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Ilyeong Heo 3 Articles
Biliary Granular Cell Tumor
Changwon Jung, Ilyeong Heo, Sang Bum Kim, Sunhoo Park, Soo Youn Cho
J Pathol Transl Med. 2015;49(1):89-91.   Published online January 15, 2015
  • 7,390 View
  • 55 Download
  • 4 Citations


Citations to this article as recorded by  
  • Granular cell tumor of the gallbladder: case report and review of the literature
    Walid E Abdelrahim, Salwa O Mekki, Fatima M A Ali, Sarra Ahmed H Mukhtar, Kamal E Elssidig, Elthir A G Khalil, Omer Alfarog
    Journal of Surgical Case Reports.2019;[Epub]     CrossRef
  • Malignant Granular Cell Tumor of the Bile Duct
    Patrick L. Quinn, Eihab Abdelfatah, Mark A. Galan, Sushil K. Ahlawat, Ravi J. Chokshi
    ACG Case Reports Journal.2019; 6(8): e00193.     CrossRef
  • Multifocal granular cell tumour of the biliary tree
    Felip Vilardell, Marina Pardina, Jorge Juan Olsina, Xavier Matias-Guiu
    BMJ Case Reports.2018; 11(1): e226352.     CrossRef
  • Solitary, multiple, benign, atypical, or malignant: the “Granular Cell Tumor” puzzle
    Isidro Machado, Julia Cruz, Javier Lavernia, Antonio Llombart-Bosch
    Virchows Archiv.2016; 468(5): 527.     CrossRef
Fine Needle Aspiration Cytology of Parathyroid Lesions
Ilyeong Heo, Sunhoo Park, Chang Won Jung, Jae Soo Koh, Seung-Sook Lee, Hyesil Seol, Hee Seung Choi, Soo Youn Cho
Korean J Pathol. 2013;47(5):466-471.   Published online October 25, 2013
  • 7,997 View
  • 70 Download
  • 25 Citations
AbstractAbstract PDF

There has been an increase in the use of fine needle aspiration cytology (FNAC) for the diagnosis of parathyroid lesions (PLs). Differentiation between a thyroid lesion and a PL is not easy because of their similar features. We reviewed parathyroid aspirates in our institution and aimed to uncover trends in diagnostic criteria.


We selected 25 parathyroid aspirates (from 6 men and 19 women) confirmed surgically or immunohistochemically from 2006 to 2011.


Major architectural findings of PLs include scattered naked nuclei, loose clusters, a papillary pattern with a fibrovascular core, tight clusters, and a follicular pattern. These architectures were commonly admixed with one another. Cytological features included anisokaryosis, stippled chromatin, a well-defined cell border, and oxyphilic cytoplasm. Eighteen of the 25 patients were diagnosed with PL using FNAC. Seven patients had been misdiagnosed with atypical cells (n=2), benign follicular cells (n=2), adenomatous goiter (n=2) and metastatic carcinoma (n=1) in FNAC. Using clinicoradiologic data, the sensitivity of the cytological diagnosis was 86.7%. The cytological sensitivity decreased to 50% without this information.


FNAC of PL is easily confused with thyroid lesions. A combination of cytological parameters and clinical data will be required to improve the diagnostic sensitivity of PLs.


