Skip Navigation
Skip to contents

JPTM : Journal of Pathology and Translational Medicine


Author index

Page Path
HOME > Articles and issues > Author index
So Dug Lim 6 Articles
Fatty acid synthetase expression in triple-negative breast cancer
Jin Hee Park, Hye Seung Han, So Dug Lim, Wook Youn Kim, Kyoung Sik Park, Young Bum Yoo, Seung Eun Lee, Wan-Seop Kim
J Pathol Transl Med. 2022;56(2):73-80.   Published online January 21, 2022
  • 2,651 View
  • 129 Download
  • 2 Citations
AbstractAbstract PDF
Triple-negative breast cancer (TNBC) has a relatively poor prognosis. Research has identified potential metabolic targets, including fatty acid metabolism, in TNBC. The absence of effective target therapies for TNBC led to exploration of the role of fatty acid synthetase (FASN) as a potential target for TNBC therapy. Here, we analyzed the expression of FASN, a representative lipid metabolism–related protein, and investigated the association between FASN expression and Ki-67 and the programmed death ligand 1 (PD-L1) biomarkers in TNBC.
Immunohistochemical expression of FASN was analyzed in 166 patients with TNBC. For analytical purposes, patients with 0–1+ FASN staining were grouped as low-grade FASN and patients with 2–3+ FASN staining as high-grade FASN.
FASN expression was observed in 47.1% of TNBC patients. Low and high expression of FASN was identified in 75.9% and 24.1%, respectively, and no statistically significant difference was found in T category, N category, American Joint Committee on Cancer stage, or recurrence rate between the low and high-FASN expression groups. Ki-67 proliferation level was significantly different between the low and high-FASN expression groups. FASN expression was significantly related to Ki-67 as the level increased. There was no significant difference in PD-L1 positivity between the low- and high-FASN expression groups.
We identified FASN expression in 166 TNBC patients. The Ki-67 proliferation index was positively correlated with FASN level, indicating higher proliferation activity as FASN increases. However, there was no statistical association with PD-L1 SP142, the currently FDA-approved assay, or FASN expression level.


Citations to this article as recorded by  
  • Bioinformatics Method Was Used to Analyze the Highly Expressed Gene FAM83A of Breast Cancer in Young Women
    Yongzhe Tang, Hao Wang, Qi He, Yuanyuan Chen, Jie Wang, Fahd Abd Algalil
    Applied Bionics and Biomechanics.2022; 2022: 1.     CrossRef
  • NCAPH promotes proliferation as well as motility of breast cancer cells by activating the PI3K/AKT pathway
    Ting Zhang, Peng Li, Wanying Guo, Qipeng Liu, Weiqiang Qiao, Miao Deng
    Physiology International.2022;[Epub]     CrossRef
Neuroendocrine Dysplasia Combined in a Tubular Adenoma of Rectum: A Case Report
So-Young Lee, Dae-Yong Hwang, Tae Sook Hwang, Wan-Seop Kim, So Dug Lim, Wook Youn Kim, Se-Hun Kim, Hye Seung Han
Korean J Pathol. 2013;47(5):495-498.   Published online October 25, 2013
  • 6,960 View
  • 46 Download
  • 4 Citations


Citations to this article as recorded by  
  • Neuroendocrine cell micronests of the colon
    Richard R. Pacheco, Maria Faraz, Hwajeong Lee
    Human Pathology Reports.2022; 28: 300644.     CrossRef
  • Incidental morphological findings in colorectal adenomas
    Parag D Dabir, Rachel S Post, Iris D Nagtegaal
    Histopathology.2021; 78(3): 348.     CrossRef
  • Large cell neuroendocrine tumor of the gastrointestinal tract with concurrent tubular adenomas
    Inayat GILL, Christienne SHAMS, Elisa QUIROZ, Subhashree M. KRISHNAN, Susanna GAIKAZIAN
    Gazzetta Medica Italiana Archivio per le Scienze Mediche.2021;[Epub]     CrossRef
  • Neuroendocrine tumor mixed with adenoma in rectum: a case report and literature review
    Jiancong Hu, Xiaochuan Chen, Dezheng Lin, Zhaoliang Yu, Juan Li, Xuefeng Guo
    International Journal of Surgery: Oncology.2019; 4(6): 79.     CrossRef
Erratum: Correction of Acknowledgments. ERG Immunohistochemistry as an Endothelial Marker for Assessing Lymphovascular Invasion
Sehun Kim, Hyung Kyu Park, Ho Young Jung, So-Young Lee, Kyueng-Whan Min, Wook Youn Kim, Hye Seung Han, Wan Seop Kim, Tae Sook Hwang, So Dug Lim
Korean J Pathol. 2013;47(5):503-503.   Published online October 25, 2013
  • 4,180 View
  • 38 Download
Rhabdoid Colorectal Carcinomas: Reports of Two Cases
Sang Hwa Lee, Hyesil Seol, Wook Youn Kim, So Dug Lim, Wan Seop Kim, Tae Sook Hwang, Hye Seung Han
Korean J Pathol. 2013;47(4):372-377.   Published online August 26, 2013
  • 6,643 View
  • 35 Download
  • 12 Citations
AbstractAbstract PDF

