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Volume 23(4); December 1989
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Original Articles
Monthy Slide Conference of the Korean Society of Pathologists: A Historical Review on it's 30-year Anniversary.
Je G Chi
Korean J Pathol. 1989;23(4):403-409.
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AbstractAbstract PDF
A brief historical review of our monthly slide conference (MSC) was made. These conferences were begun by several pathologists in Seoul in 1959 under the name of "Monthly Meeting of Seoul Pathologists" acting on a proposal of Dr. Kristen Arnesen. Dr. Arnesen, a Scandinavian pathologist, was the first head of the Department of Pathology of the National Medical Center (NMC), which had been established in 1958 by the joint efforts of the U.N.Korean Reconstruction Agency, the goverments of the three Scandinavian countries and the goverment of the Republic of Korea. Seoul National University, Yonsei University, National Medical Center and Holy Ghost Medical College (now Catholic Medical College) were the first 4 participants who joined the conference from the beginning, and the conferences were held at Seoul National University or at the NMC. This conference was incorporated into the official academic activity of the Korean Society of Pathologists by 1965. The history of MSC was arbitrarily divided into five developmental stages: the first stage (1959-1960), second stage (1961-1963), third stage (1964-1970), fourth stage (1971-1983) and the fifth stage (1984-1988). The number of participating institutions increased to 11 by the end of 1973, 24 by the end of 1983 and 41 by the end of 1988. The total number of cases discussed at the MSC was 1,805 by the end of 1988. An average 100 members have participated each month in the meeting since 1980, and a total of 65 slide sets have been distributed since 1986. This conference has contributed enormously in training resident pathologists and refining diagnostic skills of specialist pathologists. It has become one of the most interesting and eagerly-awaited meeting of the Korean Society of Pathologists. It is author's hope that this brief overview may convey some inspiration to our young pathologist collegues and instigate increased efforts to refine their diagnostic skills and also to explore the vast and, as yet, unsolved problems in the pathology field in this country.
Computerization of Surgical Pathology Reporting and Data Storage by Automatic Coding System using Personal Computer.
Woo Ho Kim, Jeong Wook Seo, Yong Il Kim
Korean J Pathol. 1989;23(4):410-415.
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AbstractAbstract PDF
The authors developed a computer program for use in report printing as well as data storage and retrieval system at the surgical pathology and its efficacy was evaluated at the Department of Pathology, Seoul National University Hospital. This program used IBM PC XT and was written in DBASE III plus language. The main features of the program included an automatic coding and decoding of the diagnosis, automatic searching of the previous biopsy during gross dictation, powerful word processing function and flexibility of the program. The data storage was carried out during the typewriting of the report, so that the typist's workload became markedly reduced. Two kinds of data files wer stored in the hard disk ; the temporary file contained full informations and the permanent file contained the core data only. Searching of a specific case was performed by pathology accession number, chart number, patient's name or by SNOMED code within a second. All the cases were arranged by copied to the diskette during the daily service automatically, with which data were easily restored in case of hard disk failure. The advantages of this program using a persosnal computer were discussed with comparison to those of larger computer system. Based on the experience of 8 months usage in Seoul National University, we assume that this program gives a sufficient solution to the surgical pathology service of many institutes where a large computer system with well designed software is not available yet.
A Study on the Pathogenesis of Renal Papillary Necrosis Induced by Endotoxin.
Kyung Rak Sohn, Tae Joong Sohn
Korean J Pathol. 1989;23(4):416-454.
