Skip Navigation
Skip to contents

JPTM : Journal of Pathology and Translational Medicine


Author index

Page Path
HOME > Articles and issues > Author index
Jae Ho Han 4 Articles
Epstein-Barr Virus–Associated Lymphoproliferative Disorders: Review and Update on 2016 WHO Classification
Hyun-Jung Kim, Young Hyeh Ko, Ji Eun Kim, Seung-Sook Lee, Hyekyung Lee, Gyeongsin Park, Jin Ho Paik, Hee Jeong Cha, Yoo-Duk Choi, Jae Ho Han, Jooryung Huh
J Pathol Transl Med. 2017;51(4):352-358.   Published online June 5, 2017
  • 14,060 View
  • 937 Download
  • 53 Citations
AbstractAbstract PDF
Epstein-Barr virus (human herpesvirus-4) is very common virus that can be detected in more than 95% of the human population. Most people are asymptomatic and live their entire lives in a chronically infected state (IgG positive). However, in some populations, the Epstein-Barr virus (EBV) has been involved in the occurrence of a wide range of B-cell lymphoproliferative disorders (LPDs), including Burkitt lymphoma, classic Hodgkin’s lymphoma, and immune–deficiency associated LPDs (post-transplant and human immunodeficiency virus–associated LPDs). T-cell LPDs have been reported to be associated with EBV with a subset of peripheral T-cell lymphomas, angioimmunoblastic T-cell lymphomas, extranodal nasal natural killer/T-cell lymphomas, and other rare histotypes. This article reviews the current evidence covering EBV-associated LPDs based on the 2016 classification of the World Health Organization. These LPD entities often pose diagnostic challenges, both clinically and pathologically, so it is important to understand their unique pathophysiology for correct diagnoses and optimal management.


Citations to this article as recorded by  
  • Pharmacological Modulation of the Crosstalk between Aberrant Janus Kinase Signaling and Epigenetic Modifiers of the Histone Deacetylase Family to Treat Cancer
    Al-Hassan M. Mustafa, Oliver H. Krämer, Lynette Daws
    Pharmacological Reviews.2023; 75(1): 35.     CrossRef
  • Autophagy-associated immune dysregulation and hyperplasia in a patient with compound heterozygous mutations in ATG9A
    Guowu Hu, Pia J Hauk, Nannan Zhang, Waleed Elsegeiny, Carlos M. Guardia, Amy Kullas, Kevin Crosby, Robin R. Deterding, Michaela Schedel, Paul Reynolds, Jordan K Abbott, Vijaya Knight, Stefania Pittaluga, Mark Raffeld, Sergio D. Rosenzweig, Juan S. Bonifac
    Autophagy.2023; 19(2): 678.     CrossRef
  • Primary head and neck cancer cell cultures are susceptible to proliferation of Epstein-Barr virus infected lymphocytes
    Senyao Shao, Lars Uwe Scholtz, Sarah Gendreizig, Laura Martínez-Ruiz, Javier Florido, Germaine Escames, Matthias Schürmann, Carsten Hain, Leonie Hose, Almut Mentz, Pascal Schmidt, Menghang Wang, Peter Goon, Michael Wehmeier, Frank Brasch, Jörn Kalinowski,
    BMC Cancer.2023;[Epub]     CrossRef
  • Outcomes of programmed death protein-1 inhibitors treatment of chronic active Epstein Barr virus infection: A single center retrospective analysis
    Yaxian Ma, Peiling Zhang, Yuhan Bao, Hui Luo, Jiachen Wang, Liang Huang, Miao Zheng
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Successful treatment by using a modified SMILE regimen and autologous hematopoietic stem cell transplantation in a pediatric primary EBV-positive nodular NK/T cell lymphoma patient
    Jian Li, Juxin Ye, Yongren Wang, Jun Wang, Yongjun Fang
    Annals of Hematology.2022; 101(2): 433.     CrossRef
