Journal of Pathology and Translational Medicine

Case Study

Imprint Cytology of Soft Tissue Myoepithelioma: A Case Study: Seok Ju Park, Ae Ri Kim, Mi Jin Gu, Joon Hyuk Choi, Duk Seop Shin; Korean J Pathol. 2013;47(3):299-303. Published online June 25, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.3.299

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Soft tissue myoepithelioma is a rare neoplasm composed of myoepithelial cells. Here, we describe the cytologic features of soft tissue myoepithelioma arising on the right forearm in an 18-year-old man. The excised tumor (3.0×1.8×1.5 cm) was well-demarcated, yellow-gray, soft, and myxoid. The cytologic smears showed round to spindle, epithelioid, and plasmacytoid cells in the myxoid background. The nuclei were uniform, round to ovoid, with finely distributed chromatin and eosinophilic or pale cytoplasm. The tumor cells demonstrated immunoreactivity for cytokeratin (AE1/AE3), epithelial membrane antigen, S100 protein, and glial fibrillary acidic protein. Electron microscopy showed intermediate filaments, desmosomes, and basal lamina.

Citations

Citations to this article as recorded by

Myoepithelial tumors of soft tissue and bone in children and young adults: A clinicopathologic study of 40 cases occurring in patients ≤ 21 Years of age
Suzanna J. Logan, Carina A. Dehner, Fatimah I. Alruwaii, Nasir Ud Din, Damon R. Olson, Karen J. Fritchie, Gregory W. Charville, Melissa M. Blessing, Andrew L. Folpe
Human Pathology.2024; 149: 10. CrossRef
Fine-needle aspiration cytopathology of soft tissue myoepithelioma: an analysis of seven cases
Paul E. Wakely, Momin T. Siddiqui
Journal of the American Society of Cytopathology.2022; 11(1): 31. CrossRef
Cytology‐histology correlation of myoepithelial tumors harboring EWSR1‐POU5F1 fusions: A report of two cases
Ian A. Gelarden, Lucy Fu, Kai Lee Yap, Aida I. Richardson, Pauline M. Chou
Diagnostic Cytopathology.2022;[Epub] CrossRef
A case of myoepithelial carcinoma of the left shoulder
Shuhei ISHII, Noriyuki FURUTA, Kyoko KOMATSU, Yoshiya SUGIURA, Noriko MOTOI, Yutaka TAKAZAWA, Yuko SUGIYAMA, Yuichi ISHIKAWA
The Journal of the Japanese Society of Clinical Cytology.2018; 57(2): 129. CrossRef
Fine‐needle aspiration of soft tissue myoepithelioma
Gang Wang, Tracy Tucker, Tony L. Ng, Carlos F. Villamil, Malcolm M. Hayes
Diagnostic Cytopathology.2016; 44(2): 152. CrossRef
A case report of spindle cell myoepithelioma with extensive lipomatous metaplasia and thick collagen bundles in the submandibular gland
Mi Jung Kwon, Hye Jeong Kim, Bumjung Park, Seong Jin Cho, Hyung Sik Shin, Hye‐Rim Park, Soo Kee Min, Jinwon Seo, Kyueng‐Whan Min, Eun Sook Nam
Diagnostic Cytopathology.2016; 44(9): 764. CrossRef
Myoepithelioma of soft tissue, a case report
Hassania Ameurtesse, Leila Chbani, JM Coindre, Hinde Elfatemi, Toufik Harmouch, Afaf Amarti
Research.2014;[Epub] CrossRef

Case Reports

Imprint Cytology of Hibernoma: A Case Report.: Joon Hyuk Choi, Duk Seop Shin; Korean J Cytopathol. 2008;19(2):200-205.; DOI: https://doi.org/10.3338/kjc.2008.19.2.200

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Abstract PDF

Hibernoma is a rare, benign adipose tumor composed of brown fat cells with eosinophilic granular or multivacuolated cytoplasm. The cytologic features of hibernoma have been rarely reported and may mimic other polygonal cell neoplasms. We report the imprint cytologic features of a case of hibernoma in the left thigh of a 68-year-old woman. Microscopic examination showed large, round, or polygonal brown fat cells. The cells were arranged in fragments or clusters. The nuclei were uniformly round with finely granular chromatin. The cytoplasm was multivacuolated or univacuolated. The abundant eosinophilic granular cytoplasm was also present. No nuclear atypia were present. Immunohistochemical staining showed that cells were positive for S-100 protein.