Rhabdoid colorectal carcinomas are very rare and only 10 cases have been previously reported. We report two cases of rhabdoid colorectal carcinoma, one arising in the sigmoid colon of a 62-year-old man and another in the rectum of an 83-year-old woman. In both cases, the patients had advanced tumors with lymph node metastases. The tumors mostly showed a diffuse arrangement with rhabdoid features and small glandular regions were combined. Transitional areas from the adenocarcinomas to the rhabdoid tumors were also noted. Adenocarcinoma cells were positive for mixed cytokeratin (CK), CK20 and epithelial membranous antigen (EMA), but focal positive for vimentin. The rhabdoid tumor cells were positive for mixed CK, but focal positive or negative for CK20 and EMA. In addition, they were diffusely positive for vimentin, but negative for desmin. The histological and immunohistologial findings of these two cases suggest that the rhabodid tumor cells originated from dedifferentiated adenocarcinomas.


Citations to this article as recorded by  
  • A Rare Case of Undifferentiated Rhabdoid Carcinoma of the Colon
    Syed Alishan Nasir, Ronak Patel, Lalaine Ruiz, Michael Bush
    Cureus.2022;[Epub]     CrossRef
  • INI1-negative colorectal undifferentiated carcinoma with rhabdoid features and postoperative rapidly growing liver metastases: a case report and review of the literature
    Masatsugu Kojima, Toru Miyake, Tomoyuki Ueki, Hiroyuki Ohta, Ryoji Kushima, Masanori Shiohara, Hiroo Mizuta, Hiroya Iida, Tsuyoshi Yamaguchi, Sachiko Kaida, Katsushi Takebayashi, Hiromitsu Maehira, Yusuke Nishina, Tomoharu Shimizu, Eiji Mekata, Masaji Tan
    Surgical Case Reports.2021;[Epub]     CrossRef
  • Undifferentiated carcinoma of the transverse colon with rhabdoid features that developed during treatment of non-small cell lung carcinoma with pembrolizumab: a case report
    Yuya Ashitomi, Mitsuhiro Yano, Michihisa Kono, Takefumi Suzuki, Ichiro Kawamura, Shinji Okazaki, Yukinori Kamio, Osamu Hachiya, Yuka Urano, Fuyuhiko Motoi
    Surgical Case Reports.2020;[Epub]     CrossRef
  • BRAF Mutation in Colorectal Rhabdoid and Poorly Differentiated Medullary Carcinomas
    Bolzacchini, Digiacomo, Marrazzo, Sahnane, Maragliano, Gill, Albarello, Sessa, Furlan, Capella
    Cancers.2019; 11(9): 1252.     CrossRef
  • Pathologic complete response to bevacizumab-FOLFIRI in metastatic colonic undifferentiated carcinoma with rhabdoid features
    Tien-Chan Hsieh, Hung-Wei Liu, Chao-Wen Hsu
    Journal of Cancer Research and Practice.2019; 6(3): 140.     CrossRef
  • Extraordinary disease-free survival in a rare malignant extrarenal rhabdoid tumor: a case report and review of the literature
    Francesco D’Amico, Alessandra Bertacco, Maurizio Cesari, Claudia Mescoli, Giorgio Caturegli, Gabriel Gondolesi, Umberto Cillo
    Journal of Medical Case Reports.2018;[Epub]     CrossRef
  • Tumor rabdoide extrarrenal maligno de colon: presentación de 3 casos y revisión de la literatura
    María José Sánchez-de las Matas Garre, José García Solano, Pablo Conesa Zamora, Fidel Fernández Fernández, Miguel Pérez-Guillermo
    Revista Española de Patología.2016; 49(2): 119.     CrossRef
  • Poorly differentiated cecal adenocarcinoma showing prominent rhabdoid feature combined with appendiceal mucinous cystadenoma: A case report and review of the literature
    Oncology Letters.2015; 9(4): 1527.     CrossRef
  • A Rare Case of Undifferentiated Carcinoma of the Colon with Rhabdoid Features: A Case Report and Review of the Literature
    E. Moussaly, J. P. Atallah
    Case Reports in Oncological Medicine.2015; 2015: 1.     CrossRef
  • Case Report of Rhabdoid Colon Cancer and Review of Literature
    Aparna Kalyan, Gurleen Pasricha, Dulabh Monga, Aatur Singhi, Nathan Bahary
    Clinical Colorectal Cancer.2015; 14(1): e5.     CrossRef
  • Malignant Rhabdoid Tumor of the Colon: A Case Report
    Elena Romera Barba, Ainhoa Sánchez Pérez, Carlos Duque Pérez, José Antonio García Marcilla, José Luis Vázquez Rojas
    Cirugía Española (English Edition).2014; 92(9): 638.     CrossRef
  • Tumor rabdoide maligno de colon: a propósito de un caso☆
    Elena Romera Barba, Ainhoa Sánchez Pérez, Carlos Duque Pérez, José Antonio García Marcilla, José Luis Vázquez Rojas
    Cirugía Española.2014; 92(9): 638.     CrossRef
ERG Immunohistochemistry as an Endothelial Marker for Assessing Lymphovascular Invasion
Sehun Kim, Hyung Kyu Park, Ho Young Jung, So-Young Lee, Kyueng-Whan Min, Wook Youn Kim, Hye Seung Han, Wan Seop Kim, Tae Sook Hwang, So Dug Lim
Korean J Pathol. 2013;47(4):355-364.   Published online August 26, 2013
  • 8,978 View
  • 56 Download
  • 19 Citations
AbstractAbstract PDF

