Journal of Pathology and Translational Medicine

Volume 5(1); June 1971

Original Articles

Statistical Analysis for 1,575 Autopsy Cases of Koreans Admitted: C,H. Chi, H. Lee; Korean J Pathol. 1971;5(1):1-11.

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Abstract PDF: Total 1.575 Autopsy cases admitted to the National Medical Center at the period of 1958∼1967 were statistically analysed according to the underlying cause of death and International Classification of diseases. The cases were observed by year, sex, age and comparison between clinical diagnosis and histopathological autopsy diagnosis were made. As the result of present study following conclusion were obtained. 1) The autopsy rate against total hospital death was annually average 55%and ranges from 17, 4%to 99.1%. 2) By sex, 820 cases of male and 360 cases of female(2.3 : 1), infant male 178 cases and female 124 cases(1.4 : 1), and Still birth male 53 cases, female 38 cases(1.4 : 1). 3) Classification according to the underlying cause of death malignant tumor (18.2%) was the highest and among those malignant cases gastrointestinal tract tumor(7.6%) was upper most underlying cause of death. In order of frequency infections and parasitic diseases(14.6%) with highest incidence of tuberculosis(8.7%), Gastro-intestinal tract disease(10.5%), Diseases of circulatory system(8.8%), Still birth(7.4%). Respiratory system(5.6%), and Central nervous system(5.2%) were observed. 4) Misdiagnosis was clarified after autopsy on 20.9% of autopsy cases including 12.6% of unclearly defined clinical diagnosis.

The Early Response of Albino Rat Skin to 3, 7-dimethylbenzanthracene: Dae Hyun Hwang, Young Che Kim; Korean J Pathol. 1971;5(1):13-16.

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Abstract PDF: It is a well known fact that the skin of rats, with a few exceptions, refractory to polycyclic hydrocarbons. The authors tried to observe whether or not the response to dimethylbenzanthracene of albino rats which are widely used in various experiments in our country is similar to that of mice as reported by Mider and Morton (1939) and Clamor and Stowell (1942) in early changes. It was confirmed that the skin reactions consisted of atrophy of the epidermis, elongation and proliferation of hair follicles, increased rate of mitotic division and squamous metaplasia of epithelial cells of the hair follicles, and cystic dilatation of the skin appendages.

A Rapid Micromethod for Determination of Serum Calcium by Means of Orthocresolphthalein Complexone: Ki Hong Kim, Joo Sup Lee; Korean J Pathol. 1971;5(1):19-23.

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Abstract PDF: This study was undertaken to evaluate the usefulness of a rapid micromethod for determination of serum calcium. In 1966 Connrty and Briggs presented a greatly improved manual spectrophotometric method based upon release of the bound calcium by means of protein precipitation and the complete masking of the response of the dye to magnesium by means of 8-quinolinol. Their method was applied to a rapid micromethod in which the process of deproteinization was omitted and only 50 microliters serum was used as a sample instead of 1ml. Clark-Collip method, Diehl-Ellingboe’s EDTA method, and a micromethod using orthocresolphthalein a colar regent were carried out with thirty samples to compare the results each other. On the other hand normal values of healthy Koreans, male 96, female 94, were surveyed by the above mentioned micromethod. The results were followings. 1. Clark-Collip method: mean 9.03 mg Diehl-Ellingboe method: mean 8.99 mg A rapid micromethod: mean 8.88 mg 2. Normal values of Koreans by the rapid micromethod: male 9.47±0.45 mg, female 8.79±0.41 mg%, without consideration of sex 9.14±0.53 mg% Serum calcium levels of Koreans appeared to be lower than those of whites.

Original Articles

Epidemiological and Bacteriological Examination on the Cholera of Taegu Area in 1970: Jae Sik Kim, Hae Jin Kim, Jyung Myung Kim; Korean J Pathol. 1971;5(1):25-31.

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Abstract PDF: The cholera prevailed at Taegu, Korea in August, 1970 was analysed for the epidemiological and bacteriological determinations from true and suspicious, total 109, cases which were admitted to Kyungpook National University Hospital. The results were as followings: 1. The isolation rate of cholera was 33.0% (36 cases) from stool culture. 2. The incidence on sex and age showed that the female group was more than 2 times higher than the male group and more high in twenties group in the female but thirties in the male group. 3. The consistencies of the feces were rice watery in 7 cases (19.4%), diarrheal in 25 cases (65.5%) and formular in 4 cases (11.1%). 4. The excretion of bacteria in feces was continued to the 5∼6th day in most cases, however there was no case continuing the excretion of bacteria from feces beyond 10th day. 5. All of the true cases were the inhibitants of peripheral area of the city or country near the city. 6. The suspected intermediate as an infectious source was generally likely to be sea fishes, fruits and sea plant etc. in order but it was impossible to determine the primary source of the infection. 7. The isolated organism was serologically Ogawa type and revealed positive indole test, Voges-Proskauer test, cholera red test, hemolytic reaction and hemagglutination test on hen red cells in most strains and were resistant to phage type IV in all strains tested. On the carbohydrate fermentation test, glucose and sucrose were fermented but lactose, mannitol, maltose and arabinose were not fermented in most strains. The sensitivity test to the various antibiotics revealed high sensitivity to streptomycin, chloramphenicol, eythromycin and penbritin but there was a tendency of resistance to tetracyclin is tested strains.

