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Seojin Kim 3 Articles
Does Polymerase Chain Reaction of Tissue Specimens Aid in the Diagnosis of Tuberculosis?
Yoo Jin Lee, Seojin Kim, Youngjin Kang, Jiyoon Jung, Eunjung Lee, Joo-Young Kim, Jeong Hyeon Lee, Youngseok Lee, Yang-seok Chae, Chul Hwan Kim
J Pathol Transl Med. 2016;50(6):451-458.   Published online October 10, 2016
  • 8,760 View
  • 210 Download
  • 6 Citations
AbstractAbstract PDF
Mycobacterial culture is the gold standard test for diagnosing tuberculosis (TB), but it is time-consuming. Polymerase chain reaction (PCR) is a highly sensitive and specific method that can reduce the time required for diagnosis. The diagnostic efficacy of PCR differs, so this study determined the actual sensitivity of TB-PCR in tissue specimens.
We retrospectively reviewed 574 cases. The results of the nested PCR of the IS6110 gene, mycobacterial culture, TB-specific antigen-induced interferon-γ release assay (IGRA), acid-fast bacilli (AFB) staining, and histological findings were evaluated.
The positivity rates were 17.6% for PCR, 3.3% for the AFB stain, 22.2% for mycobacterial culture, and 55.4% for IGRA. PCR had a low sensitivity (51.1%) and a high specificity (86.3%) based on the culture results of other studies. The sensitivity was higher (65.5%) in cases with necrotizing granuloma but showed the highest sensitivity (66.7%) in those with necrosis only. The concordance rate between the methods indicated that PCR was the best method compared to mycobacterial culture, and the concordance rate increased for the methods using positive result for PCR or histologic features.
PCR of tissue specimens is a good alternative to detect tuberculosis, but it may not be as sensitive as previously suggested. Its reliability may also be influenced by some histological features. Our data showed a higher sensitivity when specimens contained necrosis, which indicated that only specimens with necrosis should be used for PCR to detect tuberculosis.


Citations to this article as recorded by  
  • Diagnostic Utility of Biplex/Multiplex Polymerase Chain Reaction in Infectious Granulomatous Dermatitis in North Indian Population
    Mayur Parkhi, Mukin Kumar S, Dipankar De, Rakesh Yadav, Sunil Sethi, Bishan Dass Radotra, Uma Nahar Saikia
    The American Journal of Dermatopathology.2021; 43(8): 567.     CrossRef
  • Reduction of turnaround time for non-tuberculous mycobacteria detection in heater–cooler units by propidium monoazide–real-time polymerase chain reaction
    S. Ditommaso, M. Giacomuzzi, G. Memoli, R. Cavallo, A. Curtoni, M. Avolio, C. Silvestre, C.M. Zotti
    Journal of Hospital Infection.2020; 104(3): 365.     CrossRef
  • Ergonomic Diagnostic Tool based on Chip Mini RT-PCR for Diagnosis of Pulmonary and Extra Pulmonary Tuberculosis
    V Mangayarkarasi, Sneka P, Sujith R, Jayaprakash Jayaprakash
    Journal of Pure and Applied Microbiology.2019; 13(2): 1185.     CrossRef
  • Cutaneous Tuberculosis: Clinicopathologic Arrays and Diagnostic Challenges
    Priyatam Khadka, Soniya Koirala, Januka Thapaliya
    Dermatology Research and Practice.2018; 2018: 1.     CrossRef
  • Utility of Real-Time Quantitative Polymerase Chain Reaction in DetectingMycobacterium tuberculosis
    Zhongquan Lv, Mingxin Zhang, Hui Zhang, Xinxin Lu
    BioMed Research International.2017; 2017: 1.     CrossRef
  • Primary Appendicular Tuberculosis
    Vipul D Yagnik
    Gastroenterology & Hepatology: Open Access.2017;[Epub]     CrossRef
Intramuscular Tenosynovial Giant Cell Tumor, Diffuse-Type
Yoo Jin Lee, Youngjin Kang, Jiyoon Jung, Seojin Kim, Chul Hwan Kim
J Pathol Transl Med. 2016;50(4):306-308.   Published online January 11, 2016
  • 7,524 View
  • 103 Download
  • 4 Citations


