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Young Sub Lee 3 Articles
Primary Neurilemmoma of the Thyroid Gland Clinically Mimicking Malignant Thyroid Nodule
Young Sub Lee, Jee Soon Kim, Arthur Minwoo Chung, Woo Chan Park, Tae-Jung Kim
J Pathol Transl Med. 2016;50(2):168-171.   Published online October 26, 2015
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  • 64 Download
  • 2 Citations


Citations to this article as recorded by  
  • Multimodal ultrasound imaging of primary thyroid schwannoma
    Hai Na Zhao, Bu Yun Ma, Feng Yan, Yu Lan Peng
    Medicine.2021; 100(16): e25517.     CrossRef
  • A Case of Anterior Cervical Intramuscular Schwannoma in the Strap Muscle
    Seul Gi Lee, Ho-Ryun Won, Bon Seok Koo, Jae Won Chang
    Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2021; 64(4): 263.     CrossRef
Histologic Disorderliness in the Arrangement of Tumor Cells as an Objective Measure of Tumor Differentiation
Sungwook Suh, Gyeongsin Park, Young Sub Lee, Yosep Chong, Youn Soo Lee, Yeong Jin Choi
Korean J Pathol. 2014;48(5):339-345.   Published online October 27, 2014
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AbstractAbstract PDF
Background: Inter-observer and intra-observer variation in histologic tumor grading are well documented. To determine whether histologic disorderliness in the arrangement of tumor cells may serve as an objective criterion for grading, we tested the hypothesis the degree of disorderliness is related to the degree of tumor differentiation on which tumor grading is primarily based. Methods: Borrowing from the statistical thermodynamic definition of entropy, we defined a novel mathematical formula to compute the relative degree of histologic disorderliness of tumor cells. We then analyzed a total of 51 photomicrographs of normal colorectal mucosa and colorectal adenocarcinoma with varying degrees of differentiation using our formula. Results: A one-way analysis of variance followed by post hoc pairwise comparisons using Bonferroni correction indicated that the mean disorderliness score was the lowest for the normal colorectal mucosa and increased with decreasing tumor differentiation. Conclusions: Disorderliness, a pathologic feature of malignant tumors that originate from highly organized structures is useful as an objective tumor grading proxy in the field of digital pathology.
Classic Papillary Thyroid Carcinoma with Tall Cell Features and Tall Cell Variant Have Similar Clinicopathologic Features
Woo Jin Oh, Young Sub Lee, Uiju Cho, Ja Seong Bae, Sohee Lee, Min Hee Kim, Dong Jun Lim, Gyeong Sin Park, Youn Soo Lee, Chan Kwon Jung
Korean J Pathol. 2014;48(3):201-208.   Published online June 26, 2014
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  • 115 Download
  • 29 Citations
AbstractAbstract PDF

The tall cell variant of papillary thyroid carcinoma (TCVPTC) is more aggressive than classic papillary thyroid carcinoma (PTC), but the percentage of tall cells needed to diagnose TCVPTC remains controversial. In addition, little is known about the clinicopathologic features of classic PTC with tall cell features (TCF).


We retrospectively selected and reviewed the clinicopathologic features and presence of the BRAF mutation in 203 cases of classic PTC, 149 cases of classic PTC with TCF, and 95 cases of TCVPTCs, which were defined as PTCs having <10%, 10-50%, and ≥50% tall cells, respectively.


TCVPTCs and classic PTCs with TCF did not vary significantly in clinicopathologic characteristics such as pathologic (p) T stage, extrathyroidal extension, pN stage, lateral lymph node metastasis, or BRAF mutations; however, these features differed significantly in TCVPTCs and classic PTCs with TCF in comparison to classic PTCs. Similar results were obtained in a subanalysis of patients with microcarcinomas (≤1.0 cm in size).


Classic PTCs with TCF showed a similar BRAF mutation rate and clinicopathologic features to TCVPTCs, but more aggressive characteristics than classic PTCs.


