- Acute Atherosis of the Uterine Spiral Arteries: Clinicopathologic Implications
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Joo-Yeon Kim, Yeon Mee Kim
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J Pathol Transl Med. 2015;49(6):462-471. Published online November 4, 2015
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DOI: https://doi.org/10.4132/jptm.2015.10.23
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Abstract
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- Acute atherosis is unique vascular changes of the placenta associated with poor placentation. It is characterized by subendothelial lipid-filled foam cells, fibrinoid necrosis of the arterial wall, perivascular lymphocytic infiltration, and it is histologically similar to early-stage atherosclerosis. Acute atherosis is rare in normal pregnancies, but is frequently observed in non- transformed spiral arteries in abnormal pregnancies, such as preeclampsia, small for gestational age (SGA), fetal death, spontaneous preterm labor and preterm premature rupture of membranes. In preeclampsia, spiral arteries fail to develop physiologic transformation and retain thick walls and a narrow lumen. Failure of physiologic transformation of spiral arteries is believed to be the main cause of uteroplacental ischemia, which can lead to the production of anti-angiogenic factors and induce endothelial dysfunction and eventually predispose the pregnancy to preeclampsia. Acute atherosis is more frequently observed in the spiral arteries of the decidua of the placenta (parietalis or basalis) than in the decidual or myometrial segments of the placental bed. The presence and deeper location of acute atherosis is associated with poorer pregnancy outcomes, more severe disease, earlier onset of preeclampsia, and a greater frequency of SGA neonates in patients with preeclampsia. Moreover, the idea that the presence of acute atherosis in the placenta may increase the risk of future cardiovascular disease in women with a history of preeclampsia is of growing concern. Therefore, placental examination is crucial for retrospective investigation of pregnancy complications and outcomes, and accurate placental pathology based on universal diagnostic criteria in patients with abnormal pregnancies is essential for clinicopathologic correlation.
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Citations
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Laura A. Woollett, Janet M. Catov, Helen N. Jones Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2022; 1867(3): 159106. CrossRef - The role of the placenta in spontaneous preterm labor and delivery with intact membranes
Sunil Jaiman, Roberto Romero, Gaurav Bhatti, Eunjung Jung, Francesca Gotsch, Manaphat Suksai, Dahiana M. Gallo, Tinnakorn Chaiworapongsa, Nicholas Kadar Journal of Perinatal Medicine.2022; 50(5): 553. CrossRef - Gestational Antibodies to C. pneumoniae, H. pylori and CMV in Women with Preeclampsia and in Matched Controls
Abdul Wajid, David Todem, Mark R. Schleiss, David F. Colombo, Nigel S. Paneth Maternal and Child Health Journal.2022; 26(10): 2040. CrossRef - Toward a new taxonomy of obstetrical disease: improved performance of maternal blood biomarkers for the great obstetrical syndromes when classified according to placental pathology
Roberto Romero, Eunjung Jung, Tinnakorn Chaiworapongsa, Offer Erez, Dereje W. Gudicha, Yeon Mee Kim, Jung-Sun Kim, Bomi Kim, Juan Pedro Kusanovic, Francesca Gotsch, Andreea B. Taran, Bo Hyun Yoon, Sonia S. Hassan, Chaur-Dong Hsu, Piya Chaemsaithong, Nardh American Journal of Obstetrics and Gynecology.2022; 227(4): 615.e1. CrossRef - Preeclampsia and Fetal Growth Restriction as Risk Factors of Future Maternal Cardiovascular Disease—A Review
Sylwia Sławek-Szmyt, Katarzyna Kawka-Paciorkowska, Aleksandra Ciepłucha, Maciej Lesiak, Mariola Ropacka-Lesiak Journal of Clinical Medicine.2022; 11(20): 6048. CrossRef - The Role of NF-κB in Uterine Spiral Arteries Remodeling, Insight into the Cornerstone of Preeclampsia
Maciej W. Socha, Bartosz Malinowski, Oskar Puk, Mateusz Wartęga, Martyna Stankiewicz, Anita Kazdepka-Ziemińska, Michał Wiciński International Journal of Molecular Sciences.2021; 22(2): 704. CrossRef - Pathogenesis of uteroplacental acute atherosis: An update on current research
Shu Li, Yan‐Wei Hu American Journal of Reproductive Immunology.2021;[Epub] CrossRef - Disorders of placental villous maturation are present in one-third of cases with spontaneous preterm labor
