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1 "Histologic types"
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Original Article
Classic Papillary Thyroid Carcinoma with Tall Cell Features and Tall Cell Variant Have Similar Clinicopathologic Features
Woo Jin Oh, Young Sub Lee, Uiju Cho, Ja Seong Bae, Sohee Lee, Min Hee Kim, Dong Jun Lim, Gyeong Sin Park, Youn Soo Lee, Chan Kwon Jung
Korean J Pathol. 2014;48(3):201-208.   Published online June 26, 2014
DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.3.201
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  • 37 Crossref
AbstractAbstract PDF
Background

The tall cell variant of papillary thyroid carcinoma (TCVPTC) is more aggressive than classic papillary thyroid carcinoma (PTC), but the percentage of tall cells needed to diagnose TCVPTC remains controversial. In addition, little is known about the clinicopathologic features of classic PTC with tall cell features (TCF).

Methods

We retrospectively selected and reviewed the clinicopathologic features and presence of the BRAF mutation in 203 cases of classic PTC, 149 cases of classic PTC with TCF, and 95 cases of TCVPTCs, which were defined as PTCs having <10%, 10-50%, and ≥50% tall cells, respectively.

Results

TCVPTCs and classic PTCs with TCF did not vary significantly in clinicopathologic characteristics such as pathologic (p) T stage, extrathyroidal extension, pN stage, lateral lymph node metastasis, or BRAF mutations; however, these features differed significantly in TCVPTCs and classic PTCs with TCF in comparison to classic PTCs. Similar results were obtained in a subanalysis of patients with microcarcinomas (≤1.0 cm in size).

Conclusions

Classic PTCs with TCF showed a similar BRAF mutation rate and clinicopathologic features to TCVPTCs, but more aggressive characteristics than classic PTCs.