Citations to this article as recorded by  
  • Intramuscular Tenosynovial Giant Cell Tumor Harboring a Novel CSF1-CD96 Fusion Transcript
    Haider Mejbel, Gene P. Siegal, Shi Wei
    International Journal of Surgical Pathology.2022; 30(3): 335.     CrossRef
  • Diffuse-Type Tenosynovial Giant Cell Tumor of the Tendon Sheath in Both Wrists
    Sunah Heo, Sun-Young Park, Jinwon Seo, Sung Hye Koh, In Jae Lee
    Journal of the Korean Society of Radiology.2021; 82(1): 250.     CrossRef
  • Limited usefulness of classic MR findings in the diagnosis of tenosynovial giant cell tumor
    Julia Crim, Samantha L Dyroff, James Derek Stensby, Andrea Evenski, Lester J Layfield
    Skeletal Radiology.2021; 50(8): 1585.     CrossRef
  • Hot shoulder PET/CT lesion: Unusual presentation of tenosynovial giant cell tumor
    Steven Lewis, Lance Edmonds, Ely Wolin
    Radiology Case Reports.2018; 13(3): 559.     CrossRef
EGFR Gene Amplification and Protein Expression in Invasive Ductal Carcinoma of the Breast
Won Hwangbo, Jeong Hyeon Lee, Sangjeong Ahn, Seojin Kim, Kyong Hwa Park, Chul Hwan Kim, Insun Kim
Korean J Pathol. 2013;47(2):107-115.   Published online April 24, 2013
  • 10,409 View
  • 63 Download
  • 14 Citations
AbstractAbstract PDF

The epidermal growth factor receptor (EGFR) is a surrogate marker for basal-like breast cancer. A recent study suggested that EGFR may be used as a target for breast cancer treatment.


A total of 706 invasive ductal carcinomas (IDC) of the breast were immunophenotyped, and 82 cases with EGFR protein expression were studied for EGFR gene amplification.


EGFR protein was expressed in 121 of 706 IDCs (17.1%); 5.9% were of luminal type, 25.3% of epidermal growth factor receptor 2 (HER-2) type, and 79.3% of basal-like tumors. EGFR gene amplification and high polysomy (fluorescent in situ hybridization [FISH]-positive) were found in 18 of 82 cases (22.0%); 41.2% of the HER-2+, EGFR+, cytokeratin 5/6- (CK5/6-) group, 11.2% of the HER-2-, EGFR+, CK5/6- group, and 19.1% of the HER-2-, EGFR+, CK5/6+ group. FISH-positive cases were detected in 8.3% of the EGFR protein 1+ expression cases, 15.9% of 2+ expression cases, and 38.5% of 3+ expression cases. In group 2, the tumors had a high Ki-67 labeling (>60%), but the patients showed better disease-free survival than those with tumors that co-expressed HER-2 or CK5/6.


EGFR-directed therapy can be considered in breast cancer patients with EGFR protein overexpression and gene amplification, and its therapeutic implication should be determined in HER-2 type breast cancer patients.


