- Infections and immunity: associations with obesity and related metabolic disorders
-
Amitabha Ray, Melissa J. L. Bonorden, Rajashree Pandit, Katai J. Nkhata, Anupam Bishayee
-
J Pathol Transl Med. 2023;57(1):28-42. Published online January 15, 2023
-
DOI: https://doi.org/10.4132/jptm.2022.11.14
-
-
8,818
View
-
250
Download
-
12
Web of Science
-
17
Crossref
-
 Abstract
 PDF
- About one-fourth of the global population is either overweight or obese, both of which increase the risk of insulin resistance, cardiovascular diseases, and infections. In obesity, both immune cells and adipocytes produce an excess of pro-inflammatory cytokines that may play a significant role in disease progression. In the recent coronavirus disease 2019 (COVID-19) pandemic, important pathological characteristics such as involvement of the renin-angiotensin-aldosterone system, endothelial injury, and pro-inflammatory cytokine release have been shown to be connected with obesity and associated sequelae such as insulin resistance/type 2 diabetes and hypertension. This pathological connection may explain the severity of COVID-19 in patients with metabolic disorders. Many studies have also reported an association between type 2 diabetes and persistent viral infections. Similarly, diabetes favors the growth of various microorganisms including protozoal pathogens as well as opportunistic bacteria and fungi. Furthermore, diabetes is a risk factor for a number of prion-like diseases. There is also an interesting relationship between helminths and type 2 diabetes; helminthiasis may reduce the pro-inflammatory state, but is also associated with type 2 diabetes or even neoplastic processes. Several studies have also documented altered circulating levels of neutrophils, lymphocytes, and monocytes in obesity, which likely modifies vaccine effectiveness. Timely monitoring of inflammatory markers (e.g., C-reactive protein) and energy homeostasis markers (e.g., leptin) could be helpful in preventing many obesity-related diseases.
-
Citations
Citations to this article as recorded by  - The Human Energy Balance: Uncovering the Hidden Variables of Obesity
Nikolaos Theodorakis, Maria Nikolaou
Diseases.2025; 13(2): 55. CrossRef - Candida infections in COVID-19 patients: A review of prevalence, risk factors, and mortality
Eduardo Franco Tulio, Fabíola Lucini, Allan Carminatti de Lima, Natalia Daiane Garoni Martins do Carmo, Marcelo dos Santos Barbosa, Gleyce Hellen de Almeida de Souza, Luana Rossato
Indian Journal of Medical Microbiology.2025; 55: 100831. CrossRef - Cell therapies for immune-mediated disorders
Natalia Wiewiórska-Krata, Bartosz Foroncewicz, Krzysztof Mucha, Radosław Zagożdżon
Frontiers in Medicine.2025;[Epub] CrossRef - Adipose Tissue in Chagas Disease: A Neglected Component of Pathogenesis
Vitória França dos Santos Pessoa, Mariana Hecht, Nadjar Nitz, Luciana Hagström
Pathogens.2025; 14(4): 339. CrossRef - Theory of the Leaky Intestine: Gender Differences in Intestinal Parasitic Infections, Cytoskeletal Wall Dysfunctions, and Hypertension
Philip Njemanze, Anthonia Chioma Amadi, Joy E. Onuchukwu, Chinwendu C. Darlington, Nneoma E. Ukeje, Clinton O. Mezu, Clara C. Ofoegbu, Chidera Okuh, Chidimma O. Ukaegbu, Linda O. Uzoma, Marvis Amuchie, Faustina N. Ojilere, Lilian C. Mbara, Esther C. Nneke
Qeios.2024;[Epub] CrossRef - The potential of DNA methylation markers in the study of obesity