ERG, a member of the ETS family of transcription factors, is a highly specific endothelial marker. We investigated whether the use of ERG immunostaining can help pathologists detect lymphovascular invasion (LVI) and decrease interobserver variability in LVI diagnosis.


Fifteen cases of surgically resected colorectal cancers with hepatic metastasis were selected and the most representative sections for LVI detection were immunostained with ERG, CD31, and D2-40. Eight pathologists independently evaluated LVI status on hematoxylin and eosin (H&E) and the corresponding immunostained sections and then convened for a consensus meeting. The results were analyzed by kappa (κ) statistics.


The average rate of LVI positivity was observed in 43% with H&E only, 10% with CD31, 29% with D2-40, and 16% with ERG. Agreement among pathologists was fair for H&E only (κ=0.27), D2-40 (κ=0.21), ERG (κ=0.23), and was moderate for CD31 (κ=0.55). Consensus revealed that ERG nuclear immunoreactivity showed better visual contrast of LVI detection than the other staining, with improved agreement and LVI detection rate (κ=0.65, LVI positivity rate 80%).


The present study demonstrated a superiority with ERG immunostaining and indicated that ERG is a promising panendothelial marker that might help pathologists increase LVI detection and decrease interobserver variability in LVI diagnosis.


Citations to this article as recorded by  
  • Single‐nucleus transcriptome analysis reveals disease‐ and regeneration‐associated endothelial cells in white matter vascular dementia
    Daniel N. Mitroi, Min Tian, Riki Kawaguchi, William E. Lowry, S. Thomas Carmichael
    Journal of Cellular and Molecular Medicine.2022; 26(11): 3183.     CrossRef
  • Gene of the month: ERG
    Dorinda Mullen, Klaudia Nowak, Runjan Chetty
    Journal of Clinical Pathology.2022; 75(9): 577.     CrossRef
  • Oncological safety of hysteroscopy in endometrial cancer
    Raquel Quintana-Bertó, Pablo Padilla-Iserte, Antonio Gil-Moreno, Reyes Oliver-Pérez, Pluvio J. Coronado, María Belén Martín-Salamanca, Manuel Pantoja-Garrido, Cristina Lorenzo, Eduardo Cazorla, Juan Gilabert-Estellés, Lourdes Sánchez, Fernando Roldán-Riva
    International Journal of Gynecologic Cancer.2022; 32(11): 1395.     CrossRef
  • Upregulated PD-1 signaling antagonizes glomerular health in aged kidneys and disease
    Jeffrey W. Pippin, Natalya Kaverina, Yuliang Wang, Diana G. Eng, Yuting Zeng, Uyen Tran, Carol J. Loretz, Anthony Chang, Shreeram Akilesh, Chetan Poudel, Hannah S. Perry, Christopher O’Connor, Joshua C. Vaughan, Markus Bitzer, Oliver Wessely, Stuart J. Sh
    Journal of Clinical Investigation.2022;[Epub]     CrossRef
  • Primary Soft Tissue Sarcoma of the Heart: An Emerging Chapter in Cardio-Oncology
    Pietro Scicchitano, Maria Chiara Sergi, Matteo Cameli, Marcelo H. Miglioranza, Marco Matteo Ciccone, Marica Gentile, Camillo Porta, Marco Tucci
    Biomedicines.2021; 9(7): 774.     CrossRef
  • Analysis on the healing of gastrointestinal ulceration by using Hemospray
    Christoph R. Werner, Lena Brücklmeier, Thomas Kratt, Nisar P. Malek, Bence Sipos, Dörte Wichmann, Martin Götz
    Scientific Reports.2021;[Epub]     CrossRef
  • Immunohistochemistry for diagnosis and prognosis of breast cancer: a review
    T. Bonacho, F. Rodrigues, J. Liberal
    Biotechnic & Histochemistry.2020; 95(2): 71.     CrossRef
  • TMEM100 is a key factor for specification of lymphatic endothelial progenitors
    Eun-Hye Moon, Yong Hwan Kim, Phuong-Nhung Vu, Hyunjin Yoo, Kwonho Hong, Young Jae Lee, S. Paul Oh
    Angiogenesis.2020; 23(3): 339.     CrossRef
