Predictive biomarker testing plays a critical role in targeted immuno-oncology, including the use of immune checkpoint inhibitors (ICI) for various solid tumors. Molecular advancements in cancers of the breast, kidney and brain have continued to propel tumor classification and precision therapy.
The linchpin of precision medicine is molecular genetic and genomic testing. Molecular biomarkers are important for establishing precise diagnoses and for predicting therapeutic responses that enable cancer patients to receive personalized and targeted treatment. Below are highlights of the current considerations in next generation sequencing (NGS) panel selection, and in molecular testing of solid tumors of the lung, digestive system, thyroid and soft tissue.
Cytology in China developed from nothing and underwent a long journey from gynecologic cytology to that of all organs, laying a solid foundation for new developments in the 21st century. Thyroid fine-needle aspiration (FNA) was primarily developed in an endocrinology department and then in the clinical laboratory department or pathology department in the 1970–80s. Wrights staining is popular in endocrine and clinical laboratory departments, while hematoxylin and eosin staining is common in pathology. Liquid based cytology is not common in thyroid FNA cytology, while BRAFV600E mutation analysis has been the most popular molecular test. The history and practice of thyroid FNA practice in China were reviewed based on retrospective study of the practice in Qilu Hospital of Shandong University.
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Deep learning to predict cervical lymph node metastasis from intraoperative frozen section of tumour in papillary thyroid carcinoma: a multicentre diagnostic study Yihao Liu, Fenghua Lai, Bo Lin, Yunquan Gu, Lili Chen, Gang Chen, Han Xiao, Shuli Luo, Yuyan Pang, Dandan Xiong, Bin Li, Sui Peng, Weiming Lv, Erik K. Alexander, Haipeng Xiao eClinicalMedicine.2023; 60: 102007. CrossRef
Comparative Study of C-TIRADS, ACR-TIRADS, and EU-TIRADS for Diagnosis and Management of Thyroid Nodules Zhe Jin, Shufang Pei, Hui Shen, Lizhu Ouyang, Lu Zhang, Xiaokai Mo, Qiuying Chen, Jingjing You, Shuixing Zhang, Bin Zhang Academic Radiology.2023; 30(10): 2181. CrossRef
The Asian Thyroid Working Group, from 2017 to 2023 Kennichi Kakudo, Chan Kwon Jung, Zhiyan Liu, Mitsuyoshi Hirokawa, Andrey Bychkov, Huy Gia Vuong, Somboon Keelawat, Radhika Srinivasan, Jen-Fan Hang, Chiung-Ru Lai Journal of Pathology and Translational Medicine.2023; 57(6): 289. CrossRef
Malignancy rates in thyroid nodules: a long-term cohort study of 17,592 patients M Grussendorf, I Ruschenburg, G Brabant European Thyroid Journal.2022;[Epub] CrossRef
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A multicenter, prospective study to observe the initial management of patients with differentiated thyroid cancer in China (DTCC study) Jie Ming, Jing-Qiang Zhu, Hao Zhang, Hui Sun, Jun Wang, Ruo-Chuan Cheng, Lei Xie, Xing-Rui Li, Wen Tian, Tao Huang BMC Endocrine Disorders.2021;[Epub] CrossRef
Differences in surgical resection rate and risk of malignancy in thyroid cytopathology practice between Western and Asian countries: A systematic review and meta‐analysis Huy Gia Vuong, Hanh Thi Tuyet Ngo, Andrey Bychkov, Chan Kwon Jung, Trang Huyen Vu, Kim Bach Lu, Kennichi Kakudo, Tetsuo Kondo Cancer Cytopathology.2020; 128(4): 238. CrossRef
Thyroid FNA cytology in Asian practice—Active surveillance for indeterminate thyroid nodules reduces overtreatment of thyroid carcinomas K. Kakudo, M. Higuchi, M. Hirokawa, S. Satoh, C. K. Jung, A. Bychkov Cytopathology.2017; 28(6): 455. CrossRef
The Use of Fine-Needle Aspiration (FNA) Cytology in Patients with Thyroid Nodules in Asia: A Brief Overview of Studies from the Working Group of Asian Thyroid FNA Cytology Chan Kwon Jung, SoonWon Hong, Andrey Bychkov, Kennichi Kakudo Journal of Pathology and Translational Medicine.2017; 51(6): 571. CrossRef