Journal of Pathology and Translational Medicine

Cytologic Distinctive Features of Brenner Tumor.: Jung Sik Jang, An Na Seo, Seon Jae Lee, Ji Young Park; Korean J Pathol. 2011;45(2):223-226.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.2.223

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Herein, we present two cases of Brenner tumor, a rarely occurring neoplasm in the ovaries, obtained via intraoperative fine needle aspiration. The borderline Brenner tumor exhibited marked squamous metaplasia, characterized by individually distributed atypical squamous cells. A benign Brenner tumor associated with mucinous cystadenoma evidenced typical mucinous metaplastic features and transitional foci. These distinctive features may prove helpful in differential diagnosis of varied ovarian tumors, and particularly for intraoperative consultation.

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Pre‐operative cytodiagnosis of an adult granulosa cell tumour: report of a case with its differential diagnosis
S. R. Jinkala, S. E. Jacob, S. Neelaiah, B. A. Badhe
Cytopathology.2014; 25(1): 63. CrossRef

Sertoli-Leydig Cell Tumor with a Coexisting Brenner Tumor of the Ovary.: Ji Youn Bae, Sang Pyo Kim, Kwan Kyu Park, Soon Do Cha; Korean J Pathol. 1996;30(3):266-268.

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Abstract PDF: Sertoli-Leydig cell tumor or Brenner tumor is a relatively rare ovarian tumor. Other associated elements in the form of epithelial, mesenchymal, and tumor components of each tumor have been reported. The Sertoli-Leydig cell tumor with a Brenner tumor element has not been documented in the literature, so we are reporting on a case of Sertoli-Leydig cell tumor coexisting with a Brenner tumor. This 62-year-old woman presented with a 4 year history of lower abdominal mass and vaginal bleeding. Exploratory laparotomy was done. The left ovary showed a multiseptated, cystic, yellow-white solid mass, measuring 17.0x13.0x5.0 cm and weighing 985.0 gm. Microscopic examination revealed a tubular or trabecular arrangement of the Sertoli cells and variable numbers of Leydig cells. There were several tumor nests with cystic spaces composed of ovoid cells showing longitudinal nuclear grooving. Sarcomatoid or heterologous elements were not found.

Malignant Brenner Tumor: Report of a case.: Kyeong Mee Park, So Young Park, Yeon Lim Suh; Korean J Pathol. 1994;28(4):405-408.

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Abstract PDF: Brenner tumors constitute about l.5~2.5% of all primary ovarian neoplasms and are almost always benign. It appears to derive from the surface epithelium of the ovary which undergoes metap1asia to form the urothelial-like components. we experienced a case of malignant Brenner tumor with adenocarcinoma and squamous cell carcinoma patterns in a 57-year-old woman. It was partly cystic tumor and contained a 4cm-sized gray yellow, lobulated or papillary solid mass, projecting from the cystic wall. Ultrastructurally, the solid mass was composed of malignant urothelial-like cells with focal glandular differentiation.

Primary Transitional Cell Carcinoma of the Ovary: A case report.: Eun Kyung Kim, Sung Ran Hong, Jae Uk Shim, Hy Sook Kim; Korean J Pathol. 1993;27(1):78-80.

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Abstract PDF: Primary ovarian transitional cell carcinoma(TCC) is a recently described, distinct subtype of ovarian carcinoma resembling TCC of the urinary bladder. TCC differs from malignant Brenner tumor(MBT) by absence of benign or proliferative Brenner component and prominent stromal calcification. TCC also represents a high-stage tumor with more aggressive biologic behavior than MBT, but it has a relatively favorable response to chemotherapy. TCC may arise from the pluripotential surface epithelium of the ovary or from the cells with urothelial differentiation, rather than from a benign or proliferative Brenner tumor precursors. We report a case of pure form of primary TCC presenting as a left ovarian mass in 45-year-old woman.

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