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Kyung-Ju Kim 4 Articles
Thyroid Fine-Needle Aspiration Cytology Practice in Korea
Yoon Jin Cha, Ju Yeon Pyo, SoonWon Hong, Jae Yeon Seok, Kyung-Ju Kim, Jee-Young Han, Jeong Mo Bae, Hyeong Ju Kwon, Yeejeong Kim, Kyueng-Whan Min, Soonae Oak, Sunhee Chang
J Pathol Transl Med. 2017;51(6):521-527.   Published online October 11, 2017
  • 6,817 View
  • 229 Download
  • 8 Citations
AbstractAbstract PDF
We reviewed the current status of thyroid fine-needle aspiration cytology (FNAC) in Korea. Thyroid aspiration biopsy was first introduced in Korea in 1977. Currently, radiologists aspirate the thyroid nodule under the guidance of ultrasonography, and cytologic interpretation is only legally approved when a cytopathologist makes the diagnosis. In 2008, eight thyroid-related societies came together to form the Korean Thyroid Association. The Korean Society for Cytopathology and the endocrine pathology study group of the Korean Society for Pathologists have been updating the cytologic diagnostic guidelines. The Bethesda System for Reporting Thyroid Cytopathology was first introduced in 2009, and has been used by up to 94% of institutions by 2016. The average diagnosis rates are as follows for each category: I (12.4%), II (57.9%), III (10.4%), IV (2.9%), V (3.7%), and VI (12.7%). The malignancy rates in surgical cases are as follows for each category: I (28.7%), II (27.8%), III (50.6%), IV (52.3%), V (90.7%), and VI (100.0%). Liquid-based cytology has been used since 2010, and it was utilized by 68% of institutions in 2016. The categorization of thyroid lesions into “atypia of undetermined significance” or “follicular lesion of undetermined significance” is necessary to draw consensus in our society. Immunocytochemistry for galectin-3 and BRAF is used. Additionally, a molecular test for BRAF in thyroid FNACs is actively used. Core biopsies were performed in only 44% of institutions. Even the institutions that perform core biopsies only perform them for less than 3% of all FNACs. However, only 5% of institutions performed core biopsies up to three times more than FNAC.


