Journal of Pathology and Translational Medicine

Case Report

Squamoid Eccrine Ductal Carcinoma of the Scalp: Yong-Han Jung, Hye-Jung Jo, Mi-Seon Kang; Korean J Pathol. 2012;46(3):278-281. Published online June 22, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.3.278

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Squamoid eccrine ductal carcinoma (SEDC) is an exceedingly rare tumor that shows both squamous and adnexal ductal differentiation. We report a case of this unusual tumor occurring on the occiput of a 53-year-old man. A histopathological examination revealed a nodular lesion infiltrating the dermis and subcutaneous tissue with numerous duct-like structure and squamoid differentiation foci. Five months later, the patient presented with a palpable mass at the site of the previous excision and the right side of the neck. Sono-guided fine needle aspiration of the right neck mass was performed and was diagnosed as a metastastasis of a lymph node. A right neck node dissection and re-excision of the occiput was performed. The histopathological findings were similar, but squamoid differentiation was more prominent than that in the previous lesion. Because of the rarity of SEDC, little is known about its biological behavior and optimal treatment.

Citations

Citations to this article as recorded by

Squamoid Eccrine Ductal Carcinoma: Treatment and Outcomes
Megan M. Lim, Jillian A. Macdonald
The American Journal of Dermatopathology.2022; 44(4): 249. CrossRef
Recurrent Squamoid Eccrine Ductal Carcinoma After Mohs Micrographic Surgery
Cardwell Gavin, Brinker Alyson
Dermatologic Surgery.2021; 47(8): 1108. CrossRef
Carcinoma ecrino: dos casos de una neoplasia inusual y revisión de la literatura
Clara Matas-Nadal, Josep Manel Fernández-Armenteros, Felip Vilardell, Josep Manel Casanova, Rafael S. Aguayo Ortiz
Piel.2020; 35(3): 159. CrossRef
Squamoid eccrine ductal carcinoma: a case report
Zeynep BAYRAMOĞLU, Betül ÜNAL
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Squamoid eccrine ductal carcinoma of the ear helix
Sunmin Yim, Yun Ho Lee, Seoung Wan Chae, Won‐Serk Kim
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Squamoid eccrine ductal carcinoma of the scalp
Hsien Chan, Vicki Howard, Denis Moir, Delwyn Dyall‐Smith
Australasian Journal of Dermatology.2016;[Epub] CrossRef
Squamoid Eccrine Ductal Carcinoma
Michiel P.J. van der Horst, Adriana Garcia-Herrera, Dorota Markiewicz, Blanca Martin, Eduardo Calonje, Thomas Brenn
American Journal of Surgical Pathology.2016; 40(6): 755. CrossRef
Squamoid eccrine ductal carcinoma
Maria Isabel Ramos Saraiva, Marcella Amaral Horta Barbosa Vieira, Larissa Karine Leite Portocarrero, Rafael Cavanellas Fraga, Priscila Kakizaki, Neusa Yuriko Sakai Valente
Anais Brasileiros de Dermatologia.2016; 91(6): 799. CrossRef
Anatomoclinical study of 30 cases of sclerosing sweat duct carcinomas (microcystic adnexal carcinoma, syringomatous carcinoma and squamoid eccrine ductal carcinoma)
E. Frouin, M.D. Vignon‐Pennamen, B. Balme, B. Cavelier‐Balloy, U. Zimmermann, N. Ortonne, A. Carlotti, L. Pinquier, J. André, B. Cribier
Journal of the European Academy of Dermatology and Venereology.2015; 29(10): 1978. CrossRef

Original Article

Prenatal Development of Eccrine Sweat Gland: Morphologic and Morphometric Analysis.: Nam Bok Cho, Tae Jin Lee, Je G Chi, Kye Yong Song; Korean J Pathol. 1997;31(2):121-134.

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Abstract PDF: To elucidate the developmental sequence of the eccrine sweat gland, a morphologic and a morphometric observation were done using developing human embryos and fetuses. Five embryos and sixty four fetuses from the 9th to the 38th week of the gestational age were studied. The skin was sampled in eight different areas, i.e., scalp, forehead, face, chest, abdomen, back, palm and sole. Routine histological sections were made for histological evaluation and morphometric analysis. The results obtained were as follows : The primordia of the eccrine sweat glands appeared first as regular undulation of the basal cells in the palm and the sole in the 13th week of getation. Subsequently, elongation and coiling of the cell cords were noted from the 16th to the 18th weeks. Intraductal lumen formation was first noted in the 20th week. Secretory segment of the eccrine sweat glands were noted from the distal part of the coiling intradermal sweat duct in the 22nd week of the gestational age. The eccrine sweat glands became fully developed by the 28th week of gestation and this included the clear cell, the dark cell and the myoepithelial cell. In the morphometric analysis, the number of eccrine epithelial buddings were decreased with aging and the highest were in the palm and the sole. The diameter of the eccrine sweat duct showed no significant change by gestational age or in the different sites observed. Straight and coiled eccrine sweat ducts or glands were lengthened into the deep reticular dermis and upper portion of the subcutaneous adipose tissue with an increase of the gestational age. The above results suggest that developmental stage and the number of eccrine glands of the skin in the fetal stage is different from other areas of the body, especially in the palm and the sole.

Case Reports

Malignant Eccrine Acrospiroma: A case report.: Gil Ro Han, In Sun Kim, Kye Yong Song, Ki Duck Kim, Beom Woo Yeom, Jong Sang Choi; Korean J Pathol. 1993;27(5):538-541.

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Abstract PDF: A case of malignant eccrine acrospiroma of the anterior chest wall is reported. This mass had been present for 20 years and during rescent 5 years it showed frequent ulceration and bleeding suggesting malignant transformation. Microscopically, several foci malignant transformation from preexisting benign eccrine acrospiroma are seen and in immunohistochemical staining, the tumor cells both benign and malignant portion, show positive reaction to cytokeratin.

Microcystic Adnexal Carcinoma: Report of a case.: Eun Deok Chang, Young Hee Jee, Sun Moo Kim; Korean J Pathol. 1993;27(3):290-292.

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Abstract PDF: Microcystic adenxal carcinoma is an unusual, locally aggressive neoplasm that has recently been recongized as a clincopathologic entity. Its histologic appearance includes both pilar and eccrine differentiation. Microscopically, the tumor consisted of small cysts and gland-like structures in superficial portion. In other area, basaloid cell nests and abortive hair follicles in the sclerotic stroma were seen. The cysts were filled with secretory eosinophilic material, which was positively stained with Periodic acid-Schiff and carcinoembryonic antigen. Immuno-peroxidase staining for carcinoembryonic antigen supported the dual differnetiation of this neoplasm. Despite the benign histologic appearance, there was deep and extensive infiltration of the subcutaneous tissue.

Eccrine Poroma: A report of five cases.: Young Shin Kim, Seok Jin Kang, Byoung Kee Kim, Sun Moo Kim; Korean J Pathol. 1991;25(4):357-362.

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Abstract PDF: The eccrine poroma was described first by Pinkus et al. in 1956 as a subgroup of benign solid hidradenoma with the histologic structure resembling acrosyringium. The histologic appearance of eccrine poroma greatly resembles that of seborrheic keratosis and basal cell carcinoma. But the clinical lesion is fairly unique and the tumor is most commonly found almost exclusively on the foot, in the skin of the plantar surface. During the past four years, the authors experienced five cases of eccrine poroma which were diagnosed by histopathological examination of the tumor mass. All the cases occurred in the sole and lateral sides of the foot as well. Clinical and pathological features were reviewed and a brief review of the literatures was done.

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