Journal of Pathology and Translational Medicine

Case Study

Diffuse Large B-Cell Lymphoma Arising in Warthin's Tumor: Case Study and Review of the Literature: Güliz Özkök, Funda Taşlı, Nazan Özsan, Rafet Öztürk, Hakan Postacı; Korean J Pathol. 2013;47(6):579-582. Published online December 24, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.6.579

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Warthin's tumor is the second most common type of salivary gland tumor. Microscopically, Warthin's tumor displays a proliferative epithelial component and lymphoid stroma. Carcinomas arising from the epithelial component are well known, but malignant transformations of the lymphoid stroma are rare. When they do occur, they are most commonly B-cell type non-Hodgkin lymphomas. A 60-year-old male patient underwent surgical resection of a parotid mass. After superficial parotidectomy, microscopic examination indicated that the tumor was of epithelial components with basaloid and oncocytic columns of cells neighboring lymphoid components. In addition to the lymphoid follicles with distinct germinal centers, there were large, bizarre and extremely atypical neoplastic cells seen in the lymphoid component. Large neoplastic cells were diffusely CD20 and CD30 positive. The patient was diagnosed with "Warthin's tumor and diffuse large B-cell lymphoma with expression of CD30." The histopathologic and clinical features are discussed along with a review of the literature.

Citations

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Warthin tumor concomitant with mantle cell lymphoma: a case report and review of literature
Hai-Chao Tong, Shuang Ma, Lan Chen, Xiangyun Meng, Ying-Chun Li, Le-Yao Li, Lingyun Dong, Wan-Lin Zhang, Tyler Wildes, Lian-He Yang, Endi Wang
Diagnostic Pathology.2024;[Epub] CrossRef
Warthin’s Tumor of the Parotid Gland With Degeneration to Diffuse Large B-cell Lymphoma: A Case Report and Review of Literature
Mauricio Gutierrez-Alvarez, Cynthia Martinez, Ana Priscila Campollo Lopez, Kevin Fuentes, Jorge Alberto Robles Aviña
Cureus.2023;[Epub] CrossRef
Pathogenesis Analysis of Salivary Gland Tumors Through the Expression of Programmed Death-Ligand 1 (PD-L1)
Aisyah Izzatul Muna, Maria Evata Krismawati Surya, Meiske Margaretha, Jane Kosasih, Mei Syafriadi
Indian Journal of Otolaryngology and Head & Neck Surgery.2023; 75(4): 3098. CrossRef
Role of cytotoxic T-lymphocyte antigen 4 (CTLA-4) expression in the pathogenesis of Warthin’s tumor growth
Alvionika Nadyah Qotrunnada, Tecky Indriana, Jane Kosasih, Meiske Margaretha, Mei Syafriadi
Dental Journal (Majalah Kedokteran Gigi).2022; 55(4): 194. CrossRef
Lymphoepithelial Carcinoma of Salivary Glands
Lester D.R. Thompson, Rumeal D. Whaley
Surgical Pathology Clinics.2021; 14(1): 75. CrossRef
Follicular Lymphoma Diagnosed in Warthin Tumor: A Case Report and Review of the Literature
Fnu Alnoor, Jatin S. Gandhi, Matthew K. Stein, Joel F. Gradowski
Head and Neck Pathology.2020; 14(2): 386. CrossRef
Prevalence of Lymphoid Neoplasia in a Retrospective Analysis of Warthin Tumor: A Single Institution Experience
F. N. U. Alnoor, Jatin S. Gandhi, Matthew K. Stein, Jorge Solares, Joel F. Gradowski
Head and Neck Pathology.2020; 14(4): 944. CrossRef
A Case of Diffuse Large B Cell Lymphoma in Submandibular Gland
Sang Hoo Park, Min Gyoung Pak, Dong Kun Lee
Journal of Clinical Otolaryngology Head and Neck Surgery.2020; 31(1): 111. CrossRef
Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours
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Advances in Therapy.2019; 36(8): 1950. CrossRef
Diffuse large B-cell lymphoma arising from follicular lymphoma with warthin’s tumor of the parotid gland - immunophenotypic and genetic features: A case report
Chang-Song Wang, Xia Chu, Di Yang, Lei Ren, Nian-Long Meng, Xue-Xia Lv, Tian Yun, Yan-Sha Cao
World Journal of Clinical Cases.2019; 7(22): 3895. CrossRef
Presentation of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma in a Warthin Tumor: Case Report and Literature Review
Hadeel Jawad, Peter McCarthy, Gerard O’Leary, Cynthia C. Heffron
International Journal of Surgical Pathology.2018; 26(3): 256. CrossRef
Bilateral Warthin tumor in psoriatic patients in therapy with multiple immunosuppressive therapy
M Burlando, E Cozzani, C Chinazzo, M larosa, M Boggio, A Parodi
International Journal of Immunopathology and Pharmacology.2015; 28(1): 138. CrossRef
Nodular Lymphocyte-Predominant Hodgkin Lymphoma in a Warthin Tumor of the Parotid Gland
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International Journal of Surgical Pathology.2015; 23(5): 419. CrossRef