Citations

Citations to this article as recorded by  
  • External validation of a deep learning-based algorithm for detection of tall cells in papillary thyroid carcinoma: A multicenter study
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    Journal of Pathology Informatics.2024; 15: 100366.     CrossRef
  • Focal Tall Cell Change in Papillary Thyroid Carcinoma: Lessons Learned from Practices Adopting Rigid Criteria (Height to Width Ratio of 3)
    Esther Diana Rossi, Liron Pantanowitz
    Endocrine Pathology.2024; 35(1): 80.     CrossRef
  • Predicting tall-cell subtype of papillary thyroid carcinomas independently with preoperative multimodal ultrasound
    Bei-Bei Ye, Yun-Yun Liu, Ying Zhang, Bo-Ji Liu, Le-Hang Guo, Qing Wei, Yi-Feng Zhang, Hui-Xiong Xu
    British Journal of Radiology.2024; 97(1159): 1311.     CrossRef
  • TERT mutations and aggressive histopathologic characteristics of radioiodine-refractory papillary thyroid cancer
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  • Papillary Thyroid Carcinomas with Tall Cell Features: An Intermediate Entity Between Classic and Tall Cell Subtypes
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    Thyroid.2023; 33(6): 697.     CrossRef
  • A novel nomogram for identifying high-risk patients among active surveillance candidates with papillary thyroid microcarcinoma
    Li Zhang, Peisong Wang, Kaixuan Li, Shuai Xue
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • The Impact of BRAF V600E Mutation Allele Frequency on the Histopathological Characteristics of Thyroid Cancer
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  • Protruding Huge Thyroid Mass Concurrent Hemorrhage and Skin Necrosis: A Case Report
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    Journal of Endocrine Surgery.2023; 23(4): 143.     CrossRef
  • CD56 Expression in Papillary Thyroid Carcinoma Is Highly Dependent on the Histologic Subtype: A Potential Diagnostic Pitfall
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    Applied Immunohistochemistry & Molecular Morphology.2022; 30(5): 389.     CrossRef
  • Aggressive histopathological variants of papillary thyroid carcinoma, diagnostic challenge, and clinical significance—A case series
    PK Pravanya, KR Anila, Shaji Thomas, A Sreekumar, K Jayasree
    Medical Journal of Dr. D.Y. Patil Vidyapeeth.2022; 15(6): 922.     CrossRef
  • Tall cell variant papillary thyroid carcinoma impacts disease-free survival at the 10 % cut-point on multivariate analysis
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    Pathology - Research and Practice.2022; 236: 154012.     CrossRef
  • A population-based study of the three major variants of papillary thyroid carcinoma
    Junming Xu, Yingying Zhang, Jun Liu, Shenglong Qiu, Min Wang
    Journal of International Medical Research.2021;[Epub]     CrossRef
  • Tall cell percentage alone in PTC without aggressive features should not guide patients’ clinical management
    Anello Marcello Poma, David Viola, Elisabetta Macerola, Agnese Proietti, Eleonora Molinaro, Dario De Vietro, Rossella Elisei, Gabriele Materazzi, Paolo Miccoli, Fulvio Basolo, Clara Ugolini
    The Journal of Clinical Endocrinology & Metabolism.2021; 106(10): e4109.     CrossRef
  • Molecular Pathology of Non-familial Follicular Epithelial–Derived Thyroid Cancer in Adults: From RAS/BRAF-like Tumor Designations to Molecular Risk Stratification
    Paula Soares, Antónia Afonso Póvoa, Miguel Melo, João Vinagre, Valdemar Máximo, Catarina Eloy, José Manuel Cameselle-Teijeiro, Manuel Sobrinho-Simões
    Endocrine Pathology.2021; 32(1): 44.     CrossRef
  • Deep Neck Infection: Atypical Presentation of Papillary Thyroid Cancer
    Apichana Mahattanapreut, Rangsima Aroonroch, Chalermchai Chintrakarn, Chutintorn Sriphrapradang, Dinesh K. Chhetri
    Case Reports in Otolaryngology.2021; 2021: 1.     CrossRef
  • The evolving concept of aggressive histological variants of differentiated thyroid cancer
    Juan C. Hernandez-Prera
    Seminars in Diagnostic Pathology.2020; 37(5): 228.     CrossRef
  • Papillary Thyroid Cancer—Aggressive Variants and Impact on Management: A Narrative Review
    Andrés Coca-Pelaz, Jatin P. Shah, Juan C. Hernandez-Prera, Ronald A. Ghossein, Juan P. Rodrigo, Dana M. Hartl, Kerry D. Olsen, Ashok R. Shaha, Mark Zafereo, Carlos Suarez, Iain J. Nixon, Gregory W. Randolph, Antti A. Mäkitie, Luiz P. Kowalski, Vincent Van
    Advances in Therapy.2020; 37(7): 3112.     CrossRef
  • Contemporary evaluation and management of tall cell variant of papillary thyroid carcinoma
    Sara Cartwright, Abbey Fingeret
    Current Opinion in Endocrinology, Diabetes & Obesity.2020; 27(5): 351.     CrossRef
  • Le carcinome papillaire de la thyroïde avec contingent à cellules hautes : facteurs pronostiques
    I. Riahi, H. Jaafoura, H. Saibi, E. Chebil, I. Ben Nacef, M. Ksentini, T. Ben Ghachem, R. Lahiani, M. Ben Salah
    Annales d'Endocrinologie.2020; 81(4): 345.     CrossRef