Citations to this article as recorded by  
  • Diagnostic value of thyroid imaging reporting and data system combined with BRAFV600E mutation analysis in Bethesda categories III–V thyroid nodules
    Liuxi Wu, Hua Shu, Wenqin Chen, Yingqian Gao, Ya Yuan, Xiao Li, Wenjuan Lu, Xinhua Ye, Hongyan Deng
    Scientific Reports.2022;[Epub]     CrossRef
  • Contribution of cytologic examination to diagnosis of poorly differentiated thyroid carcinoma
    Na Rae Kim, Jae Yeon Seok, Yoo Seung Chung, Joon Hyop Lee, Dong Hae Chung
    Journal of Pathology and Translational Medicine.2020; 54(2): 171.     CrossRef
  • Systematic thyroid screening in myotonic dystrophy: link between thyroid volume and insulin resistance
    Adrien Ben Hamou, Stéphanie Espiard, Christine Do Cao, Miriam Ladsous, Camille Loyer, Alexandre Moerman, Samuel Boury, Maéva Kyheng, Claire-Marie Dhaenens, Vincent Tiffreau, Pascal Pigny, Gilles Lebuffe, Robert Caiazzo, Sébastien Aubert, Marie Christine V
    Orphanet Journal of Rare Diseases.2019;[Epub]     CrossRef
  • The History of Korean Thyroid Pathology
    Soon Won Hong, Chan Kwon Jung
    International Journal of Thyroidology.2018; 11(1): 15.     CrossRef
  • BRAFV600E Mutation is a Strong Preoperative Indicator for Predicting Malignancy in Thyroid Nodule Patients with Atypia of Undetermined Significance Identified by Fine Needle Aspiration
    Hye Rang Choi, Bo-Yoon Choi, Jae Hoon Cho, Young Chang Lim
    Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2018; 61(11): 600.     CrossRef
  • The Usefulness of Immunocytochemistry of CD56 in Determining Malignancy from Indeterminate Thyroid Fine-Needle Aspiration Cytology
    Hyunseo Cha, Ju Yeon Pyo, Soon Won Hong
    Journal of Pathology and Translational Medicine.2018; 52(6): 404.     CrossRef
  • Thyroid FNA cytology in Asian practice-Active surveillance for indeterminate thyroid nodules reduces overtreatment of thyroid carcinomas
    K. Kakudo, M. Higuchi, M. Hirokawa, S. Satoh, C. K. Jung, A. Bychkov
    Cytopathology.2017; 28(6): 455.     CrossRef
  • The Use of Fine-Needle Aspiration (FNA) Cytology in Patients with Thyroid Nodules in Asia: A Brief Overview of Studies from the Working Group of Asian Thyroid FNA Cytology
    Chan Kwon Jung, SoonWon Hong, Andrey Bychkov, Kennichi Kakudo
    Journal of Pathology and Translational Medicine.2017; 51(6): 571.     CrossRef
CD9 Expression in Colorectal Carcinomas and Its Prognostic Significance
Kyung-Ju Kim, Hee Jung Kwon, Min Chong Kim, Young Kyung Bae
J Pathol Transl Med. 2016;50(6):459-468.   Published online October 25, 2016
  • 7,391 View
  • 142 Download
  • 10 Citations
AbstractAbstract PDF
CD9, a member of the tetraspanin superfamily, is a tumor suppressor in many malignancies. The aim of this study was to evaluate the immunohistochemical expression of CD9 in colorectal carcinomas (CRCs) and determine clinicopathological and prognostic significance of its expression.
The CD9 expression status of 305 CRCs was evaluated using a semi-quantitative scoring system in tumor cells (T-CD9) and immune cells (I-CD9) by classifying the results as high and low expression.
High T-CD9 (T-CD9 [+]) expression was detected in 175 samples (57.6%) and high I-CD9 (I-CD9 [+]) expression was detected in 265 samples (86.9%). Using Kaplan- Meier survival analysis, the T-CD9 (+) group showed a tendency for better disease-free survival (DFS) (p = .057). In left-sided tumors, DFS was significantly longer in the T-CD9 (+) group (p = .021) but no statistical significance was observed with right-sided tumors (p = .453). I-CD9 (+) CRCs significantly correlated with well/moderately differentiation (p = .014). In Kaplan-Meier analysis, the I-CD9 (+) group had a tendency towards worse DFS compared to the I-CD9 (–) group (p = .156). In combined survival analysis of T-CD9 and I-CD9, we found that the longest DFS was among patients in the T-CD9 (+)/I-CD9 (–) group, whereas the T-CD9 (–)/I-CD9 (+) group showed the shortest DFS (p = .054).
High expression of T-CD9 was associated with a favorable DFS, especially in left-sided CRCs. Combined evaluation of T-CD9 and I-CD9 is required to determine the comprehensive prognostic effect of CD9 in CRCs.


