Journal of Pathology and Translational Medicine

Original Article

A multicenter study of interobserver variability in pathologic diagnosis of papillary breast lesions on core needle biopsy with WHO classification: Hye Ju Kang, Sun Young Kwon, Ahrong Kim, Woo Gyeong Kim, Eun Kyung Kim, Ae Ree Kim, Chungyeul Kim, Soo Kee Min, So Young Park, Sun Hee Sung, Hye Kyoung Yoon, Ahwon Lee, Ji Shin Lee, Hyang Im Lee, Ho Chang Lee, Sung Chul Lim, Sun Young Jun, Min Jung Jung, Chang Won Jung, Soo Youn Cho, Eun Yoon Cho, Hye Jeong Choi, So Yeon Park, Jee Yeon Kim, In Ae Park, Youngmee Kwon; J Pathol Transl Med. 2021;55(6):380-387. Published online October 6, 2021; DOI: https://doi.org/10.4132/jptm.2021.07.29

4,459 View
205 Download
4 Web of Science
4 Crossref

Background
Papillary breast lesions (PBLs) comprise diverse entities from benign and atypical lesions to malignant tumors. Although PBLs are characterized by a papillary growth pattern, it is challenging to achieve high diagnostic accuracy and reproducibility. Thus, we investigated the diagnostic reproducibility of PBLs in core needle biopsy (CNB) specimens with World Health Organization (WHO) classification.
Methods
Diagnostic reproducibility was assessed using interobserver variability (kappa value, κ) and agreement rate in the pathologic diagnosis of 60 PBL cases on CNB among 20 breast pathologists affiliated with 20 medical institutions in Korea. This analysis was performed using hematoxylin and eosin (H&E) staining and immunohistochemical (IHC) staining for cytokeratin 5 (CK5) and p63. The pathologic diagnosis of PBLs was based on WHO classification, which was used to establish simple classifications (4-tier, 3-tier, and 2-tier).
Results
On WHO classification, H&E staining exhibited ‘fair agreement’ (κ = 0.21) with a 47.0% agreement rate. Simple classifications presented improvement in interobserver variability and agreement rate. IHC staining increased the kappa value and agreement rate in all the classifications. Despite IHC staining, the encapsulated/solid papillary carcinoma (EPC/SPC) subgroup (κ = 0.16) exhibited lower agreement compared to the non-EPC/SPC subgroup (κ = 0.35) with WHO classification, which was similar to the results of any other classification systems.
Conclusions
Although the use of IHC staining for CK5 and p63 increased the diagnostic agreement of PBLs in CNB specimens, WHO classification exhibited a higher discordance rate compared to any other classifications. Therefore, this result warrants further intensive consensus studies to improve the diagnostic reproducibility of PBLs with WHO classification.

Citations

Citations to this article as recorded by

Invasive papillary carcinoma of the breast
Shijing Wang, Qingfu Zhang, Xiaoyun Mao
Frontiers in Oncology.2024;[Epub] CrossRef
Recommendations for Performance Evaluation of Machine Learning in Pathology: A Concept Paper From the College of American Pathologists
Matthew G. Hanna, Niels H. Olson, Mark Zarella, Rajesh C. Dash, Markus D. Herrmann, Larissa V. Furtado, Michelle N. Stram, Patricia M. Raciti, Lewis Hassell, Alex Mays, Liron Pantanowitz, Joseph S. Sirintrapun, Savitri Krishnamurthy, Anil Parwani, Giovann
Archives of Pathology & Laboratory Medicine.2024; 148(10): e335. CrossRef
Encapsulated papillary carcinoma of the breast: A single institution experience
Liang Xu, Qixin Mao, Qiuming Liu, Yufeng Gao, Lihua Luo, Chungen Guo, Wei Qu, Ningning Yan, Yali Cao
Oncology Letters.2023;[Epub] CrossRef
High-risk and selected benign breast lesions diagnosed on core needle biopsy: Evidence for and against immediate surgical excision
Aparna Harbhajanka, Hannah L. Gilmore, Benjamin C. Calhoun
Modern Pathology.2022; 35(11): 1500. CrossRef

Case Study

Primary Myxoid Leiomyoma of the Liver: Hee Seung Choi, Chang Won Jung, Soo Youn Cho, Sang Bum Kim, Sunhoo Park; Korean J Pathol. 2014;48(1):54-57. Published online February 25, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.1.54

7,977 View
61 Download
2 Crossref

Abstract PDF

Herein, we report a case of primary myxoid leiomyoma of the liver. A 60-year-old woman complained of upper abdominal fullness. Computed tomography showed a solid tumor (8 cm) in the liver. The patient underwent right hepatectomy and histological findings from the resected specimen revealed scattered bland spindle cells in a background of exuberant myxoid material. The tumor cells were immunoreactive for smooth muscle actin and desmin. No other lesions were found elsewhere in the body. Thus, the tumor was diagnosed as a primary myxoid leiomyoma of the liver.