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AbstractAbstract PDF
The author carried out an experimentation to clarify a possible pathogenesis of renal papillary necrosis induced by an univisceral Shwartzman reaction. The experimental animals were healthy white rabbits in weighing between 1.7 kg and 3.0 kg. Under the condition of ureterostomy, animals were pretreated with 0.5 cc of 50% ethyl alcohol and followed by administration of 0.2 ~ 1.5 mg endotoxin (E. coli 026 : B6, bacto lipopolysaccharide B. Difco, U.S.A.) as preparation in the renal pelvis. And then sacrificed at 10 minutes, 30 minutes, 1 hour, 2 hours, 6 hours and 24 hours after intravenous injection of 0.2 mg or 0.6 mg endotoxin through the ear veins, subjection to examine light and electron microscopically. The obtained results were summarized as follows: Papillary necrosis was developed in 88% among 18 cases excluding 6 cases died before sacrification. There were two types of necrosis, namely papillary and medullary type, but the former and combined forms of both types were the most common findings. Initial main target site of injury in renal papilla induced by endotoxiin was the endothelium of vasa recta and then followed by the Henle's loop, interstitial cell and collecting tubule respectively. Vascular injuries such as swelling and detachment of endothelium were observed since 10 minutes after endotoxin injection. Henle's loop showed stratification of basement membrane without consistent features with time lapses and initially observed fatty vaculoes at 1 hour after endotoxin injection were more eminent in 24 hours group. Main changes of interstitial cells were decrease of lipid droplets while increase of fatty vacuoles; the latter were initially observed in 1 hour group and more eminent in 24 hours group. Collecting tubule showed many fatty vacuoles especially in 24 hours group. It is thought that emergence of fatty vacuoles seems to be a kind of immature lipid droplets to compensate the increased demand of PC release due to continuous ischemic condition. In conclusion, it is thought that ischemic injury due to the vascular changes is pathogenic mechanism producing renal papillary necrosis. Endotoxin induced univisceral Shwartzman reaction in the kidney may be a good experimental model in studying renal papillary necrosis.
Transthoracic Fine Needle Aspiration Cytology: Review of 213 cases.
Kyung Ja Cho, Na Hye Myong, Ja June Jang, Soo Yil Chin, Ki Hwan Kim, Hong Sik Byun, Duk Lim
Korean J Pathol. 1989;23(4):455-460.
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AbstractAbstract PDF
A total of 213 fine needle aspirations from pulmonary lesions in 193 patients performed from January, 1986 to March, 1989 were analyzed. The cytologic diagnoses were unsatisfactory in 10, negative in 60, atypical in 6, suspicious in 11 and malignant in 126 cases. The cytologic types of the malignant cases were 47 squamous cell carcinomas, 40 adenocarcinomas, 10 small cell carcinomas, 6 large cell carcinomas and 10 metastatic tumors. They were verified by the histologic confirmation in 31 cases and by the clinical data in the remainder. There were 5 false-negative cases and none was false-positive, representing 96% sensitivity and 100% specificity. Primary lung cancers were accurately typed in 73% of histologically confirmed case. Cell blocks, prepared in 99 cases, were helpful in tumor typing of 11 cases.
Case Report
Primary Meningioma of the Nasal Cavity and Paranasal Sinuses: A report of a case.
Chang Ok Kim, Mi Kyung Jee, Ki Hwa Yang, Chang Suck Kang, Seok Jin Gang, Byoung Kee Kim, Sun Moo Kim
Korean J Pathol. 1989;23(4):461-464.
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AbstractAbstract PDF
Primary extracranial and extraspinal meningiomas are rare.
Case
s involving the orbit, skin, nasal cavity, paranasal sinuses, oral cavity and parotid gland have been reported. The histogenesis of primary extracranial meningioma is still nucertain, but it has been thought that this tumor originates from arachnoid cell rests in displaced during embryonal development. The authors observed a case of primary meningioma of the nasal cavity and paranasal sinuses occurring in a thirty-eight year old male patient in Feb. 1989. He suffered from bulging in the medio-superior portion of left orbit for 15 years, and left nasal obstruction and headache for 5 years, A head CT scan revealed numberous polypoid masses filling the left frontal sinus left ethmoidal sinus, left maxillary sinus and left nasal cavity. During the operation, a connection to the dura was not found. Microscopically, there were discrete lobules or netst of meningothelial cells, beneath the nasal mucosa. They showed an occasional whorling pattern and psammoma bodies. Therefore, this case was diagnosed as primary meningioma, meningotheliomatous type involving the left nasal cavity and paranasal sinuses.
Original Articles
Development of Desmoid and Mesenteric Fibromas following Total Colectomy for Adenomatous Polyposis Coli in Gardner's syndrome.
Jung Hee Cho, Yong Il Kim
Korean J Pathol. 1989;23(4):465-469.
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AbstractAbstract PDF
We describe a case of polyposis coli, which was followed by development of desmoid in the rectus adbominis muscle and fibromas in the mesentery during an interval of two years. This case supports the hypothesis that, in Garder's syndrome, the traumatic injury by colectomy triggers an unusual fibrous proliferation in the peritoneal cavity and incision site under the possible genetic basis.
Ki-1 Positive T-Cell Lymphoma of Bone in a Child.
Hye Seon Ahn, Gil Ro Han, Jin Hee Sohn, Jung Il Suh, Young Hyeh Ko
Korean J Pathol. 1989;23(4):470-475.
