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Min-Kyung Kim 1 Article
Epithelioid Trophoblastic Tumor: Clinicopathologic and Immunohistochemical Analysis of Three Cases
Woo Jung Sung, Hyeong Chan Shin, Min-Kyung Kim, Mi Jin Kim
Korean J Pathol. 2013;47(1):67-73.   Published online February 25, 2013
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AbstractAbstract PDF

Epithelioid trophoblastic tumor is an unusual type of trophoblastic tumor. Here we report on the clinicopathologic and immunohistochemical features of three cases of epithelioid trophoblastic tumor. All three patients were of reproductive age and presented with vaginal bleeding and mild elevation of human chorionic gonadotropin (hCG). All patients underwent a hysterectomy. The tumors consisted of epithelioid intermediate trophoblastic cells that were mononucleated and eosinophilic, or showed clear cytoplasm on microscopic examination. One case presented with a focal choriocarcinoma component. Immunohistochemically, the tumors displayed diffuse positivity for cytokeratin 18, E-cadherin, epidermal growth factor receptor, and p53 and focal positivity for p63 and hCG. However, expression of α-inhibin and placental alkaline phosphatase was almost negative. Tests for human placental lactogen and epithelial membrane antigen were also negative in all cases.


Citations to this article as recorded by  
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    Seyran Yigit, Eylul Gun, Bulent Yilmaz, Zafer Kolsuz
    Indian Journal of Pathology and Microbiology.2020; 63(5): 98.     CrossRef
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    Indian Journal of Cancer.2020;[Epub]     CrossRef
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    Chunfeng Yang, Jianqi Li, Yuanyuan Zhang, Hanzhen Xiong, Xiujie Sheng
    Journal of Medical Case Reports.2020;[Epub]     CrossRef
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    Gynecologic Oncology.2019; 153(3): 684.     CrossRef
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    Yujia Kong, Guangshi Tao, Liju Zong, Junjun Yang, Xirun Wan, Wenze Wang, Yang Xiang
    Frontiers in Oncology.2019;[Epub]     CrossRef
  • A Case Series of Five Patients With Pure or Mixed Gestational Epithelioid Trophoblastic Tumors and a Literature Review on Mixed Tumors
    Ka Yu Tse, Keith Wan Hang Chiu, Karen Kar Loen Chan, Mandy Man Yee Chu, Siew Fei Ngu, Annie Nga Yin Cheung, Hextan Yuen Sheung Ngan, Philip Pun Ching Ip
    American Journal of Clinical Pathology.2018; 150(4): 318.     CrossRef
  • MR Imaging of Uterine Epithelioid Trophoblastic Tumor: A Case Report
    Sakiko KAGEYAMA, Masafumi KANOTO, Yukio SUGAI, Takeshi SUTO, Satoru NAGASE, Mitsumasa OSAKABE, Takaaki HOSOYA
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  • Pharmacotherapy of placental site and epithelioid trophoblastic tumours
    Fiona Taylor, Barry W Hancock
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  • A Well-Circumscribed Border with Peripheral Doppler Signal in Sonographic Image Distinguishes Epithelioid Trophoblastic Tumor from Other Gestational Trophoblastic Neoplasms
    Jiale Qin, Weiwen Ying, Xiaodong Cheng, Xiaodong Wu, Bingjian Lu, Yun Liang, Xinyu Wang, Xiaoyun Wan, Xing Xie, Weiguo Lu, Hai-Yan Lin
    PLoS ONE.2014; 9(11): e112618.     CrossRef

JPTM : Journal of Pathology and Translational Medicine