Citations

Citations to this article as recorded by

Hepatic Myxoid Leiomyoma: A Very Rare Tumor
João Fraga, Rui Caetano Oliveira, Luigi Terracciano, Mário Rui Silva, Maria Augusta Cipriano
GE - Portuguese Journal of Gastroenterology.2020; 27(5): 352. CrossRef
A Firm Hepatic Mass Cannot Be Penetrated by US-Guided Needle Biopsy
Suk Hyun Jang, Sun Moon Kim, Jang Sihn Sohn, Ki Hyun Ryu, Hyung Bin Yuk
Clinical Ultrasound.2016; 1(2): 126. CrossRef

Original Articles

Fine Needle Aspiration Cytology of Parathyroid Lesions: Ilyeong Heo, Sunhoo Park, Chang Won Jung, Jae Soo Koh, Seung-Sook Lee, Hyesil Seol, Hee Seung Choi, Soo Youn Cho; Korean J Pathol. 2013;47(5):466-471. Published online October 25, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.5.466

9,266 View
100 Download
33 Crossref

Abstract PDF

Background

There has been an increase in the use of fine needle aspiration cytology (FNAC) for the diagnosis of parathyroid lesions (PLs). Differentiation between a thyroid lesion and a PL is not easy because of their similar features. We reviewed parathyroid aspirates in our institution and aimed to uncover trends in diagnostic criteria.

Methods

We selected 25 parathyroid aspirates (from 6 men and 19 women) confirmed surgically or immunohistochemically from 2006 to 2011.

Results

Major architectural findings of PLs include scattered naked nuclei, loose clusters, a papillary pattern with a fibrovascular core, tight clusters, and a follicular pattern. These architectures were commonly admixed with one another. Cytological features included anisokaryosis, stippled chromatin, a well-defined cell border, and oxyphilic cytoplasm. Eighteen of the 25 patients were diagnosed with PL using FNAC. Seven patients had been misdiagnosed with atypical cells (n=2), benign follicular cells (n=2), adenomatous goiter (n=2) and metastatic carcinoma (n=1) in FNAC. Using clinicoradiologic data, the sensitivity of the cytological diagnosis was 86.7%. The cytological sensitivity decreased to 50% without this information.

Conclusions

FNAC of PL is easily confused with thyroid lesions. A combination of cytological parameters and clinical data will be required to improve the diagnostic sensitivity of PLs.

