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- Volume 12(3); October 1978
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Etcs
- Review of Leukemoid Reaction
- Wha Soon Chung, In Pl Kim, Choon Won Kim, Ki Hong Kim
- Korean J Cytopathol. 1978;12(3):211-217.
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Abstract
- The term of "leukemoid reaction" was introduced by krumbharr (1926) and he mentioned that a condition could not be differentiated by only peripheral blood picture. The authors reviewed 109,307 cases of peripheral blood examination of which 160 cases were selected. The selected 160 cases showed over 50, 000/cu mm in total white cell count or more than 2% of immature cells in differential count, respectively. The results were as followings: 1. The leukemia was in 84 cases (52%) and the leukemoid reaction was in 76 cases (48%), respectively. 2. The causes of leukemoid reaction in these cases were as followings ; infection in 32 cases (42%), metabolic disturbance with or without tissue necrosis in 11 cases (14.4%), intoxication in 11 cases (14.4%), malignancy in 8 cases (10.5%) severe hemorrhange in 6 cases (7.9%), and miscellaneous in 6 cases (7.9%). 3. In comparision of peripheal blood findings of leukemoid reaction with leukemia, anemia was prominent in leukemia than leukemoid reaction; in leukemia, mean hemoglobin value was 7.6 gm/dl. and hematocrit was 23.2%, and in leukemoid reaction, mean hemoglobin value was 10.7 gm/dl. and hematocrit was 33.6%, and also total white blood cell count were extremely higher in leukemia with average 82,600/cu mm than leukemoid reaction with average 22,100/cu mm.
- Detection of Platelet Antibody in the sera of Thrombocytopenia Subject and Gravida by Platelet factor 3 Assay.
- Kyung Soon Song, Samuel Y. Lee
- Korean J Cytopathol. 1978;12(3):219-224.
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Abstract
- The increasing use of platelet transfusion in the treatment of thrombocytopenia has stimulated significant advances in the understanding of platelet immunology. A number of antigens which are also shared by granulocytes and Iymphocytes have been found on platelets. These have been shown more recently to be histocompatibility antigens, which are clinically important in causing neonatal and posttransfusion thrombocytopenia and in decreasing the platelet survival of transfused platelets in individuals receiving multiple transfusions. In recent years, many attempts have been made to replace the cumbersome and insensitive complement fixation test with more sensitive methods. These tests have included inhibition of serotonine uptake, release of 51Cr from platelets and assay of platelet factor 3. In this study, the simplified platelet factor 3 assay (Hirschman & Gralnick, 1974) was evaluated in 50 sera from thrombocytopenia with various clinical disorders and in 20 sera from the pregnant women. The results are as follows; 1. About 40% of patients with thrombocytopenia had the malignant tumors and leukemia. Other clinical disorders with thrombocytopenia include hepatic disease, idiopathic thrombocytopenic purpura, disseminated intravascular coagulation, salmonellosis, aplastic anemia and etc. 2. Detection of platelet antibody by PF 3 assay were significantly frequent in the patients with past history of transfusions. 3. By PF 3 assay, platelet antibodies are detectable in 9 cases among 20 pregnant women and the positive frequency was increased with the number of pregnancy. 4. By PF 3 assay, platelet antibody was detectable in 3 out of 4 cases of idiopathic thrombocytopenic purpura. 5. The platelet factor 3 assay appear to be sensitive and applicable in most clinical laboratories. 6. The PF 3 assay may be used as a pretransfusion compatibility test for the patients refractory to platelet transfusions. 7. Studies on the false positive reactions and reproducibility need to be further investigated.
- A Case of Functioning Pheochromocytoma with Erythrocytosis -light and electron microscopic observation-
- Tai Seung Kim, Jae Yun Ro, Yoo Bock Lee
- Korean J Cytopathol. 1978;12(3):225-231.
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Abstract
- Light and electron microscopic observation of a case of functioning pheochromocytoma arising from the right adrenal gland of 67 year old man were made. Chief clinical complaints were paroxysmal hypertension, sweating, palpitation and flushing of the face for 1 year period. Pertinent laboratory findings were 24 hour urinary catecholamine content of 6,307 ㎍ and 25.8 mg of VMA. Hemogram showed 18mg% of hemoglobin and 53% of hematocrit values. Extirpated right adrenal consisted of a well encapsulated tumor mass weighing 30㎎s and measuring 7 cm in the greatest diameter. Cut surface revealed gray to brown color with areas of hemorrhage and necrosis. Microscopically, the tumor showed various shape of large cells containing chromaffin granules in cytoplasm by special staining. On electron microscopy, cytoplasm of the tumor cells was packed with round to oval dense cored secretory granules surrounded by clear halo which are limited by a single membrane. The majority of granules were norepinephrine type and only a few were epinephrine type. Postoperatively, all clinical symptoms disappeared and erythrocytosis returned to normal value.
- Multiple fibromas of tunica vaginalis testis
- Yui Han Kim, Chang Sup Sim, Hyo Soo Jung, Seung Yong Paik
- Korean J Cytopathol. 1978;12(3):233-236.
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Abstract
- Primary benign tumors of the structures within the scrotum are rare. When they occur, the importance of clinical recognition and correct identification is great, both from a standpoint of treatment and prognosis. At this time, the question is raised as to whether they ever represent true fibroma or whether they are fibroid reaction to a chronic inflammatory process. We had a case of multiple fibromas of intrascrotal origin, possibly arising from tunica vaginalis, which herein reported and the literatures are reviewed.
- Sex Cord Tumor with Annular Tubules -A Case report with review of the literature-
- ln Sun Kim, Hynn Sook Kwak, Joo Hong Yoon, Seung Yong Paik
- Korean J Cytopathol. 1978;12(3):239-245.
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Abstract
- The rare "sex cord tumor with annular tubules" is commonly multifocal and of microscopic size and histologically characterized by the presence of simple and complex annular tubules with hyaline bodies and a tendency to calcification. It is thought to prise from granulosa cells but to grow in a pattern of Sertoli ceIls. It occurs disproportionateIy often in patients with Peutz-Jeghers syndrome. In some cases, estrogenic manifestations are present. There is vigorous histogenic and taxonomic controversy in ovarian stroma and sex cord origin tumors including sex cord tumor with annular tubules. It is due in part to a lack of agreement regarding basic embryologic concepts of gonadogenesis and in part to the potential of genital ridges for differentiating in either testis or ovary. Recently authors experienced a case of sex cord tumor with annular tubules in a 11 year old female who revealed precocious breast enlargement and the emergence of pubic and axillary hairs. The size of the tumor(25×15×15cm) seemed to be the largest among the reported cases and the histology is identical with Scully’s cases. A case report with review of the literature was performed.
- Pulmonary blastoma -A case report-
- Nai In Lim, Jae Yun Ro, Yoo Bock Lee
- Korean J Cytopathol. 1978;12(3):247-251.
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Abstract
- The case was a foully years old man who was admitted with complaints of left chest pain and dyspnea. X-ray of the chest revealed a relatively round and well defined mass shadow in the left lower lobe of the lung. Left lower lobectomy was performed under the diagnosis of a tumor. Grossly, a large, soft, necrotic and friable tumor wart located at the peripheral portion of the lobe. No encapsulation was noted tut the border was relatively well demarcated. Microscopically, the tumor was composed of tubular and glandular epithelial component and spindle-shaped stromal element. Both element exhibited malignant nature. The Picture looked like a carcinosarcoma on one hand, and reminiscent to developing fetal lung one the other hand. After reviewing of the literature, the lesion is best considered to a case of pulmonary blastoma which differ in prognosis from carcinosarcoma.
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