Citations to this article as recorded by  
  • Diagnosis of parathyroid incidentaloma detected on thyroid ultrasonography: the role of fine-needle aspiration cytology and washout parathyroid hormone measurements
    Boeun Lee, Sae Rom Chung, Young Jun Choi, Tae-Yon Sung, Dong Eun Song, Tae Yong Kim, Jeong Hyun Lee, Jung Hwan Baek
    Ultrasonography.2023; 42(1): 129.     CrossRef
  • Intrathyroidal parathyroid adenomas: Scoping review on clinical presentation, preoperative localization, and surgical treatment
    Shravan V. Gowrishankar, Rohan Bidaye, Tilak Das, Veronika Majcher, Brian Fish, Ruth Casey, Liam Masterson
    Head & Neck.2023; 45(3): 706.     CrossRef
  • The Value of Preoperative and Intraoperative Ultrasound in the Localization of Intrathyroidal Parathyroid Adenomas
    Wei Zhao, Ruigang Lu, Li Yin, Bojun Wei, Mulan Jin, Chun Zhang, Ruijun Guo, Xiuzhang Lv
    Journal of Investigative Surgery.2022; 35(4): 752.     CrossRef
  • Cyto‐morphological features of parathyroid lesions: Fine‐needle aspiration cytology series from an endocrine tumor referral center
    Sanna Steen, Martin Hysek, Jan Zedenius, Henrik Falhammar, Carl Christofer Juhlin
    Diagnostic Cytopathology.2022; 50(2): 75.     CrossRef
  • Non‐secreting parathyroid carcinoma in a dog
    Giovanni Tremolada, Paula Schaffer, Kathryne Pitt
    Veterinary Record Case Reports.2022;[Epub]     CrossRef
  • Fine needle aspiration of an intrathyroidal parathyroid carcinoma mimicking a primary thyroid anaplastic carcinoma: A case report with review of the literature
    Fatima Mir, Prih Rohra, Nfn Aakash, Karina Furlan, Ritu Ghai, Vijaya Reddy, Lin Cheng, Paolo Gattuso
    Diagnostic Cytopathology.2021;[Epub]     CrossRef
  • Fine‐needle aspiration of parathyroid adenomas: Indications as a diagnostic approach
    Ayana Suzuki, Mitsuyoshi Hirokawa, Risa Kanematsu, Aki Tanaka, Naoki Yamao, Miyoko Higuchi, Toshitetsu Hayashi, Seiji Kuma, Akihiro Miya, Akira Miyauchi
    Diagnostic Cytopathology.2021; 49(1): 70.     CrossRef
  • Two-year changes of biochemical profiles and bone mineral density after percutaneous ultrasound-guided microwave ablation for primary hyperparathyroidism
    Wenjun Wu, Qi Zhou, Shihao Xu, Siqin An, Feixia Shen, Huanbin Li, Xiaohua Gong, Xiaojun Chen
    Endocrine.2021; 71(2): 476.     CrossRef
  • Multimodal imaging of thyroid cancer
    Katrin Brauckhoff, Martin Biermann
    Current Opinion in Endocrinology, Diabetes & Obesity.2020; 27(5): 335.     CrossRef
  • Major Clues and Pitfalls in the Differential Diagnosis of Parathyroid and Thyroid Lesions Using Fine Needle Aspiration Cytology
    Hwa Jeong Ha, Eun Ju Kim, Jung-Soon Kim, Myung-Soon Shin, Insup Noh, Sunhoo Park, Jae Soo Koh, Seung-Sook Lee
    Medicina.2020; 56(11): 558.     CrossRef
  • Comparison of ultrasound-guided percutaneous microwave ablation and parathyroidectomy for primary hyperparathyroidism
    Fangyi Liu, Xiaoling Yu, Zhoulu Liu, Zhi Qiao, Jianping Dou, Zhigang Cheng, Zhiyu Han, Jie Yu, Ping Liang
    International Journal of Hyperthermia.2019; 36(1): 834.     CrossRef
  • Giant parathyroid adenoma: a case report and review of the literature
    Mohamed S. Al-Hassan, Menatalla Mekhaimar, Walid El Ansari, Adham Darweesh, Abdelrahman Abdelaal
    Journal of Medical Case Reports.2019;[Epub]     CrossRef
  • Water Clear Cell Parathyroid Adenoma: A Report of Two Cases
    Abdelrahman M. Radaideh, Hisham Alkhalidi, Mohamad Nusier, Mohammad Alqudah
    Arab Gulf Journal of Scientific Research.2019; : 33.     CrossRef
  • Cytological challenges in the diagnosis of intrathyroidal parathyroid carcinoma: A case report and review of literature
    Meera Balakrishnan, Smiley Annie George, Sayed Hashim Rajab, Issam M Francis, Kusum Kapila
    Diagnostic Cytopathology.2018; 46(1): 47.     CrossRef
  • Association of parathyroid carcinoma and thyroid disorders: A clinical review
    Alfredo Campennì, Salvatore Giovinazzo, Salvatore Antonio Pignata, Francesca Di Mauro, Domenico Santoro, Lorenzo Curtò, Francesco Trimarchi, Rosaria Maddalena Ruggeri, Sergio Baldari
    Endocrine.2017; 56(1): 19.     CrossRef
  • Fine needle cytology pre-surgical differentiation of parathyroid neoplasms: Is it reliable?
    A. Caleo, M. Vitale, L. Valvano, M. Siano, B. Angrisani, M. Forlenza, A. Massari, A. Puzziello, F. Salzano, P. Zeppa
    Cytopathology.2017; 28(4): 273.     CrossRef
  • Identification of parathyroid tissue in thyroid fine-needle aspiration: A combined approach using cytology, immunohistochemical, and molecular methods
    Robert P. Domingo, Lorna L. Ogden, Laura C. Been, Giulia C. Kennedy, S. Thomas Traweek
    Diagnostic Cytopathology.2017; 45(6): 526.     CrossRef
  • Cytomorphologic features distinguishing Bethesda category IV thyroid lesions from parathyroid
    Simon Sung, Anjali Saqi, Elizabeth M. Margolskee, John P. Crapanzano
    CytoJournal.2017; 14: 10.     CrossRef
  • Core-needle biopsy for the preoperative diagnosis of follicular neoplasm in thyroid nodule screening: A validation study
    Sung Hak Lee, Gyeong Sin Park, So Lyung Jung, Min-Hee Kim, Ja Seong Bae, Dong Jun Lim, Chan Kwon Jung
    Pathology - Research and Practice.2016; 212(1): 44.     CrossRef
  • Parathyroid lesions: Difficult diagnosis on cytology
    Charu Agarwal, Manju Kaushal
    Diagnostic Cytopathology.2016; 44(8): 704.     CrossRef
  • Intrathyroidal parathyroid adenoma: Diagnostic pitfalls on fine-needle aspiration: Two case reports and literature review
    Chang Shi, Hongwei Guan, Wenjing Qi, Jialin Ji, Jialing Wu, Feng Yan, Huali Wang
    Diagnostic Cytopathology.2016; 44(11): 921.     CrossRef
  • Diagnostic value of GATA-3 in cytological identification of parathyroid tissues
    Nami Takada, Mitsuyoshi Hirokawa, Ayana Suzuki, Miyoko Higuchi, Seiji Kuma, Akira Miyauchi
    Endocrine Journal.2016; 63(7): 621.     CrossRef
    Naval Kishore Bajaj, Shrinivas Somalwar, Akhtar Mohammad, Ezhil Arasi Nagamuthu
    Journal of Evidence Based Medicine and Healthcare.2016; 3(71): 3849.     CrossRef
  • Fine-Needle Aspiration Cytology of Parathyroid Lesions
    Teklu Legesse, Paul N. Staats
    Pathology Case Reviews.2015; 20(5): 227.     CrossRef
  • A nonfunctioning parathyroid carcinoma misdiagnosed as a follicular thyroid nodule
    Filomena Cetani, Gianluca Frustaci, Liborio Torregrossa, Silvia Magno, Fulvio Basolo, Alberto Campomori, Paolo Miccoli, Claudio Marcocci
    World Journal of Surgical Oncology.2015;[Epub]     CrossRef
Primary Monophasic Synovial Sarcoma Arising in the Mesentery: Case Report of an Extremely Rare Mesenteric Sarcoma Confirmed by Molecular Detection of a SYT-SSX2 Fusion Transcript
Han Suk Ryu, Ilyeong Heo, Jae Soo Koh, Sung-Ho Jin, Hye Jin Kang, Soo Youn Cho
Korean J Pathol. 2012;46(2):187-191.   Published online April 25, 2012
  • 5,514 View
  • 29 Download
  • 2 Citations
AbstractAbstract PDF

