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Original Articles
SIRT1 Expression Is Associated with Good Prognosis in Colorectal Cancer
Wonkyung Jung, Kwang Dae Hong, Woon Yong Jung, Eunjung Lee, Bong Kyung Shin, Han Kyeom Kim, Aeree Kim, Baek-hui Kim
Korean J Pathol. 2013;47(4):332-339.   Published online August 26, 2013
DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.4.332
  • 10,021 View
  • 81 Download
  • 38 Crossref
AbstractAbstract PDF
Background

Silent mating type information regulation 2 homolog 1 (SIRT1), an NAD+-dependent deacetylase, might act as a tumor promoter by inhibiting p53, but may also as a tumor suppressor by inhibiting several oncogenes such as β-catenin and survivin. Deleted in breast cancer 1 (DBC1) is known as a negative regulator of SIRT1.

Methods

Immunohistochemical expressions of SIRT1, DBC1, β-catenin, surviving, and p53 were evaluated using 2 mm tumor cores from 349 colorectal cancer patients for tissue microarray.

Results

Overexpression of SIRT1, DBC1, survivin, and p53 was seen in 235 (67%), 183 (52%), 193 (55%), and 190 (54%) patients, respectively. Altered expression of β-catenin was identified in 246 (70%) patients. On univariate analysis, overexpression of SIRT1 (p=0.029) and altered expression of β-catenin (p=0.008) were significantly associated with longer overall survival. Expression of SIRT1 was significantly related to DBC1 (p=0.001), β-catenin (p=0.001), and survivin (p=0.002), but not with p53. On multivariate analysis, age, tumor stage, differentiation, and expression of SIRT1 were independent prognostic factors significantly associated with overall survival.

Conclusions

SIRT1 overexpression is a good prognostic factor for colorectal cancer, and SIRT1 may interact with β-catenin and survivin rather than p53.

