Skip Navigation
Skip to contents

J Pathol Transl Med : Journal of Pathology and Translational Medicine

OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
1 "Lymphotoxin-alpha"
Filter
Filter
Article category
Keywords
Publication year
Authors
Original Article
TNF-α and TNF-β Polymorphisms are Associated with Susceptibility to Osteoarthritis in a Korean Population
Lin Han, Joo Hyoun Song, Jung Hwan Yoon, Yong Gyu Park, Suk Woo Lee, Yoo Jin Choi, Suk Woo Nam, Jung Young Lee, Won Sang Park
Korean J Pathol. 2012;46(1):30-37.   Published online February 23, 2012
DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.1.30
  • 9,877 View
  • 49 Download
  • 28 Crossref
AbstractAbstract PDF
Background

The tumor necrosis factor (TNF) is believed to play an important role in the pathophysiology of osteoarthritis (OA). Evidence shows that genetic polymorphisms make substantial contributions to the etiology of OA.

Methods

We investigated the genotypes TNF-α and TNF-β in 301 OA patients and 291 healthy subjects as controls. We employed a polymerase chain reaction-restriction fragment length polymorphism and a polymerase chain reaction-single strand conformation polymorphism assay to identify the genotypes TNFA -G308A and TNFB +G252A, respectively.

Results

For TNFA -G308A, the percentages of genotypes GG, AG, and AA were 26.3% (79/301), 62.5% (188/301), and 11.3% (34/301) in OA patients and 88.7% (258/291), 11.3% (33/291), and 0% (0/291) in controls. For TNFB +G252A, the percentages of genotypes GG, AG, and AA were 15.3% (46/301), 41.9% (126/301), and 42.9% (129/301) in OA patients and 12% (35/291), 52.6% (153/291), and 35.4% (103/291) in controls. There were significant differences in genotypes and alleles of TNFA -308 between OA patients and controls (p<0.0001) and in alleles of TNFB +252 (p=0.0325). The risk of OA was significantly higher for carriers of the TNFA -308A allele and the TNFB +252 AA homozygote (p=0.0224).

Conclusions

The results suggest close relationships between TNFA -G308A and TNFB +G252A polymorphisms and individual susceptibility to OA in the Korean population.