Studies on Rapid Fractionation of Serum Protein by Salting Out Method: Jae Sik Kim, Hae Kyo Hong; Korean J Pathol. 1971;5(1):33-37.

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Abstract PDF: A study on rapid fractionation of the serum protein by salting out method rather than expensive electrophoresis was performed with standard normal serum and 100 sera of the normal persons as an evaluation of the usefulness in the screening or replacent of the paper electrophoretic procedure. The results were as followings: 1. The filtration procedure was less time consuming and more simple than surface active agent, span ether, treatment in albumin fractionation. 2. The values obtained from the 100 sera of normal persons were 6.99±0.49gm% in the total protein, 4.13±0.37 gm% in the albumin, 2.86±0.35gm% in the total globulin, 0.95±0.21gm% in the alpha globulin, 0.92±0.29gm% in the beta globulin, 0.99±0.24gm% in the gamma globulin and 1.44±0.25 in the A-G ratio, while the standard normal serum revealed 6.60gm% in the total protein, 3.80gm% in the albumin, 2.80 gm% in the total globulin, 0.80gm% in the alpha globulin, 1.17 gm% in the beta globulin 0.93gm% in the gamma globulin and 1.35 in the A-G ratio. 3. From the above results, it see%ed to be approximated to the values of the paper electrophoresis of another authors.

Autoradiographic Studies of Early Incorporation of L-Leucine-U-14C into the Lung of Burned Mice: Sang Hak Kang, Young Che Kim; Korean J Pathol. 1971;5(1):39-44.

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Abstract PDF: Non-specific pulmonary diseases of the lung new constitute one of the most important medical, social and economic problems of modern civilization. For the causes of non-specific pulmonary diseases it is well documented that the single basic or common property is hypersecretion of branchial mucus. Also it seems to be acceptable that the disturbance of mucus secretion plays a role in the pathogenesis of pulmonary diseases. Hu(1966) in our laboratory revealed that injury (stress) induced marked regressive changes of respiratory mucosa and decreased mucus secretion. Sue (1969) confirmed by autoradiographic method that injury affect profoundly the respiratory tract and bring forth regressive changes in the ciliated epithelium, goblet cells and mixed glands, and reduce mucus secretion due to the interference of uptake of 35S (Na₂³⁵SO₄) into the goblet cells. Kim (1966) demonstrated the amounts of RNA of the lung tissues is decreased by injury. Therefore the authors performed the autoradiographic observation of early incorporation of L- leucine-U-l4C into the epithelium both of the main bronchus and bronchioles in both of normal and∼burned mice in order to confirm that injury may affect on protein metabolism of the epithelium of those tissues. The results were as follows: In the burned mice, the incorporation rate of L-leucine-U-l4C into the epithelial cells of the main bronchus decreased, and that of the bronchioles increased and reached its maximum later than those of normal mice.

The Early Response of Adrenalectomized Albino Rat Skin to 3, 7-Dimethylbenzanthracene: Dae Young Lee, Young Che Kim; Korean J Pathol. 1971;5(1):47-51.

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Abstract PDF: It is a well known fact that the skin of rats, wit& a few exceptions, refractory to polycyclic hydrocarbons. Hwang and Kim (1971) in our laboratory reported that the early skin reactions of amino rats to dimethylbenzanthracene. Reports concerning the chemically induced tumors have been made clear that large number of them by some investigators were shown to be antigenic and it is suggested that the oncogenesis due to chemical carcinogen may be related to immune mechanism. On the other hand adrenalectomy causes marked proliferation of lymphoid tissues, which are main organs concerning to immune mechanism. Therefore the authors tried to observe the response of adrenalectomized albino rat skin to 3, 7-dimethylbenzanthracene. It was confirmed that the skin reactions in the skin of the adrenalectomized rats painted with 3, 7-dimethylbenzanthracene simultaneously, consisted of a marked atrophy of hair follicles, whereas those of the rats pre- or post- painted, a marked proliferation of hair follicles, proliferation and increased rate of mitotic division of epithelial cells of the hair follicles.

A Case of Acardiac Fetus: Sang Ho Kim, Hoon Suk Song, Young Che Kim; Korean J Pathol. 1971;5(1):53-65.

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Abstract PDF: The term monster ’fetus acardius’ is the one of the monozygotic twin who is greatly malformed, reduced and has atrophied or rudimentary body component but no heart or very imperfect one, mainly due to abnormal anastomosis of umbilical vessel in the common placenta between normal and malformed twin. Up today, many cases are reported as the four types, acardius ancephalus, acardius acephalus, acardius acormus and acardius amorphus. Here, we have a good opportunity to study one case of fetus acardius at the Department of Pathology, Catholic Medical College.

A Case of Silicosis: Won Ill Kim, Young Che Kim, Em Goung Yun, Kyu Sang Cho; Korean J Pathol. 1971;5(1):67-72.

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Abstract PDF: This is a first autopsy case in Korea. The patient was a 48 years old male who had been exposed for about 13 years to dust as a miner. Both lungs are massive fibrous adhesion to the pleura. The cut surface of the lung shows excess of pigmentation throughout, but striking and distinctive feature is the presence of round nodules. These are dense and black or gray in colour. Microscopically fibrosis extends into the parenchyma between such nodules and eventually convert the area or the entire lobe into a massive fibrous scar, with only small intervening areas of emphysematous lung parenchyma. The X-ray finding of the lungs show a cavity, measuring 3×4cm and silicotic dense shadow. The silica was confirmed by qualitative test chemically.

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