Sunil Jaiman, Roberto Romero, Percy Pacora, Offer Erez, Eunjung Jung, Adi L. Tarca, Gaurav Bhatti, Lami Yeo, Yeon Mee Kim, Chong Jai Kim, Jung-Sun Kim, Faisal Qureshi, Suzanne M. Jacques, Nardhy Gomez-Lopez, Chaur-Dong Hsu Journal of Perinatal Medicine.2021; 49(4): 412. CrossRef - The COVID-19 Pandemic: an Appraisal of its Impact on Human Immunodeficiency Virus Infection and Pre-Eclampsia
Rowen Govender, Jagidesa Moodley, Thajasvarie Naicker Current Hypertension Reports.2021;[Epub] CrossRef - Acute Atherosis Lesions at the Fetal-Maternal Border: Current Knowledge and Implications for Maternal Cardiovascular Health
Daniel Pitz Jacobsen, Heidi Elisabeth Fjeldstad, Guro Mørk Johnsen, Ingrid Knutsdotter Fosheim, Kjartan Moe, Patji Alnæs-Katjavivi, Ralf Dechend, Meryam Sugulle, Anne Cathrine Staff Frontiers in Immunology.2021;[Epub] CrossRef - Aetiology, prophylaxis and management of preeclampsia
Karolina Gronkowska Acta Universitatis Lodziensis. Folia Biologica et Oecologica.2021; 17: 111. CrossRef - HMOX1 is partly responsible for phenotypic and functional abnormalities in mesenchymal stem cells/stromal cells from placenta of preeclampsia (PE) patients
Yasser S. Basmaeil, Dana Algudiri, Reem Alenzi, Abdullah Al Subayyil, Ayodele Alaiya, Tanvir Khatlani Stem Cell Research & Therapy.2020;[Epub] CrossRef - Analyzing Preeclampsia as the Tip of the Iceberg Represented by Women with Long-Term Cardiovascular Disease, Atherosclerosis, and Inflammation
Angélica Lemos Debs Diniz, Maria Marta Bini Martins Paes, Aline Debs Diniz Current Atherosclerosis Reports.2020;[Epub] CrossRef - Lipids in preeclampsia: pathogenic parallels to atherosclerosis
V. I. Shcherbakov, Ya. V. Polonskaya, E. V. Kashtanova, A. V. Shirinskaya "Arterial’naya Gipertenziya" ("Arterial Hypertension").2020; 26(2): 163. CrossRef - Transthyretin increases migration and invasion of rat placental trophoblast cells
Xiao‐Peng Ma, Chong‐Dong Liu, Guang‐Ming Cao, Zhen‐Yu Zhang FEBS Open Bio.2020; 10(8): 1568. CrossRef - Early Onset Preeclampsia Is Associated With Glycocalyx Degradation and Reduced Microvascular Perfusion
Tracey L. Weissgerber, Oscar Garcia‐Valencia, Natasa M. Milic, Elizabeth Codsi, Hajrunisa Cubro, Meryl C. Nath, Wendy M. White, Karl A. Nath, Vesna D. Garovic Journal of the American Heart Association.2019;[Epub] CrossRef - The immunophenotype of decidual macrophages in acute atherosis
Navleen Gill, Yaozhu Leng, Roberto Romero, Yi Xu, Bogdan Panaitescu, Derek Miller, Afrah Arif, Salma Mumuni, Faisal Qureshi, Chaur‐Dong Hsu, Sonia S. Hassan, Anne Cathrine Staff, Nardhy Gomez‐Lopez American Journal of Reproductive Immunology.2019; 81(4): e13098. CrossRef - The potential effects of pomegranate peel extract and bee venom in improving the diabetes induced damaging of spiral artery
HIH El-Sayyad, HA El-Ghawet, AMA El-Sayed Studies on Stem Cells Research and Therapy.2019; 5(1): 007. CrossRef - Race and risk of maternal vascular malperfusion lesions in the placenta
Vanessa Assibey-Mensah, W. Tony Parks, Alison D. Gernand, Janet M. Catov Placenta.2018; 69: 102. CrossRef - Preclinical atherosclerosis at the time of pre-eclamptic pregnancy and up to 10 years postpartum: systematic review and meta-analysis
N. M. Milic, J. Milin-Lazovic, T. L. Weissgerber, G. Trajkovic, W. M. White, V. D. Garovic Ultrasound in Obstetrics & Gynecology.2017; 49(1): 110. CrossRef - Is an episode of suspected preterm labor that subsequently leads to a term delivery benign?
Roberto Romero, Offer Erez, Eli Maymon, Percy Pacora American Journal of Obstetrics and Gynecology.2017; 216(2): 89. CrossRef - Establishment of the Human Uteroplacental Circulation: A Historical Perspective
Kenna Degner, Ronald R. Magness, Dinesh M. Shah Reproductive Sciences.2017; 24(5): 753. CrossRef - Preeclampsia and coronary plaque erosion: Manifestations of endothelial dysfunction resulting in cardiovascular events in women
Saskia C.A. de Jager, John A.L. Meeuwsen, Freeke M. van Pijpen, Gerbrand A. Zoet, Arjan D. Barendrecht, Arie Franx, Gerard Pasterkamp, Bas B. van Rijn, Marie-José Goumans, Hester M. den Ruijter European Journal of Pharmacology.2017; 816: 129. CrossRef - Placental histopathology lesions and pregnancy outcome in pregnancies complicated with symptomatic vs. non-symptomatic placenta previa
Eran Weiner, Hadas Miremberg, Ehud Grinstein, Letizia Schreiber, Shimon Ginath, Jacob Bar, Michal Kovo Early Human Development.2016; 101: 85. CrossRef - Porphyromonas gingivalis within Placental Villous Mesenchyme and Umbilical Cord Stroma Is Associated with Adverse Pregnancy Outcome
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