  • Genetic errors of immunity distinguish pediatric nonmalignant lymphoproliferative disorders
    Lisa R. Forbes, Olive S. Eckstein, Nitya Gulati, Erin C. Peckham-Gregory, Nmazuo W. Ozuah, Joseph Lubega, Nader K. El-Mallawany, Jennifer E. Agrusa, M. Cecilia Poli, Tiphanie P. Vogel, Natalia S. Chaimowitz, Nicholas L. Rider, Emily M. Mace, Jordan S. Ora
    Journal of Allergy and Clinical Immunology.2022; 149(2): 758.     CrossRef
  • EBV-positive B-cell ulcerative proliferation in the oral cavity associated with EBV-negative follicular lymphoma in a patient with common variable immunodeficiency: A case report and review of the literature
    Waleed A. Alamoudi, Antoine Azar, Stefan K. Barta, Faizan Alawi, Takako I. Tanaka, Eric T. Stoopler, Thomas P. Sollecito
    Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2022; 133(1): e10.     CrossRef
  • Necrotizing Follicular Lymphoma of the Inguinal Region with Sternbergoid Cells: Clinical–Pathological Features of a Challenging Entity
    Federico Scarmozzino, Marco Pizzi, Marta Sbaraglia, Luisa Santoro, Luca Frison, Silvia Nalio, Laura Bonaldi, Livio Trentin, Angelo Paolo Dei Tos
    Applied Sciences.2022; 12(3): 1290.     CrossRef
  • High percentages of peripheral blood T-cell activation in childhood Hodgkin's lymphoma are associated with inferior outcome
    Fengqing Cai, Hui Gao, Zhongsheng Yu, Kun Zhu, Weizhong Gu, Xiaoping Guo, Xiaojun Xu, Hongqiang Shen, Qiang Shu
    Frontiers in Medicine.2022;[Epub]     CrossRef
  • Case Report of a Novel NFkB Mutation in a Lymphoproliferative Disorder Patient
    Khashayar Danandeh, Parnian Jabbari, Elham Rayzan, Samaneh Zoghi, Sepideh Shahkarami, Raul Jimenez Heredia, Ana Krolo, Bibi Shahin Shamsian, Kaan Boztug, Nima Rezaei
    Endocrine, Metabolic & Immune Disorders - Drug Targets.2022; 22(10): 1040.     CrossRef
  • When to suspect inborn errors of immunity in Epstein–Barr virus–related lymphoproliferative disorders
    Keith A. Sacco, Luigi D. Notarangelo, Ottavia M. Delmonte
    Clinical Microbiology and Infection.2022;[Epub]     CrossRef
  • EBV-associated diseases: Current therapeutics and emerging technologies
    Srishti Chakravorty, Behdad Afzali, Majid Kazemian
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • Clinical and genetic characterization of Epstein-Barr virus–associated T/NK-cell lymphoproliferative diseases
    Hui Luo, Dan Liu, Wenbing Liu, Jin Jin, Xiaoman Bi, Peiling Zhang, Jia Gu, Miao Zheng, Min Xiao, Xin Liu, Jianfeng Zhou, Qian-Fei Wang
    Journal of Allergy and Clinical Immunology.2022;[Epub]     CrossRef
  • Clinical features and treatment strategies for post-transplant and iatrogenic immunodeficiency-associated lymphoproliferative disorders
    Akihiro Ohmoto, Shigeo Fuji
    Blood Reviews.2021; 49: 100807.     CrossRef
  • Comparative Study on Epstein-Barr Virus-Positive Mucocutaneous Ulcer and Methotrexate-Associated Lymphoproliferative Disorders Developed in the Oral Mucosa: A Case Series of 10 Patients and Literature Review
    Kyoichi Obata, Tatsuo Okui, Sawako Ono, Koki Umemori, Shoji Ryumon, Kisho Ono, Mayumi Yao, Norie Yoshioka, Soichiro Ibaragi, Akira Sasaki
    Diagnostics.2021; 11(8): 1375.     CrossRef
  • Primary age‐related EBV‐associated effusion‐based lymphoma successfully treated with rituximab and thoracentesis
    Justin J. Kuhlman, Muhamad Alhaj Moustafa, Alexander J. Tun, David M. Menke, Han W. Tun, Liuyan Jiang
    Clinical Case Reports.2021;[Epub]     CrossRef