Synovial sarcoma arises in the para-articular tissues, and it can also occur in various unexpected sites. We report a rare case of primary monophasic synovial sarcoma (MSS) arising in the mesentery. A 59-year-old man presented with a palpable abdominal mass. On microscopic examination, the entire tumor comprised a dense proliferation of the spindle cells without epithelial components. The tumor cells were positive for transducin-like enhancer of split 1, bcl-2, epithelial membrane antigen and CD99 but negative for CD34, CD117, alpha-smooth muscle actin, cytokeratin, and calretinin on immunohistochemistry. The reverse transcriptase-polymerase chain reaction revealed a single 151-bp fragment representing the SYT-SSX2 fusion transcript. Because mesenteric MSS is extremely rare and many cases display histologic findings that overlap with those of more frequently involved tumors such as hemangiopericytoma and gastrointestinal stromal tumor, there is a chance of making an incorrect diagnosis that can result in an inappropriate treatment.


Citations to this article as recorded by  
  • Giant solitary fibrous tumor of the pelvis: A case report and review of literature
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    International Journal of Surgery Case Reports.2020; 77: S52.     CrossRef
  • Tumeur neuroectodermique gastro-intestinale (GNET) : à propos d’un cas de tumeur du grêle avec métastases hépatiques
    Thibault Kervarrec, Claire Lecointre, Rémy Kerdraon, Guido Bens, Arnaud Piquard, Patrick Michenet
    Annales de Pathologie.2015; 35(6): 506.     CrossRef

JPTM : Journal of Pathology and Translational Medicine