  • Updates in the Pathologic Classification of Thyroid Neoplasms: A Review of the World Health Organization Classification
    Yanhua Bai, Kennichi Kakudo, Chan Kwon Jung
    Endocrinology and Metabolism.2020; 35(4): 696.     CrossRef
  • Tall Cell Variant of Papillary Thyroid Carcinoma: Impact of Change in WHO Definition and Molecular Analysis
    Kristine S. Wong, Sara E. Higgins, Ellen Marqusee, Matthew A. Nehs, Trevor Angell, Justine A. Barletta
    Endocrine Pathology.2019; 30(1): 43.     CrossRef
  • Histopatological and molecular genetic characteristics of clinically aggressive variants of papillary thyroid carcinoma
    A. V. Bogolyubova, A. Yu. Abrosimov, L. S. Selivanova, P. V. Belousov
    Arkhiv patologii.2019; 81(1): 46.     CrossRef
  • Papillary Thyroid Cancers with Focal Tall Cell Change are as Aggressive as Tall Cell Variants and Should Not be Considered as Low-Risk Disease
    Pim J. Bongers, Wouter P. Kluijfhout, Raoul Verzijl, Mattan Lustgarten, Marloes Vermeer, David P. Goldstein, Karen Devon, Lorne E. Rotstein, Sylvia L. Asa, James D. Brierley, Richard W. Tsang, Shereen Ezzat, Menno R. Vriens, Ozgur Mete, Jesse D. Pasternak
    Annals of Surgical Oncology.2019; 26(8): 2533.     CrossRef
  • A case-based approach to aggressive variants of papillary thyroid carcinoma with literature review
    JosephAntoine Flordelis Chatto, AnnetteLaurente Salillas
    Thyroid Research and Practice.2019; 16(3): 128.     CrossRef
  • Clinically Relevant Prognostic Parameters in Differentiated Thyroid Carcinoma
    Tyler Janovitz, Justine A. Barletta
    Endocrine Pathology.2018; 29(4): 357.     CrossRef
  • Prediction of novel target genes and pathways involved in tall cell variant papillary thyroid carcinoma
    Fada Xia, Bo Jiang, Yong Chen, Xin Du, Yao Peng, Wenlong Wang, Zhuolu Wang, Xinying Li
    Medicine.2018; 97(51): e13802.     CrossRef
  • Papillary thyroid carcinoma with tall cell features is as aggressive as tall cell variant: a meta-analysis
    Huy Gia Vuong, Nguyen Phuoc Long, Nguyen Hoang Anh, Tran Diem Nghi, Mai Van Hieu, Le Phi Hung, Tadao Nakazawa, Ryohei Katoh, Tetsuo Kondo
    Endocrine Connections.2018; 7(12): R286.     CrossRef
  • TERT Promoter Mutation in an Aggressive Cribriform Morular Variant of Papillary Thyroid Carcinoma
    Eun Ji Oh, Sohee Lee, Ja Seong Bae, Yourha Kim, Sora Jeon, Chan Kwon Jung
    Endocrine Pathology.2017; 28(1): 49.     CrossRef
  • Update on the cytologic features of papillary thyroid carcinoma variants
    Marc Pusztaszeri, Manon Auger
    Diagnostic Cytopathology.2017; 45(8): 714.     CrossRef
  • Molecular correlates and rate of lymph node metastasis of non-invasive follicular thyroid neoplasm with papillary-like nuclear features and invasive follicular variant papillary thyroid carcinoma: the impact of rigid criteria to distinguish non-invasive f
    Uiju Cho, Ozgur Mete, Min-Hee Kim, Ja Seong Bae, Chan Kwon Jung
    Modern Pathology.2017; 30(6): 810.     CrossRef
  • BRAF-positive paucicellular variant of anaplastic carcinoma in the presence of tall cell variant papillary thyroid cancer
    O. V. Dolzhansky, E. M. Paltseva, D. N. Khmelkova, F. A. Konovalov, I. V. Kanivets, A. V. Lavrov, D. V. Pyankov, S. A. Korostelev, O. A. Levendyuk, V. M. Pominalnaya, D. N. Fedorov
    Arkhiv patologii.2017; 79(3): 27.     CrossRef
  • A comparison of the clinicopathological features and prognoses of the classical and the tall cell variant of papillary thyroid cancer: a meta-analysis
    Zeming Liu, Wen Zeng, Tianwen Chen, Yawen Guo, Chao Zhang, Chunping Liu, Tao Huang
    Oncotarget.2017; 8(4): 6222.     CrossRef
  • Clinical utility of TERT promoter mutations and ALK rearrangement in thyroid cancer patients with a high prevalence of the BRAF V600E mutation
    Ja Seong Bae, Yourha Kim, Sora Jeon, Se Hee Kim, Tae Jung Kim, Sohee Lee, Min-Hee Kim, Dong Jun Lim, Youn Soo Lee, Chan Kwon Jung
    Diagnostic Pathology.2016;[Epub]     CrossRef
  • Tall cell variant of papillary thyroid carcinoma: current evidence on clinicopathologic features and molecular biology
    Xiaofei Wang, Wenli Cheng, Chongqing Liu, Jingdong Li
    Oncotarget.2016; 7(26): 40792.     CrossRef
  • The Warthin-Like Variant of Papillary Thyroid Carcinoma: A Comparison with Classic Type in the Patients with Coexisting Hashimoto’s Thyroiditis
    Min-kyung Yeo, Ja Seong Bae, Sohee Lee, Min-Hee Kim, Dong-Jun Lim, Youn Soo Lee, Chan Kwon Jung
    International Journal of Endocrinology.2015; 2015: 1.     CrossRef
  • BRAF Immunohistochemistry Using Clone VE1 is Strongly Concordant with BRAFV600E Mutation Test in Papillary Thyroid Carcinoma
    Jung-Soo Pyo, Jin Hee Sohn, Guhyun Kang
    Endocrine Pathology.2015; 26(3): 211.     CrossRef
  • Pathologie de la thyroïde. Cas no 3. Carcinome papillaire de la thyroïde, variante à cellules hautes
    Emmanuelle Leteurtre
    Annales de Pathologie.2015; 35(5): 402.     CrossRef

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