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Original Articles
- A multicenter study of interobserver variability in pathologic diagnosis of papillary breast lesions on core needle biopsy with WHO classification
- Hye Ju Kang, Sun Young Kwon, Ahrong Kim, Woo Gyeong Kim, Eun Kyung Kim, Ae Ree Kim, Chungyeul Kim, Soo Kee Min, So Young Park, Sun Hee Sung, Hye Kyoung Yoon, Ahwon Lee, Ji Shin Lee, Hyang Im Lee, Ho Chang Lee, Sung Chul Lim, Sun Young Jun, Min Jung Jung, Chang Won Jung, Soo Youn Cho, Eun Yoon Cho, Hye Jeong Choi, So Yeon Park, Jee Yeon Kim, In Ae Park, Youngmee Kwon
- J Pathol Transl Med. 2021;55(6):380-387. Published online October 6, 2021
- DOI: https://doi.org/10.4132/jptm.2021.07.29
- 4,459 View
- 205 Download
- 4 Web of Science
- 4 Crossref
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Abstract
PDF
Supplementary Material - Background
Papillary breast lesions (PBLs) comprise diverse entities from benign and atypical lesions to malignant tumors. Although PBLs are characterized by a papillary growth pattern, it is challenging to achieve high diagnostic accuracy and reproducibility. Thus, we investigated the diagnostic reproducibility of PBLs in core needle biopsy (CNB) specimens with World Health Organization (WHO) classification.
Methods
Diagnostic reproducibility was assessed using interobserver variability (kappa value, κ) and agreement rate in the pathologic diagnosis of 60 PBL cases on CNB among 20 breast pathologists affiliated with 20 medical institutions in Korea. This analysis was performed using hematoxylin and eosin (H&E) staining and immunohistochemical (IHC) staining for cytokeratin 5 (CK5) and p63. The pathologic diagnosis of PBLs was based on WHO classification, which was used to establish simple classifications (4-tier, 3-tier, and 2-tier).
Results
On WHO classification, H&E staining exhibited ‘fair agreement’ (κ = 0.21) with a 47.0% agreement rate. Simple classifications presented improvement in interobserver variability and agreement rate. IHC staining increased the kappa value and agreement rate in all the classifications. Despite IHC staining, the encapsulated/solid papillary carcinoma (EPC/SPC) subgroup (κ = 0.16) exhibited lower agreement compared to the non-EPC/SPC subgroup (κ = 0.35) with WHO classification, which was similar to the results of any other classification systems.
Conclusions
Although the use of IHC staining for CK5 and p63 increased the diagnostic agreement of PBLs in CNB specimens, WHO classification exhibited a higher discordance rate compared to any other classifications. Therefore, this result warrants further intensive consensus studies to improve the diagnostic reproducibility of PBLs with WHO classification. -
Citations
Citations to this article as recorded by
- Invasive papillary carcinoma of the breast
Shijing Wang, Qingfu Zhang, Xiaoyun Mao
Frontiers in Oncology.2024;[Epub] CrossRef - Recommendations for Performance Evaluation of Machine Learning in Pathology: A Concept Paper From the College of American Pathologists
Matthew G. Hanna, Niels H. Olson, Mark Zarella, Rajesh C. Dash, Markus D. Herrmann, Larissa V. Furtado, Michelle N. Stram, Patricia M. Raciti, Lewis Hassell, Alex Mays, Liron Pantanowitz, Joseph S. Sirintrapun, Savitri Krishnamurthy, Anil Parwani, Giovann
Archives of Pathology & Laboratory Medicine.2024; 148(10): e335. CrossRef - Encapsulated papillary carcinoma of the breast: A single institution experience
Liang Xu, Qixin Mao, Qiuming Liu, Yufeng Gao, Lihua Luo, Chungen Guo, Wei Qu, Ningning Yan, Yali Cao
Oncology Letters.2023;[Epub] CrossRef - High-risk and selected benign breast lesions diagnosed on core needle biopsy: Evidence for and against immediate surgical excision
Aparna Harbhajanka, Hannah L. Gilmore, Benjamin C. Calhoun
Modern Pathology.2022; 35(11): 1500. CrossRef
- Invasive papillary carcinoma of the breast
- PLAG1, SOX10, and Myb Expression in Benign and Malignant Salivary Gland Neoplasms
- Ji Hyun Lee, Hye Ju Kang, Chong Woo Yoo, Weon Seo Park, Jun Sun Ryu, Yuh-Seog Jung, Sung Weon Choi, Joo Yong Park, Nayoung Han
- J Pathol Transl Med. 2019;53(1):23-30. Published online November 14, 2018
- DOI: https://doi.org/10.4132/jptm.2018.10.12
- 8,554 View
- 352 Download
- 24 Web of Science
- 28 Crossref
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Abstract
PDF
- Background
Recent findings in molecular pathology suggest that genetic translocation and/oroverexpression of oncoproteins is important in salivary gland tumorigenesis and diagnosis. Weinvestigated PLAG1, SOX10, and Myb protein expression in various salivary gland neoplasm tissues.
