Background Macrophages are a component of a tumor’s microenvironment and have various roles in tumor progression and metastasis. This study evaluated the relationships between tumor-associated macrophage (TAM) density and clinical outcomes in 14 different types of human cancers. Methods: We investigated TAM density in human tissue microarray sections from 14 different types of human cancers (n = 266) and normal thyroid, lung, and breast tissues (n = 22). The five-year survival rates of each cancer were obtained from the 2011 Korea Central Cancer Registry. Results: Among 13 human cancers, excluding thyroid cancer, pancreas, lung, and gallbladder cancers had the highest density of CD163-positive macrophages (7.0±3.5%, 6.9±7.4%, and 6.9 ± 5.5%, respectively). The five-year relative survival rates of these cancers (pancreas, 8.7%; lung, 20.7%; gallbladder, 27.5%) were lower than those of other cancers. The histological subtypes in thyroid cancer exhibited significantly different CD163-positive macrophages densities (papillary, 1.8 ± 1.6% vs anaplastic, 22.9 ± 17.1%; p < .001), but no significant difference between histological subtypes was detected in lung and breast cancers. Moreover, there was no significant difference in CD163-positive macrophages densities among the TNM stages in lung, breast, and thyroid cancers. Conclusions: Cancers with higher TAM densities (pancreas, lung, anaplastic thyroid, and gallbladder) were associated with poor survival rate.
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Tumor-associated macrophage infiltration in meningioma Dustin T Proctor, Jordan Huang, Sanju Lama, Abdulrahman Albakr, Guido Van Marle, Garnette R Sutherland Neuro-Oncology Advances.2019;[Epub] CrossRef
Immune and Inflammatory Cells in Thyroid Cancer Microenvironment Silvia Martina Ferrari, Poupak Fallahi, Maria Rosaria Galdiero, Ilaria Ruffilli, Giusy Elia, Francesca Ragusa, Sabrina Rosaria Paparo, Armando Patrizio, Valeria Mazzi, Gilda Varricchi, Gianni Marone, Alessandro Antonelli International Journal of Molecular Sciences.2019; 20(18): 4413. CrossRef
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Chloroquine and nanoparticle drug delivery: A promising combination Joe Pelt, Sara Busatto, Mauro Ferrari, E. Aubrey Thompson, Kabir Mody, Joy Wolfram Pharmacology & Therapeutics.2018; 191: 43. CrossRef
Conditioned medium from stimulated macrophages inhibits growth but induces an inflammatory phenotype in breast cancer cells Wenzhe Song, Parth Thakor, David A. Vesey, Glenda C. Gobe, Christudas Morais Biomedicine & Pharmacotherapy.2018; 106: 247. CrossRef
Potential involvement of neutrophils in human thyroid cancer Maria Rosaria Galdiero, Gilda Varricchi, Stefania Loffredo, Claudio Bellevicine, Tiziana Lansione, Anne Lise Ferrara, Raffaella Iannone, Sarah di Somma, Francesco Borriello, Eduardo Clery, Maria Triassi, Giancarlo Troncone, Gianni Marone, Fabrizio Mattei PLOS ONE.2018; 13(6): e0199740. CrossRef
Tumor heterogeneity and nanoparticle-mediated tumor targeting: the importance of delivery system personalization K. Laxmi Swetha, Aniruddha Roy Drug Delivery and Translational Research.2018; 8(5): 1508. CrossRef
Immune Gene Signature Delineates a Subclass of Papillary Thyroid Cancer with Unfavorable Clinical Outcomes Kyuryung Kim, Sora Jeon, Tae-Min Kim, Chan Jung Cancers.2018; 10(12): 494. CrossRef
Bone marrow-derived cells are recruited by the melanoma tumor with endothelial cells contributing to tumor vasculature R. Bonfim-Silva, L. E. B. Souza, F. U. F. Melo, V. C. Oliveira, D. A. R. Magalhães, H. F. Oliveira, D. T. Covas, A. M. Fontes Clinical and Translational Oncology.2017; 19(1): 125. CrossRef
Stromal contributions to the carcinogenic process Mark Spaw, Shrikant Anant, Sufi Mary Thomas Molecular Carcinogenesis.2017; 56(4): 1199. CrossRef
The Role of Cancer-Associated Fibroblasts and Fibrosis in Liver Cancer Silvia Affo, Le-Xing Yu, Robert F. Schwabe Annual Review of Pathology: Mechanisms of Disease.2017; 12(1): 153. CrossRef
PEDF increases the tumoricidal activity of macrophages towards prostate cancer cells in vitro Dalia Martinez-Marin, Courtney Jarvis, Thomas Nelius, Werner de Riese, Olga V. Volpert, Stéphanie Filleur, Chih-Hsin Tang PLOS ONE.2017; 12(4): e0174968. CrossRef
