Skip Navigation
Skip to contents

JPTM : Journal of Pathology and Translational Medicine


Author index

Page Path
HOME > Articles and issues > Author index
Sang Sook Lee 2 Articles
IMP3, a Promising Prognostic Marker in Clear Cell Renal Cell Carcinoma
Ji Young Park, Misun Choe, Yuna Kang, Sang Sook Lee
Korean J Pathol. 2014;48(2):108-116.   Published online April 28, 2014
  • 6,545 View
  • 32 Download
  • 2 Citations
AbstractAbstract PDF

Insulin-like growth factor II mRNA-binding protein 3 (IMP3) has been reported as a prognostic biomarker in various cancers. To validate IMP3 as a prognostic biomarker in renal cell carcinoma (RCC), we investigated the expression of IMP3, p53, and Ki-67, and their associations with clinicopathologic outcomes.


We studied 148 clear cell RCCs (CCRCCs) from patients who underwent radical nephrectomy. The expression levels of IMP3, p53, and Ki-67 were assessed by immunohistochemical staining and the clinical and pathologic parameters were retrospectively reviewed.


Twenty-nine percent of CCRCCs expressed IMP3. Forty-one percent of IMP3-immunopositive tumors developed metastases, while only 11.4% of IMP3-negative tumors developed metastases (p<.001). A Kaplan-Meier curve showed that patients with IMP3-immunopositive tumors had lower metastasis-free survival and cancer-specific survival than did those with IMP3-immunonegative tumors (p<.001 and p<.001, respectively). Expression of high Ki-67 proliferation index was also associated with a higher metastatic rate. In the multivariate Cox regression analysis, pT stage and IMP3-positivity were independently associated with disease-specific survival.


IMP3 is an independent prognostic biomarker for patients with CCRCC to predict metastasis and poor outcome.


Citations to this article as recorded by  
  • Prognostic value of insulin‑like growth factor 2 mRNA‑binding protein 3 and vascular endothelial growth factor‑A in patients with primary non‑small‑cell lung cancer
    Jiannan Liu, Ying Liu, Wenjing Gong, Xiangshuo Kong, Congcong Wang, Shuhua Wang, Aina Liu
    Oncology Letters.2019;[Epub]     CrossRef
  • Epithelial‑mesenchymal transition in colorectal carcinoma cells is mediated by DEK/IMP3
    Shuping You, Yun Guan, Weihong Li
    Molecular Medicine Reports.2017;[Epub]     CrossRef
A Soft Tissue Perineurioma and a Hybrid Tumor of Perineurioma and Schwannoma
Ji Young Park, Nam Jo Park, Sang Pyo Kim, Kun Young Kwon, Sang Sook Lee
Korean J Pathol. 2012;46(1):75-78.   Published online February 23, 2012
  • 6,339 View
  • 54 Download
  • 13 Citations
AbstractAbstract PDF

Perineuriomas are composed of differentiated perineurial cells. Perineuriomas have been recently recognized by the immunoreactivity for epithelial membrane antigen (EMA). Microscopically, perineuriomas show proliferation of spindle cells with wavy nuclei and delicate elongated bipolar cytoplasmic processes. The tumor cells are usually negative for the S-100 protein. Ultrastructurally, perineurial cells reveal slender, nontapered processes containing pinocytic vesicles and discontinuous basal lamina. Interestingly, hybrid tumors of benign peripheral nerve sheath tumor (PNST) have been recently reported by using immunohistochemical and ultrastructural investigations. Herein, we report a case of soft tissue perineurioma arising in the skin of a 56-year-old female; another case of a hybrid tumor of perineurioma and schwannoma in the posterior mediastinum occurred in a 53-year-old male, which is the first case of the hybrid PNST tumor reported in Korea.


Citations to this article as recorded by  
  • Hybrid tumors with perineurioma components: a systematic review of the literature and illustrative case
    Karina A. Lenartowicz, Dileep D. Monie, Kimberly K. Amrami, Christopher J. Klein, Caterina Giannini, Robert J. Spinner
    Acta Neurochirurgica.2022;[Epub]     CrossRef
  • Hybrid Schwannoma/Perineurioma: Morphologic Variations and Genetic Profiles
    Takanori Hirose, Anna Kobayashi, Sumihito Nobusawa, Naoe Jimbo
    Applied Immunohistochemistry & Molecular Morphology.2021; 29(6): 433.     CrossRef
  • Mesenchymal Tumors of the Mediastinum: An Update on Diagnostic Approach
    Joon Hyuk Choi, Jae Y. Ro
    Advances in Anatomic Pathology.2021; 28(5): 351.     CrossRef
  • Neurogenic Tumors of the Mediastinum
    Erika F. Rodriguez, Robert Jones, Daniel Miller, Fausto J. Rodriguez
    Seminars in Diagnostic Pathology.2020; 37(4): 179.     CrossRef
  • A Rare Perineurioma/Granular Cell Tumor Hybrid Peripheral Nerve Sheath Tumor
    Koorosh Haghayeghi, Gladys Telang, Sonja Chen, Jack Bevivino, Shamlal Mangray, Yiang Hui, Leslie Robinson-Bostom
    The American Journal of Dermatopathology.2020; 42(10): 762.     CrossRef
  • Hibrid periferik sinir kılıfı tümörleri
    Emine Kilic Bagir, Arbil Acikalin, Gulfiliz Gonlusen, Suzan Zorludemir, Mehmet Ali Deveci
    Cukurova Medical Journal.2019; 44(3): 1.     CrossRef
  • Primary intraosseous hybrid epithelioid schwannoma/perineurioma in the proximal tibia: a case report of benign hybrid neoplasm with local hypercellularity
    Yuejiao Lang, Dawei Liu, Pei Xiang, Jilin Wang, Yang Li
    Diagnostic Pathology.2019;[Epub]     CrossRef
  • Hybrid peripheral nerve sheath tumors: report of five cases and detailed review of literature
    Nasir Ud Din, Zubair Ahmad, Jamshid Abdul-Ghafar, Rashida Ahmed
    BMC Cancer.2017;[Epub]     CrossRef
  • Primary intraosseous hybrid nerve sheath tumor of femur: A hitherto undescribed occurrence in bone with secondary aneurysmal bone cyst formation resulting in pathological fracture
    Louis Tsun Cheung Chow
    Pathology - Research and Practice.2015; 211(5): 409.     CrossRef
  • Mesenchymal tumours of the mediastinum—part II
    Michael A. den Bakker, Alexander Marx, Kiyoshi Mukai, Philipp Ströbel
    Virchows Archiv.2015; 467(5): 501.     CrossRef
  • Primary pleural hybrid cellular schwannoma/perineurioma: A case report
    Danny Soria-Céspedes, Carlos Robles-Vidal, Arturo Gómez-González, Rosalinda Peñaloza-Ramírez, Carlos Ortiz-Hidalgo
    Respiratory Investigation.2014; 52(4): 269.     CrossRef
  • Hybrid peripheral nerve sheath tumour with intermingled perineuriomatous and schwannomatous areas reflected in skin ultrasonography image
    H. Saeki, K. Ito, Y. Nobeyama, T. Ishiji, M. Fukunaga, H. Nakagawa
    Clinical and Experimental Dermatology.2014; 39(6): 747.     CrossRef
  • Périneuriome extraneural des tissus mous localisé au nez
    A. Zaouak, R. Benmously, M. Belhadj Salah, W. Koubaa, A. Debbiche, I. Mokhtar
    Annales de Dermatologie et de Vénéréologie.2013; 140(8-9): 540.     CrossRef

JPTM : Journal of Pathology and Translational Medicine