E-submission
Search
- Page Path
- HOME > Search
Original Article
- Expression of Minichromosome Maintenance Protein 7 and Smad 4 in Squamous Cell Carcinoma of the Esophagus.
- Ji Hyun Ahn, Hee Kyung Chang
- Korean J Pathol. 2010;44(4):346-353.
- DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.4.346
- 3,563 View
- 23 Download
- 5 Crossref
-
Abstract
PDF - BACKGROUND
Minichromosome maintenance protein 7 (MCM 7) performs a direct role in the initiation of DNA replication, which suggests that it may prove useful as a marker of cell proliferation. Smad 4 is a tumor suppressor gene that mediates the transforming growth factor beta pathway. The principal objective of this study was to characterize the expression of MCM 7 and Smad 4 and to analyze their relationship to clinicopathological parameters in patients with esophageal squamous cell carcinoma.
METHODS
Expression levels of MCM 7 and Smad 4 were evaluated via immunohistochemistry on formalin-fixed and paraffin-embedded tissues from 67 cases of esophageal squamous cell carcinoma.
RESULTS
High levels of MCM 7 expression were detected in 53 cases (74.6%), and were associated with higher T stages (p = 0.030). Kaplan-Meier survival curves demonstrated that patients with higher levels of MCM 7 expression had poorer prognoses, although this association was not significant (p = 0.086). Loss of Smad 4 expression was noted in 18 cases (23.4%), and was not associated with clinicopathological characteristics, including MCM 7 expression, or prognosis.
CONCLUSIONS
MCM 7 expression is associated with the invasiveness of esophageal squamous cell carcinoma. Altered expression of Smad 4 does not appear to have pathobiological significance in esophageal carcinoma. -
Citations
Citations to this article as recorded by
- scDiffCoAM: A complete framework to identify potential biomarkers for esophageal squamous cell carcinoma using scRNA-Seq data analysis
Manaswita Saikia, Dhruba K Bhattacharyya, Jugal K Kalita
Journal of Biosciences.2024;[Epub] CrossRef - Immunohistochemical analysis of proliferating cell nuclear antigen and minichromosome maintenance complex component 7 in benign and malignant salivary gland tumors
Nafiseh Shamloo, Nasim Taghavi, Samane Ahmadi, Soudeh Shalpoush
Dental Research Journal.2022; 19(1): 17. CrossRef - Expression of Minichromosome Maintenance Proteins in Actinic Keratosis and Squamous Cell Carcinoma
Jelena Stojkovic-Filipovic, Dimitrije Brasanac, Martina Bosic, Novica Boricic, Branislav Lekic
Applied Immunohistochemistry & Molecular Morphology.2018; 26(3): 165. CrossRef - Ki-67 protein predicts survival in oral squamous carcinoma cells: an immunohistochemical study
Verena Karla Monteiro LOPES, Adriana Souza de JESUS, Lucas Lacerda de SOUZA, Ligia Akiko Ninokata MIYAHARA, Douglas Magno GUIMARÃES, Helder Antônio Rebelo PONTES, Flavia Sirotheau Correa PONTES, Pedro Luiz de CARVALHO
Brazilian Oral Research.2017;[Epub] CrossRef - Immunohistochemical Expression of MCM2 in Nonmelanoma Epithelial Skin Cancers
Asmaa Gaber Abdou, Mohammed Gaber Abd Elwahed, Marwa Mohammed Serag El-dien, Dina Sharaf Eldien
The American Journal of Dermatopathology.2014; 36(12): 959. CrossRef
- scDiffCoAM: A complete framework to identify potential biomarkers for esophageal squamous cell carcinoma using scRNA-Seq data analysis
Case Reports
- Malignant Gastrointestinal Stromal Tumor of the Esophagus: A Case Report.
- Hae Joung Sul, Kyeong Hee Kim, Dae Young Kang
- Korean J Pathol. 2001;35(3):252-255.
- 1,640 View
- 14 Download
-
Abstract
PDF
- Gastrointestinal stromal tumors (GISTs) predominate in the stomach and small intestine but have rarely been documented in the esophagus. We report a rare case of GIST of the esophagus in a 47-year-old woman. Histologically, the tumors showed a combination of solid, myxoid, and perivascular collar-like patterns, with spindle and epithelioid cells. The tumor cells were positive for CD117, CD34, and S-100 protein and negative for desmin and -smooth muscle actin.
- Adenocarcinoma Arising from Heterotopic Gastric Mucosa in Cervical Esophagus: A Case Report.
- Young Ok Hong, Jeong Eun Hwang, In Chul Lee, Jin Hyuk Lee, Seung Il Park, Kyung Ja Cho
- Korean J Pathol. 2008;42(1):33-36.
- 1,663 View
- 15 Download
-
Abstract
PDF
- Heterotopic gastric mucosa (HGM) of the upper esophagus, referred as "cervical inlet patch (CIP)", is a benign lesion that is present in 3.8-10% of the adult population. Adenocarcinomas arising from HGM of the upper esophagus are exceedingly rare. The authors report one additional case of histologically confirmed adenocarcinoma arising from a CIP. The patient had concomitant primary adenocarcinoma of the colon. The right hemicolectomy specimen and total esophagectomy specimen after preoperative chemoradiotherapy showed histologically different adenocarcinomas. The residual esophageal tumor was characterized by large mucin pools, fibrous septa, and floating tumor cells. HGM of both the fundic and antral types was seen on the surface and sides of the tumor. The independent origins of the two cancers were confirmed by immunohistochemical studies for cytokeratins 7 and 20. Without further treatment, the patient remained free of disease after 29 months of follow-up.
First
Prev