Citations to this article as recorded by  
  • Identification of a cross-talk between EGFR and Wnt/beta-catenin signaling pathways in HepG2 liver cancer cells
    Gurjinder Singh, Md Mehedi Hossain, Aadil Qadir Bhat, Mir Owais Ayaz, Nasima Bano, Rafiqa Eachkoti, Mohd Jamal Dar
    Cellular Signalling.2021; 79: 109885.     CrossRef
  • Blocking c-MET/ERBB1 Axis Prevents Brain Metastasis in ERBB2+ Breast Cancer
    Shailendra K. Gautam, Ranjana K. Kanchan, Jawed A. Siddiqui, Shailendra K. Maurya, Sanchita Rauth, Naveenkumar Perumal, Pranita Atri, Ramakanth C. Venkata, Kavita Mallya, Sameer Mirza, Moorthy P. Ponnusamy, Vimla Band, Sidharth Mahapatra, Maneesh Jain, Su
    Cancers.2020; 12(10): 2838.     CrossRef
  • Evaluation of lapatinib cytotoxicity and genotoxicity on MDA-MB-231 breast cancer cell line
    Mona A.M. Abo-Zeid, Mahmoud T. Abo-Elfadl, Amira M. Gamal-Eldeen
    Environmental Toxicology and Pharmacology.2019; 71: 103207.     CrossRef
  • Improved characterization of the relationship between long intergenic non‐coding RNA Linc00152 and the occurrence and development of malignancies
    Jiasheng Xu, Jingjing Guo, Yangkai Jiang, Yujun Liu, Kaili Liao, Zhonghua Fu, Zhenfang Xiong
    Cancer Medicine.2019; 8(10): 4722.     CrossRef
  • Relationship between EGFR expression and subcellular localization with cancer development and clinical outcome
    Ge Yan, Mohamed E.M. Saeed, Sebastian Foersch, Jose Schneider, Wilfried Roth, Thomas Efferth
    Oncotarget.2019; 10(20): 1918.     CrossRef
  • A novel matrine derivative WM622 inhibits hepatocellular carcinoma by inhibiting PI3K/AKT signaling pathways
    Xiao Sun, Xiao-bin Zhuo, Yi-ping Hu, Xuan Zheng, Qing-jie Zhao
    Molecular and Cellular Biochemistry.2018; 449(1-2): 47.     CrossRef
  • lncRNA LINC00152 knockdown had effects to suppress biological activity of lung cancer via EGFR/PI3K/AKT pathway
    Yan Zhang, Cheng Xiang, Yuling Wang, Yuanyuan Duan, Ci Liu, Yongli Jin, Yajing Zhang
    Biomedicine & Pharmacotherapy.2017; 94: 644.     CrossRef
  • Copy Number Profiling of MammaPrint™ Genes Reveals Association with the Prognosis of Breast Cancer Patients
    Areej Fatima, Fomaz Tariq, Muhammad Faraz Arshad Malik, Muhammad Qasim, Farhan Haq
    Journal of Breast Cancer.2017; 20(3): 246.     CrossRef
  • Evaluation of serum epidermal growth factor receptor (EGFR) in correlation to circulating tumor cells in patients with metastatic breast cancer
    Malgorzata Banys-Paluchowski, Isabell Witzel, Sabine Riethdorf, Brigitte Rack, Wolfgang Janni, Peter A. Fasching, Erich-Franz Solomayer, Bahriye Aktas, Sabine Kasimir-Bauer, Klaus Pantel, Tanja Fehm, Volkmar Müller
    Scientific Reports.2017;[Epub]     CrossRef
  • EGFR Is Regulated by TFAP2C in Luminal Breast Cancer and Is a Target for Vandetanib
    James P. De Andrade, Jung M. Park, Vivian W. Gu, George W. Woodfield, Mikhail V. Kulak, Allison W. Lorenzen, Vincent T. Wu, Sarah E. Van Dorin, Philip M. Spanheimer, Ronald J. Weigel
    Molecular Cancer Therapeutics.2016; 15(3): 503.     CrossRef
  • Prognostic and predictive values of EGFR overexpression and EGFR copy number alteration in HER2-positive breast cancer
    H J Lee, A N Seo, E J Kim, M H Jang, Y J Kim, J H Kim, S-W Kim, H S Ryu, I A Park, S-A Im, G Gong, K H Jung, H J Kim, S Y Park
    British Journal of Cancer.2015; 112(1): 103.     CrossRef
  • Epidermal growth factor receptor protein overexpression and gene amplification are associated with aggressive biological behaviors of esophageal squamous cell carcinoma
    Oncology Letters.2015; 10(2): 901.     CrossRef
  • Immunohistochemical Classification of Primary and Secondary Glioblastomas
    Kyu Sang Lee, Gheeyoung Choe, Kyung Han Nam, An Na Seo, Sumi Yun, Kyung Ju Kim, Hwa Jin Cho, Sung Hye Park
    Korean Journal of Pathology.2013; 47(6): 541.     CrossRef
  • A Comparison of Tumor Biology in Primary Ductal CarcinomaIn SituRecurring as Invasive Carcinoma versus a NewIn Situ
    Wenjing Zhou, Christine Johansson, Karin Jirström, Anita Ringberg, Carl Blomqvist, Rose-Marie Amini, Marie-Louise Fjallskog, Fredrik Wärnberg
    International Journal of Breast Cancer.2013; 2013: 1.     CrossRef

JPTM : Journal of Pathology and Translational Medicine