  • Viral Manipulation of the Host Epigenome as a Driver of Virus-Induced Oncogenesis
    Shimaa Hassan AbdelAziz Soliman, Arturo Orlacchio, Fabio Verginelli
    Microorganisms.2021; 9(6): 1179.     CrossRef
  • Spontaneous regression of chronic epstein –Barr virus infection-related lymphoproliferative disease
    Bharti Kumari, Akshata Rao, ManickaSaravanan Subramanian, AparajitBallav Dey
    Journal of the Indian Academy of Geriatrics.2021; 17(1): 40.     CrossRef
  • The Pivotal Role of Viruses in the Pathogeny of Chronic Lymphocytic Leukemia: Monoclonal (Type 1) IgG K Cryoglobulinemia and Chronic Lymphocytic Leukemia Diagnosis in the Course of a Human Metapneumovirus Infection
    Jérémy Barben, Alain Putot, Anca-Maria Mihai, Jérémie Vovelle, Patrick Manckoundia
    Viruses.2021; 13(1): 115.     CrossRef
  • B cells in multiple sclerosis — from targeted depletion to immune reconstitution therapies
    Maria T. Cencioni, Miriam Mattoscio, Roberta Magliozzi, Amit Bar-Or, Paolo A. Muraro
    Nature Reviews Neurology.2021; 17(7): 399.     CrossRef
  • Development of Mast Cell and Eosinophil Hyperplasia and HLH/MAS-Like Disease in NSG-SGM3 Mice Receiving Human CD34+ Hematopoietic Stem Cells or Patient-Derived Leukemia Xenografts
    Laura J. Janke, Denise M. Imai, Heather Tillman, Rosalinda Doty, Mark J. Hoenerhoff, Jiajie J. Xu, Zachary T. Freeman, Portia Allen, Natalie Wall Fowlkes, Ilaria Iacobucci, Kirsten Dickerson, Charles G. Mullighan, Peter Vogel, Jerold E. Rehg
    Veterinary Pathology.2021; 58(1): 181.     CrossRef
  • Viral coinfections in COVID‐19
    Parisa S. Aghbash, Narges Eslami, Milad Shirvaliloo, Hossein B. Baghi
    Journal of Medical Virology.2021; 93(9): 5310.     CrossRef
  • Genetic predisposition to lymphomas: Overview of rare syndromes and inherited familial variants
    Bartosz Szmyd, Wojciech Mlynarski, Agata Pastorczak
    Mutation Research/Reviews in Mutation Research.2021; 788: 108386.     CrossRef
  • Acute Epstein‐Barr virus associated haemophagocytosis in an Asian female: What is the diagnosis?
    Soumya Ojha, Guiyi Ho, Cheryl X. Q. Lim, Siok B. Ng, Sanjay Mel
    American Journal of Hematology.2021; 96(11): 1541.     CrossRef
  • Epstein Barr Virus: Development of Vaccines and Immune Cell Therapy for EBV-Associated Diseases
    Xinle Cui, Clifford M. Snapper
    Frontiers in Immunology.2021;[Epub]     CrossRef
  • Recent Advances in Diagnosis and Therapy of Angioimmunoblastic T Cell Lymphoma
    Mostafa F. Mohammed Saleh, Ahmed Kotb, Ghada E. M. Abdallah, Ibrahim N. Muhsen, Riad El Fakih, Mahmoud Aljurf
    Current Oncology.2021; 28(6): 5480.     CrossRef
  • Intestinal ulcers as an initial finding in EBV-associated lymphoproliferative disorder
    Sizhu Wang, Yinghuan Dai, Jie Zhang, Dalian Ou, Chunhui Ouyang, Fanggen Lu
    Medicine.2020; 99(3): e18764.     CrossRef
  • Microbes as Master Immunomodulators: Immunopathology, Cancer and Personalized Immunotherapies
    Joana R. Lérias, Georgia Paraschoudi, Eric de Sousa, João Martins, Carolina Condeço, Nuno Figueiredo, Carlos Carvalho, Ernest Dodoo, Mireia Castillo-Martin, Antonio Beltrán, Dário Ligeiro, Martin Rao, Alimuddin Zumla, Markus Maeurer
    Frontiers in Cell and Developmental Biology.2020;[Epub]     CrossRef
  • Epstein Barr Virus-associated Pediatric Neoplasms
    Mozhgan Hashemieh, Fariba Shirvani
    Archives of Pediatric Infectious Diseases.2020;[Epub]     CrossRef
  • Novel IRF8 and PD-L1 molecular aberrations in systemic EBV-positive T-cell lymphoma of childhood