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AbstractAbstract PDF
Ki-1 monoclonal antibody is a well known marker for Reed-Sternberg cells in Hodgkin's disease, but also occasionally reacts with activated lymphoid cells of either benign or malignant nature. Recently, Ki-1 antibody positive Non-Hodgkin's lymphoma, usually of large cell and/or polymorphous type, has been reported in the lymph nodes, skin, soft tissue, and stomach, but not in the bone. We report a case of multifocal primary bone lymphoma in a seven-year old body involving the left shoulder and right frontal bone, which proved to be a large cell, polymorphous lymphoma, helper T-cell type expressing Ki-1 antigen.
Case Reports
Hurthle Cell Tumor of the Thyroid Gland in an Infant: A case report.
Kyoung Ho Kim, Mi Kyung Lee, Dong Hwan Shin, Tae Seung Kim, Eui Ho Hwang
Korean J Pathol. 1989;23(4):476-481.
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AbstractAbstract PDF
Hurthle cell tumors are an infrequent neoplasm of the thyroid gland in adults. Hurthle cell tumors represent 4. 5% to 10% of all primary thyroid epithelial neoplasms in the foreign literature. It has been known as Hurthle cell tumor since Ewing was the first to use this term in 1928. Tumor occurring in an infant was described by Symmers(1941) and Morrow(1945). The authors experienced a case of congenital Hurthle cell tumor of the thyroid gland in a 2 months old boy. He was admitted to the pediatric surgical department because of a growing mass in the neck since birth. Ultrasonogram showed a huge lobulated homogenous solid mass with medium level echogenicity in the region of the thyroid gland. Subtotal thyroidectomy of right lobe and total thyroidectomy of left lobe were done. The specimen measures 2x3x1.5 cm and 7x3x3 cm, respectively. It was an encapsulated, yellow gray firm and solid mass. The cut surface was smooth, glistening and homogenous. Microscopicully, the tumor was composed of tightly packed regular follicles lined by polyhedral, cuboidal, large cells with a granular acidophilic cytoplasms. The nuclei are vesicular, usually only a little bit larger than those of normal thyroid cells.
Amniotic Band Syndrome: An autopsy case report.
Hye Seon Ahn, Gil Ro Han, Jin Hee Sohn, Jung Il Suh
Korean J Pathol. 1989;23(4):482-486.
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AbstractAbstract PDF
We report an autopsy case of amniotic band syndrome exhibiting microcephaly, asymmetric encephalocele, microphthalmia, nasal deformity, cleft lip and palate accompanied by left maxillary and zygomatic bone deformities. The amniotic membrane of the placenta was also attached to the herniated brain. The twenty-year-old primigravid mother had no history of taking drug, irradiation, infection or trauma before or during pregnancy.
Holoacardius Hemisomus Acephalus: A case report.
Tae Jin Kim, Chong Jai Kim, Sung Hye Park, Suk Keun Lee, Je G Chi
Korean J Pathol. 1989;23(4):487-489.
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AbstractAbstract PDF
An autopsy case of holoacardius hemisomus acephalus is reported. She weighed 2,190 gm and the height was 38 cm. The head and upper extremities were absent, while the vertebrae and lower extremities were relatively well developed, but severely edematous. The heart, lungs, stomach, liver, spleen, and pancreas were missing, but the lower abdominal organs including kidneys, adrenal, urinary bladder, and genital organs were present. The intestine was blind-ended at jejunal level but opened into a normal anus. The umbilical cord had two arteries and one vein.
Spinal Enterogenous Cyst: A report of a case.
Ki Hwa Yang, Kyo Young Lee, Young Sup Park, Seok Jin Kang, Byoung Kee Kim, Sun Moo Kim
Korean J Pathol. 1989;23(4):490-493.
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AbstractAbstract PDF
Although varying types of cystic lesion, true to false, in the spinal cord have been described, spinal enterogenous cyst is a rare condition. It is considered as a result of congenital remnant of primitive foregut. The authors experienced a case of a spinal enterogenous cyst in the intradural space along the fouth, fifth and sixth cervical spine, occurred in a twenty-seven years old male patient. The cyst was composed of hyalinized fibrous wall with single layered lining epithelium, such as simple non-ciliated cuboidal epithelium or ciliated tall columnar epithelium with focal mucinous columnar epithelium.

JPTM : Journal of Pathology and Translational Medicine