Citations to this article as recorded by  
  • CD56 Expression in Papillary Thyroid Carcinoma Is Highly Dependent on the Histologic Subtype: A Potential Diagnostic Pitfall
    Uiju Cho, Yourha Kim, Sora Jeon, Chan Kwon Jung
    Applied Immunohistochemistry & Molecular Morphology.2022; 30(5): 389.     CrossRef
  • Aggressive histopathological variants of papillary thyroid carcinoma, diagnostic challenge, and clinical significance—A case series
    PK Pravanya, KR Anila, Shaji Thomas, A Sreekumar, K Jayasree
    Medical Journal of Dr. D.Y. Patil Vidyapeeth.2022;[Epub]     CrossRef
  • Tall cell variant papillary thyroid carcinoma impacts disease-free survival at the 10 % cut-point on multivariate analysis
    Shabnam Samankan, Leah Militello, Gabriella Seo, Sedef Everest, Quinn O'Malley, Sarah L. Spaulding, Monica Xing, Ammar Matloob, John Beute, Raymond Chai, Scott Doyle, Mark L. Urken, Margaret Brandwein-Weber
    Pathology - Research and Practice.2022; 236: 154012.     CrossRef
  • A population-based study of the three major variants of papillary thyroid carcinoma
    Junming Xu, Yingying Zhang, Jun Liu, Shenglong Qiu, Min Wang
    Journal of International Medical Research.2021; 49(2): 030006052098461.     CrossRef
  • Tall cell percentage alone in PTC without aggressive features should not guide patients’ clinical management
    Anello Marcello Poma, David Viola, Elisabetta Macerola, Agnese Proietti, Eleonora Molinaro, Dario De Vietro, Rossella Elisei, Gabriele Materazzi, Paolo Miccoli, Fulvio Basolo, Clara Ugolini
    The Journal of Clinical Endocrinology & Metabolism.2021; 106(10): e4109.     CrossRef
  • Molecular Pathology of Non-familial Follicular Epithelial–Derived Thyroid Cancer in Adults: From RAS/BRAF-like Tumor Designations to Molecular Risk Stratification
    Paula Soares, Antónia Afonso Póvoa, Miguel Melo, João Vinagre, Valdemar Máximo, Catarina Eloy, José Manuel Cameselle-Teijeiro, Manuel Sobrinho-Simões
    Endocrine Pathology.2021; 32(1): 44.     CrossRef
  • Deep Neck Infection: Atypical Presentation of Papillary Thyroid Cancer
    Apichana Mahattanapreut, Rangsima Aroonroch, Chalermchai Chintrakarn, Chutintorn Sriphrapradang, Dinesh K. Chhetri
    Case Reports in Otolaryngology.2021; 2021: 1.     CrossRef
  • The evolving concept of aggressive histological variants of differentiated thyroid cancer
    Juan C. Hernandez-Prera
    Seminars in Diagnostic Pathology.2020; 37(5): 228.     CrossRef
  • Papillary Thyroid Cancer—Aggressive Variants and Impact on Management: A Narrative Review
    Andrés Coca-Pelaz, Jatin P. Shah, Juan C. Hernandez-Prera, Ronald A. Ghossein, Juan P. Rodrigo, Dana M. Hartl, Kerry D. Olsen, Ashok R. Shaha, Mark Zafereo, Carlos Suarez, Iain J. Nixon, Gregory W. Randolph, Antti A. Mäkitie, Luiz P. Kowalski, Vincent Van
    Advances in Therapy.2020; 37(7): 3112.     CrossRef
  • Contemporary evaluation and management of tall cell variant of papillary thyroid carcinoma
    Sara Cartwright, Abbey Fingeret
    Current Opinion in Endocrinology, Diabetes & Obesity.2020; 27(5): 351.     CrossRef
  • Le carcinome papillaire de la thyroïde avec contingent à cellules hautes : facteurs pronostiques
    I. Riahi, H. Jaafoura, H. Saibi, E. Chebil, I. Ben Nacef, M. Ksentini, T. Ben Ghachem, R. Lahiani, M. Ben Salah
    Annales d'Endocrinologie.2020; 81(4): 345.     CrossRef
  • Updates in the Pathologic Classification of Thyroid Neoplasms: A Review of the World Health Organization Classification
    Yanhua Bai, Kennichi Kakudo, Chan Kwon Jung
    Endocrinology and Metabolism.2020; 35(4): 696.     CrossRef
  • Tall Cell Variant of Papillary Thyroid Carcinoma: Impact of Change in WHO Definition and Molecular Analysis
    Kristine S. Wong, Sara E. Higgins, Ellen Marqusee, Matthew A. Nehs, Trevor Angell, Justine A. Barletta
    Endocrine Pathology.2019; 30(1): 43.     CrossRef
  • Histopatological and molecular genetic characteristics of clinically aggressive variants of papillary thyroid carcinoma
    A. V. Bogolyubova, A. Yu. Abrosimov, L. S. Selivanova, P. V. Belousov
    Arkhiv patologii.2019; 81(1): 46.     CrossRef
