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Original Articles
- Peripheral type squamous cell carcinoma of the lung: clinicopathologic characteristics in comparison to the central type
- Yeoun Eun Sung, Uiju Cho, Kyo Young Lee
- J Pathol Transl Med. 2020;54(4):290-299. Published online June 17, 2020
- DOI: https://doi.org/10.4132/jptm.2020.05.04
- 6,444 View
- 186 Download
- 10 Web of Science
- 12 Crossref
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Abstract
PDF - Background
Squamous cell carcinomas (SqCCs) of the lung are known to arise more often in a central area but reports of peripheral SqCCs have increased, with a pathogenesis that is obscured. In this study, the clinicopathologic characteristics of peripheral lung SqCCs were studied and compared with those of the central type.
Methods
This study included 63 peripheral lung SqCCs and 48 randomly selected central cases; hematoxylin and eosin-stained slides of surgically resected specimens were reviewed in conjunction with radiologic images and clinical history. Cytokeratin-7 immunohistochemical staining of key slides and epidermal growth factor receptor (EGFR)/KRAS mutations tested by DNA sequencing were also included.
Results
Stages of peripheral SqCCs were significantly lower than central SqCCs (p=.016). Cystic change of the mass (p=.007), presence of interstitial fibrosis (p=0.007), and anthracosis (p=.049) in the background lung were significantly associated with the peripheral type. Cytokeratin-7 positivity was also higher in peripheral SqCCs with cutoffs of both 10% and 50% (p=.011). Pathogenic mutations in EGFR and KRAS were observed in only one case out of the 72 evaluated. The Cox proportional hazard model indicated a significantly better disease-free survival (p=.009) and the tendency of better overall survival (p=.106) in the peripheral type.
Conclusions
In peripheral type, lower stage is a favorable factor for survival but more frequent interstitial fibrosis and older age are unfavorable factors. Multivariate Cox analysis revealed that peripheral type is associated with better disease-free survival. The pathogenesis of peripheral lung SqCCs needs further investigation, together with consideration of the background lung conditions. -
Citations
Citations to this article as recorded by
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Sabina Berezowska, Marie Maillard, Mark Keyter, Bettina Bisig
Histopathology.2024; 84(1): 32. CrossRef - Assessment of seasonal variability of PM, BC and UFP levels at a highway toll stations and their associated health risks
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Environmental Research.2024; 245: 118028. CrossRef - Association between Airport Ultrafine Particles and Lung Cancer Risk: The Multiethnic Cohort Study
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- Pulmonary squamous cell carcinoma and lymphoepithelial carcinoma – morphology, molecular characteristics and differential diagnosis
- Clear Cell Papillary Renal Cell Carcinoma: A Report of 15 Cases Including Three Cases of Concurrent Other-Type Renal Cell Carcinomas
- Jeong Hwan Park, Cheol Lee, Ja Hee Suh, Kyung Chul Moon
- Korean J Pathol. 2012;46(6):541-547. Published online December 26, 2012
- DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.6.541
- 7,490 View
- 61 Download
- 23 Crossref
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Abstract
PDF
Background Clear cell papillary renal cell carcinoma (CCPRCC) is a recently established subtype of renal epithelial tumor. The aim of this study was to identify the diagnostic criteria of CCPRCC with an emphasis on immunohistochemical studies, and to report three cases with concurrent other-type renal cell carcinoma (RCC).
Methods A total of 515 RCC patients that consecutively underwent surgical resection at Seoul National University Hospital from 1 January 2010 to 31 December 2011 were screened. Each case was reviewed based on the histologic features and was evaluated immunohistochemically.
Results A total of 15 CCPRCCs were identified, which composed 2.9% of the total RCCs. The mean age was 52 years, and the average tumor size was 1.65 cm. All 15 cases showed low nuclear grade, no lymph node metastasis and no distant metastasis. The CCPRCCs showed variable architectural patterns including cystic, trabecular, papillary, and acinar. All of the cases showed moderate to intense immunoreactivity for cytokeratin 7 (CK7). CD10 was negative or showed focal weak positivity. Three cases had concurrent other-type RCC, including a clear cell RCC and an acquired cystic disease-associated RCC.
Conclusions The strong CK7 and negative or focal weak CD10 expression will be useful for the diagnosis of CCPRCC.
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Citations
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