Follicular dendritic cell sarcoma (FDCS) is a rare malignancy arising from the antigen-presenting cells in the lymph node and extranodal tissue. We describe a 31-year-old male patient who presented with a swelling of the left parapharynx. The radiologic findings showed a 4.7×4.5×1.9 cm-sized, ill-defined mass in the left parapharyngeal space. A fine-needle aspiration cytology was performed and it showed scattered, irregular, cohesive clusters of tumor cells with a spindle-to-ovoid shape with irregular contours in a background of lymphocytes. Based on these findings, a diagnosis of spindle cell neoplasm was made. The surgically resected tumor was composed of elongated, ovoid or polygonal cells showing positive immunohistochemistry for CD21, CD23, and CD35. Postoperatively, the residual tumor was observed to undergo a rapidly growth. There is an overlap in the cytologic and histologic findings between FDCS of the parapharynx and other tumors. Pathologists should therefore be aware of its characteristics not only to provide an accurate diagnosis but also to recommend the appropriate clinical management.

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• Extranodal Follicular Dendritic Cell Sarcoma of the Head and Neck Region: A Clinicopathological Study of 7 Cases
  Nasir Ud Din, Zubair Ahmad, Shabina Rahim, Karen Fritchie, Muhammad Usman Tariq, Arsalan Ahmed
  International Journal of Surgical Pathology.2023; 31(6): 1067.     CrossRef
• Cytomorphology of follicular dendritic cell sarcoma: a report of 7 cases with an emphasis on the diagnostic challenges
  Cody Weimholt, Jalal B. Jalaly, Cedric Bailey
  Journal of the American Society of Cytopathology.2023; 12(3): 229.     CrossRef
• Follicular dendritic cells
  Seham A. Abd El‐Aleem, Entesar Ali Saber, Neven M. Aziz, Hani El‐Sherif, Asmaa M. Abdelraof, Laiche Djouhri
  Journal of Cellular Physiology.2022; 237(4): 2019.     CrossRef
• Clinicopathological characteristics of extranodal follicular dendritic cell sarcoma: A report of two cases
  Xing Zhao, Dayong Sun, Gang Zhang
  Oncology Letters.2021;[Epub]     CrossRef
• Cytological diagnosis of follicular dendritic cell sarcoma: A case report and review of literature
  A. Dutta, P. Arun, P. Roy, I. Arun
  Cytopathology.2018; 29(5): 461.     CrossRef
• Follicular dendritic cells and related sarcoma
  Fabio Facchetti, Luisa Lorenzi
  Seminars in Diagnostic Pathology.2016; 33(5): 262.     CrossRef
• Extranodal follicular dendritic cell sarcoma: A clinicopathological report of four cases and a literature review
  RUI-FEN WANG, WEI HAN, LEI QI, LI-HUI SHAN, ZHENG-CAI WANG, LI-FENG WANG
  Oncology Letters.2015; 9(1): 391.     CrossRef
• Follicular Dendritic Cell Sarcoma of Parapharyngeal Space: A Case Report and Review of the Literature
  Turki Al-Hussain, Muhammad Saleem, Suresh Babu Velagapudi, Mohammad Anas Dababo
  Head and Neck Pathology.2015; 9(1): 135.     CrossRef
• Clinical and pathological features of head and neck follicular dendritic cell sarcoma
  Ji Li, Min-Li Zhou, Shui-Hong Zhou
  Hematology.2015; 20(10): 571.     CrossRef