Journal of Pathology and Translational Medicine

Young Hee Maeng

3 Articles

A Rare Case of Nodular Mucinosis of the Breast: Hyun Min Koh, Young Hee Maeng, Bo Geun Jang, Jae Hyuk Choi, Chang lim Hyun; J Pathol Transl Med. 2017;51(3):332-334. Published online December 5, 2016; DOI: https://doi.org/10.4132/jptm.2016.07.26

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Practical approach to diagnosis of breast lesions with heterologous components
Abeer M Shaaban, Cecily Quinn, Emad Rakha
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Nodular Mucinosis of the Breast: A Case Report
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New and emerging conditions of acquired cutaneous mucinoses in adults
F. Rongioletti
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Altered presence of extra cellular matrix components in murine skin cancer: Modulation by Azadirachta indica leaf extract
N.A. Chugh, A. Koul
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Mucinosis nodular de la mama
Bernardo Weil Lara, Daniela Pérez Martínez, Beatriz Romero Madrid
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Lycopene enriched tomato extract suppresses chemically induced skin tumorigenesis in mice
Ashwani Koul, Mohinder Pal Bansal, Aniqa Aniqa, Harsh Chaudhary, Neha Arora Chugh
International Journal for Vitamin and Nutrition Research.2020; 90(5-6): 493. CrossRef
A review of mucinous lesions of the breast
Paula S. Ginter, Xiaoyu Tang, Sandra J. Shin
The Breast Journal.2020; 26(6): 1168. CrossRef
Mesenchymal Lesions of the Breast: What Radiologists Need to Know
Debra S. Whorms, Michael D. C. Fishman, Priscilla J. Slanetz
American Journal of Roentgenology.2018; 211(1): 224. CrossRef

Aurora Kinase A Is a Prognostic Marker in Colorectal Adenocarcinoma: Hyun Min Koh, Bo Geun Jang, Chang Lim Hyun, Young Sill Kim, Jin Won Hyun, Weon Young Chang, Young Hee Maeng; J Pathol Transl Med. 2017;51(1):32-39. Published online December 25, 2016; DOI: https://doi.org/10.4132/jptm.2016.10.17

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Abstract PDF

Background
Aurora kinase A (AURKA), or STK15/BTAK, is a member of the serine/threonine kinase family and plays important roles in mitosis and chromosome stability. This study investigated the clinical significance of AURKA expression in colorectal cancer patients in Korea.
Methods
AURKA protein expression was evaluated by immunohistochemistry in 151 patients with colorectal adenocarcinoma using tissue microarray blocks. We analyzed the relationship between clinicopathological characteristics and AURKA expression. In addition, the prognostic significance of various clinicopathological data for progression-free survival (PFS) was assessed. Also we evaluated copy number variations by array comparative genomic hybridization and AURKA gene amplification using fluorescence in situ hybridization in colorectal carcinoma tissues.
Results
AURKA gene amplification was found more frequently in the 20q13.2–13.33 gain-positive group than the group with no significant gain on the AURKA-containing locus. AURKA protein expression was detected in 45% of the cases (68/151). Positive staining for AURKA was observed more often in male patients (p = .035) and distally located tumors (p = .021). PFS was shorter in patients with AURKA expression compared to those with low-level AURKA expression (p < .001). Univariate analysis revealed that AURKA expression (p = .001), age (p = .034), lymphatic invasion (p = .001), perineural invasion (p = .002), and TNM stage (p = .013) significantly affected PFS. In a multivariate analysis of PFS, a Cox proportional hazard model confirmed that AURKA expression was an independent and significant prognostic factor in colorectal adenocarcinoma (hazard ratio, 3.944; p < .001).
Conclusions
AURKA could serve as an independent factor to predict a poor prognosis in Korean colorectal adenocarcinoma patients.

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Early Colorectal Epithelial Neoplasm in Korea: A Multicenter Survey of Pathologic Diagnosis: Yun Kyung Kang, So-Young Jin, Mee Soo Chang, Jung Yeon Kim, Gyeong Hoon Kang, Hye Seung Lee, Jin Hee Sohn, Ho Sung Park, Kye Won Kwon, Mi Jin Gu, Young Hee Maeng, Jong Eun Joo, Haeng Ji Kang, Hee Kyung Kim, Kee-Taek Jang, Mi Ja Lee, Hee Kyung Chang, Joon Mee Kim, Hye Seung Han, Won Ae Lee, Yoon Jung Choi, Dong Wook Kang, Sunhoo Park, Jae Hyuk Lee, Mee-Yon Cho; Korean J Pathol. 2013;47(3):245-251. Published online June 25, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.3.245

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Abstract PDF

Background

The incidence of early colorectal epithelial neoplasm (ECEN) is increasing, and its pathologic diagnosis is important for patient care. We investigated the incidence of ECEN and the current status of its pathologic diagnosis.

Methods

We collected datasheets from 25 institutes in Korea for the incidence of colorectal adenoma with high grade dysplasia (HGD) and low grade dysplasia in years 2005, 2007, and 2009; and early colorectal carcinoma in the year 2009. We also surveyed the diagnostic terminology of ECEN currently used by the participating pathologists.

Results

The average percentage of diagnoses of adenoma HGD was 7.0%, 5.0%, and 3.4% in years 2005, 2007, and 2009, respectively. The range of incidence rates of adenoma HGD across the participating institutes has gradually narrowed over the years 2005 to 2009. The incidence rate of early colorectal carcinoma in the year 2009 was 21.2%. The participants did not share a single criterion or terminology for the diagnosis of adenoma HGD. The majority accepted the diagnostic terms that distinguished noninvasive, mucosal confined, and submucosal invasive carcinoma.

Conclusions

Further research requirements suggested are a diagnostic consensus for the histopathologic diagnosis of ECEN; and standardization of diagnostic terminology critical for determining the disease code.

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Diminutive and Small Colorectal Polyps: The Pathologist's Perspective
Yun Kyung Kang
Clinical Endoscopy.2014; 47(5): 404. CrossRef

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