Citations

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Hibernoma-A rare tumor on rare site
Himachal Mishra, Manika Alexander
IP Journal of Diagnostic Pathology and Oncology.2023; 7(4): 276. CrossRef

Intraosseous Lipoma A report of four cases.: Hye Jeong Choi, Mi Jin Gu, Joon Hyuk Choi, Duk Seop Shin, Kil Ho Cho; Korean J Pathol. 1999;33(6):467-470.

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Abstract PDF: Intraosseous lipoma is a very rare primary tumor of the bone. We report four cases of intraosseous lipoma. The patient ranged in age from 34 to 59-year-old (median age: 35 year-old). There were three men and one woman. All of four cases presented with pain. The involved bones were calcaneus in two cases, tibia in one case and ilium in one case, respectively. In all cases plain x-ray film revealed well-defined lytic lesion. Their size ranged 2 to 4.5 cm (mean size: 3.5 cm). Histologic examination showed mature adipose tissue. Three cases showed secondary changes such as atrophic bone, fat necrosis, fibrosis, dystrophic calcification, and reactive ischemic bone formation. The clinicopathologic and roentgenographic correlation are necessary in establishing correct diagnosis of this tumor.

Fine Needle Aspiration Cytology of Alveolar Soft Part Sarcoma: A Case Report.: Joon Hyuk Choi, Young Ran Shim, Duk Seop Shin, Kil Ho Cho; Korean J Cytopathol. 2006;17(1):69-74.

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Abstract PDF: Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma, which occurs predominantly in adolescents and young adults. The cytological characteristics of this condition have been described only rarely in the literature. Here, we report a case of alveolar soft part sarcoma. A 28-year-old man presented with a mass in his right buttock, which had persisted for three years. The mass was subjected to a fine needle aspiration cytology (FNAC). The smears were cellular. The observed tumor cells were round or polygonal, and exhibited vesicular nuclei with prominent nucleoli and finely granular cytoplasm. Naked nuclei were frequently detected. Tumor cells were arranged singularly, but occasionally in a pseudoalveolar pattern.

Synovial Sarcoma with Massive Myxoid Feature: A Case Report.: Joon Hyuk Choi, Young Ran Shim, Young Kyung Bae, Mi Jin Kim, Duk Seop Shin, Kil Ho Cho; Korean J Pathol. 2005;39(4):273-277.

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Abstract PDF: Focal myxoid change in synovial sarcoma is not uncommon, although the presence of predominantly myxoid stroma is very rare. Recognition of synovial sarcomas with massive myxoid feature is important because these can easily be mistaken for other myxoid soft tissue neoplasms. We report a case of a synovial sarcoma with massive myxoid feature in the left thigh of a 54-year-old woman. Wide excision of an 8.5*7.0*5.0 cm, well-circumscribed and lobulated tumor was performed. The cut surface was gray, soft, and myxoid. Histological examination showed proliferation of spindle cells in the predominantly myxoid stroma. There were small areas with features more typical of synovial sarcoma, including uniform, spindled cells with fascicular growth patterns, collagenous stroma, mast cell infiltration, and hemangiopericytoma-like vascular patterns. Immunohistochemical examination showed focal positivity of the tumor cells for epithelial membrane antigen (EMA). Tumor cells were all negative for cytokeratin (AE1/AE3), cytokeratin 7, S-100 protein, smooth muscle actin, and desmin. Ultrastructurally, tumor cells showed desmosomes and microvilli. Our case underscores that, in order to make a correct diagnosis, immunohistochemical and ultrastructural examination is essential.

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