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Original Article
- Aurora Kinase A Is a Prognostic Marker in Colorectal Adenocarcinoma
- Hyun Min Koh, Bo Geun Jang, Chang Lim Hyun, Young Sill Kim, Jin Won Hyun, Weon Young Chang, Young Hee Maeng
- J Pathol Transl Med. 2017;51(1):32-39. Published online December 25, 2016
- DOI: https://doi.org/10.4132/jptm.2016.10.17
- 8,647 View
- 185 Download
- 24 Web of Science
- 26 Crossref
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Abstract
PDF - Background
Aurora kinase A (AURKA), or STK15/BTAK, is a member of the serine/threonine kinase family and plays important roles in mitosis and chromosome stability. This study investigated the clinical significance of AURKA expression in colorectal cancer patients in Korea.
Methods
AURKA protein expression was evaluated by immunohistochemistry in 151 patients with colorectal adenocarcinoma using tissue microarray blocks. We analyzed the relationship between clinicopathological characteristics and AURKA expression. In addition, the prognostic significance of various clinicopathological data for progression-free survival (PFS) was assessed. Also we evaluated copy number variations by array comparative genomic hybridization and AURKA gene amplification using fluorescence in situ hybridization in colorectal carcinoma tissues.
Results
AURKA gene amplification was found more frequently in the 20q13.2–13.33 gain-positive group than the group with no significant gain on the AURKA-containing locus. AURKA protein expression was detected in 45% of the cases (68/151). Positive staining for AURKA was observed more often in male patients (p = .035) and distally located tumors (p = .021). PFS was shorter in patients with AURKA expression compared to those with low-level AURKA expression (p < .001). Univariate analysis revealed that AURKA expression (p = .001), age (p = .034), lymphatic invasion (p = .001), perineural invasion (p = .002), and TNM stage (p = .013) significantly affected PFS. In a multivariate analysis of PFS, a Cox proportional hazard model confirmed that AURKA expression was an independent and significant prognostic factor in colorectal adenocarcinoma (hazard ratio, 3.944; p < .001).
Conclusions
AURKA could serve as an independent factor to predict a poor prognosis in Korean colorectal adenocarcinoma patients. -
Citations
Citations to this article as recorded by
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Brief Case Report
- A Rare Case of Nodular Mucinosis of the Breast
- Hyun Min Koh, Young Hee Maeng, Bo Geun Jang, Jae Hyuk Choi, Chang lim Hyun
- J Pathol Transl Med. 2017;51(3):332-334. Published online December 5, 2016
- DOI: https://doi.org/10.4132/jptm.2016.07.26
- 7,322 View
- 127 Download
- 6 Web of Science
- 8 Crossref
-
PDF
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Citations
Citations to this article as recorded by- Practical approach to diagnosis of breast lesions with heterologous components
Abeer M Shaaban, Cecily Quinn, Emad Rakha
Diagnostic Histopathology.2024; 30(2): 100. CrossRef - Nodular Mucinosis of the Breast: A Case Report
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Revista Española de Patología.2020; 53(1): 42. CrossRef - Lycopene enriched tomato extract suppresses chemically induced skin tumorigenesis in mice
Ashwani Koul, Mohinder Pal Bansal, Aniqa Aniqa, Harsh Chaudhary, Neha Arora Chugh
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- Practical approach to diagnosis of breast lesions with heterologous components
Case Report
- Undifferentiated Carcinoma Arising in a Choledochal Cyst: A Case Report.
- Hee Eun Lee, Chang Lim Hyun, You Jeong Lee, Hye Sil Seol, Ja June Jang
- Korean J Pathol. 2006;40(6):461-465.
- 1,606 View
- 17 Download
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Abstract
PDF
- An association between choledochal cyst and carcinoma is well established. Here, we report an extremely rare case of undifferentiated carcinoma exhibiting extensive sarcomatous features arising in a choledochal cyst. The patient in our case had a radiologically confirmed choledochal cyst and anomalous pancreaticobiliary ductal union, and mild wall thickening in the cyst was observed on endoscopic retrograde cholangiopancreatography. The patient underwent common bile duct excision and cholecystectomy. In the choledochal cyst, a nodule measuring 1.5x1 cm was detected. The lesion was composed of atypical, spindle-shaped and large, round pleomorphic tumor cells simulating sarcoma. Neither glandular nor squamous differentiation was observed. These cells were immunoreactive for both vimentin and cytokeratin by immunohistochemistry. These histologic and immunohistochemical findings were consistent with undifferentiated carcinoma, spindle and giant cell type, according to the WHO classification.
Original Article
- Pathological Analysis of 1,000 Cases of Transrectal Ultrasoundguided Systematic Prostate Biopsy: Establishment of New Sample Processing Method and Diagnostic Utility of Immunohistochemistry.
- Chang Lim Hyun, Hee Eun Lee, Haeryung Kim, Hye Seung Lee, So Yeon Park, Jin Haeng Chung, Gheeyoung Choe
- Korean J Pathol. 2006;40(6):406-419.
- 1,860 View
- 36 Download
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Abstract
PDF
- BACKGROUND
We developed a new processing method for extended prostate needle biopsy, and evaluated diagnostic utility of routine immunohistochemistry in 1,000 consecutive unselected cases of transrectal ultrasound-guided systematic prostate biopsy.
METHODS
Four to five biopsy cores were embedded in one paraffin block. All the biopsy cores were immunohistochemically stained with basal cell markers.
RESULTS
The new sample processing method was technically perfect for making a diagnosis from extended prostate needle biopsy. Among 1,000 cases, there were 323 cases (32.3%) of adenocarcinoma, 5 cases of other malignant tumors, 9 cases of high-grade prostatic intraepithelial neoplasia without a carcinoma, and only 8 cases of atypical small acinar proliferation. Among the 323 cases of adenocarcinoma, there were 38 cases (11.8%) of microcarcinomas <0.1 cm and 101 cases (31.3%) of small adenocarcinomas <0.3 cm in length. In the needle biopsy specimens, 59 cases (18.3%) were classified as clinically insignificant carcinomas. Among them, 37 cases underwent radical prostatectomy, which turned out to be clinically significant carcinomas in 24 cases (64.9%).
CONCLUSIONS
Routinely performed immunohistochemistry combined with the new sample processing method is very effective for detecting microscopic carcinoma foci as well as differentiating carcinoma from benign conditions mimicking cancer.
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