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Young-Ok Kim 4 Articles
Primary Cutaneous Mucinous Carcinoma with Extramammary Paget’s Disease: Eccrine or Apocrine?
Sun-Ju Oh, Young-Ok Kim
J Pathol Transl Med. 2018;52(4):238-242.   Published online January 25, 2018
  • 5,685 View
  • 115 Download
  • 1 Citations
AbstractAbstract PDF
Primary cutaneous mucinous carcinoma (PCMC) is an uncommon tumor of the sweat gland origin. The occurrence of PCMC is mostly in middle-aged and older patients, with a slight male predominance. Most cases of PCMC arise on the head, with a preference for eyelids. The histogenesis of PCMC, whether eccrine or apocrine, remains controversial. We report a rare case of PCMC with secondary extramammary Paget’s disease in the groin of a 75-year-old man, which favored an apocrine origin. Furthermore, based on a review of the literature, we provide several histologic clues that can be used to differentiate PCMC from metastatic mucinous carcinoma.


Citations to this article as recorded by  
  • A Case of Eccrine Mucinous Carcinoma Involving Scalp
    Ramsha Saleem, Sachin Vaidya
    Cureus.2021;[Epub]     CrossRef
Late Bone Metastasis of Histologically Bland Struma Ovarii: The Unpredictability of Its Biologic Behavior
Sun-Ju Oh, Minjung Jung, Young-Ok Kim
J Pathol Transl Med. 2015;49(4):343-345.   Published online June 15, 2015
  • 6,907 View
  • 67 Download
  • 3 Citations


Citations to this article as recorded by  
  • Malignant Clinical Course of “Proliferative” Ovarian Struma: Diagnostic Challenges and Treatment Pitfalls
    Aleksandra Asaturova, Alina Magnaeva, Anna Tregubova, Vlada Kometova, Yevgeniy Karamurzin, Sergey Martynov, Yuliya Lipatenkova, Leila Adamyan, Andrea Palicelli
    Diagnostics.2022; 12(6): 1411.     CrossRef
  • Malignant struma ovarii with late recurrence harbouring high microsatellite instability
    Su Yun Chung, Jeffrey Chi, Jennifer Park, Veena John, Nagashree Seetharamu
    BMJ Case Reports.2021; 14(6): e242081.     CrossRef
  • Isolated Scapular Metastasis in a Patient with Malignant Struma Ovarii
    Juliane Comunello, Fábio Fernando Eloi Pinto, Suely Akiko Nakagawa, Wu Tu Chung, Felipe D’Almeida Costa, Américo Delgado Brilhante
    JBJS Case Connector.2017; 7(4): e82.     CrossRef
Lipoma within Inverted Meckel's Diverticulum: A Case Report
Su-Mi Kim, Min-Jung Jung, Young-Ok Kim
Korean J Pathol. 2013;47(1):86-88.   Published online February 25, 2013
  • 5,396 View
  • 51 Download
  • 4 Citations


Citations to this article as recorded by  
  • Intestinal obstruction due to a rare tumor in the meckel's diverticulum in a 10-month-old boy
    Gulan Maree, Mohammad Nasser
    Journal of Pediatric Surgery Case Reports.2022; 79: 102210.     CrossRef
  • A Pediatric Case of Inverted Meckel’s Diverticulum Presenting with Cyclic Vomiting-like Symptoms: A Case Report and Literature Review
    Yoshiko Endo, Keisuke Jimbo, Nobuyasu Arai, Takanori Ochi, Mitsuyoshi Suzuki, Atsuyuki Yamataka, Toshiaki Shimizu
    Children.2022; 9(12): 1817.     CrossRef
  • Inverted Meckel’s diverticulum: a case report 
    Lovenish Bains, Rahul Bhatia, Rohit Kaushik, Pawan Lal, Gayatri Rajpaul, Veerpal
    Journal of Medical Case Reports.2021;[Epub]     CrossRef
  • Adult Intussusception Caused by Inverted Meckel’s Diverticulum Containing Mesenteric Heterotopic Pancreas and Smooth Muscle Bundles
    Seungkoo Lee, Seong Whi Cho
    Journal of Pathology and Translational Medicine.2017; 51(1): 96.     CrossRef
Clinicopathologic Implications of PIWIL2 Expression in Colorectal Cancer
Sun-Ju Oh, Su-Mi Kim, Young-Ok Kim, Hee-Kyung Chang
Korean J Pathol. 2012;46(4):318-323.   Published online August 23, 2012
  • 5,955 View
  • 47 Download
  • 31 Citations
AbstractAbstract PDF

