Skip Navigation
Skip to contents

JPTM : Journal of Pathology and Translational Medicine


Author index

Page Path
HOME > Articles and issues > Author index
Jin Won Hyun 1 Article
Aurora Kinase A Is a Prognostic Marker in Colorectal Adenocarcinoma
Hyun Min Koh, Bo Geun Jang, Chang Lim Hyun, Young Sill Kim, Jin Won Hyun, Weon Young Chang, Young Hee Maeng
J Pathol Transl Med. 2017;51(1):32-39.   Published online December 25, 2016
  • 7,655 View
  • 175 Download
  • 20 Citations
AbstractAbstract PDF
Aurora kinase A (AURKA), or STK15/BTAK, is a member of the serine/threonine kinase family and plays important roles in mitosis and chromosome stability. This study investigated the clinical significance of AURKA expression in colorectal cancer patients in Korea.
AURKA protein expression was evaluated by immunohistochemistry in 151 patients with colorectal adenocarcinoma using tissue microarray blocks. We analyzed the relationship between clinicopathological characteristics and AURKA expression. In addition, the prognostic significance of various clinicopathological data for progression-free survival (PFS) was assessed. Also we evaluated copy number variations by array comparative genomic hybridization and AURKA gene amplification using fluorescence in situ hybridization in colorectal carcinoma tissues.
AURKA gene amplification was found more frequently in the 20q13.2–13.33 gain-positive group than the group with no significant gain on the AURKA-containing locus. AURKA protein expression was detected in 45% of the cases (68/151). Positive staining for AURKA was observed more often in male patients (p = .035) and distally located tumors (p = .021). PFS was shorter in patients with AURKA expression compared to those with low-level AURKA expression (p < .001). Univariate analysis revealed that AURKA expression (p = .001), age (p = .034), lymphatic invasion (p = .001), perineural invasion (p = .002), and TNM stage (p = .013) significantly affected PFS. In a multivariate analysis of PFS, a Cox proportional hazard model confirmed that AURKA expression was an independent and significant prognostic factor in colorectal adenocarcinoma (hazard ratio, 3.944; p < .001).
AURKA could serve as an independent factor to predict a poor prognosis in Korean colorectal adenocarcinoma patients.


