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Joo-Heon Kim 1 Article
Expression of HuR and Cyclooxygenase-2 in Nodular Fasciitis and Low-Grade Sarcoma: An Immunohistochemical Study
Hyun-Jin Son, Tae-Hwa Baek, Seung Yun Lee, Joo-Heon Kim, Dong-Wook Kang, Hye-Kyung Lee, Mee-Ja Park
Korean J Pathol. 2014;48(4):270-275.   Published online August 26, 2014
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AbstractAbstract PDF

Nodular fasciitis is the most common reactive mesenchymal lesion to be misidentified as a type of sarcoma. HuR is an mRNA-binding protein that can stabilize cyclooxygenase-2 (COX-2) mRNA leading to COX-2 overexpression. The aim of this study is a comparison of the expressions of COX-2 and HuR and the relationships between their expressions and the clinicopathological parameters in nodular fasciitis and low-grade sarcoma.


We measured the expression of HuR and COX-2 in 21 cases of nodular fasciitis and 37 cases of low-grade sarcoma using immunohistochemistry.


The frequency of cytoplasmic immunoreactivity for HuR was 5 of 21 cases of nodular fasciitis (23.8%) and 23 of 37 cases of low-grade sarcoma (62.1%) (p=.013). COX-2 expression was moderate or strong in nodular fasciitis (12/21, 57.1%) and in low-grade sarcoma (29/37, 78.4%) (p=.034). In addition, a significant difference existed between these two entities in terms of the relationship between moderate or strong COX-2 expression and HuR cytoplasmic immunoreactivity (p=.009). Moderate or strong COX-2 immunoreactivity correlated with nuclear (p=.016) or cytoplasmic HuR (p=.024) expression in low-grade sarcoma but not in nodular fasciitis.


This study suggests that HuR and COX-2 expression may be useful to differentiate nodular fasciitis from low-grade sarcoma.


Citations to this article as recorded by  
  • Nodular fasciitis of the anterior chest wall mimicking myxofibrosarcoma: A case report and literature review
    Antonino Cattafi, Mariarosaria Galeano, Pietro Pitrone, Carmelo Sofia, Maria Adele Marino, Giorgio Ascenti, Maria Lentini, Antonio Ieni, Roberta Cardia, Alfio Luca Costa, Dario Familiari, Mario Barone, Francesco Monaco, Michele Rosario Colonna
    Radiology Case Reports.2021; 16(6): 1557.     CrossRef

JPTM : Journal of Pathology and Translational Medicine