Malakoplakia is a characteristic inflammatory condition, which is usually seen in the urogenital tract, and less frequently in the gastrointestinal tract. We present a case of colonic malakoplakia in an immunocompromised patient. A 55-year-old female visited the outpatient clinic for routine cancer surveillance. Her past medical history was significant for kidney transplantation 11 years ago, and she had been taking immunosuppressants. A colonoscopy revealed several depressed flat lesions and elevated polyps, which were 0.3 to 0.4 cm in size and accompanied by whitish exudates. A biopsy revealed an infiltration of histiocytes with ample granular eosinophilic cytoplasm, with some lymphocytes and plasma cells. Many histiocytes had the characteristic morphology, described as Michaelis-Gutmann bodies: one or several round basophilic structures of approximately 1 to 10 µm in size with some being laminated, some appearing homogeneous, and others having a dense central core with a targetoid appearance. These Michaelis-Gutmann bodies were positively stained on von Kossa stain, and were diagnostic for malakoplakia.

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• A Surgical Challenge Generated by Colonic Malakoplakia in Disguise as a Locally Advanced Colonic Malignancy—A Case Report
  Cristina Șerban, Alexandra Toma, Dragoș Cristian Voicu, Constantin Popazu, Dorel Firescu, George Țocu, Raul Mihailov, Laura Rebegea
  Medicina.2023; 59(1): 156.     CrossRef
• Colonic malakoplakia in a cardiac transplant recipient: A case report
  Sadiya Shafijan
  Indian Journal of Pathology and Microbiology.2020; 63(2): 322.     CrossRef
• Immunosuppressive drugs and the gastrointestinal tract in renal transplant patients
  Merel M. Tielemans, Gerben A.J. van Boekel, Teun van Gelder, Eric T. Tjwa, Luuk B. Hilbrands
  Transplantation Reviews.2019; 33(2): 55.     CrossRef
• Malakoplakia of the colon following renal transplantation in a 73 year old woman: report of a case presenting as intestinal perforation
  Andrew Mitchell, Alexandre Dugas
  Diagnostic Pathology.2019;[Epub]     CrossRef
• Colonic malakoplakia in a liver transplant recipient: A case report
  Rana Ajabnoor, Mohammad Mawardi, Abdulmonem Almutawa
  Human Pathology: Case Reports.2019; 18: 200323.     CrossRef
• Malakoplakia after kidney transplantation: Case report and literature review
  John Fredy Nieto-Ríos, Isabel Ramírez, Mónica Zuluaga-Quintero, Lina María Serna-Higuita, Federico Gaviria-Gil, Alejandro Velez-Hoyos
  Transplant Infectious Disease.2017; 19(5): e12731.     CrossRef
• Megalocytic Interstitial Nephritis Following Acute Pyelonephritis with Escherichia coli Bacteremia: A Case Report
  Hee Jin Kwon, Kwai Han Yoo, In Young Kim, Seulkee Lee, Hye Ryoun Jang, Ghee Young Kwon
  Journal of Korean Medical Science.2015; 30(1): 110.     CrossRef