Citations

Citations to this article as recorded by  
  • ZMIZ1 Regulates Proliferation, Autophagy and Apoptosis of Colon Cancer Cells by Mediating Ubiquitin–Proteasome Degradation of SIRT1
    Min Huang, Junfeng Wang, Zhengrong Zhang, Xueliang Zuo
    Biochemical Genetics.2024; 62(4): 3245.     CrossRef
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    Dong Hoon Shin, Jeong Yeon Jo, Minyoung Choi, Kyung-Hee Kim, Young-Ki Bae, Sang Soo Kim
    Experimental & Molecular Medicine.2023; 55(10): 2220.     CrossRef
  • Association of β-Catenin, APC, SMAD3/4, Tp53, and Cyclin D1 Genes in Colorectal Cancer: A Systematic Review and Meta-Analysis
    Hongfeng Yan, Fuquan Jiang, Jianwu Yang, Ying-Kun Xu
    Genetics Research.2022; 2022: 1.     CrossRef
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    BIOCELL.2022; 46(12): 2525.     CrossRef
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    Amna Matly, Jean A. Quinn, Donald C. McMillan, James H. Park, Joanne Edwards
    Critical Reviews in Oncology/Hematology.2021; 163: 103337.     CrossRef
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    Liz M. Garcia-Peterson, Xiaoling Li
    Biochimica et Biophysica Acta (BBA) - General Subjects.2021; 1865(9): 129952.     CrossRef
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    Cancer Letters.2017; 409: 104.     CrossRef
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    Oncotarget.2017; 8(37): 62589.     CrossRef
  • Prognostic and clinicopathological significance of SIRT1 expression in NSCLC: a meta-analysis
    Yifei Chen, Tao Wang, Wei Wang, Jiahao Hu, Ruiting Li, Shaojun He, Jiong Yang
    Oncotarget.2017; 8(37): 62537.     CrossRef
  • The prognostic role of Sirt1 expression in solid malignancies: a meta-analysis
    Changwen Wang, Wen Yang, Fang Dong, Yawen Guo, Jie Tan, Shengnan Ruan, Tao Huang
    Oncotarget.2017; 8(39): 66343.     CrossRef
  • SIRT1 induces tumor invasion by targeting epithelial mesenchymal transition-related pathway and is a prognostic marker in triple negative breast cancer
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    Tumor Biology.2016; 37(4): 4743.     CrossRef
  • Survivin and SIRT1: can be two prognostic factors in chronic myeloid leukemia?
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  • Clinicopathological significance of SIRT1 expression in colorectal cancer: A systematic review and meta analysis
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    International Journal of Surgery.2016; 26: 32.     CrossRef
  • The small molecule survivin inhibitor YM155 may be an effective treatment modality for colon cancer through increasing apoptosis
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    Biochemical and Biophysical Research Communications.2016; 471(2): 309.     CrossRef
  • Nuclear expression and/or reduced membranous expression of β-catenin correlate with poor prognosis in colorectal carcinoma
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    Medicine.2016; 95(49): e5546.     CrossRef
  • Association of SIRT1 and HMGA1 expression in non-small cell lung cancer
    SHUANG-YAN LIN, FANG PENG
    Oncology Letters.2016; 11(1): 782.     CrossRef
  • SIRT1 is a regulator of autophagy: Implications in gastric cancer progression and treatment
    Guanglin Qiu, Xuqi Li, Xiangming Che, Chao Wei, Shicai He, Jing Lu, Zongliang Jia, Ke Pang, Lin Fan
    FEBS Letters.2015; 589(16): 2034.     CrossRef
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    BMC Gastroenterology.2015;[Epub]     CrossRef
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    Yul Ri Chung, Hyojin Kim, Soo Young Park, In Ae Park, Ja June Jang, Ji-Young Choe, Yoon Yang Jung, Seock-Ah Im, Hyeong-Gon Moon, Kyung-Hun Lee, Koung Jin Suh, Tae-Yong Kim, Dong-Young Noh, Wonshik Han, Han Suk Ryu
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  • Expression of ROR1, pAkt, and pCREB in gastric adenocarcinoma
    Hyeyoon Chang, Woon Yong Jung, Youngran Kang, Hyunjoo Lee, Aeree Kim, Baek-hui Kim
    Annals of Diagnostic Pathology.2015; 19(5): 330.     CrossRef
  • miR-34a inhibits cell proliferation in prostate cancer by downregulation of SIRT1 expression
    KUN DUAN, YONG-CHAO GE, XUE-PEI ZHANG, SHU-YI WU, JIN-SHUN FENG, SHI-LIN CHEN, LI ZHANG, ZHI-HAO YUAN, CHAO-HONG FU
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    C. E. Harbison, F. Taheri, H. Knight, A. D. Miller
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  • Fentanyl Increases Colorectal Carcinoma Cell Apoptosis by Inhibition of NF-κB in a Sirt1-dependent Manner
    Xiu-Lai Zhang, Min-Li Chen, Sheng-Li Zhou
    Asian Pacific Journal of Cancer Prevention.2014; 15(22): 10015.     CrossRef
  • Elevated HOXB9 expression promotes differentiation and predicts a favourable outcome in colon adenocarcinoma patients
    J Zhan, M Niu, P Wang, X Zhu, S Li, J Song, H He, Y Wang, L Xue, W Fang, H Zhang
    British Journal of Cancer.2014; 111(5): 883.     CrossRef
  • Prognostic Factors for Metastatic Colorectal Cancer after First-line Chemotherapy with FOLFOX-4 or FOLFIRI Regimen
    Jae Hyun Kim, Pyoung Rak Choi, Seun Ja Park, Moo In Park, Won Moon, Sung Eun Kim, Gyu Won Lee
    The Korean Journal of Gastroenterology.2014; 63(4): 209.     CrossRef
  • Down-Regulation of mir-221 and mir-222 Restrain Prostate Cancer Cell Proliferation and Migration That Is Partly Mediated by Activation of SIRT1
    Xiao Yang, Yingmei Yang, Rong Gan, Lingxu Zhao, Wei Li, Huaibin Zhou, Xiaojuan Wang, Jianxin Lu, Qing H. Meng, George Calin
    PLoS ONE.2014; 9(6): e98833.     CrossRef
Expression of SIRT1 and DBC1 in Gastric Adenocarcinoma
Youngran Kang, Woon Yong Jung, Hyunjoo Lee, Eunjung Lee, Aeree Kim, Baek-hui Kim
Korean J Pathol. 2012;46(6):523-531.   Published online December 26, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.6.523
  • 8,367 View
  • 48 Download
  • 29 Crossref
AbstractAbstract PDF
Background

Sirtuin 1 (SIRT1) and deleted in breast cancer 1 (DBC1) are known as tumor suppressor or promoter genes. This may be due to their diverse functions and interaction with other proteins. Gastric adenocarcinoma is one of the most common malignancies, but little is known about its carcinogenesis. Therefore, we investigated the association of immunohistochemical expression of SIRT1, DBC1, p53, and β-catenin and their variable clinicopathological characteristics.

Methods

We obtained samples from 452 patients who underwent gastrectomy. Tissue microarray blocks were constructed and immonohistochemical staining was performed.

Results

Expression of DBC1 and SIRT1 was associated with lower histologic grade, intestinal type of Lauren classification, and lower pT (p<0.001) and pN stage (DBC1, p=0.002; SIRT1, p<0.001). Association between absence of lymphatic invasion, and SIRT1 (p=0.001) and DBC1 (p=0.004) was observed. Cytoplasmic β-catenin expression was associated with lower histologic grade, pT, pN, tumor-node-metastasis (TNM) stage, DBC1 (p<0.001), and SIRT1 (p=0.001). Expression of SIRT1 and DBC1 was not associated with p53 (p=0.063 and p=0.060). DBC1 was an independent good prognostic factor in multivariate analysis (p=0.012).

Conclusions

SIRC1 and DBC1 can be considered to be good prognostic factors in gastric adenocarcinoma.

Citations

Citations to this article as recorded by  
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