  • Spectral photon-counting CT imaging of colorectal peritoneal metastases: initial experience in rats
    Arnaud Thivolet, Salim Si-Mohamed, Pierre-Emmanuel Bonnot, Christophe Blanchet, Vahan Képénékian, Loïc Boussel, Philippe Douek, Pascal Rousset
    Scientific Reports.2020;[Epub]     CrossRef
  • Diagnostic and reporting issues of preneoplastic polyps of the large intestine with early carcinoma
    Dale C. Snover
    Annals of Diagnostic Pathology.2019; 39: 1.     CrossRef
  • Feasibility of Endoscopic Resection in Early Gastric Cancer with Lymphovascular Invasion
    Jeung Hui Pyo, Hyuk Lee, Yang Won Min, Byung-Hoon Min, Jun Haeng Lee, Kyoung-Mee Kim, Hyeseung Kim, Kyunga Kim, Jae J. Kim
    Annals of Surgical Oncology.2019; 26(2): 449.     CrossRef
  • Lymphovascular Invasion and the Decision for Postmastectomy Radiation Therapy
    J. Arthur Jensen, Rania Bakkar, Michele Burnison, Armando E. Giuliano
    Plastic and Reconstructive Surgery - Global Open.2019; 7(2): e2115.     CrossRef
  • Utility of ERG Immunohistochemistry for Evaluation of Lymphovascular Invasion in Testicular Germ Cell Tumors: A Retrospective Pilot Study
    Aaron M. Udager, Jonathan B. McHugh, Todd M. Morgan, Daniel E. Spratt, Arul M. Chinnaiyan, Rohit Mehra
    Applied Immunohistochemistry & Molecular Morphology.2019; 27(5): 392.     CrossRef
  • An interesting observation from our experiences with circulating tumour cells
    Kok H. Lim, Yong W. Chua, Tony K.H. Lim, Angela M. Takano
    Lung Cancer.2017; 108: 247.     CrossRef
  • Differences in Prevalence of Lymphovascular Invasion among Early Gastric Cancers between Korea and Japan
    Sun-Young Lee, Naohisa Yoshida, Osamu Dohi, Sang Pyo Lee, Daisuke Ichikawa, Jeong Hwan Kim, In-Kyung Sung, Hyung Seok Park, Eigo Otsuji, Yoshito Itoh, Chan Sup Shim, Hye Seung Han, Mitsuo Kishimoto, Yuji Naito
    Gut and Liver.2017; 11(3): 383.     CrossRef
  • Tumor Budding Is an Independent Adverse Prognostic Factor in Pancreatic Ductal Adenocarcinoma
    Kate O’Connor, Hector H. Li-Chang, Steven E. Kalloger, Renata D. Peixoto, Douglas L. Webber, David A. Owen, David K. Driman, Richard Kirsch, Stefano Serra, Charles H. Scudamore, Daniel J. Renouf, David F. Schaeffer
    American Journal of Surgical Pathology.2015; 39(4): 472.     CrossRef
  • P2X7Receptor Expression in Coexistence of Papillary Thyroid Carcinoma with Hashimoto's Thyroiditis
    Ji Hyun Kwon, Eun Sook Nam, Hyung Sik Shin, Seong Jin Cho, Hye Rim Park, Mi Jung Kwon
    Korean Journal of Pathology.2014; 48(1): 30.     CrossRef
  • Evaluation of colon cancer histomorphology: a comparison between formalin and PAXgene tissue fixation by an international ring trial
    Sibylle Gündisch, Julia Slotta-Huspenina, Paolo Verderio, Chiara Maura Ciniselli, Sara Pizzamiglio, Christina Schott, Enken Drecoll, Christian Viertler, Kurt Zatloukal, Marcel Kap, Peter Riegman, Irene Esposito, Katja Specht, Gregor Babaryka, Martin Assla
    Virchows Archiv.2014; 465(5): 509.     CrossRef
  • Tumor Sprouting in Papillary Thyroid Carcinoma Is Correlated with Lymph Node Metastasis and Recurrence
    Eunjung Lee, Wonkyung Jung, Jeong-Soo Woo, Jae Bok Lee, Bong Kyung Shin, Han Kyeom Kim, Aeree Kim, Baek-hui Kim
    Korean Journal of Pathology.2014; 48(2): 117.     CrossRef
A Case of Multifocal Papillary Thyroid Carcinoma Consisting of One Encapsulated Follicular Variant with BRAF K601E Mutation and Three Conventional Types with BRAF V600E Mutation
Wook Youn Kim, Young Sin Ko, Tae Sook Hwang, Hye Seung Han, So Dug Lim, Wan Seop Kim, Seo Young Oh
Korean J Pathol. 2013;47(3):293-298.   Published online June 25, 2013
  • 7,199 View
  • 43 Download
  • 6 Citations
AbstractAbstract PDF