Citations to this article as recorded by  
  • Prognostic value and multifaceted roles of tetraspanin CD9 in cancer
    Róbert Ondruššek, Barbora Kvokačková, Karolína Kryštofová, Světlana Brychtová, Karel Souček, Jan Bouchal
    Frontiers in Oncology.2023;[Epub]     CrossRef
  • Anti-Human CD9 Fab Fragment Antibody Blocks the Extracellular Vesicle-Mediated Increase in Malignancy of Colon Cancer Cells
    Mark F. Santos, Germana Rappa, Simona Fontana, Jana Karbanová, Feryal Aalam, Derek Tai, Zhiyin Li, Marzia Pucci, Riccardo Alessandro, Chikao Morimoto, Denis Corbeil, Aurelio Lorico
    Cells.2022; 11(16): 2474.     CrossRef
  • The Study of the Extracellular Matrix in Chronic Inflammation: A Way to Prevent Cancer Initiation?
    Asia Marangio, Andrea Biccari, Edoardo D’Angelo, Francesca Sensi, Gaya Spolverato, Salvatore Pucciarelli, Marco Agostini
    Cancers.2022; 14(23): 5903.     CrossRef
  • In vivo expansion of a CD9+ decidual-like NK cell subset following autologous hematopoietic stem cell transplantation
    Ane Orrantia, Enrique Vázquez-De Luis, Gabirel Astarloa-Pando, Iñigo Terrén, Ainhoa Amarilla-Irusta, Diego Polanco-Alonso, Carmen González, Alasne Uranga, Tomás Carrascosa, Juan J. Mateos-Mazón, Juan C. García-Ruiz, Sergio Callejas, Ana Quintas, Ana Dopaz
    iScience.2022; 25(10): 105235.     CrossRef
  • Inhibition of cancer-cell migration by tetraspanin CD9-binding peptide
    Thanawat Suwatthanarak, Masayoshi Tanaka, Yoshitaka Miyamoto, Kenji Miyado, Mina Okochi
    Chemical Communications.2021; 57(40): 4906.     CrossRef
  • High expression of tumor susceptibility gene 101 (TSG101) is associated with more aggressive behavior in colorectal carcinoma
    Elmira Gheytanchi, Leili Saeednejad Zanjani, Roya Ghods, Maryam Abolhasani, Marzieh Shahin, Somayeh Vafaei, Marzieh Naseri, Fahimeh Fattahi, Zahra Madjd
    Journal of Cancer Research and Clinical Oncology.2021; 147(6): 1631.     CrossRef
  • Increased CD9 expression predicts favorable prognosis in human cancers: a systematic review and meta-analysis
    Hyun Min Koh, Bo Gun Jang, Dong Hui Lee, Chang Lim Hyun
    Cancer Cell International.2021;[Epub]     CrossRef
  • Prognostic Value of CD9 in Solid Tumor: A Systematic Review and Meta-Analysis
    Ping Zeng, Meng Si, Rui-xia Sun, Xu Cheng, Xiao-yang Li, Min-bin Chen
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Matrix Effect in the Isolation of Breast Cancer-Derived Nanovesicles by Immunomagnetic Separation and Electrochemical Immunosensing—A Comparative Study
    Silio Lima Moura, Mercè Martì, María Isabel Pividori
    Sensors.2020; 20(4): 965.     CrossRef
  • CD9 expression indicates a poor outcome in acute lymphoblastic leukemia
    Peiqi Liang, Miao Miao, Zhuogang Liu, Hongtao Wang, Wei Jiang, Shiyu Ma, Chuan Li, Rong Hu
    Cancer Biomarkers.2018; 21(4): 781.     CrossRef
Mediastinal Glomus Tumor: A Case Report and Literature Review
Si-Hyong Jang, Hyun Deuk Cho, Ji-Hye Lee, Hyun Ju Lee, Hae Yoen Jung, Kyung-Ju Kim, Sung Sik Cho, Mee-Hye Oh
J Pathol Transl Med. 2015;49(6):520-524.   Published online August 4, 2015
  • 8,951 View
  • 59 Download
  • 9 Citations
AbstractAbstract PDF
A glomus tumor in the mediastinum is very uncommon, and only five cases have been reported in the English literature. We recently encountered a 21-year-old woman with an asymptomatic mediastinal mass that measured 5.3 × 4.0 cm. Surgical excision was performed, and the tumor was finally diagnosed as mediastinal glomus tumor with an uncertain malignant potential. After reviewing this case and previous reports, we analyzed the clinicopathologic features associated with progression of such a tumor.