    Atif Saleem, Rohan Joshi, Li Lei, Lhara Lezama, Shyam S. Raghavan, Nastaran Neishaboori, Mohana Roy, Joe Schroers-Martin, Gregory W. Charville, Christian Kunder, Brent Tan, Beth A. Martin, Yasodha Natkunam
    Human Pathology: Case Reports.2020; 19: 200356.     CrossRef
  • Fatal SARS-CoV-2 coinfection in course of EBV-associated lymphoproliferative disease
    Luca Roncati, Beatrice Lusenti, Vincenzo Nasillo, Antonio Manenti
    Annals of Hematology.2020; 99(8): 1945.     CrossRef
  • Epstein-Barr Virus and the Eye
    Emmett T. Cunningham, Manfred Zierhut
    Ocular Immunology and Inflammation.2020; 28(4): 533.     CrossRef
  • An atypical systemic form of chronic active EBV infection
    Neha Gupta, Adam Bagg
    Leukemia & Lymphoma.2020; 61(12): 3030.     CrossRef
  • A Shared TCR Bias toward an Immunogenic EBV Epitope Dominates in HLA-B*07:02–Expressing Individuals
    Louise C. Rowntree, Thi H. O. Nguyen, Carine Farenc, Hanim Halim, Luca Hensen, Jamie Rossjohn, Tom C. Kotsimbos, Anthony W. Purcell, Katherine Kedzierska, Stephanie Gras, Nicole A. Mifsud
    The Journal of Immunology.2020; 205(6): 1524.     CrossRef
  • Chronic active Epstein–Barr virus infection manifesting as coronary artery aneurysm and uveitis
    Haijuan Xiao, Bing Hu, Rongmu Luo, Huili Hu, Junmei Zhang, Weiying Kuang, Rui Zhang, Li Li, Gang Liu
    Virology Journal.2020;[Epub]     CrossRef
  • Epstein-Barr Virus (EBV)-induced B-cell Lymphoproliferative Disorder Mimicking the Recurrence of EBV-associated Hemophagocytic Lymphohistiocytosis
    Yuki Yatsushiro, Takuro Nishikawa, Aki Saito, Yozo Nakazawa, Ken-Ichi Imadome, Shunsuke Nakagawa, Yuichi Kodama, Yasuhiro Okamoto, Hirokazu Kanegane, Yoshifumi Kawano
    Journal of Pediatric Hematology/Oncology.2019; 41(1): e44.     CrossRef
  • Epstein-Barr Virus (EBV)-Related Lymphoproliferative Disorders in Ataxia Telangiectasia: Does ATM Regulate EBV Life Cycle?
    Moussab Tatfi, Olivier Hermine, Felipe Suarez
    Frontiers in Immunology.2019;[Epub]     CrossRef
  • The factors associated with the early diagnosis of nasal NK/T-cell lymphoma with prominent ocular symptoms and general nasal NKTL
    Zhen zhen Hu, Ying Wang
    American Journal of Otolaryngology.2019; 40(3): 353.     CrossRef
  • Unusual lymphoid malignancy and treatment response in two children with Down syndrome
    Ashley Geerlinks, Jennifer Keis, Bo Ngan, Amer Shammas, Reza Vali, Johann Hitzler
    Pediatric Blood & Cancer.2019;[Epub]     CrossRef
  • Extreme Peripheral Blood Plasmacytosis Mimicking Plasma Cell Leukemia as a Presenting Feature of Angioimmunoblastic T-Cell Lymphoma (AITL)
    Kelsey Sokol, Saritha Kartan, William T. Johnson, Onder Alpdogan, Neda Nikbakht, Bradley M. Haverkos, Jerald Gong, Pierluigi Porcu
    Frontiers in Oncology.2019;[Epub]     CrossRef
  • High-Throughput Sequence Analysis of Peripheral T-Cell Lymphomas Indicates Subtype-Specific Viral Gene Expression Patterns and Immune Cell Microenvironments
    Hani Nakhoul, Zhen Lin, Xia Wang, Claire Roberts, Yan Dong, Erik Flemington, Blossom Damania
    mSphere.2019;[Epub]     CrossRef
  • Quercetin Interrupts the Positive Feedback Loop Between STAT3 and IL-6, Promotes Autophagy, and Reduces ROS, Preventing EBV-Driven B Cell Immortalization
    Granato, Gilardini Montani, Zompetta, Santarelli, Gonnella, Romeo, D’Orazi, Faggioni, Cirone
    Biomolecules.2019; 9(9): 482.     CrossRef
