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Review Article
- Solitary fibrous tumor: an updated review
- Joon Hyuk Choi
- J Pathol Transl Med. 2026;60(1):20-46. Published online December 29, 2025
- DOI: https://doi.org/10.4132/jptm.2025.10.08
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- 5 Web of Science
- 7 Crossref
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Abstract
PDF - Solitary fibrous tumor (SFT) is a fibroblastic neoplasm characterized by a branching, thin-walled dilated staghorn-shaped (hemangiopericytoma-like) vasculature and a NAB2::STAT6 gene fusion. SFTs can occur in almost any anatomical location, including superficial and deep soft tissues, visceral organs, and bone. They most commonly occur in extrapleural locations, equally affect both sexes, and are typically present in adults. Although metastasis is rare, SFTs frequently show local recurrence. The diagnosis of SFTs is difficult because of their broad histological and morphological overlap with other neoplasms. An accurate diagnosis is important for guiding disease management and prognosis. Despite advances in molecular diagnostics and therapeutic strategies, the biological complexity and unpredictable clinical behavior of SFTs present significant challenges. This review provides an updated overview of SFT, with a focus on its molecular genetics, histopathological features, and diagnostic considerations.
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Citations
Citations to this article as recorded by
- Clinicopathological characteristics and prognosis of central nervous system solitary fibrous tumor: An analysis of 271 cases
Wanwan Gao, Ming Li, Xiaojia Liu, Lingyang Hua, Hong Chen, Haixia Cheng
Pathology - Research and Practice.2026; 284: 156520. CrossRef - Pelvic solitary fibrous tumor, historically classified as hemangiopericytoma, presenting with venous compression and pelvic congestion: A case report
Dejan Svilar, Jovana Đošić, Anđela Đurić, Bojan Stojanović
Halo 194.2026; 32(1): 31. CrossRef - Robot-assisted laparoscopic resection of giant pelvic solitary fibrous tumor: a case report with literature review
Binbin Wang, Gengchen Huang, Wei Wei, Tie Mao, Zihan Gao, Yutao Ma, Yiming Gu
Frontiers in Oncology.2026;[Epub] CrossRef - Laparoscopic Resection of a Mesorectal Solitary Fibrous Tumor: A Case Report and Review of the Literature
Atsushi Sugimoto, Hiroshi Tsuchihashi, Hiroyuki Fujimoto, Masayasu Kawasaki
Cureus.2026;[Epub] CrossRef - Construction and Characterization of Paired Patient-Derived Cell Models for Solitary Fibrous Tumors (SFTs)
Farhan Vahdat Azad, Paulina I. Trevino, Aishwarya Kappagantu, Maliha Mehjabin, Eleni Balla, Clark A. Meyer, Leonidas Bleris, Yi Li
Cancers.2026; 18(15): 2385. CrossRef - Case report: Reactive nodular fibrous pseudotumor: report of 4 new cases including a rare pulmonary presentation and a literature review covering 40 cases
Xinyao Liu, Chenghui Wang, Weiran Kong, Bangdong Liu, Tianlun Li, Susu Shi, Linlin Zhang, Shuai Chen
Frontiers in Medicine.2026;[Epub] CrossRef - Clinical and hematological indices as prognosticators in localized solitary fibrous tumors: A retrospective study
Ariel Yoong Yi KOH, Ryan Mao Heng LIM, Jason Yongsheng CHAN
Therapeutic Advances in Medical Oncology.2026;[Epub] CrossRef
- Clinicopathological characteristics and prognosis of central nervous system solitary fibrous tumor: An analysis of 271 cases
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