Histiocytosis
    Jennifer Picarsic, Ronald Jaffe
    Hematology/Oncology Clinics of North America.2015; 29(5): 799.     CrossRef
  • A subset of Rosai-Dorfman disease cases show increased IgG4-positive plasma cells: another red herring or a true association with IgG4-related disease?
    Madhu P Menon, Moses O Evbuomwan, Juan Rosai, Elaine S Jaffe, Stefania Pittaluga
    Histopathology.2014; 64(3): 455.     CrossRef
The Ratio of Atypical Ductal Hyperplasia Foci to Core Numbers in Needle Biopsy: A Practical Index Predicting Breast Cancer in Subsequent Excision
Jeong-Ju Lee, Hee Jin Lee, Jun Kang, Jeong-Hyeon Jo, Gyungyub Gong
Korean J Pathol. 2012;46(1):15-21.   Published online February 23, 2012
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AbstractAbstract PDF

Although core needle biopsy (CNB) is considered to be the standard technique for histological diagnosis of breast lesions, it is less reliable for diagnosing atypical ductal hyperplasia (ADH). We therefore assessed the characteristics of CNB-diagnosed ADH that are more likely to be associated with more advanced lesions on subsequent surgical excision.


We retrospectively examined 239 consecutive CNBs, 127 of which were diagnosed as ADH following surgical excision, performed at Asan Medical Center between 1995 and 2010. Archival slides were analyzed for the number of cores per specimen, the number of ADH foci, and the ratio of ADH foci to number of cores (FC ratio).


We found that ADH foci in 3 or more cores (p=0.003) and the presence of ADH in 3 or more foci (p=0.002) were correlated with malignancy following excision lesion. Moreover, an FC>1.1 was significantly associated with malignancy in the subsequent excision (p=0.000).


Including the number of ADH foci, the number of cores involved according to ADH, FC ratio, and histologic type in a pathology report of CNB may help in making clinical decisions about surgical excision.

WITHDRAWN:A Clinicopathologic Study of 220 Cases of Pulmonary Sclerosing Pneumocytoma in Korea: A Nationwide Survey
Myunghee Kang, Seung Yeon Ha, Joung Ho Han, Mee Sook Roh, Se Jin Jang, Hee Jin Lee, Heae Surng Park, Geon Kook Lee, Kyo Young Lee, Jin-Haeng Chung, Yoo Duk Choi, Chang Hun Lee, Lucia Kim, Myoung Ja Chung, Soon Hee Jung, Gou Young Kim, Wan-Seop Kim
Received April 4, 2018  Accepted July 9, 2018  Published online July 16, 2018  
DOI:    [Accepted]
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JPTM : Journal of Pathology and Translational Medicine