  • Diffuse Large B-Cell Lymphoma Arising within Ileal Neobladder: An Expanding Spectrum of Diffuse Large B-Cell Lymphoma Associated with Chronic Inflammation
    Hyekyung Lee, Hyunbin Shin, Nae Yu Kim, Hyun Sik Park, Jinsung Park
    Cancer Research and Treatment.2019; 51(4): 1666.     CrossRef
  • EBV-associated lymphoproliferative disorder involving the gastrointestinal tract which mimic IBD in immunocompetent patients: case reports and literature review
    Yanhua Zhou, Yanlin Zhang, Haiying Zhao, Xuan Cui, Yongqiu Wei, Yongdong Wu, Shutian Zhang, Ye Zong
    International Journal of Colorectal Disease.2019; 34(11): 1989.     CrossRef
  • Mechanistic Insights into Chemoresistance Mediated by Oncogenic Viruses in Lymphomas
    Jungang Chen, Samantha Kendrick, Zhiqiang Qin
    Viruses.2019; 11(12): 1161.     CrossRef
  • Rapidly Fatal Encephalitis Associated with Atypical Lymphoid Proliferations of the Basal Ganglia Subsequent to Aneurysmal Subarachnoid Hemorrhage
    Ayesha Kar, Evin L. Guilliams, Joshua A. Cuoco, Eric A. Marvin
    Clinics and Practice.2019; 9(4): 1187.     CrossRef
  • Clinicopathologic features of adult EBV-associated B-cell lymphoproliferative disease
    Sonja Wörner, Hans-Konrad Mueller-Hermelink, Hans-Ullrich Voelker
    Pathology - Research and Practice.2018; 214(2): 207.     CrossRef
  • Primary Intestinal Epstein–Barr Virus-associated Natural Killer/T-cell Lymphoproliferative Disorder: A Disease Mimicking Inflammatory Bowel Disease
    Zhujun Wang, Wenyan Zhang, Chengxin Luo, Min Zhu, Yu Zhen, Jingxi Mu, Yan Zhang, Renwei Hu, Yufang Wang, Zhonghui Wen, Qin Ouyang, Shuyuan Xiao, Hu Zhang
    Journal of Crohn's and Colitis.2018; 12(8): 896.     CrossRef
  • Downregulation of CD5 and dysregulated CD8+T-cell activation
    Taizo Wada
    Pediatrics International.2018; 60(9): 776.     CrossRef
  • Chronic active Epstein-Barr virus infection of T-cell type, systemic form in an African migrant: case report and review of the literature on diagnostics standards and therapeutic options
    Maxi Wass, Marcus Bauer, Roald Pfannes, Kerstin Lorenz, Andreas Odparlik, Lutz P Müller, Claudia Wickenhauser
    BMC Cancer.2018;[Epub]     CrossRef
  • Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1/2 inhibitor therapy
    Edit Porpaczy, Sabrina Tripolt, Andrea Hoelbl-Kovacic, Bettina Gisslinger, Zsuzsanna Bago-Horvath, Emilio Casanova-Hevia, Emmanuelle Clappier, Thomas Decker, Sabine Fajmann, Daniela A. Fux, Georg Greiner, Sinan Gueltekin, Gerwin Heller, Harald Herkner, Gr
    Blood.2018; 132(7): 694.     CrossRef
  • Gammaherpesviral infections in patients with immunological disorders
    Anna Żuk-Wasek, Maciej Przybylski, Natalia Żeber, Grażyna Młynarczyk, Tomasz Dzieciątkowski
    Postępy Mikrobiologii - Advancements of Microbiology.2018; 57(2): 145.     CrossRef
    N. G. Chernova, D. S. Tihomirov, N. P. Soboleva, S. A. Mariina, Y. V. Sidorova, M. N. Sinitsyna, V. N. Dvirnyk, S. M. Kulikov, T. A. Tupoleva, E. E. Zvonkov
    Problems of Virology.2018; 63(4): 171.     CrossRef
Evaluation of the VE1 Antibody in Thyroid Cytology Using Ex Vivo Papillary Thyroid Carcinoma Specimens
Yon Hee Kim, Hyunee Yim, Yong-Hee Lee, Jae Ho Han, Kyi Beom Lee, Jeonghun Lee, Euy Young Soh, Seon-Yong Jeong, Jang-Hee Kim
J Pathol Transl Med. 2016;50(1):58-66.   Published online December 14, 2015
  • 8,504 View
  • 70 Download
  • 8 Citations
AbstractAbstract PDF