Citations

Citations to this article as recorded by

Sonographic Features of Atypical and Initially Missed Parathyroid Adenomas: Lessons Learned From a Single-Center Cohort
Seyfettin Ilgan, Berna İmge Aydoğan, Özdeş Emer, Cüneyd Anıl, Alptekin Gürsoy, Mustafa Cesur, Banu Bilezikçi
The Journal of Clinical Endocrinology & Metabolism.2024; 109(2): 439. CrossRef
Fine needle aspiration biopsy of parathyroid; is it meaningful? A cytologic study of 81 cases with histological and clinical correlations
Elwira Bakuła‐Zalewska, Joanna Długosińska, Agata Stanek‐Widera, Piotr Góralski, Jacek Gałczyński, Agnieszka Żyłka, Monika Durzyńska, Marek Dedecjus
Cytopathology.2024; 35(3): 362. CrossRef
Primary hyperparathyroidism with intrathyroidal location of parathyroid adenoma
M. I. Fadeeva, L. Z. Vasifova, E. A. Savelyeva, L. S. Urusova, A. K. Eremkina, N. G. Mokrysheva
Meditsinskiy sovet = Medical Council.2024; (16): 230. CrossRef
Diagnosis of parathyroid incidentaloma detected on thyroid ultrasonography: the role of fine-needle aspiration cytology and washout parathyroid hormone measurements
Boeun Lee, Sae Rom Chung, Young Jun Choi, Tae-Yon Sung, Dong Eun Song, Tae Yong Kim, Jeong Hyun Lee, Jung Hwan Baek
Ultrasonography.2023; 42(1): 129. CrossRef
Intrathyroidal parathyroid adenomas: Scoping review on clinical presentation, preoperative localization, and surgical treatment
Shravan V. Gowrishankar, Rohan Bidaye, Tilak Das, Veronika Majcher, Brian Fish, Ruth Casey, Liam Masterson
Head & Neck.2023; 45(3): 706. CrossRef
A stepwise approach to fine needle aspiration cytology of lymph nodes
Yosep Chong, Gyeongsin Park, Hee Jeong Cha, Hyun-Jung Kim, Chang Suk Kang, Jamshid Abdul-Ghafar, Seung-Sook Lee
Journal of Pathology and Translational Medicine.2023; 57(4): 196. CrossRef
The Utility of Fine Needle Aspiration (FNA) Biopsy in the Diagnosis of Mediastinal Lesions
Uma Kundu, Qiong Gan, Deepak Donthi, Nour Sneige
Diagnostics.2023; 13(14): 2400. CrossRef
Case presentation of the smallest non-functional parathyroid carcinoma and review of the literature
S. Ivaniš, M. Jovanović, D. Dunđerović, G. Zorić, B. Odalović, N. Slijepčević, K. Taušanović, B. Rovčanin, M. Buzejić, D. Vučen, B. Stepanović, J. Ilić, M. Parezanović, M. Marinković, M. Stojanović, A. Tošković, I. Mojsić, V. Živaljević
European Archives of Oto-Rhino-Laryngology.2023; 280(12): 5637. CrossRef
Utility of parathyroid hormone immunocytochemistry in fine needle aspiration diagnosis of parathyroid tissue
Ruhani Sardana, Rita Abi‐Raad, Adebowale J. Adeniran, Guoping Cai
Cytopathology.2023; 34(6): 597. CrossRef
Parathyroid carcinoma: impact of preoperative diagnosis on the choice of surgical procedure
Yoshitaka Kawai, Yo Kishimoto, Hisanobu Tamaki, Takashi Fujiwara, Ryo Asato, Koji Ushiro, Shogo Shinohara, Shinpei Kada, Shinji Takebayashi, Tsuyoshi Kojima, Shuya Otsuki, Masakazu Miyazaki, Yohei Kumabe, Koichi Omori
Endocrine Journal.2023; 70(10): 969. CrossRef
The Value of Preoperative and Intraoperative Ultrasound in the Localization of Intrathyroidal Parathyroid Adenomas
Wei Zhao, Ruigang Lu, Li Yin, Bojun Wei, Mulan Jin, Chun Zhang, Ruijun Guo, Xiuzhang Lv
Journal of Investigative Surgery.2022; 35(4): 752. CrossRef
Cyto‐morphological features of parathyroid lesions: Fine‐needle aspiration cytology series from an endocrine tumor referral center
Sanna Steen, Martin Hysek, Jan Zedenius, Henrik Falhammar, Carl Christofer Juhlin
Diagnostic Cytopathology.2022; 50(2): 75. CrossRef
Non‐secreting parathyroid carcinoma in a dog
Giovanni Tremolada, Paula Schaffer, Kathryne Pitt
Veterinary Record Case Reports.2022;[Epub] CrossRef
Fine needle aspiration of an intrathyroidal parathyroid carcinoma mimicking a primary thyroid anaplastic carcinoma: A case report with review of the literature
Fatima Mir, Prih Rohra, Nfn Aakash, Karina Furlan, Ritu Ghai, Vijaya Reddy, Lin Cheng, Paolo Gattuso
Diagnostic Cytopathology.2021;[Epub] CrossRef
Fine‐needle aspiration of parathyroid adenomas: Indications as a diagnostic approach
Ayana Suzuki, Mitsuyoshi Hirokawa, Risa Kanematsu, Aki Tanaka, Naoki Yamao, Miyoko Higuchi, Toshitetsu Hayashi, Seiji Kuma, Akihiro Miya, Akira Miyauchi
Diagnostic Cytopathology.2021; 49(1): 70. CrossRef