Citations to this article as recorded by  
  • Exploring Core Genes by Comparative Transcriptomics Analysis for Early Diagnosis, Prognosis, and Therapies of Colorectal Cancer
    Md. Ariful Islam, Md. Bayazid Hossen, Md. Abu Horaira, Md. Alim Hossen, Md. Kaderi Kibria, Md. Selim Reza, Khanis Farhana Tuly, Md. Omar Faruqe, Firoz Kabir, Rashidul Alam Mahumud, Md. Nurul Haque Mollah
    Cancers.2023; 15(5): 1369.     CrossRef
  • Disease Modeling on Tumor Organoids Implicates AURKA as a Therapeutic Target in Liver Metastatic Colorectal Cancer
    Sophie L. Boos, Leon P. Loevenich, Sebastian Vosberg, Thomas Engleitner, Rupert Öllinger, Jörg Kumbrink, Matjaz Rokavec, Marlies Michl, Philipp A. Greif, Andreas Jung, Heiko Hermeking, Jens Neumann, Thomas Kirchner, Roland Rad, Peter Jung
    Cellular and Molecular Gastroenterology and Hepatology.2022; 13(2): 517.     CrossRef
  • Colorectal cancer on a dish: exploring the 3D-sphere culture of primary colorectal cancer cells from an Indonesian perspective
    Murdani Abdullah, DR Noor, Amanda Pitarini Utari, Virly Nanda Muzellina, Nur Rahadiani, Radiana Dhewayani Antarianto
    F1000Research.2022; 11: 182.     CrossRef
  • Mitotic protein kinase-driven crosstalk of machineries for mitosis and metastasis
    Chang-Hyeon Kim, Da-Eun Kim, Dae-Hoon Kim, Ga-Hong Min, Jung-Won Park, Yeo-Bin Kim, Chang K. Sung, Hyungshin Yim
    Experimental & Molecular Medicine.2022; 54(4): 414.     CrossRef
  • AURKA is a prognostic biomarker for good overall survival in stage II colorectal cancer patients
    Peter Jung, David Horst, Thomas Kirchner, Frederick Klauschen, Jens Neumann
    Pathology - Research and Practice.2022; 235: 153936.     CrossRef
  • Therapeutic Potential of Mitotic Kinases’ Inhibitors in Cancers of the Gastrointestinal System
    Aadil Javed, Gianluca Malagraba, Mahdieh Yarmohammadi, Catalina M. Perelló-Reus, Carles Barceló, Teresa Rubio-Tomás
    Future Pharmacology.2022; 2(3): 214.     CrossRef
  • Bioinformatics Analysis of RNA-seq Data Reveals Genes Related to Cancer Stem Cells in Colorectal Cancerogenesis
    Kristian Urh, Nina Zidar, Emanuela Boštjančič
    International Journal of Molecular Sciences.2022; 23(21): 13252.     CrossRef
  • Unweaving the mitotic spindle: A focus on Aurora kinase inhibitors in lung cancer
    Alessio Stefani, Geny Piro, Francesco Schietroma, Alessandro Strusi, Emanuele Vita, Simone Fiorani, Diletta Barone, Federico Monaca, Ileana Sparagna, Giustina Valente, Miriam Grazia Ferrara, Ettore D’Argento, Mariantonietta Di Salvatore, Carmine Carbone,
    Frontiers in Oncology.2022;[Epub]     CrossRef
  • Increased expression levels of AURKA and KIFC1 are promising predictors of progression and poor survival associated with gastric cancer
    Jiyoon Jung, Hoiseon Jeong, Jung-Woo Choi, Hye-Sun Kim, Hwa Eun Oh, Eung Seok Lee, Young-Sik Kim, Ju-Han Lee
    Pathology - Research and Practice.2021; 224: 153524.     CrossRef
  • SALL Proteins; Common and Antagonistic Roles in Cancer
    Claudia Álvarez, Aracelly Quiroz, Diego Benítez-Riquelme, Elizabeth Riffo, Ariel F. Castro, Roxana Pincheira
    Cancers.2021; 13(24): 6292.     CrossRef
  • AURKA gene polymorphisms and central nervous system tumor susceptibility in Chinese children
    Yong-Ping Chen, Li Yuan, Hui-Ran Lin, Xiao-Kai Huang, Ji-Chen Ruan, Zhen-Jian Zhuo
    Discover Oncology.2021;[Epub]     CrossRef
  • Palmatine induces G2/M phase arrest and mitochondrial-associated pathway apoptosis in colon cancer cells by targeting AURKA
    Xiaojiang Liu, Yaru Zhang, Siqi Wu, Minmin Xu, Youfeng Shen, Min Yu, Jinhua Fan, Sijia Wei, Chaohang Xu, Lu Huang, Han Zhao, Xuegang Li, Xiaoli Ye
    Biochemical Pharmacology.2020; 175: 113933.     CrossRef
  • New landscapes and horizons in hepatocellular carcinoma therapy
    Melchiorre Cervello, Maria R. Emma, Giuseppa Augello, Antonella Cusimano, Lydia Giannitrapani, Maurizio Soresi, Shaw M. Akula, Stephen L. Abrams, Linda S. Steelman, Alessandro Gulino, Beatrice Belmonte, Giuseppe Montalto, James A. McCubrey
    Aging.2020; 12(3): 3053.     CrossRef
  • The New Paradigm of Network Medicine to Analyze Breast Cancer Phenotypes
    Anna Maria Grimaldi, Federica Conte, Katia Pane, Giulia Fiscon, Peppino Mirabelli, Simona Baselice, Rosa Giannatiempo, Francesco Messina, Monica Franzese, Marco Salvatore, Paola Paci, Mariarosaria Incoronato
    International Journal of Molecular Sciences.2020; 21(18): 6690.     CrossRef
  • The GTEx Consortium atlas of genetic regulatory effects across human tissues
    François Aguet, Shankara Anand, Kristin G. Ardlie, Stacey Gabriel, Gad A. Getz, Aaron Graubert, Kane Hadley, Robert E. Handsaker, Katherine H. Huang, Seva Kashin, Xiao Li, Daniel G. MacArthur, Samuel R. Meier, Jared L. Nedzel, Duyen T. Nguyen, Ayellet V.
    Science.2020; 369(6509): 1318.     CrossRef
  • Upregulation of aurora kinase A promotes vascular smooth muscle cell proliferation and migration by activating the GSK-3β/β-catenin pathway in aortic-dissecting aneurysms
    Jia Meng, He-Liang Liu, Dong Ma, Hong-Yan Wang, Yue Peng, Hong-Li Wang
    Life Sciences.2020; 262: 118491.     CrossRef
  • Inhibition of AURKA Reduces Proliferation and Survival of Gastrointestinal Cancer Cells With Activated KRAS by Preventing Activation of RPS6KB1
    Lihong Wang-Bishop, Zheng Chen, Ahmed Gomaa, Albert Craig Lockhart, Safia Salaria, Jialiang Wang, Keeli B. Lewis, Jeffrey Ecsedy, Kay Washington, Robert Daniel Beauchamp, Wael El-Rifai
    Gastroenterology.2019; 156(3): 662.     CrossRef
  • Discovery and Validation of Novel Biomarkers for Detection of Epithelial Ovarian Cancer
    Kulbe, Otto, Darb-Esfahani, Lammert, Abobaker, Welsch, Chekerov, Schäfer, Dragun, Hummel, Leser, Sehouli, Braicu
    Cells.2019; 8(7): 713.     CrossRef
  • Epigenetic regulation of AURKA by miR-4715-3p in upper gastrointestinal cancers
    Ahmed Gomaa, Dunfa Peng, Zheng Chen, Mohammed Soutto, Khaled Abouelezz, Alejandro Corvalan, Wael El-Rifai
    Scientific Reports.2019;[Epub]     CrossRef
  • The functional diversity of Aurora kinases: a comprehensive review
    Estelle Willems, Matthias Dedobbeleer, Marina Digregorio, Arnaud Lombard, Paul Noel Lumapat, Bernard Rogister
    Cell Division.2018;[Epub]     CrossRef

JPTM : Journal of Pathology and Translational Medicine