Recently, VE1, a monoclonal antibody against the BRAFV600E mutant protein, has been investigated in terms of its detection of the BRAFV600E mutation. Although VE1 immunostaining and molecular methods used to assess papillary thyroid carcinoma in surgical specimens are in good agreement, evaluation of VE1 in thyroid cytology samples is rarely performed, and its diagnostic value in cytology has not been well established. In present study, we explored VE1 immunoexpression in cytology samples from ex vivo papillary thyroid carcinoma specimens in order to minimize limitations of low cellularity and sampling/targeting errors originated from thyroid fineneedle aspiration and compared our results with those obtained using the corresponding papillary thyroid carcinoma tissues. Methods: The VE1 antibody was evaluated in 21 cases of thyroid cytology obtained directly from ex vivo thyroid specimens. VE1 immunostaining was performed using liquid-based cytology, and the results were compared with those obtained using the corresponding tissues. Results: Of 21 cases, 19 classic papillary thyroid carcinomas had BRAFV600E mutations, whereas two follicular variants expressed wild-type BRAF. VE1 immunoexpression varied according to specimen type. In detection of the BRAFV600E mutation, VE1 immunostaining of the surgical specimen exhibited 100% sensitivity and 100% specificity, whereas VE1 immunostaining of the cytology specimen exhibited only 94.7% sensitivity and 0% specificity. Conclusions: Our data suggest that VE1 immunostaining of a cytology specimen is less specific than that of a surgical specimen for detection of the BRAFV600E mutation, and that VE1 immunostaining of a cytology specimen should be further evaluated and optimized for clinical use.


Citations to this article as recorded by  
  • VE1 immunohistochemistry is an adjunct tool for detection of BRAF V600E mutation: Validation in thyroid cancer patients
    Faiza A. Rashid, Sobia Tabassum, Mosin S. Khan, Hifzur R. Ansari, Muhammad Asif, Ahmareen K. Sheikh, Syed Aga
    Journal of Clinical Laboratory Analysis.2021;[Epub]     CrossRef
  • Effective utilization of liquid-based cytology for thyroid lesions
    Yukie YAMAYA
    The Journal of the Japanese Society of Clinical Cytology.2021; 60(3): 164.     CrossRef
  • Diagnostic efficacy of brafv600e immunocytochemistry in thyroid aspirates in bethesda category iv and papillary thyroid carcinoma
    Nidhi Anand, Tushar Agrawal, Anurag Gupta, Saumya Shukla, Roma Pradhan, Nuzhat Husain
    Journal of Cytology.2021; 38(3): 113.     CrossRef
  • The immunocytochemical expression ofVE‐1 (BRAFV600E‐related) antibody identifies the aggressive variants of papillary thyroid carcinoma on liquid‐based cytology
    Patrizia Straccia, Chiara Brunelli, Esther D. Rossi, Paola Lanza, Maurizio Martini, Teresa Musarra, Celestino Pio Lombardi, Alfredo Pontecorvi, Guido Fadda
    Cytopathology.2019; 30(5): 460.     CrossRef
  • Utility of the BRAF p.V600E immunoperoxidase stain in FNA direct smears and cell block preparations from patients with thyroid carcinoma
    Amber L. Smith, Michelle D. Williams, John Stewart, Wei-Lien Wang, Savitri Krishnamurthy, Maria E. Cabanillas, Sinchita Roy-Chowdhuri
    Cancer Cytopathology.2018; 126(6): 406.     CrossRef
  • Refinement of the criteria for ultrastructural peritubular capillary basement membrane multilayering in the diagnosis of chronic active/acute antibody-mediated rejection
    Heounjeong Go, Sung Shin, Young Hoon Kim, Duck Jong Han, Yong Mee Cho
    Transplant International.2017; 30(4): 398.     CrossRef