Methods
A total of 113 cases of surgically resected salivary gland neoplasms at the NationalCancer Center from January 2007 to March 2017 were identified. Immunohistochemical stainingof PLAG1, SOX10, and Myb in tissue samples was performed using tissue microarrays.
Results
Among the 113 cases, 82 (72.6%) were benign and 31 (27.4%) were malignant. PLAG1 showednuclear staining and normal parotid gland was not stained. Among 48 cases of pleomorphicadenoma, 29 (60.4%) were positive for PLAG1. All other benign and malignant salivary glandneoplasms were PLAG1-negative. SOX10 showed nuclear staining. In normal salivary gland tissuesSOX10 was expressed in cells of acinus and intercalated ducts. In benign tumors, SOX10 expressionwas observed in all pleomorphic adenoma (48/48), and basal cell adenoma (3/3), but not inother benign tumors. SOX10 positivity was observed in nine of 31 (29.0%) malignant tumors.Myb showed nuclear staining but was not detected in normal parotid glands. Four of 31 (12.9%)malignant tumors showed Myb positivity: three adenoid cystic carcinomas (AdCC) and onemyoepithelial carcinoma with focal AdCC-like histology.
Conclusions
PLAG1 expression is specificto pleomorphic adenoma. SOX10 expression is helpful to rule out excretory duct origin tumor,but its diagnostic value is relatively low. Myb is useful for diagnosing AdCC when histology isunclear in the surgical specimen. -
Citations
Citations to this article as recorded by- Immunohistochemical Characterization of a Large Cohort of Triple Negative Breast Cancer
Rachel Han, Sharon Nofech-Mozes, Dina Boles, Hannah Wu, Nikolina Curcin, Elzbieta Slodkowska
International Journal of Surgical Pathology.2024; 32(2): 239. CrossRef - Proceedings of the 2024 North American Society of Head and Neck Pathology Companion Meeting, Baltimore, MD, March 24, 2024: Navigating Ancillary Studies in Basaloid/Blue Salivary Tumors
Kristine S. Wong
Head and Neck Pathology.2024;[Epub] CrossRef - Insights into the molecular alterations of PLAG1 and HMGA2 associated with malignant phenotype acquisition in pleomorphic adenoma
Reydson Alcides de Lima-Souza, Gustavo de Souza Vieira, Talita de Carvalho Kimura, João Figueira Scarini, Luccas Lavareze, Tayná Figueiredo Maciel, Moisés Willian Aparecido Gonçalves, Erika Said Abu Egal, Albina Altemani, Fernanda Viviane Mariano
Critical Reviews in Oncology/Hematology.2024; 204: 104494. CrossRef - Expanding the Molecular Spectrum of Carcinoma Ex Pleomorphic Adenoma
Reydson Alcides de Lima-Souza, Albina Altemani, Michal Michal, Fernanda Viviane Mariano, Ilmo Leivo, Alena Skálová
American Journal of Surgical Pathology.2024; 48(12): 1491. CrossRef - The Challenge of “Monomorphic” Mucoepidermoid Carcinoma—Report of a Rare Case with Pure Spindle-Clear Cell Morphology
Xinyi Qu, Edwin Jun Chen Chew, Sathiyamoorthy Selvarajan, Bingcheng Wu, Abbas Agaimy, Fredrik Petersson
Head and Neck Pathology.2023; 17(3): 864. CrossRef - SOX10
Albert L Sy, Mai P Hoang
