Journal of Pathology and Translational Medicine

Case Study

Mucinous Carcinoma with Extensive Signet Ring Cell Differentiation: A Case Report: Hye Min Kim, Eun Kyung Kim, Ja Seung Koo; J Pathol Transl Med. 2017;51(2):176-179. Published online December 5, 2016; DOI: https://doi.org/10.4132/jptm.2016.08.17

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Breast cancers that present with mucin include mucinous carcinoma and carcinoma with signet ring cell differentiation. The former shows extracellular mucin and the latter shows abundant intracellular mucin. Here, we report a case of breast cancer showing both extracellular mucin and extensive signet ring cell differentiation due to abundant intracellular mucin. Unlike mucinous carcinoma, this case had the features of high-grade nuclear pleomorphism, high mitotic index, estrogen receptor negativity, progesterone receptor negativity, human epidermal growth factor receptor-2 positivity, and ductal type with positivity for E-cadherin. In a case with signet ring cell differentiation, differential diagnosis with metastatic signet ring cell carcinoma of the stomach and colon is essential. In this case, the presence of accompanied ductal carcinoma in situ component and mammaglobin and gross cystic disease fluid protein-15 positivity were findings that suggested the breast as the origin.

Citations

Citations to this article as recorded by

Research on the Histological Features and Pathological Types of Gastric Adenocarcinoma With Mucinous Differentiation
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Journal of Pathology and Translational Medicine.2020; 54(1): 95. CrossRef
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Original Article

Incidence and Malignancy Rates of Diagnoses in the Bethesda System for Reporting Thyroid Aspiration Cytology: An Institutional Experience: Ji Hye Park, Sun Och Yoon, Eun Ju Son, Hye Min Kim, Ji Hae Nahm, SoonWon Hong; Korean J Pathol. 2014;48(2):133-139. Published online April 28, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.133

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Abstract PDF

Background

The Bethesda System for Reporting Thyroid Cytopathology (BSRTC) uses six diagnostic categories to standardize communication of thyroid fine-needle aspiration (FNA) interpretations between clinicians and cytopathologists. Since several studies have questioned the diagnostic accuracy of this system, we examined its accuracy in our hospital.

Methods

We calculated the incidences and malignancy rates of each diagnostic category in the BSRTC for 1,730 FNAs that were interpreted by four cytopathologists in Gangnam Severance Hospital between October 1, 2011, and December 31, 2011.

Results

The diagnostic incidences of categories I-VI were as follows: 13.3%, 40.6%, 9.1%, 0.4%, 19.3%, and 17.3%, respectively. Similarly, the malignancy rates of these categories were as follows: 35.3%, 5.6%, 69.0%, 50.0%, 98.7%, and 98.9%, respectively. In categories II, V, and VI, there were no statistically significant differences in the ranges of the malignancy rates among the four cytopathologists. However, there were significant differences in the ranges for categories I and III.

Conclusions

Our findings suggest that institutions that use the BSRTC should regularly update their diagnostic criteria. We also propose that institutions issue an annual report of incidences and malignancy rates to help other clinicians improve the case management of patients with thyroid nodules.

Citations

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Merve Bagıs, Nuray Can, Necdet Sut, Ebru Tastekin, Ezgi Genc Erdogan, Buket Yilmaz Bulbul, Yavuz Atakan Sezer, Osman Kula, Elif Mercan Demirtas, Inci Usta
Endocrine Pathology.2024; 35(1): 51. CrossRef
Evaluation of the Efficacy of Thyroid Imaging Reporting and Data Systems Classification in Risk Stratification and in the Management of Thyroid Swelling by Comparing It With Fine-Needle Aspiration Cytology and Histopathological Examination
Abhishek K Saw, Zenith H Kerketta, Khushboo Rani, Krishna Murari, Kritika Srivastava, Ajay Kumar, Sunny LNU, Anish Baxla, Nabu Kumar, Nusrat Noor
Cureus.2024;[Epub] CrossRef
A COMPARATIVE STUDY BETWEEN CONVENTIONAL METHOD AND THE BETHESDA SYSTEM FOR REPORTING THYROID CYTOPATHOLOGY
Pooja Mangal, Arti Gupta
GLOBAL JOURNAL FOR RESEARCH ANALYSIS.2023; : 67. CrossRef
Study of Fine Needle Aspiration Cytology (FNAC) of Thyroid Gland According to the Bethesda System
Keval A Patel, Garima Anandani, Bhawana S Sharma, Riddhi A Parmar
Cureus.2023;[Epub] CrossRef
Correlation of Thyroid Fine Needle Aspiration Biopsy With Histopathological Results
Cemalettin Durgun
Cureus.2023;[Epub] CrossRef
The Bethesda System for Reporting Thyroid Cytopathology: Validating at Tribhuvan University Teaching Hospital
Kunjan Acharya, Shreya Shrivastav, Prashant Triipathi, Bigyan Raj Gyawali, Bijaya Kharel, Dharma Kanta Baskota, Pallavi Sinha
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Sapir Pinhas, Idit Tessler, Luba Pasherstnik Bizer, Khaled khalilia, Meir Warman, Meital Adi, Doron Halperin, Oded Cohen
European Archives of Oto-Rhino-Laryngology.2022; 279(1): 383. CrossRef
ANALYSIS OF FINE NEEDLE ASPIRATIONS OF THE THYROID: CYTOLOGICAL-HISTOPATHOLOGICAL CORRELATION AND OUTCOMES OF THE BETHESDA SYSTEM
Ayca TAN
SDÜ Tıp Fakültesi Dergisi.2022; 29(2): 213. CrossRef
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Sasmita Panda, Mamita Nayak, Lucy Pattanayak, Paresh Kumar Behera, Sagarika Samantaray, Sashibhusan Dash
Journal of Microscopy and Ultrastructure.2022; 10(4): 174. CrossRef
Comparative analysis of cytomorphology of thyroid lesion on conventional cytology versus liquid-based cytology and categorize the lesions according to The Bethesda System for Reporting Thyroid Cytopathology
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Cytopathology.2021; 32(2): 205. CrossRef
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Application of the Bethesda system for reporting thyroid cytopathology for classification of thyroid nodules: A clinical and cytopathological characteristics in Bhutanese population
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Cytopathology.2021; 32(4): 472. CrossRef
Ultrasound-guided fine needle aspiration cytology and ultrasound examination of thyroid nodules in the UAE: A comparison
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PLOS ONE.2021; 16(4): e0247807. CrossRef
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European Thyroid Journal.2018; 7(3): 133. CrossRef
The impact of rapid on‐site evaluation on thyroid fine‐needle aspiration biopsy: A 2‐year cancer center institutional experience
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Cancer Cytopathology.2018; 126(10): 846. CrossRef
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K. Kakudo, M. Higuchi, M. Hirokawa, S. Satoh, C. K. Jung, A. Bychkov
Cytopathology.2017; 28(6): 455. CrossRef
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World Journal of Clinical Oncology.2017; 8(2): 151. CrossRef
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Scientific Reports.2015;[Epub] CrossRef
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Biomedical Journal.2015; 38(6): 517. CrossRef
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International Archives of Medicine.2014; 7(1): 46. CrossRef

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