Original Article

A Different Perspective on Macroscopic Sampling of Cholecystectomy Specimens: Asuman Argon, Ayşe Yağcı, Funda Taşlı, Tulu Kebat, Senem Deniz, Nazif Erkan, Gül Kitapçıoğlu, Enver Vardar; Korean J Pathol. 2013;47(6):519-525. Published online December 24, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.6.519

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Abstract PDF

Background

Because there may be interdepartmental differences in macroscopic sampling of cholecystectomy specimens, we aimed to investigate differences between the longitudinal sampling technique and our classical sampling technique in cholecystectomy specimens in which there was no obvious malignancy.

Methods

Six hundred eight cholecystectomy specimens that were collected between 2011 and 2012 were included in this study. The first group included 273 specimens for which one sample was taken from each of the fundus, body, and neck regions (our classical technique). The second group included 335 specimens for which samples taken from the neck region and lengthwise from the fundus toward the neck were placed together in one cassette (longitudinal sampling). The Pearson chi-square, Fisher exact, and ANOVA tests were used and differences were considered significant at p<.05.

Results

In the statistical analysis, although gallbladders in the first group were bigger, the average length of the samples taken in the second group was greater. Inflammatory cells, pyloric metaplasia, intestinal metaplasia, low grade dysplasia, and invasive carcinoma were seen more often in the second group.

Conclusions

In our study, the use of a longitudinal sampling technique enabled us to examine a longer mucosa and to detect more mucosal lesions than did our classical technique. Thus, longitudinal sampling can be an effective technique in detecting preinvasive lesions.

Citations

Citations to this article as recorded by

Cholecystectomy in children: indications, clinical, laboratory and histopathological findings and cost analysis
Aysel Ünlüsoy Aksu, Nebiyye Genel, Gülseren Şahin, Ferda Özbay Hoşnut, Ayşegül Tok, Ayşe Karaman
The Turkish Journal of Pediatrics.2024; 66(4): 473. CrossRef
Ultrasonographic features of gallbladder wall thickening in dogs with hypoalbuminemia
Masahiro Murakami, Hock Gan Heng, Sarah Steinbach, Mario Sola
Veterinary Quarterly.2023; 43(1): 1. CrossRef
Can the sampling method affect the detection of incidental gallbladder carcinoma? Comparative analysis of two sampling methods
Ezgi Hacihasanoglu, Esra Pasaoglu, Merve Cin, Enver Yarikkaya, Nevra Dursun, Sevim Baykal Koca
Annals of Diagnostic Pathology.2023; 67: 152187. CrossRef
Current management of incidental gallbladder cancer: A review
Claudio F. Feo, Giorgio C. Ginesu, Alessandro Fancellu, Teresa Perra, Chiara Ninniri, Giulia Deiana, Antonio M. Scanu, Alberto Porcu
International Journal of Surgery.2022; 98: 106234. CrossRef
Accuracy of Right Upper Quadrant Ultrasound in Estimating Gallbladder Wall Thickness
Lindsay Cefalu, Robert McMurray, Grant Sizemore, Gerald Bieniek, Michael Lustik, Christopher Yheulon
Surgical Laparoscopy, Endoscopy & Percutaneous Techniques.2019; 29(1): 26. CrossRef
Optimal block sampling of routine, non‐tumorous gallbladders
Newton A C S Wong
Histopathology.2017; 71(1): 162. CrossRef
The Relationship Between Intracholecystic Papillary-Tubular Neoplasms and Invasive Carcinoma of the Gallbladder
Asuman Argon, Funda Yılmaz Barbet, Deniz Nart
International Journal of Surgical Pathology.2016; 24(6): 504. CrossRef

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