We present herein the occurrence of multifocal adenocarcinomas with a minute signet ring cell carcinoma that arose within a gastric inverted hyperplastic polyp (IHP) in a 40-year-old woman. Endoscopic ultrasonography demonstrated a heterogeneous hypoechoic mass in the third layer of the gastric wall. The endoscopic submucosal dissection specimen measuring 3.5×3.2×1.8 cm was a well-circumscribed protruding lesion that had a slit-shaped cavity. Histologically, the lesion consisted mainly of endophytic proliferation of hyperplastic columnar cells resembling normal foveolar epithelium. In addition, six foci of adenocarcinomas and a minute focus of signet ring cell carcinoma were randomly distributed in the superficial and deep regions. The adenocarcinoma was gradually transitioning from dysplasia, while the signet ring cell carcinoma was surrounded by hyperplastic foveolar epithelium. This is the first report of a gastric IHP with multifocal intramucosal adenocarcinomas and a signet ring cell carcinoma, and endoscopic submucosal dissection is used to completely resect it.

Citations

Citations to this article as recorded by  

• Clinicopathologic and endoscopic characteristics of ten patients with gastric hamartomatous inverted polyp: a single center case series
  Ningning Dong, Fandong Meng, Bing Yue, Junzhen Hou
  BMC Gastroenterology.2024;[Epub]     CrossRef
• Gastric hamartomatous inverted polyp: Report of three cases with a review of the endoscopic and clinicopathological features
  Takuya Ohtsu, Yu Takahashi, Mitsuo Tokuhara, Tomomitsu Tahara, Mitsuaki Ishida, Chika Miyasaka, Koji Tsuta, Makoto Naganuma
  DEN Open.2023;[Epub]     CrossRef
• Gastric Inverted Hyperplastic Polyp Removed Using Endoscopic Submucosal Dissection
  Jee Won Boo, Joon Sung Kim, Byung-Wook Kim
  The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2023; 23(1): 63.     CrossRef
• The Many Faces of Gastric Inverted Polyps: a case report
  S.I. Kim, M.Y. Agapov, T.F. Savostyanov, A.A. Paratovskaya, I.A. Sokolova
  Dokazatel'naya gastroenterologiya.2023; 12(2): 88.     CrossRef
• Large gastric hamartomatous inverted polyp accompanied by advanced gastric cancer: A case report
  Gyerim Park, Jihye Kim, Sung Hak Lee, Younghoon Kim
  World Journal of Clinical Cases.2023; 11(28): 6967.     CrossRef
• Activating KRAS and GNAS mutations in heterotopic submucosal glands of the stomach
  Hourin Cho, Taiki Hashimoto, Tomoaki Naka, Yasushi Yatabe, Ichiro Oda, Yutaka Saito, Takaki Yoshikawa, Shigeki Sekine
  Journal of Gastroenterology.2022; 57(5): 333.     CrossRef
• Gastric Inverted Polyps—Distinctive Subepithelial Lesions of the Stomach
  Ji-Ye Kim, Soomin Ahn, Kyoung-Mee Kim, Sun Hee Chang, Han Seong Kim, Jun Haeng Lee, Jae J. Kim, Tae Sung Sohn, Hye Ju Kang, Mee Joo
  American Journal of Surgical Pathology.2021; 45(5): 680.     CrossRef
• Signet-ring Cell Carcinoma in Hyperplastic Polyp of the Stomach
  Kenta Yoshida, Tatsuya Mikami, Takao Oyama, Yuki Sato, Taro Saito, Takafumi Mikami, Chieko Itabashi, Yasushi Soma, Shinsaku Fukuda
  Internal Medicine.2019; 58(24): 3531.     CrossRef
• Inverted Hyperplastic Polyp in Stomach: A Case Report and Literature Review
  Yeon Ho Lee, Moon Kyung Joo, Beom Jae Lee, Ji-Ae Lee, Taehyun Kim, Jin Gu Yoon, Jung Min Lee, Jong-Jae Park
  The Korean Journal of Gastroenterology.2016; 67(2): 98.     CrossRef
• Inflammatory myofibroblastic tumor‐like stromal proliferation within gastric inverted hyperplastic polyp
  Byeong‐Joo Noh, Ji Won Min, Ji‐Youn Sung, Yong‐Koo Park, Juhie Lee, Youn Wha Kim
  Pathology International.2016; 66(3): 180.     CrossRef
• Gastric inverted hyperplastic polyp: A rare cause of iron deficiency anemia
  Jin Tak Yun, Seung Woo Lee, Dong Pil Kim, Seung Hwa Choi, Seok-Hwan Kim, Jun Kyu Park, Sun Hee Jang, Yun Jung Park, Ye Gyu Sung, Hae Jung Sul
  World Journal of Gastroenterology.2016; 22(15): 4066.     CrossRef
• Gastric Inverted Hyperplasic Polyp Composed Only of Pyloric Glands
  Minsun Jung, Kyueng-Whan Min, Young-Joon Ryu
  International Journal of Surgical Pathology.2015; 23(4): 313.     CrossRef
• A Pedunculated Submucosal Lesion in the Stomach with Inverted Downgrowth
  Yoshihiko Miyamoto, Naoki Muguruma, Seisuke Okamura, Yasuyuki Okada, Shinji Kitamura, Koichi Okamoto, Akiko Yoneda, Noriko Kagawa, Tetsuji Takayama
  Internal Medicine.2014; 53(15): 1625.     CrossRef