A. F. Nikolaeva, K. O. Petrova, O. V. Vasyukova, R. M. Guseinova, I. R. Minniakhmetov, R. I. Khusainova, N. G. Mokrysheva, V. O. Sigin
Obesity and metabolism.2024; 20(4): 301. CrossRef - Dysbiosis of the gut microbiota and its effect on α-synuclein and prion protein misfolding: consequences for neurodegeneration
Nasir Uddin Mahbub, Md Minarul Islam, Seong-Tshool Hong, Hea-Jong Chung
Frontiers in Cellular and Infection Microbiology.2024;[Epub] CrossRef - Sarcoma Size and Limb Dimensions Predict Complications, Recurrence, and Death in Patients with Soft Tissue Sarcoma in the Thigh: A Multidimensional Analysis
Rami Elmorsi, Luis Camacho, David D. Krijgh, Gordon S. Tilney, Heather Lyu, Raymond S. Traweek, Russell G. Witt, Margaret S. Roubaud, Christina L. Roland, Alexander F. Mericli
Annals of Surgical Oncology.2024; 31(8): 5421. CrossRef - Theory of the Leaky Intestine: Sex Differences in Intestinal Parasitic Infections, Cytoskeletal Wall Dysfunctions, and Hypertension
Philip Njemanze, Anthonia Chioma Amadi, Joy E. Onuchukwu, Chinwendu C. Darlington, Nneoma E. Ukeje, Clinton O. Mezu, Clara C. Ofoegbu, Chidera Okuh, Chidimma O. Ukaegbu, Linda O. Uzoma, Marvis Amuchie, Faustina N. Ojilere, Lilian C. Mbara, Esther C. Nneke
Qeios.2024;[Epub] CrossRef - Cellular immune response to a single dose of live attenuated hepatitis a virus vaccine in obese children and adolescents
Tanatchabhorn Soponkanabhorn, Narissara Suratannon, Supranee Buranapraditkun, Chomchanat Tubjareon, Sittichoke Prachuapthunyachart, Sutha Eiamkulbutr, Voranush Chongsrisawat
Heliyon.2024; 10(16): e36610. CrossRef - Increased Fruit and Vegetable Consumption Prevents Dysregulated Immune and Inflammatory Responses in High-Fat Diet-Induced Obese Mice
Weimin Guo, Dayong Wu, Lijun Li, Erin D Lewis, Simin Nikbin Meydani
The Journal of Nutrition.2024; 154(10): 3144. CrossRef - Sex differences in the inflammation-depression link: A systematic review and meta-analysis
Dana A. Jarkas, Ally H. Villeneuve, Ayeila Z.B. Daneshmend, Paul J. Villeneuve, Robyn J. McQuaid
Brain, Behavior, and Immunity.2024; 121: 257. CrossRef - The Strong Effect of Propolis in Suppressing NF-κB, CysC, and ACE2 on a High-fat Diet
Muhammad Reza Primaguna, Haerani Rasyid, Makbul Aman, Syakib Bakri, Hasyim Kasim, Harun Iskandar, Ressy Dwiyanti, Ade Rifka Junita, Ridwan Ridwan, Rizki Amelia Noviyanthi, Nur Indah Purnamasar, Mochammad Hatta
Biomedical and Pharmacology Journal.2024; 17(3): 1539. CrossRef - How market integration impacts human disease ecology
Lev Kolinski, Tyler M Barrett, Randall A Kramer, Charles L Nunn
Evolution, Medicine, and Public Health.2024; 12(1): 229. CrossRef - Molecular Pathways Linking High-Fat Diet and PM2.5 Exposure to Metabolically Abnormal Obesity: A Systematic Review and Meta-Analysis
Sagrario Lobato, Víctor Manuel Salomón-Soto, Claudia Magaly Espinosa-Méndez, María Nancy Herrera-Moreno, Beatriz García-Solano, Ernestina Pérez-González, Facundo Comba-Marcó-del-Pont, Mireya Montesano-Villamil, Marco Antonio Mora-Ramírez, Claudia Mancilla
Biomolecules.2024; 14(12): 1607. CrossRef - Anti-Obesity Effects of Marine Macroalgae Extract Caulerpa lentillifera in a Caenorhabditis elegans Model
Kawita Chumphoochai, Preeyanuch Manohong, Nakorn Niamnont, Montakan Tamtin, Prasert Sobhon, Krai Meemon
Marine Drugs.2023; 21(11): 577. CrossRef - Obesity and consequent changes in the body
Bojana Kisić, Dragana Puhalo-Sladoje, Dijana Mirić, Dragiša Rašić, Tatjana Novaković
Praxis medica.2022; 51(3): 35. CrossRef
|
E-submission