Two-year changes of biochemical profiles and bone mineral density after percutaneous ultrasound-guided microwave ablation for primary hyperparathyroidism
Wenjun Wu, Qi Zhou, Shihao Xu, Siqin An, Feixia Shen, Huanbin Li, Xiaohua Gong, Xiaojun Chen
Endocrine.2021; 71(2): 476. CrossRef
Multimodal imaging of thyroid cancer
Katrin Brauckhoff, Martin Biermann
Current Opinion in Endocrinology, Diabetes & Obesity.2020; 27(5): 335. CrossRef
Major Clues and Pitfalls in the Differential Diagnosis of Parathyroid and Thyroid Lesions Using Fine Needle Aspiration Cytology
Hwa Jeong Ha, Eun Ju Kim, Jung-Soon Kim, Myung-Soon Shin, Insup Noh, Sunhoo Park, Jae Soo Koh, Seung-Sook Lee
Medicina.2020; 56(11): 558. CrossRef
Comparison of ultrasound-guided percutaneous microwave ablation and parathyroidectomy for primary hyperparathyroidism
Fangyi Liu, Xiaoling Yu, Zhoulu Liu, Zhi Qiao, Jianping Dou, Zhigang Cheng, Zhiyu Han, Jie Yu, Ping Liang
International Journal of Hyperthermia.2019; 36(1): 834. CrossRef
Giant parathyroid adenoma: a case report and review of the literature
Mohamed S. Al-Hassan, Menatalla Mekhaimar, Walid El Ansari, Adham Darweesh, Abdelrahman Abdelaal
Journal of Medical Case Reports.2019;[Epub] CrossRef
Water Clear Cell Parathyroid Adenoma: A Report of Two Cases
Abdelrahman M. Radaideh, Hisham Alkhalidi, Mohamad Nusier, Mohammad Alqudah
Arab Gulf Journal of Scientific Research.2019; : 33. CrossRef
Cytological challenges in the diagnosis of intrathyroidal parathyroid carcinoma: A case report and review of literature
Meera Balakrishnan, Smiley Annie George, Sayed Hashim Rajab, Issam M Francis, Kusum Kapila
Diagnostic Cytopathology.2018; 46(1): 47. CrossRef
Association of parathyroid carcinoma and thyroid disorders: A clinical review
Alfredo Campennì, Salvatore Giovinazzo, Salvatore Antonio Pignata, Francesca Di Mauro, Domenico Santoro, Lorenzo Curtò, Francesco Trimarchi, Rosaria Maddalena Ruggeri, Sergio Baldari
Endocrine.2017; 56(1): 19. CrossRef
Fine needle cytology pre‐surgical differentiation of parathyroid neoplasms: Is it reliable?
A. Caleo, M. Vitale, L. Valvano, M. Siano, B. Angrisani, M. Forlenza, A. Massari, A. Puzziello, F. Salzano, P. Zeppa
Cytopathology.2017; 28(4): 273. CrossRef
Identification of parathyroid tissue in thyroid fine‐needle aspiration: A combined approach using cytology, immunohistochemical, and molecular methods
Robert P. Domingo, Lorna L. Ogden, Laura C. Been, Giulia C. Kennedy, S. Thomas Traweek
Diagnostic Cytopathology.2017; 45(6): 526. CrossRef
Cytomorphologic features distinguishing Bethesda category IV thyroid lesions from parathyroid
Simon Sung, Anjali Saqi, Elizabeth M. Margolskee, John P. Crapanzano
CytoJournal.2017; 14: 10. CrossRef
Core-needle biopsy for the preoperative diagnosis of follicular neoplasm in thyroid nodule screening: A validation study
Sung Hak Lee, Gyeong Sin Park, So Lyung Jung, Min-Hee Kim, Ja Seong Bae, Dong Jun Lim, Chan Kwon Jung
Pathology - Research and Practice.2016; 212(1): 44. CrossRef
Parathyroid lesions: Difficult diagnosis on cytology
Charu Agarwal, Manju Kaushal
Diagnostic Cytopathology.2016; 44(8): 704. CrossRef
Intrathyroidal parathyroid adenoma: Diagnostic pitfalls on fine‐needle aspiration: Two case reports and literature review
Chang Shi, Hongwei Guan, Wenjing Qi, Jialin Ji, Jialing Wu, Feng Yan, Huali Wang
Diagnostic Cytopathology.2016; 44(11): 921. CrossRef
Diagnostic value of GATA-3 in cytological identification of parathyroid tissues
Nami Takada, Mitsuyoshi Hirokawa, Ayana Suzuki, Miyoko Higuchi, Seiji Kuma, Akira Miyauchi
Endocrine Journal.2016; 63(7): 621. CrossRef
PARATHYROID CYTOLOGY: A DIAGNOSTIC DILEMMA
Naval Kishore Bajaj, Shrinivas Somalwar, Akhtar Mohammad, Ezhil Arasi Nagamuthu
Journal of Evidence Based Medicine and Healthcare.2016; 3(71): 3849. CrossRef
Fine-Needle Aspiration Cytology of Parathyroid Lesions
Teklu Legesse, Paul N. Staats
Pathology Case Reviews.2015; 20(5): 227. CrossRef
A nonfunctioning parathyroid carcinoma misdiagnosed as a follicular thyroid nodule
Filomena Cetani, Gianluca Frustaci, Liborio Torregrossa, Silvia Magno, Fulvio Basolo, Alberto Campomori, Paolo Miccoli, Claudio Marcocci
World Journal of Surgical Oncology.2015;[Epub] CrossRef