Citations to this article as recorded by  
  • A case of mediastinal mesenchymal tumor with pericytic neoplasm feature that responded to radiation therapy
    Miho Muramoto, Shintaro Kanda, Takashi Kobayashi, Hisashi Tamada, Ayumu Fukazawa, Keiichirou Koiwai, Tomonobu Koizumi
    Thoracic Cancer.2023;[Epub]     CrossRef
  • Total-Body Irradiation Is Associated With Increased Incidence of Mesenchymal Neoplasia in a Radiation Late Effects Cohort of Rhesus Macaques (Macaca mulatta)
    W. Shane Sills, Janet A. Tooze, John D. Olson, David L. Caudell, Greg O. Dugan, Brendan J. Johnson, Nancy D. Kock, Rachel N. Andrews, George W. Schaaf, Richard A. Lang, J. Mark Cline
    International Journal of Radiation Oncology*Biology*Physics.2022; 113(3): 661.     CrossRef
  • Mesenchymal Tumors of the Mediastinum: An Update on Diagnostic Approach
    Joon Hyuk Choi, Jae Y. Ro
    Advances in Anatomic Pathology.2021; 28(5): 351.     CrossRef
  • La glomangiomatose médiastinale postérieure : localisation exceptionnelle d’une tumeur rare. À propos d’un cas
    A. Machboua, S. Hamraoui, S. Zarouki, I. Kamaoui, I. Alloubi
    Revue des Maladies Respiratoires.2021; 38(8): 848.     CrossRef
  • An unusual case of chest wall glomus tumor presenting with axillary pain: a case report and literature review
    Leila Oryadi Zanjani, Bahman Shafiee Nia, Farzad Vosoughi, Elham Mirzaian, Leila Aghaghazvini, Aidin Arabzadeh
    European Journal of Medical Research.2021;[Epub]     CrossRef
  • Clinical Implications of 18F-FDG PET/CT in Malignant Glomus Tumors of the Esophagus
    Romain-David Seban, Laurence Bozec, Laurence Champion
    Clinical Nuclear Medicine.2020; 45(6): e301.     CrossRef
  • Symplastic glomus tumor of the urinary bladder treated by robot-assisted partial cystectomy: a case report and literature review
    Franco Palmisano, Franco Gadda, Matteo G. Spinelli, Marco Maggioni, Bernardo Rocco, Emanuele Montanari
    Urologia Journal.2018; 85(3): 130.     CrossRef
  • Thoracoscopic Surgery for Glomus Tumor: An Uncommon Mediastinal Neoplasm and Iatrogenic Tracheal Rupture
    Zhongjie Fang, Dehua Ma, Baofu Chen, Huarong Luo
    Case Reports in Surgery.2017; 2017: 1.     CrossRef
  • Asymptomatic Glomus Tumor of the Mediastinum
    Meletios Kanakis, Nikoletta Rapti, Maria Chorti, Achilleas Lioulias
    Case Reports in Surgery.2015; 2015: 1.     CrossRef
Differential Features of Microsatellite-Unstable Colorectal Carcinomas Depending on EPCAM Expression Status
Jung Ho Kim, Jeong Mo Bae, Kyung-Ju Kim, Ye-Young Rhee, Younghoon Kim, Nam-Yun Cho, Hye Seung Lee, Mee Soo Chang, Gyeong Hoon Kang
Korean J Pathol. 2014;48(4):276-282.   Published online August 26, 2014
  • 9,957 View
  • 57 Download
  • 14 Citations
AbstractAbstract PDF

Recent studies have revealed that a small subset of Lynch syndrome-associated colorectal carcinomas (CRCs) is caused by a germline EPCAM deletion-induced MSH2 epimutation. Based on the finding of this genetic alteration, we investigated the implications of EPCAM expression changes in microsatellite instability-high (MSI-H) CRCs.


Expression of EPCAM and DNA mismatch repair proteins was assessed by immunohistochemistry in 168 MSI-H CRCs. Using DNA samples of these tumors, MLH1 promoter methylation status was also determined by methylation-specific real-time polymerase chain reaction method (MethyLight).


Among 168 MSI-H CRCs, complete loss (CL) and focal loss (FL) of EPCAM expression was observed in two (1.2%) and 22 (13.1%) cases, respectively. Both of the EPCAM-CL cases were found in MSH2-negative tumors without MLH1 promoter methylation. However, only nine of the 22 EPCAM-FL tumors had MSH2 deficiency. Of the 22 EPCAM-FL tumors, 13 showed MLH1 loss, and among them, nine cases were determined to have MLH1 methylation. EPCAM-FL was significantly associated with advanced stage (p=.043), distant metastasis (p=.003), poor differentiation (p=.001), and signet ring cell component (p=.004).


Loss of EPCAM expression is differentially associated with clinicopathological and molecular features, depending on the completeness of the loss, in MSI-H CRCs.