Citations

Citations to this article as recorded by  
  • The Exosomes of Stem Cells from Human Exfoliated Deciduous Teeth Suppress Inflammation in Osteoarthritis
    Chuang-Yu Lin, Parichart Naruphontjirakul, Te-Yang Huang, Yi-Chia Wu, Wei-Hsuan Cheng, Wen-Ta Su
    International Journal of Molecular Sciences.2024; 25(16): 8560.     CrossRef
  • Health benefits of astaxanthin against age-related diseases of multiple organs: A comprehensive review
    Phaniendra Alugoju, V. K. D. Krishna Swamy, Naga Venkata Anusha Anthikapalli, Tewin Tencomnao
    Critical Reviews in Food Science and Nutrition.2023; 63(31): 10709.     CrossRef
  • Complete sequence and comparative analysis of the mitochondrial genome of the rare and endangered Clematis acerifolia, the first clematis mitogenome to provide new insights into the phylogenetic evolutionary status of the genus
    Dan Liu, Kai Qu, Yangchen Yuan, Zhiheng Zhao, Ying Chen, Biao Han, Wei Li, Yousry A. El-Kassaby, Yangyang Yin, Xiaoman Xie, Boqiang Tong, Hongshan Liu
    Frontiers in Genetics.2023;[Epub]     CrossRef
  • Intra-articular Treatment with Triamcinolone Hexacetonide Associated with Gold Nanoparticles Reduces Cartilage Degeneration in an Animal Model of Osteoarthritis
    Daniela Pacheco dos Santos Haupenthal, Marcus Barg Resmini, Leandro Almeida Da Silva, Mateus Cardoso Colares, Laura de Roch Casagrande, Ligia Milanez Venturini, Thiago Antônio Moretti de Andrade, Fernando Russo Costa do Bomfim, Anand Thirupathi, Paulo Emi
    Current Drug Targets.2023; 24(3): 287.     CrossRef
  • Vitamin D Receptor Gene Polymorphisms and Risk of Knee Osteoarthritis: Possible Correlations with TNF-α, Macrophage Migration Inhibitory Factor, and 25-Hydroxycholecalciferol Status
    Mohammed H. Hassan, Amer Alkot Mostafa Elsadek, Marwa Ahmed Mahmoud, Bakheet E. M. Elsadek
    Biochemical Genetics.2022; 60(2): 611.     CrossRef
  • Complement System Inhibition Modulates the Inflammation Induced by the Venom of Premolis semirufa, an Amazon Rainforest Moth Caterpillar
    Joel J. M. Gabrili, Isadora Maria Villas-Boas, Giselle Pidde, Carla Cristina Squaiella-Baptistão, Trent M. Woodruff, Denise V. Tambourgi
    International Journal of Molecular Sciences.2022; 23(21): 13333.     CrossRef
  • Azilsartan prevented AGE‐induced inflammatory response and degradation of aggrecan in human chondrocytes through inhibition of Sox4
    Jie Lei, Mengyin He, Liangzhou Xu, Chengjian He, Jie Li, Wei Wang
    Journal of Biochemical and Molecular Toxicology.2021;[Epub]     CrossRef
  • TNF-α Carried by Plasma Extracellular Vesicles Predicts Knee Osteoarthritis Progression
    Xin Zhang, Ming-Feng Hsueh, Janet L. Huebner, Virginia B. Kraus
    Frontiers in Immunology.2021;[Epub]     CrossRef
  • Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case–control study and meta-analysis
    Chih-Chien Wang, Chih-Yun Huang, Meng-Chang Lee, Dung-Jang Tsai, Chia-Chun Wu, Sui-Lung Su, Mingqing Xu
    PLOS ONE.2021; 16(11): e0259561.     CrossRef
  • Sex-, Age-, and Metabolic Disorder-Dependent Distributions of Selected Inflammatory Biomarkers among Community-Dwelling Adults
    So Mi Jemma Cho, Hokyou Lee, Jee-Seon Shim, Hyeon Chang Kim
    Diabetes & Metabolism Journal.2020; 44(5): 711.     CrossRef
  • Tumor necrosis factor-α: Molecular assessment of gene expression, genetic variants and serum level in Egyptian patients with knee osteoarthritis
    Nermin Raafat, Amal F. Gharib, Doaa S. Atta, Shimaa M. AbdElwahab, Doaa M. Sharaf
    Gene Reports.2020; 21: 100922.     CrossRef
  • Effect of a functional variant of tumor necrosis factor‐β gene in temporomandibular disorders: A pilot study
    Kaan Yerliyurt, Ayse Feyda Nursal, Akin Tekcan, Nevin Karakus, Mehmet K. Tumer, Serbulent Yigit
    Journal of Clinical Laboratory Analysis.2019;[Epub]     CrossRef
  • Interleukin-6 (-572) and Tumor Necrosis Factor α (-308 and -238) Polymorphisms and Risk of Knee Osteoarthritis in a Pakistani Population: A Case–Control Study
    Syeda Kanwal Batool Naqvi, Maria Bibi, Iram Murtaza, Qamar Javed