  • Papillary Thyroid Cancers with Focal Tall Cell Change are as Aggressive as Tall Cell Variants and Should Not be Considered as Low-Risk Disease
    Pim J. Bongers, Wouter P. Kluijfhout, Raoul Verzijl, Mattan Lustgarten, Marloes Vermeer, David P. Goldstein, Karen Devon, Lorne E. Rotstein, Sylvia L. Asa, James D. Brierley, Richard W. Tsang, Shereen Ezzat, Menno R. Vriens, Ozgur Mete, Jesse D. Pasternak
    Annals of Surgical Oncology.2019; 26(8): 2533.     CrossRef
  • A case-based approach to aggressive variants of papillary thyroid carcinoma with literature review
    JosephAntoine Flordelis Chatto, AnnetteLaurente Salillas
    Thyroid Research and Practice.2019; 16(3): 128.     CrossRef
  • Clinically Relevant Prognostic Parameters in Differentiated Thyroid Carcinoma
    Tyler Janovitz, Justine A. Barletta
    Endocrine Pathology.2018; 29(4): 357.     CrossRef
  • Prediction of novel target genes and pathways involved in tall cell variant papillary thyroid carcinoma
    Fada Xia, Bo Jiang, Yong Chen, Xin Du, Yao Peng, Wenlong Wang, Zhuolu Wang, Xinying Li
    Medicine.2018; 97(51): e13802.     CrossRef
  • Papillary thyroid carcinoma with tall cell features is as aggressive as tall cell variant: a meta-analysis
    Huy Gia Vuong, Nguyen Phuoc Long, Nguyen Hoang Anh, Tran Diem Nghi, Mai Van Hieu, Le Phi Hung, Tadao Nakazawa, Ryohei Katoh, Tetsuo Kondo
    Endocrine Connections.2018; 7(12): R286.     CrossRef
  • TERT Promoter Mutation in an Aggressive Cribriform Morular Variant of Papillary Thyroid Carcinoma
    Eun Ji Oh, Sohee Lee, Ja Seong Bae, Yourha Kim, Sora Jeon, Chan Kwon Jung
    Endocrine Pathology.2017; 28(1): 49.     CrossRef
  • Update on the cytologic features of papillary thyroid carcinoma variants
    Marc Pusztaszeri, Manon Auger
    Diagnostic Cytopathology.2017; 45(8): 714.     CrossRef
  • Molecular correlates and rate of lymph node metastasis of non-invasive follicular thyroid neoplasm with papillary-like nuclear features and invasive follicular variant papillary thyroid carcinoma: the impact of rigid criteria to distinguish non-invasive f
    Uiju Cho, Ozgur Mete, Min-Hee Kim, Ja Seong Bae, Chan Kwon Jung
    Modern Pathology.2017; 30(6): 810.     CrossRef
  • BRAF-positive paucicellular variant of anaplastic carcinoma in the presence of tall cell variant papillary thyroid cancer
    O. V. Dolzhansky, E. M. Paltseva, D. N. Khmelkova, F. A. Konovalov, I. V. Kanivets, A. V. Lavrov, D. V. Pyankov, S. A. Korostelev, O. A. Levendyuk, V. M. Pominalnaya, D. N. Fedorov
    Arkhiv patologii.2017; 79(3): 27.     CrossRef
  • A comparison of the clinicopathological features and prognoses of the classical and the tall cell variant of papillary thyroid cancer: a meta-analysis
    Zeming Liu, Wen Zeng, Tianwen Chen, Yawen Guo, Chao Zhang, Chunping Liu, Tao Huang
    Oncotarget.2017; 8(4): 6222.     CrossRef
  • Clinical utility of TERT promoter mutations and ALK rearrangement in thyroid cancer patients with a high prevalence of the BRAF V600E mutation
    Ja Seong Bae, Yourha Kim, Sora Jeon, Se Hee Kim, Tae Jung Kim, Sohee Lee, Min-Hee Kim, Dong Jun Lim, Youn Soo Lee, Chan Kwon Jung
    Diagnostic Pathology.2016;[Epub]     CrossRef
  • Tall cell variant of papillary thyroid carcinoma: current evidence on clinicopathologic features and molecular biology
    Xiaofei Wang, Wenli Cheng, Chongqing Liu, Jingdong Li
    Oncotarget.2016; 7(26): 40792.     CrossRef
  • The Warthin-Like Variant of Papillary Thyroid Carcinoma: A Comparison with Classic Type in the Patients with Coexisting Hashimoto’s Thyroiditis
    Min-kyung Yeo, Ja Seong Bae, Sohee Lee, Min-Hee Kim, Dong-Jun Lim, Youn Soo Lee, Chan Kwon Jung
    International Journal of Endocrinology.2015; 2015: 1.     CrossRef
  • BRAF Immunohistochemistry Using Clone VE1 is Strongly Concordant with BRAFV600E Mutation Test in Papillary Thyroid Carcinoma
    Jung-Soo Pyo, Jin Hee Sohn, Guhyun Kang
    Endocrine Pathology.2015; 26(3): 211.     CrossRef
  • Pathologie de la thyroïde. Cas no 3. Carcinome papillaire de la thyroïde, variante à cellules hautes
    Emmanuelle Leteurtre
    Annales de Pathologie.2015; 35(5): 402.     CrossRef

JPTM : Journal of Pathology and Translational Medicine