There are no established reports about the expression of the Piwil gene, a subfamily of the Piwi gene involved in RNA silencing and self-renewal, in colorectal carcinomas. It is known that the degree of PIWIL2 expression is higher in colorectal carcinomas. But its clinicopathologic significance remains undetermined. This study reassessed the relationship between PIWIL2 expression and the clinicopathologic parameters in colorectal carcinomas.


An immunohistochemistry of PIWIL2 expression was done in 60 cases of colorectal carcinoma. This was followed by an analysis of the correlation between PIWIL2 expression and clinicopathologic features and a survival analysis.


There were 44 cases (73.3%) where the degree of PIWIL2 expression was relatively higher. The high degree of PIWIL2 expression was significantly correlated with the lower degree of differentiation (p=0.039), deep invasion (p=0.019) and perineural invasion (p=0.027). The overall survival was longer in patients with the lower degree of PIWIL2 expression than in those with the higher degree of PIWIL2 expression.


Our results showed that the degree of PIWIL2 expression was relatively higher in colorectal carcinomas and it was significantly correlated with variable clinicopathologic indicators for a poor prognosis. This indicates that PIWIL2-positive cells contribute to the progression of colorectal cancer.


Citations to this article as recorded by  
  • Piwi-interacting RNAs (piRNAs) and Colorectal Carcinoma: Emerging Non-invasive diagnostic Biomarkers with Potential Therapeutic Target Based Clinical Implications
    Suman Kumar Ray, Sukhes Mukherjee
    Current Molecular Medicine.2023; 23(4): 300.     CrossRef
  • piRNA: A promising biomarker in early detection of gastrointestinal cancer
    Melika Ameli Mojarad, Mandana Ameli Mojarad, Bahador Shojaee, Ehsan Nazemalhosseini-Mojarad
    Pathology - Research and Practice.2022; 230: 153757.     CrossRef
  • The function of novel small non‐coding RNAs (piRNAs, tRFs) and PIWI protein in colorectal cancer
    Mandana AmeliMojarad, Melika AmeliMojarad, Jian Wang
    Cancer Treatment and Research Communications.2022; 31: 100542.     CrossRef
  • Morbid Obesity in Women Is Associated with an Altered Intestinal Expression of Genes Related to Cancer Risk and Immune, Defensive, and Antimicrobial Response
    Ailec Ho-Plágaro, Cristina Rodríguez-Díaz, Concepción Santiago-Fernández, Carlos López-Gómez, Sara García-Serrano, Flores Martín-Reyes, Francisca Rodríguez-Pacheco, Alberto Rodríguez-Cañete, Guillermo Alcaín-Martínez, Luis Vázquez-Pedreño, Sergio Valdés,
    Biomedicines.2022; 10(5): 1024.     CrossRef
  • Emerging roles of PIWI-interacting RNAs (piRNAs) and PIWI proteins in head and neck cancer and their potential clinical implications
    Trisha Chattopadhyay, Priyajit Biswal, Anthony Lalruatfela, Bibekanand Mallick
    Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2022; 1877(5): 188772.     CrossRef
  • Cytokine-mediated crosstalk between cancer stem cells and their inflammatory niche from the colorectal precancerous adenoma stage to the cancerous stage: Mechanisms and clinical implications
    Guanglin Cui, Ziqi Wang, Hanzhe Liu, Zhigang Pang
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • piRNAs and PIWI proteins: From biogenesis to their role in cancer
    Negar Balmeh, Samira Mahmoudi, Anasik Karabedianhajiabadi
    Gene Reports.2021; 22: 101013.     CrossRef
  • Epigenetic roles of PIWI proteins and piRNAs in colorectal cancer
    Fatemeh Sadoughi, Seyyed Mehdi Mirhashemi, Zatollah Asemi
    Cancer Cell International.2021;[Epub]     CrossRef
  • PIWI interacting RNAs perspectives: a new avenues in future cancer investigations
    Pooneh Mokarram, Maryam Niknam, Mohammadamin Sadeghdoust, Farnaz Aligolighasemabadi, Morvarid Siri, Sanaz Dastghaib, Hassan Brim, Hassan Ashktorab
    Bioengineered.2021; 12(2): 10401.     CrossRef
  • PIWI family proteins as prognostic markers in cancer: a systematic review and meta-analysis
    Alexios-Fotios A. Mentis, Efthimios Dardiotis, Nicholas A. Romas, Athanasios G. Papavassiliou
    Cellular and Molecular Life Sciences.2020; 77(12): 2289.     CrossRef
  • Identification of Genomic Alterations of Perineural Invasion in Patients with Stage II Colorectal Cancer

