Journal of Pathology and Translational Medicine

Review Article

Ganglioglioma and gangliocytoma: a review for pathologists: Gianfranco E. Umeres-Francia, Melissa Mejia-Bautista, Pouya Jamshidi, Jared T. Ahrendsen; J Pathol Transl Med. 2026;60(4):379-387. Published online July 15, 2026; DOI: https://doi.org/10.4132/jptm.2026.06.06

Abstract PDF: Ganglioglioma and gangliocytoma are rare, predominantly low-grade neuroepithelial tumors that commonly present with epilepsy in children and young adults. Advances in molecular profiling have improved understanding of their pathogenesis, highlighting key roles for the mitogen-activated protein kinase/ERK signaling pathway. Diagnosis relies on a combination of clinical, radiologic, and histopathologic features, with complete surgical resection offering the best clinical outcomes. This review summarizes current knowledge on their epidemiology, etiology, clinical presentation, imaging characteristics, pathology, treatment strategies, and prognosis.

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