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  • Outcomes of Definitive Treatment of Signet Ring Cell Carcinoma of the Rectum: Is Minimal Invasive Surgery Detrimental in Signet Ring Rectal Cancers?
    S. Raghavan, Deepak Kumar Singh, J. Rohila, A. DeSouza, R. Engineer, A. Ramaswamy, V. Ostwal, A. Saklani
    Indian Journal of Surgical Oncology.2020; 11(4): 597.     CrossRef
  • Evaluation of the Role of Circulating Tumor Cells and Microsatellite Instability Status in Predicting Outcome of Advanced CRC Patients
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    Journal of Personalized Medicine.2020; 10(4): 235.     CrossRef
  • Is Ep-CAM Expression a Diagnostic and Prognostic Biomarker for Colorectal Cancer? A Systematic Meta-Analysis
    Susu Han, Shaoqi Zong, Qi Shi, Hongjia Li, Shanshan Liu, Wei Yang, Wen Li, Fenggang Hou
    EBioMedicine.2017; 20: 61.     CrossRef
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    Bo Young Oh, Jung Wook Huh, Yoon Ah Park, Yong Beom Cho, Seong Hyeon Yun, Hee Cheol Kim, Woo Yong Lee, Ho-Kyung Chun
    Surgery.2016; 159(5): 1372.     CrossRef
  • Clinical significance of fibroblast growth factor receptor 2 expression in patients with residual rectal cancer after preoperative chemoradiotherapy: relationship with KRAS or BRAF mutations and MSI status
    Ghilsuk Yoon, Hwayoung Lee, Jae-Hoon Kim, Keun Hur, An Na Seo
    Tumor Biology.2016; 37(8): 10209.     CrossRef
  • Subcellular differential expression of Ep-ICD in oral dysplasia and cancer is associated with disease progression and prognosis
    Raj Thani Somasundaram, Jatinder Kaur, Iona Leong, Christina MacMillan, Ian J. Witterick, Paul G. Walfish, Ranju Ralhan
    BMC Cancer.2016;[Epub]     CrossRef
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    PLOS ONE.2016; 11(3): e0151865.     CrossRef
  • Twist1-induced epithelial-mesenchymal transition according to microsatellite instability status in colon cancer cells
    Bo Young Oh, So-Young Kim, Yeo Song Lee, Hye Kyung Hong, Tae Won Kim, Seok Hyung Kim, Woo Yong Lee, Yong Beom Cho
    Oncotarget.2016; 7(35): 57066.     CrossRef
  • Clinicopathologic, molecular, and prognostic implications of the loss of EPCAM expression in colorectal carcinoma
    Jung Ho Kim, Jeong Mo Bae, Young Seok Song, Nam-Yun Cho, Hye Seung Lee, Gyeong Hoon Kang
    Oncotarget.2016; 7(12): 13372.     CrossRef
  • Pathologic Factors Associated with Prognosis after Adjuvant Chemotherapy in Stage II/III Microsatellite-Unstable Colorectal Cancers
    Jung Ho Kim, Jeong Mo Bae, Hyeon Jeong Oh, Hye Seung Lee, Gyeong Hoon Kang
    Journal of Pathology and Translational Medicine.2015; 49(2): 118.     CrossRef
  • HER3 protein expression in relation to HER2 positivity in patients with primary colorectal cancer: clinical relevance and prognostic value
    An Na Seo, Yoonjin Kwak, Woo Ho Kim, Duck-Woo Kim, Sung-Bum Kang, Gheeyoung Choe, Hye Seung Lee
    Virchows Archiv.2015; 466(6): 645.     CrossRef
  • Clinical and prognostic value of MET gene copy number gain and chromosome 7 polysomy in primary colorectal cancer patients
    An Na Seo, Kyoung Un Park, Gheeyoung Choe, Woo Ho Kim, Duck-Woo Kim, Sung-Bum Kang, Hye Seung Lee
    Tumor Biology.2015; 36(12): 9813.     CrossRef
  • c-MYC Copy-Number Gain Is an Independent Prognostic Factor in Patients with Colorectal Cancer
    Kyu Sang Lee, Yoonjin Kwak, Kyung Han Nam, Duck-Woo Kim, Sung-Bum Kang, Gheeyoung Choe, Woo Ho Kim, Hye Seung Lee, Andreas Krieg
    PLOS ONE.2015; 10(10): e0139727.     CrossRef
  • Nuclear Ep-ICD accumulation predicts aggressive clinical course in early stage breast cancer patients
    Gunjan Srivastava, Jasmeet Assi, Lawrence Kashat, Ajay Matta, Martin Chang, Paul G Walfish, Ranju Ralhan
    BMC Cancer.2014;[Epub]     CrossRef

JPTM : Journal of Pathology and Translational Medicine