Journal of Clinical Pathology.2023; 76(10): 649. CrossRef - Activating Transcription Factor 1 (ATF1) Immunohistochemical Marker Distinguishes HCCC from MEC
Wafaey Badawy, Asmaa S. Abdelfattah, Haneen A. Sallam
Journal of Molecular Pathology.2023; 4(3): 178. CrossRef - Rare case of pleomorphic adenoma presenting as peritonsilar tumor
Anđelina Jovanović, Svetlana Valjarević, Milan Jovanović
Medicinska istrazivanja.2023; 56(3): 95. CrossRef - Pleomorphic Adenoma of a Minor Salivary Gland of the Hard Palate: A Case Report
Ishank Panchal, Anil Wanjari
Cureus.2023;[Epub] CrossRef - Advanced Diagnostic Methods for Salivary Glands Diseases: A Narrative Review Study
Malak Mohammed AlOsaimi, Abdulaziz Mohammed AlSubaheen, Taif Saleh Jameel, Rand Abdulrahman AlSalamah, Dalal Naseh AlAnzi, Norah Ameen AlOushan, Fahad Fadhel AlShammari, Cristalle Soman
Clinical Cancer Investigation Journal.2023; 12(4): 19. CrossRef - Clinical Significance of SOX10 Expression in Human Pathology
Hisham F. Bahmad, Aran Thiravialingam, Karthik Sriganeshan, Jeffrey Gonzalez, Veronica Alvarez, Stephanie Ocejo, Alvaro R. Abreu, Rima Avellan, Alejandro H. Arzola, Sana Hachem, Robert Poppiti
Current Issues in Molecular Biology.2023; 45(12): 10131. CrossRef - NR4A3 Immunostain Is a Highly Sensitive and Specific Marker for Acinic Cell Carcinoma in Cytologic and Surgical Specimens
Kartik Viswanathan, Shaham Beg, Bing He, Taotao Zhang, Richard Cantley, Daniel J Lubin, Qiuying Shi, Zahra Maleki, Saeed Asiry, Rema Rao, Nora Katabi, Masato Nakaguro, William C Faquin, Peter M Sadow, Momin T Siddiqui, Theresa Scognamiglio
American Journal of Clinical Pathology.2022; 157(1): 98. CrossRef - Recent Advances on Immunohistochemistry and Molecular Biology for the Diagnosis of Adnexal Sweat Gland Tumors
Nicolas Macagno, Pierre Sohier, Thibault Kervarrec, Daniel Pissaloux, Marie-Laure Jullie, Bernard Cribier, Maxime Battistella
Cancers.2022; 14(3): 476. CrossRef - Diagnostic accuracy of human transcriptional activator (Myb) expression by ELISA technique versus immunohistochemistry in detecting salivary gland carcinomas
Yousra Refaey, OlfatGamil Shaker, Ayman Abdelwahab, ImanAdel Mohamed Abdelmoneim, Fat’heyaMohamed Zahran
Journal of International Oral Health.2022; 14(1): 61. CrossRef - SLUG is a key regulator of epithelial-mesenchymal transition in pleomorphic adenoma
Hyesung Kim, Seung Bum Lee, Jae Kyung Myung, Jeong Hwan Park, Eunsun Park, Dong Il Kim, Cheol Lee, Younghoon Kim, Chul-Min Park, Min Bum Kim, Gil Chai Lim, Bogun Jang
Laboratory Investigation.2022; 102(6): 631. CrossRef - Assessment of MEF2C as a novel myoepithelial marker using normal salivary gland and pleomorphic adenoma: An immunohistochemical study
Ikuko Takakura, Satoko Kujiraoka, Rika Yasuhara, Junichi Tanaka, Fumio Ide, Kenji Mishima
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology.2022; 34(4): 523. CrossRef - Update on selective special types of breast neoplasms: Focusing on controversies, differential diagnosis, and molecular genetic advances