  • Thyroid Fine-Needle Aspiration Cytology Practice in Korea
    Yoon Jin Cha, Ju Yeon Pyo, SoonWon Hong, Jae Yeon Seok, Kyung-Ju Kim, Jee-Young Han, Jeong Mo Bae, Hyeong Ju Kwon, Yeejeong Kim, Kyueng-Whan Min, Soonae Oak, Sunhee Chang
    Journal of Pathology and Translational Medicine.2017; 51(6): 521.     CrossRef
  • Use of monoclonal antibodies to detect specific mutations in formalin-fixed, paraffin-embedded tissue sections
    Zhenying Guo, Ricardo V. Lloyd
    Human Pathology.2016; 53: 168.     CrossRef
Primary Gastric Histiocytic Sarcoma Reminiscent of Inflammatory Pseudotumor: A Case Report with Review of the Literature
Dakeun Lee, Young-Bae Kim, Sook Hee Chung, Sang-Ryung Lee, Cheul Su Byun, Sang-Uk Han, Jae Ho Han
Korean J Pathol. 2014;48(3):258-262.   Published online June 26, 2014
  • 6,117 View
  • 35 Download
  • 3 Citations


Citations to this article as recorded by  
  • Small bowel and lung histiocytic sarcoma revealed by acute peritonitis: A case report with review of literature
    Ahlem Bellalah, Ibtissem korbi, Seifeddine Ben Hammouda, Asma Achour, Nouha Ben Abdeljelil, Manel Njima, Amira Daldoul, Rim Hadhri, Leila Njim, Abdelfatteh Zakhama
    Annals of Medicine and Surgery.2021; 68: 102638.     CrossRef
  • An unexpected diagnosis of histiocytic sarcoma
    Joshua T. Byers, Samuel W. French
    Experimental and Molecular Pathology.2019; 106: 60.     CrossRef
  • NLRX1 suppresses tumorigenesis and attenuates histiocytic sarcoma through the negative regulation of NF-λB signaling
    Sheryl Coutermarsh-Ott, Alysha Simmons, Vittoria Capria, Tanya LeRoith, Justin E. Wilson, Bettina Heid, Casandra W. Philipson, Qizhi Qin, Raquel Hontecillas-Magarzo, Josep Bassaganya-Riera, Jenny P-Y Ting, Nikolaos Dervisis, Irving C. Allen
    Oncotarget.2016; 7(22): 33096.     CrossRef
Characteristics of Cutaneous Lymphomas in Korea According to the New WHO-EORTC Classification: Report of a Nationwide Study
Jae Ho Han, Young-Hyeh Ko, Yun Kyung Kang, Wan-Seop Kim, Yoon Jung Kim, Insun Kim, Hyun-Jung Kim, Soo Kee Min, Chan-Kum Park, Chan-Sik Park, Bong-Kyung Shin, Woo Ick Yang, Young-Ha Oh, Jong Sil Lee, Juhie Lee, Tae Hui Lee, Hyekyung Lee, Ho Jung Lee, Yoon Kyung Jeon, Hee Jeong Cha, Yoo-Duk Choi, Chul Woo Kim
Korean J Pathol. 2014;48(2):126-132.   Published online April 28, 2014
  • 7,381 View
  • 77 Download
  • 11 Citations
AbstractAbstract PDF

Previously, cutaneous lymphomas were classified according to either the European Organization for the Research and Treatment of Cancer (EORTC) or the World Health Organization (WHO) classification paradigms. The aim of this study was to determine the relative frequency of Korean cutaneous lymphoma according to the new WHO-EORTC classification system.


A total of 517 patients were recruited during a recent 5 year-period (2006-2010) from 21 institutes and classified according to the WHO-EORTC criteria.


The patients included 298 males and 219 females, and the mean age at diagnosis was 49 years. The lesions preferentially affected the trunk area (40.2%). The most frequent subtypes in order of decreasing prevalence were mycosis fungoides (22.2%), peripheral T-cell lymphoma (17.2%), CD30+ T-cell lymphoproliferative disorder (13.7%), and extranodal natural killer/T (NK/T) cell lymphoma, nasal type (12.0%). Diffuse large B-cell lymphoma accounted for 11.2% of cases, half of which were secondary cutaneous involvement; other types of B-cell lymphoma accounted for less than 1% of cases.


