Macrophages have been shown to have pleiotropic functions in various pathophysiologies, especially in terms of anti-inflammatory and regenerative activity. Recently, the novel functions of bone marrow resident macrophages (called osteal macrophages) were intensively studied in bone development, remodeling and tissue repair processes. This review discusses the current evidence for a role of osteal macrophages in bone modeling, remodeling, and fracture healing processes.
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Nano wear particles and the periprosthetic microenvironment in aseptic loosening induced osteolysis following joint arthroplasty Yu Xie, Yujie Peng, Guangtao Fu, Jiewen Jin, Shuai Wang, Mengyuan Li, Qiujian Zheng, Feng-Juan Lyu, Zhantao Deng, Yuanchen Ma Frontiers in Cellular and Infection Microbiology.2023;[Epub] CrossRef
Integrated computational and in vivo models reveal Key Insights into macrophage behavior during bone healing Etienne Baratchart, Chen Hao Lo, Conor C. Lynch, David Basanta, Dominik Wodarz PLOS Computational Biology.2022; 18(5): e1009839. CrossRef
Strategies of Macrophages to Maintain Bone Homeostasis and Promote Bone Repair: A Narrative Review Yingkun Hu, Jinghuan Huang, Chunying Chen, Yi Wang, Zhuowen Hao, Tianhong Chen, Junwu Wang, Jingfeng Li Journal of Functional Biomaterials.2022; 14(1): 18. CrossRef
Macrophages and Stem Cells—Two to Tango for Tissue Repair? Emilia Manole, Cristina Niculite, Ioana Maria Lambrescu, Gisela Gaina, Octavian Ioghen, Laura Cristina Ceafalan, Mihail Eugen Hinescu Biomolecules.2021; 11(5): 697. CrossRef
Bone remodeling stages under physiological conditions and glucocorticoid in excess: Focus on cellular and molecular mechanisms V. V. Povoroznyuk, N. V. Dedukh, M. A. Bystrytska, V. S. Shapovalov Regulatory Mechanisms in Biosystems.2021; 12(2): 212. CrossRef
Menaquinone-7 Supplementation Improves Osteogenesis in Pluripotent Stem Cell Derived Mesenchymal Stem Cells Asim Cengiz Akbulut, Grzegorz B. Wasilewski, Nikolas Rapp, Francesco Forin, Heike Singer, Katrin J. Czogalla-Nitsche, Leon J. Schurgers Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef
The Effects of Biomaterial Implant Wear Debris on Osteoblasts Li Zhang, El-Mustapha Haddouti, Kristian Welle, Christof Burger, Dieter C. Wirtz, Frank A. Schildberg, Koroush Kabir Frontiers in Cell and Developmental Biology.2020;[Epub] CrossRef
Local Cellular Responses to Metallic and Ceramic Nanoparticles from Orthopedic Joint Arthroplasty Implants
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Mesenchymal stem cell-macrophage crosstalk and bone healing Jukka Pajarinen, Tzuhua Lin, Emmanuel Gibon, Yusuke Kohno, Masahiro Maruyama, Karthik Nathan, Laura Lu, Zhenyu Yao, Stuart B. Goodman Biomaterials.2019; 196: 80. CrossRef
Inflammation, mesenchymal stem cells and bone regeneration Hongrui Liu, Dongfang Li, Yi Zhang, Minqi Li Histochemistry and Cell Biology.2018; 149(4): 393. CrossRef
Inflammatory and degenerative phases resulting from anterior cruciate rupture in a non‐invasive murine model of post‐traumatic osteoarthritis Sophie J. Gilbert, Cleo S. Bonnet, Paulina Stadnik, Victor C. Duance, Deborah J. Mason, Emma J. Blain Journal of Orthopaedic Research.2018; 36(8): 2118. CrossRef
M2 macrophages are closely associated with accelerated clavicle fracture healing in patients with traumatic brain injury: a retrospective cohort study Ran Zhang, Yi Liang, Shuxiang Wei Journal of Orthopaedic Surgery and Research.2018;[Epub] CrossRef
Digesting the role of bone marrow macrophages on hematopoiesis Esther Heideveld, Emile van den Akker Immunobiology.2017; 222(6): 814. CrossRef
Concise Review: Stem Cells in Osteoimmunology Fernando A. Fierro, Jan A. Nolta, Iannis E. Adamopoulos Stem Cells.2017; 35(6): 1461. CrossRef
Aging, inflammation, stem cells, and bone healing Emmanuel Gibon, Laura Lu, Stuart B. Goodman Stem Cell Research & Therapy.2016;[Epub] CrossRef
The roles of immune cells in bone healing; what we know, do not know and future perspectives Jehan J. El-Jawhari, Elena Jones, Peter V. Giannoudis Injury.2016; 47(11): 2399. CrossRef