Shi Wei
Seminars in Diagnostic Pathology.2022; 39(5): 367. CrossRef - Cutaneous Melanomas: A Single Center Experience on the Usage of Immunohistochemistry Applied for the Diagnosis
Costantino Ricci, Emi Dika, Francesca Ambrosi, Martina Lambertini, Giulia Veronesi, Corti Barbara
International Journal of Molecular Sciences.2022; 23(11): 5911. CrossRef - Distinct clinicopathological and genomic features in solid and basaloid adenoid cystic carcinoma of the breast
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Scientific Reports.2022;[Epub] CrossRef - NR4A3 fluorescence in situ hybridization analysis in cytologic and surgical specimens of acinic cell carcinoma
Qiuying Shi, Bin Zhang, Caroline Bsirini, Liqiong Li, Ellen J. Giampoli, Kelly R. Magliocca, Michelle Reid, Zhongren Zhou
Human Pathology.2022; 127: 86. CrossRef - Evaluation of NR4A3 immunohistochemistry (IHC) and fluorescence in situ hybridization and comparison with DOG1 IHC for FNA diagnosis of acinic cell carcinoma
John M. Skaugen, Raja R. Seethala, Simion I. Chiosea, Michael S. Landau
Cancer Cytopathology.2021; 129(2): 104. CrossRef -
MYB-NFIB Translocation by FISH in Adenoid Cystic Carcinoma of the Head and Neck in Nigerian Patients: A Preliminary Report
Adepitan A. Owosho, Olufunlola M. Adesina, Oluwole Odujoko, Olujide O. Soyele, Akinwumi Komolafe, Robert Bauer, Kallie Holte, Kurt F. Summersgill
Head and Neck Pathology.2021; 15(2): 433. CrossRef - Liquid-based cytology of oral brushings in a case of adenoid cystic carcinoma arising from the palate
Ryo MAKINO, Akihiko KAWAHARA, Hideyuki ABE, Yorihiko TAKASE, Chihiro FUKUMITSU, Kazuya MURATA, Tomoko YOSHIDA, Yukako SHINODA, Yoshiki NAITO, Jun AKIBA
The Journal of the Japanese Society of Clinical Cytology.2021; 60(1): 33. CrossRef - MYB Translocations in Both Myoepithelial and Ductoglandular Epithelial Cells in Adenoid Cystic Carcinoma: A Histopathologic and Genetic Reappraisal in Six Primary Cutaneous Cases
Keisuke Goto, Kazuyoshi Kajimoto, Takashi Sugino, Shin-ichi Nakatsuka, Makoto Yoshida, Mai Noto, Michihiro Kono, Toshihiro Takai
The American Journal of Dermatopathology.2021; 43(4): 278. CrossRef - Co-expression of Myoepithelial and Melanocytic Features in Carcinoma Ex Pleomorphic Adenoma
Costantino Ricci, Federico Chiarucci, Francesca Ambrosi, Tiziana Balbi, Barbara Corti, Ottavio Piccin, Ernesto Pasquini, Maria Pia Foschini
Head and Neck Pathology.2021; 15(4): 1385. CrossRef - Juvenile onset pleomorphic adenoma presenting as giant tumor of parotid gland in a young female
Surender Verma, Shivika Aggarwal, Pradeep Garg, Anjali Verma, Mridul Gera, SwaranS Yadav
Journal of Dr. NTR University of Health Sciences.2021; 10(4): 286. CrossRef - Cytopathology and diagnostics of Warthin's tumour
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- Immunohistochemical Characterization of a Large Cohort of Triple Negative Breast Cancer
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