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- Overview of IgG4-Related Tubulointerstitial Nephritis and Its Mimickers
- Hyeon Joo Jeong, Su-Jin Shin, Beom Jin Lim
- J Pathol Transl Med. 2016;50(1):26-36. Published online December 14, 2015
- DOI: https://doi.org/10.4132/jptm.2015.11.09
- 10,479 View
- 214 Download
- 12 Web of Science
- 10 Crossref
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Abstract
PDF - Tubulointerstitial nephritis (TIN) is the most common form of renal involvement in IgG4-related disease. It is characterized by a dominant infiltrate of IgG4-positive plasma cells in the interstitium and storiform fibrosis. Demonstration of IgG4-positive plasma cells is essential for diagnosis, but the number of IgG4-positive cells and the ratio of IgG4-positive/IgG-positive plasma cells may vary from case to case and depending on the methods of tissue sampling even in the same case. IgG4-positive plasma cells can be seen in TIN associated with systemic lupus erythematosus, Sjögren syndrome, or anti-neutrophil cytoplasmic antibody–associated vasculitis, which further add diagnostic confusion and difficulties. To have a more clear view of IgG4-TIN and to delineate differential points from other TIN with IgG4-positive plasma cell infiltrates, clinical and histological features of IgG4-TIN and its mimickers were reviewed. In the rear part, cases suggesting overlap of IgG4-TIN and its mimickers and glomerulonephritis associated with IgG4-TIN were briefly described.
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Citations
Citations to this article as recorded by
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- IgG4-related kidney disease: Clinicopathologic features, differential diagnosis, and mimics
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