Fine-Needle Aspiration Cytology of Pleomorphic Carcinomas of the Lung: Hee Seung Choi, Hyesil Seol, Il Yeong Heo, Chang Won Jung, Soo Youn Cho, Sunhoo Park, Jae Soo Koh, Seung-Sook Lee; Korean J Pathol. 2012;46(6):576-582. Published online December 26, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.6.576

7,101 View
41 Download
5 Crossref

Abstract PDF

Background

Pleomorphic carcinoma (PC) is a rare pulmonary malignancy. Because of its rarity and histological heterogeneity, cytopathologists might suspect PC only rarely on the basis of its cytological specimen. In addition, cytological findings from fine needle aspiration (FNA) specimens have rarely been described. Hence, we investigated the cytological features of FNA in the cases of PC.

Methods

We reviewed 7 FNA specimens of PC. The patients had undergone surgical resection at the Korea Cancer Center Hospital between 2007 and 2011. The cytological features of PC were assessed and compared with the histopathological features of the corresponding surgical specimen. Immunocytochemical analysis with cytokeratin and vimentin was performed on the cell blocks.

Results

The tumor cells were either dispersed or arranged in loose aggregates, and generally lacked any glandular or squamous differentiation. Pleomorphic or spindle shape tumor cells were observed, and mono-, bi-, or multi-nucleated giant cells were frequently observed. The background showed necrosis and contained numerous lymphocytes and neutrophils. Immunocytochemically, the tumor cells were positive for cytokeratin and vimentin.

Conclusions

PC displays characteristic cytological features. It might therefore be possible to make an accurate diagnosis of PC by assessing the degree of nuclear atypia.

Citations

Citations to this article as recorded by

Sarcomatoid carcinoma in cytology: Report of a rare entity presenting in pleural and pericardial fluid preparations
Atreyee Basu, Andre L. Moreira, Anthony Simms, Tamar C. Brandler
Diagnostic Cytopathology.2019; 47(8): 813. CrossRef
Cytological Evaluation of Pleomorphic Carcinoma of the Lung
Kevin Kuan, Samer N. Khader, Siba El Hussein
Diagnostic Cytopathology.2019; 47(9): 961. CrossRef
Combined small cell carcinoma with giant cell carcinoma component of the lung: A case successfully diagnosed by computed tomography‑guided fine‑needle aspiration cytology
Yusuke Ebisu, Mitsuaki Ishida, Tomohito Saito, Tomohiro Murakawa, Yoshiko Uemura, Koji Tsuta
Oncology Letters.2017;[Epub] CrossRef
Pulmonary Pleomorphic Carcinoma Detected as a Result of Pneumothorax and the Subsequent Occurrence of Multiple Cystic Metastases
Hideaki Yamakawa, Masahiro Yoshida, Masami Yabe, Yuri Baba, Emiri Baba, Hiroaki Katagi, Takeo Ishikawa, Masamichi Takagi, Takeo Nakada, Tadashi Akiba, Kazuyoshi Kuwano
Case Reports in Medicine.2014; 2014: 1. CrossRef
Pulmonary pleomorphic carcinoma with multiple metastases to the right posterior knee complicated by paraneoplastic hypercalcemia
PENG-FEI LI, CHENG-HSIANG LO, SHAN-HAN YANG, PING-YING CHUNG, CHING-LIANG HO
Oncology Letters.2014; 7(2): 452. CrossRef

First
Prev
Page of 1
Next
Last

Search