Journal of Pathology and Translational Medicine

Original Articles

Expression of MUC1 and MUC4 in Gallbladder Adenocarcinoma: Su-Mi Kim, Sun-Ju Oh, Bang Hur; Korean J Pathol. 2012;46(5):429-435. Published online October 25, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.5.429

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Background

Recent reports have indicated that overexpression of mucin (MUC) 1 and/or MUC4 correlates with the occurrence and progression of extra-hepatobiliary malignancy. In this study, we investigated the expression of MUC1 and MUC4 and their prognostic significance in gallbladder adenocarcinoma.

Methods

We examined 54 surgical gallbladder adenocarcinoma samples by immunohistochemistry for MUC1 and MUC4 expression. Staining was evaluated as a sum score of extent and intensity, dividing the samples into low and high expression groups.

Results

The low expression group for both MUC1 and MUC4 was 10 samples (18.5%), and the high expression group was 44 samples (81.5%). High MUC1 expression was significantly correlated with more differentiated tumors (p=0.033), whereas high expression of MUC4 correlated with negative nodal status (p=0.012). Other pathological features were not correlated with MUC expression. Multivariate cox regression analysis showed that neither MUC1 nor MUC4 expression correlated with survival.

Conclusions

Although there were some correlations found, a prognostic role for either MUC1 or MUC4 expression in gallbladder carcinoma was not identified in this study. Further investigation is required.

Citations

Citations to this article as recorded by

Environmental and Metabolic Risk Factors Linked to Gallbladder Dysplasia
Andrei Bojan, Catalin Pricop, Manuela Ciocoiu, Maria Cristina Vladeanu, Iris Bararu Bojan, Oana Viola Badulescu, Minerva Codruta Badescu, Carmen Elena Plesoianu, Dan Iliescu Halitchi, Liliana Georgeta Foia
Metabolites.2024; 14(5): 273. CrossRef
Expression of Mucoproteins in Gallbladder Cancer
Puneet Kumar, Priyesh Shukla, Soni Kumari, Ruhi Dixit, Gopeshwar Narayan, V. K. Dixit, A. K. Khanna
Indian Journal of Surgery.2022; 84(3): 456. CrossRef
Prognostic and clinicopathological value of MUC1 expression in colorectal cancer
Chao Li, Tao Liu, Libin Yin, Didi Zuo, Yuyang Lin, Lei Wang
Medicine.2019; 98(9): e14659. CrossRef
Prognostic Significance of Mucin Antigen MUC1 in Various Human Epithelial Cancers
Feng Xu, Fuquan Liu, Hongwei Zhao, Guangyu An, Guosheng Feng
Medicine.2015; 94(50): e2286. CrossRef
Increased Expression of CCN2, Epithelial Membrane Antigen, and Fibroblast Activation Protein in Hepatocellular Carcinoma with Fibrous Stroma Showing Aggressive Behavior
Gi Jeong Kim, Hyungjin Rhee, Jeong Eun Yoo, Jung Eun Ko, Jee San Lee, Hyunki Kim, Jin Sub Choi, Young Nyun Park, Philip C. Trackman
PLoS ONE.2014; 9(8): e105094. CrossRef
State-of-the-art in the management of locally advanced and metastatic gallbladder cancer
Mairéad G. McNamara, Cristiane Metran-Nascente, Jennifer J. Knox
Current Opinion in Oncology.2013; 25(4): 425. CrossRef
Clinicopathological and Prognostic Significance of MUC-2, MUC-4 and MUC-5AC Expression in Japanese Gastric Carcinomas
Li-Jun Xiao, Shuang Zhao, En-Hong Zhao, Xin Zheng, Wen-Feng Gou, Ya-Nan Xing, Yasuo Takano, Hua-Chuan Zheng
Asian Pacific Journal of Cancer Prevention.2012; 13(12): 6447. CrossRef

Alterations of the Mucin Glycoprotein Expression and Their Relationship with the Pathologic Prognostic Factors in Gastric Carcinoma.: Mee Sook Roh, Gi Yeong Huh, Sook Hee Hong; Korean J Pathol. 1999;33(1):15-24.

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Abstract: Alterations of the mucin-type glycoproteins may contribute to changes in cancer cell growth regulation, immune regulation, and cellular adhesion, which in turn may influence the invasive and metastatic capabilities of the cancer. Many of the cancer-associated antigens such as mucin antigens have been identified recently and alterations in the glycosylation of the mucins have been described in the cancer. Immunohistochemical studies of 3 antigens associated with alteration of the mucin glycoprotein (MUC1, MUC2, STn) were done to evaluate their relationship with known pathologic prognostic factors and their usefulness in assessment of the progression of gastric carcinoma in 127 gastric carcinoma tissues. The MUC1 was detected in 57 (44.9%), MUC2 in 76 (59.8%) and STn antigen in 77 (60.6%) out of 127 cases of gastric carcinomas. The expression rate of MUC1 was significantly correlated with depth of tumor invasion, lymph node and distant metastases, and advanced tumor stage (p=0.001). The expression rate of MUC2 was not significantly correlated with pathologic findings and known prognostic factors. The STn antigen was significantly associated with incidence of lymph node metastasis (p=0.02). The coexpression of both MUC1 and MUC2 or MUC1 and STn was more frequent in tumors with deep invasion, lymph node metastasis and advanced tumor stage than one or none expression (p<0.05). These results suggest that the alterations of expression of the mucin proteins, especially MUC1 and carbohydrate antigen (STn) are associated with poor biological behavior of the gastric carcinoma.

Expression Patterns of Tumor Related Proteins for Differential Diagnoses of Intrahepatic Adenocarcinomas.: Ghil Suk Yoon, Mi Sung Kim, Young Hwa Li, Ji Hyun Uhm, Sun Ju Kim, Tae Sook Kim, In Su Suh, Han Ik Bae; Korean J Pathol. 2005;39(4):229-235.

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Abstract PDF: Background
: Differential diagnoses of intrahepatic adenocarcinomas (IHAC) play an important role in the detecting primary sites and the determining type of treatment and overall prognosis of the patient. However, histopathologic findings alone have limitations of differential diagnoses of IHAC. Methods : To clarify which tumor related proteins (TRP) are useful for differential diagnoses of IHAC, TRP expression were investigated immunohistochemically, using MUC5AC, MUC2, mAb 91.9H, MUC1, and pS2, and by high iron diamine (HID) staining in 61 clinically confirmed IHACs. Results : MUC5AC (9/18, p<0.05) and MUC1 (17/18, p>0.05) displayed the most frequent expression in cholangiocarcinomas, and MUC2 (11/18, p<0.05), mAb 91.9H (16/18, p<0.05), and HID (16/18, p<0.05) in colorectal adenocarcinomas. pS2 (3/11, p>0.05) was expressed more often in pancreatic adenocarcinomas than other IHAC, while MUC2 and 91.9H were not expressed at all in pancreatic adenocarcinomas. The positivity of several TRP did not correlate with tumor differentiation. Conclusions : MUC5AC, MUC2, mAb 91.9H, and HID may be useful in differentiating cholangiocarcinomas from colorectal adenocarcinomas.

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