Anaplastic thyroid carcinoma: from clinicopathology to genetics and advanced therapies Eleonora Molinaro, Cristina Romei, Agnese Biagini, Elena Sabini, Laura Agate, Salvatore Mazzeo, Gabriele Materazzi, Stefano Sellari-Franceschini, Alessandro Ribechini, Liborio Torregrossa, Fulvio Basolo, Paolo Vitti, Rossella Elisei Nature Reviews Endocrinology.2017; 13(11): 644. CrossRef
Iron Induces Anti-tumor Activity in Tumor-Associated Macrophages Milene Costa da Silva, Michael O. Breckwoldt, Francesca Vinchi, Margareta P. Correia, Ana Stojanovic, Carl Maximilian Thielmann, Michael Meister, Thomas Muley, Arne Warth, Michael Platten, Matthias W. Hentze, Adelheid Cerwenka, Martina U. Muckenthaler Frontiers in Immunology.2017;[Epub] CrossRef
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Correlation of tumor-associated macrophages and NK cells with bladder cancer size and T stage in patients with solitary low-grade urothelial carcinoma Kristian Krpina, Emina Babarović, Josip Španjol, Gordana Đorđević, Tobias Maurer, Nives Jonjić Wiener klinische Wochenschrift.2016; 128(7-8): 248. CrossRef
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Jacalin-Activated Macrophages Exhibit an Antitumor Phenotype Cláudia Danella Polli, Luciana Pereira Ruas, Luciana Chain Veronez, Thais Herrero Geraldino, Fabiana Rossetto de Morais, Maria Cristina Roque-Barreira, Gabriela Pereira-da-Silva BioMed Research International.2016; 2016: 1. CrossRef
The immune network in thyroid cancer Maria Rosaria Galdiero, Gilda Varricchi, Gianni Marone OncoImmunology.2016; 5(6): e1168556. CrossRef
The Expression and Relationship of CD68-Tumor-Associated Macrophages and Microvascular Density With the Prognosis of Patients With Laryngeal Squamous Cell Carcinoma
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Role of pulmonary macrophages in initiation of lung metastasis in anaplastic thyroid cancer Xiu Juan Li, Prakash Gangadaran, Senthilkumar Kalimuthu, Ji Min Oh, Liya Zhu, Shin Young Jeong, Sang‐Woo Lee, Jaetae Lee, Byeong‐Cheol Ahn International Journal of Cancer.2016; 139(11): 2583. CrossRef
Perspectives for immunotherapy in endocrine cancer S Latteyer, V Tiedje, B Schilling, D Führer Endocrine-Related Cancer.2016; 23(10): R469. CrossRef
Macrophage Densities Correlated with CXC Chemokine Receptor 4 Expression and Related with Poor Survival in Anaplastic Thyroid Cancer Dae In Kim, Eunyoung Kim, Young A Kim, Sun Wook Cho, Jung Ah Lim, Young Joo Park Endocrinology and Metabolism.2016; 31(3): 469. CrossRef
High expression of C-C chemokine receptor 2 associates with poor overall survival in gastric cancer patients after surgical resection Ruochen Li, Heng Zhang, Hao Liu, Chao Lin, Yifan Cao, Weijuan Zhang, Zhenbin Shen, Jiejie Xu Oncotarget.2016; 7(17): 23909. CrossRef
Polycationic carbosilane dendrimer decreases angiogenesis and tumor-associated macrophages in tumor-bearing mice Ana Judith Perisé-Barrios, María Jesús Serramia, Javier de la Mata, Rafael Gomez, Angel Luis Corbí, Ángeles Domínguez-Soto, María Ángeles Muñoz-Fernandez RSC Advances.2015; 5(126): 104110. CrossRef
BACKGROUND Id proteins are a family of helix-loop-helix proteins and are regarded to be negative regulators of cell differentiation. In general, Id-1 and Id-2 expressions are upregulated during tumor development and progression in a variety of neoplasms, and these expressions may be associated with aggressive tumor behavior. However, little is known about the roles of Id-1 and Id-2 in thyroid neoplasms. METHODS The expressions of Id-1 and Id-2 were assessed immunohistochemically in 310 normal, hyperplastic, and neoplastic thyroid tissues using tissue microarrays. RESULTS Normal thyroid tissues rarely expressed Id-1 or Id-2. Moreover, whilst Id-1 expression was more elevated in malignant thyroid tissue than in hyperplastic thyroid tissue, Id-2 expression was more variable. No significant differences were observed between histologic subtypes of thyroid carcinomas with respect to Id-1 or Id-2 expression.
Follicular adenomas showed higher expressions of Id-1 and Id-2 than thyroid carcinomas. No significant association was found between clinicopathological parameters and Id-1 expression, though Id-2 expression was significantly reduced in metastatic, stage IV tumors. CONCLUSION The expressions of Id-1 and Id-2 were elevated in hyperplastic and neoplastic thyroid tissues. However, neither appears suitable as a marker of malignancy or an aggressive phenotype, although Id-2 expression in advanced thyroid carcinomas may reflect a favorable prognosis.