    Hao Su, Chen Chang, Jiajie Hao, Xin Xu, Mandula Bao, Shou Luo, Chuanduo Zhao, Qian Liu, Xishan Wang, Zhixiang Zhou, Haitao Zhou
    OncoTargets and Therapy.2020; Volume 13: 11571.     CrossRef
  • Biological function and molecular mechanism of piRNA in cancer
    Ghanbar Mahmoodi Chalbatani, Hassan Dana, Feridon Memari, Elahe Gharagozlou, Shirin Ashjaei, Peyman Kheirandish, Vahid Marmari, Habibollah Mahmoudzadeh, Farnaz Mozayani, Ali Reza Maleki, Ehsan Sadeghian, Elham Zainali Nia, Seyed Rohollah Miri, Neda zainal
    Practical Laboratory Medicine.2019; 13: e00113.     CrossRef
  • Molecular and Functional Characterization of the Somatic PIWIL1/piRNA Pathway in Colorectal Cancer Cells
    Assunta Sellitto, Konstantinos Geles, Ylenia D’Agostino, Marisa Conte, Elena Alexandrova, Domenico Rocco, Giovanni Nassa, Giorgio Giurato, Roberta Tarallo, Alessandro Weisz, Francesca Rizzo
    Cells.2019; 8(11): 1390.     CrossRef
  • Emerging roles of piRNAs in cancer: challenges and prospects
    Ye Cheng, Qian Wang, Wei Jiang, Yonghua Bian, Yang zhou, Anxing Gou, Wenling Zhang, Kai Fu, Weihong Shi
    Aging.2019; 11(21): 9932.     CrossRef
  • Differential expression of PIWIL2 in papillary thyroid cancers
    Ibrahim Halil Erdogdu, Onder Yumrutas, M. Ozgur Cevik, Ibrahim Bozgeyik, Miyase Erdogdu, Hacı Mehmet Inan, Haydar Bagis
    Gene.2018; 649: 8.     CrossRef
  • High expression of PIWIL2 promotes tumor cell proliferation, migration and predicts a poor prognosis in glioma
    Jinquan Li, Li Xu, Zhen Bao, Peng Xu, Hao Chang, Jingjing Wu, Yuanqi Bei, Liuwan Xia, Peizhang Wu, Gang Cui
    Oncology Reports.2017; 38(1): 183.     CrossRef
  • The meaning of PIWI proteins in cancer development
    Monika Litwin, Anna Szczepańska-Buda, Aleksandra Piotrowska, Piotr Dzięgiel, Wojciech Witkiewicz
    Oncology Letters.2017; 13(5): 3354.     CrossRef
  • An unusual intragenic promoter ofPIWIL2contributes to aberrant activation of oncogenicPL2L60
    Shan-Shan Liu, Ning Liu, Meng-Yao Liu, Lei Sun, Wu-Yan Xia, Hong-Min Lu, Yu-Jie Fu, Guo-Liang Yang, Juan-Jie Bo, Xiao-Xing Liu, Haizhong Feng, Hailong Wu, Lin-Feng Li, Jian-Xin Gao
    Oncotarget.2017; 8(28): 46104.     CrossRef
  • Manipulations in HIWI level exerts influence on the proliferation of human non-small cell lung cancer cells
    Experimental and Therapeutic Medicine.2016; 11(5): 1971.     CrossRef
  • High expression of piwi-like RNA-mediated gene silencing 1 is associated with poor prognosis via regulating transforming growth factor-β receptors and cyclin-dependent kinases in breast cancer
    Molecular Medicine Reports.2016; 13(3): 2829.     CrossRef
  • PIWI-Interacting RNAs in Gliomagenesis: Evidence from Post-GWAS and Functional Analyses
    Daniel I. Jacobs, Qin Qin, Michael C. Lerro, Alan Fu, Robert Dubrow, Elizabeth B. Claus, Andrew T. DeWan, Guilin Wang, Haifan Lin, Yong Zhu