Multifocal papillary thyroid carcinoma (mPTC) comprises about 20-30% of PTC. In mPTC, individual tumor foci can be identical or frequently composed of different histological types including follicular, solid, tall-cell or conventional patterns. We report a case of mPTC consisting of one encapsulated follicular variant of papillary thyroid carcinoma (FVPTC) and three conventional PTCs in a 44-year-old woman. This case genetically demonstrates unique features including the simultaneous presence of the BRAF V600E (T1799A) mutation and the BRAF K601E (A1801G) mutation in conventional PTC and FVPTC, respectively.


Citations to this article as recorded by  
  • Case of aggressive metastatic follicular variant papillary thyroid carcinoma with BRAF K601E and BCORL1 mutations
    Doaa Attia, Alexander Lurie, Qihui Zhai, Robert Smallridge
    BMJ Case Reports.2020; 13(6): e234208.     CrossRef
  • BRAF gene: From human cancers to developmental syndromes
    Muhammad Ramzan Manwar Hussain, Mukhtiar Baig, Hussein Sheik Ali Mohamoud, Zaheer Ulhaq, Daniel C. Hoessli, Ghaidaa Siraj Khogeer, Ranem Radwan Al-Sayed, Jumana Yousuf Al-Aama
    Saudi Journal of Biological Sciences.2015; 22(4): 359.     CrossRef
  • Clinical significance of BRAF V600E mutation in 154 patients with thyroid nodules
    Oncology Letters.2015; 9(6): 2633.     CrossRef
  • Clinicopathological Features of Rare BRAF Mutations in Korean Thyroid Cancer Patients
    Uiju Cho, Woo Jin Oh, Ja Seong Bae, Sohee Lee, Young Sub Lee, Gyeong Sin Park, Youn Soo Lee, Chan Kwon Jung
    Journal of Korean Medical Science.2014; 29(8): 1054.     CrossRef
  • Recurrent Thyroid Papillary Carcinoma in Children Under Ten Years Old: Report of Two Cases and Literature Review
    Byeong-Joo Noh, Ji-Youn Sung, Youn-Wha Kim, Yong-Koo Park
    Korean Journal of Pathology.2014; 48(4): 297.     CrossRef
  • Anaplastic Transformation of Papillary Thyroid Carcinoma in a Young Man: A Case Study with Immunohistochemical andBRAFAnalysis
    Ji Hye Park, Hyeong Ju Kwon, Cheong Soo Park, SoonWon Hong
    Korean Journal of Pathology.2014; 48(3): 234.     CrossRef

JPTM : Journal of Pathology and Translational Medicine