    Iranian Journal of Science and Technology, Transactions A: Science.2019; 43(4): 1485.     CrossRef
  • Role of resistin genetic variations in knee osteoarthritis pathogenesis, a cross sectional study
    Syeda Kanwal Batool Naqvi, Iram Murtaza, Qamar Javed
    Molecular Biology Reports.2019; 46(3): 2657.     CrossRef
  • Relationship Between Genetic Polymorphisms of the TNF Gene and Hallux Valgus Susceptibility
    Jie Yang, Junhu Wang, Xiaojun Liang, Hongmou Zhao, Jun Lu, Qiang Ma, Feng Tian
    Genetic Testing and Molecular Biomarkers.2019; 23(6): 380.     CrossRef
  • Functional status and severity of osteoarthritis in elderly is associated to the polymorphism of TNFA gene
    Marcos Tadeu Parron Fernandes, Karen Barros Parron Fernandes, Fernanda Freitas Anibal, Walquíria Shimoya-Bittencourt, Viviane Martins Santos, Priscila Daniele de Oliveira Perrucini, Regina Célia Poli-Frederico
    Advances in Rheumatology.2019;[Epub]     CrossRef
  • Association of TNF-α-308 G > A and −238G > A polymorphisms with knee osteoarthritis risk: A case-control study and meta-analysis
    Mohammad Reza Sobhan, Masoud Mahdinezhad-Yazdi, Kazem Aghili, Masoud Zare-Shehneh, Shohreh Rastegar, Jalal Sadeghizadeh-Yazdi, Hossein Neamatzadeh
    Journal of Orthopaedics.2018; 15(3): 747.     CrossRef
  • Association between tumor necrosis factor alpha rs1800629 polymorphism and risk of osteoarthritis in a Chinese population
    Jie Chen, Yu Wu, Jiannong Yu, Jinming Shen
    Brazilian Journal of Medical and Biological Research.2018;[Epub]     CrossRef
  • Association of cytokine gene polymorphisms with osteoarthritis susceptibility
    Otilia Rogoveanu, Daniela Calina, Mihai Cucu, Florin Burada, Anca Docea, Simona Sosoi, Emilian Stefan, Mihai Ioana, Emilia Burada
    Experimental and Therapeutic Medicine.2018;[Epub]     CrossRef
  • TNF‑α increases the expression of inflammatory factors in synovial fibroblasts by inhibiting the PI3K/AKT pathway in a rat model of monosodium iodoacetate‑induced osteoarthritis
    Hongxi Li, Shujuan Xie, Yunlong Qi, Huazhe Li, Rui Zhang, Yongyun Lian
    Experimental and Therapeutic Medicine.2018;[Epub]     CrossRef
  • The single-nucleotide polymorphism (SNP) of tumor necrosis factor α −308G/A gene is associated with early-onset primary knee osteoarthritis in an Egyptian female population
    Sahar M. Abdel Galil, Nillie Ezzeldin, Faten Fawzy, Mohamed El-Boshy
    Clinical Rheumatology.2017; 36(11): 2525.     CrossRef
  • Roxatidine Attenuates Degradation of Extracellular Matrix
    Renhao Ze, Shangyu Wang, Mao Xie, Bo Zhang, Xin Tang, Jin Li
    Biomedicine & Pharmacotherapy.2017; 95: 1156.     CrossRef
  • The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis
    Piotr Wojdasiewicz, Łukasz A. Poniatowski, Dariusz Szukiewicz
    Mediators of Inflammation.2014; 2014: 1.     CrossRef
  • Meta-analysis of tumor necrosis factor alpha -308 polymorphism and knee osteoarthritis risk
    Suotang Kou, Yaochi Wu
    BMC Musculoskeletal Disorders.2014;[Epub]     CrossRef
  • Astaxanthin reduces matrix metalloproteinase expression in human chondrocytes
    Wei-Ping Chen, Yan Xiong, Yong-Xiang Shi, Peng-Fei Hu, Jia-Peng Bao, Li-Dong Wu
    International Immunopharmacology.2014; 19(1): 174.     CrossRef
  • Variations in the TNFα gene and their interactions with the IL4R and IL10 genes in relation to hand osteoarthritis
    Satu Hämäläinen, Svetlana Solovieva, Tapio Vehmas, Päivi Leino-Arjas, Ari Hirvonen
    BMC Musculoskeletal Disorders.2014;[Epub]     CrossRef
  • Tumor necrosis factor gene polymorphisms and endometriosis in Asians: a systematic review and meta-analysis
    Jiangtao Lyu, Hua Yang, Jinghe Lang, Xianjie Tan
    Chinese Medical Journal.2014; 127(9): 1761.     CrossRef
  • Association analysis of two candidate polymorphisms in the Tumour Necrosis Factor-α gene with osteoarthritis in a Chinese population
    Bin Ji, Jixiang Shi, Xiangyu Cheng, Junjie Zhou, Qiang Zhou, Chengfu Cao, Jinhui Pang
    International Orthopaedics.2013; 37(10): 2061.     CrossRef

J Pathol Transl Med : Journal of Pathology and Translational Medicine
TOP