    Cancer Epidemiology, Biomarkers & Prevention.2016; 25(7): 1073.     CrossRef
  • Hiwi downregulation, mediated by shRNA, reduces the proliferation and migration of human hepatocellular carcinoma cells
    Molecular Medicine Reports.2015; 11(2): 1455.     CrossRef
  • Emerging roles for PIWI proteins in cancer
    Y. Tan, L. Liu, M. Liao, C. Zhang, S. Hu, M. Zou, M. Gu, X. Li
    Acta Biochimica et Biophysica Sinica.2015; 47(5): 315.     CrossRef
  • Genetic variants in noncoding PIWI-interacting RNA and colorectal cancer risk
    Haiyan Chu, Liping Xia, Xiaonan Qiu, Dongying Gu, Linjun Zhu, Jing Jin, Gaoyun Hui, Qiuhan Hua, Mulong Du, Na Tong, Jinfei Chen, Zhengdong Zhang, Meilin Wang
    Cancer.2015; 121(12): 2044.     CrossRef
  • Piwil2 modulates the invasion and metastasis of prostate cancer by regulating the expression of matrix metalloproteinase-9 and epithelial-mesenchymal transitions
    Oncology Letters.2015; 10(3): 1735.     CrossRef
  • Piwil 2 Expression Is Correlated with Disease-Specific and Progression-Free Survival of Chemotherapy-Treated Bladder Cancer Patients
    Helge Taubert, Sven Wach, Rudolf Jung, Michael Pugia, Bastian Keck, Simone Bertz, Elke Nolte, Robert Stoehr, Jan Lehmann, Carsten-H. Ohlmann, Michael Stöckle, Bernd Wullich, Arndt Hartmann
    Molecular Medicine.2015; 21(1): 371.     CrossRef
  • Overexpression of Hiwi Promotes Growth of Human Breast Cancer Cells
    Da-Wei Wang, Zhao-Hui Wang, Ling-Ling Wang, Yang Song, Gui-Zhen Zhang
    Asian Pacific Journal of Cancer Prevention.2014; 15(18): 7553.     CrossRef
  • Lactobacillus acidophilus and Lactobacillus crispatus Culture Supernatants Downregulate Expression of Cancer-testis Genes in the MDA-MB-231 Cell Line
    Rosa Azam, Soudeh Ghafouri-Fard, Mina Tabrizi, Mohammad-Hossein Modarressi, Reza Ebrahimzadeh-Vesal, Maryam Daneshvar, Maryam Beigom Mobasheri, Elahe Motevaseli
    Asian Pacific Journal of Cancer Prevention.2014; 15(10): 4255.     CrossRef
  • Expression Profiles of PIWIL2 Short Isoforms Differ in Testicular Germ Cell Tumors of Various Differentiation Subtypes
    Ildar V. Gainetdinov, Yulia V. Skvortsova, Elena A. Stukacheva, Oksana S. Bychenko, Sofia A. Kondratieva, Marina V. Zinovieva, Tatyana L. Azhikina, Jian-Xin Gao
    PLoS ONE.2014; 9(11): e112528.     CrossRef
  • PIWIL2 induces c-Myc expression by interacting with NME2 and regulates c-Myc-mediated tumor cell proliferation
    Youlin Yao, Chao Li, Xiaoyan Zhou, Yu Zhang, Yilu Lu, Jianhui Chen, Xulei Zheng, Dachang Tao, Yunqiang Liu, Yongxin Ma
    Oncotarget.2014; 5(18): 8466.     CrossRef
  • Novel dimensions of piRNAs in cancer
    Yuping Mei, David Clark, Li Mao
    Cancer Letters.2013; 336(1): 46.     CrossRef

JPTM : Journal of Pathology and Translational Medicine