In comparison with data from Western countries, this study revealed relatively lower rates of mycosis fungoides and B-cell lymphoma in Korean patients, as well as higher rates of subcutaneous panniculitis-like T-cell lymphoma and NK/T cell lymphoma.


Citations to this article as recorded by  
  • The First Case of Acute Myeloid Leukemia With t(10;11)(p13;q21);PICALM-MLLT10 Rearrangement Presenting With Extensive Skin Involvement
    Min-Seung Park, Hyun-Young Kim, Jae Joon Lee, Duck Cho, Chul Won Jung, Hee-Jin Kim, Sun-Hee Kim
    Annals of Laboratory Medicine.2023; 43(3): 310.     CrossRef
  • Recent advances on cutaneous lymphoma epidemiology
    G. Dobos, M. Miladi, L. Michel, C. Ram-Wolff, M. Battistella, M. Bagot, A. de Masson
    La Presse Médicale.2022; 51(1): 104108.     CrossRef
  • Specific cutaneous infiltrates in patients with haematological neoplasms: a retrospective study with 49 patients
    Rebeca Calado, Maria Relvas, Francisca Morgado, José Carlos Cardoso, Oscar Tellechea
    Australasian Journal of Dermatology.2021;[Epub]     CrossRef
  • Epidemiology of Cutaneous T-Cell Lymphomas: A Systematic Review and Meta-Analysis of 16,953 Patients
    Gabor Dobos, Anne Pohrt, Caroline Ram-Wolff, Céleste Lebbé, Jean-David Bouaziz, Maxime Battistella, Martine Bagot, Adèle de Masson
    Cancers.2020; 12(10): 2921.     CrossRef
  • Primary cutaneous lymphoma in Argentina: a report of a nationwide study of 416 patients
    Alejandra Abeldaño, Paula Enz, Matias Maskin, Andrea B. Cervini, Natallia Torres, Ana C. Acosta, Marina Narbaitz, Silvia Vanzulli, Mirta Orentrajch, Marta A. Villareal, Maria L. Garcia Pazos, Mariana Arias, Evelyn A. Zambrano Franco, Maria I. Fontana, Rob
    International Journal of Dermatology.2019; 58(4): 449.     CrossRef
  • Post-thymic CD4 positive cytotoxic T cell infiltrates of the skin: A clinical and histomorphologic spectrum of the unique CD4 positive T cell of immunosenescence
    Cynthia M. Magro, Luke C. Olson, Shabnam Momtahen
    Annals of Diagnostic Pathology.2019; 38: 99.     CrossRef
  • Cutaneous lymphomas in Taiwan: A review of 118 cases from a medical center in southern Taiwan
    Chaw-Ning Lee, Chao-Kai Hsu, Kung-Chao Chang, Cheng-Lin Wu, Tsai-Yun Chen, Julia Yu-Yun Lee
    Dermatologica Sinica.2018; 36(1): 16.     CrossRef
  • Imaging analysis of superficial soft tissue lymphomas
    In Sook Lee, You Seon Song, Seung Hyun Lee, Young Jin Choi, Sung Moon Lee
    Clinical Imaging.2018; 49: 111.     CrossRef
  • Epidemiologic, clinical and demographic features of primary cutaneous lymphomas in Castilla-La Mancha, Spain: are we different?
    C. Ramos-Rodríguez, M. García-Rojo, G. Romero-Aguilera, M. García-Arpa, L. González-López, M.P. Sánchez-Caminero, J. González-García, M. Delgado-Portela, M.P. Cortina-De La Calle, M.F. Relea-Calatayud, F. Martín-Dávila, R. López-Pérez, M. Ramos-Rodríguez
    Journal of the European Academy of Dermatology and Venereology.2018; 32(5): e168.     CrossRef
  • Nasal-type NK/T-cell lymphomas are more frequently T rather than NK lineage based on T-cell receptor gene, RNA, and protein studies: lineage does not predict clinical behavior
    Mineui Hong, Taehee Lee, So Young Kang, Suk-Jin Kim, Wonseog Kim, Young-Hyeh Ko
    Modern Pathology.2016; 29(5): 430.     CrossRef
  • Cutaneous lymphoma: Kids are not just little people
    Katalin Ferenczi, Hanspaul S. Makkar
    Clinics in Dermatology.2016; 34(6): 749.     CrossRef

JPTM : Journal of Pathology and Translational Medicine