Journal of Pathology and Translational Medicine

Original Article

Accuracy of Core Needle Biopsy Versus Fine Needle Aspiration Cytology for Diagnosing Salivary Gland Tumors: In Hye Song, Joon Seon Song, Chang Ohk Sung, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim, Jeong Hyun Lee, Jung Hwan Baek, Kyung-Ja Cho; J Pathol Transl Med. 2015;49(2):136-143. Published online March 12, 2015; DOI: https://doi.org/10.4132/jptm.2015.01.03

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Background
Core needle biopsy is a relatively new technique used to diagnose salivary gland lesions, and its role in comparison with fine needle aspiration cytology needs to be refined. Methods: We compared the results of 228 ultrasound-guided core needle biopsy and 371 fine needle aspiration procedures performed on major salivary gland tumors with their postoperative histological diagnoses. Results: Core needle biopsy resulted in significantly higher sensitivity and more accurate tumor subtyping, especially for malignant tumors, than fine needle aspiration. No patient developed major complications after core needle biopsy. Conclusions: We recommend ultrasoundguided core needle biopsy as the primary diagnostic tool for the preoperative evaluation of patients with salivary gland lesions, especially when malignancy is suspected.

Citations

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Giant Pleomorphic Adenoma of Submandibular Gland
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Indications for Submandibulectomy Within a 20-Year Period
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Evaluation of the anterior processes of the parotid gland: an ultrasonographic study
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Soudamini Mahapatra, Chinmaya Sundar Ray, Aparajita Mishra, Dileswari Pradhan
Cureus.2024;[Epub] CrossRef
Preoperative cytopathological investigatory aids in the diagnosis of salivary gland lesions
S Vidyalakshmi, K Shanmugasamy
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Machine Learning on Ultrasound Texture Analysis Data for Characterizing of Salivary Glandular Tumors: A Feasibility Study
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Association of Membranous Basal Cell Adenoma and Basal Cell Adenocarcinoma With Brooke-Spiegler Syndrome
Lexi Goehring, Debby Rampisela, Jordan L Pleitz
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The Usefulness of Ultrasound-Guided Core Needle Biopsy Compared to Fine Needle Aspiration in Pre-Operative Diagnosis of Cystic-Predominant Parotid Tumors
Youn Jin Cho, Young Rok Jo, Hyun Jun Hong, Hye Ran Lee
Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2023; 66(8): 532. CrossRef
The Value of Ultrasound-guided Core Needle Biopsy in Differentiating Benign from Malignant Salivary Gland Lesions
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Indian Journal of Otolaryngology and Head & Neck Surgery.2023; 75(2): 266. CrossRef
Schnellschnittdiagnostik bei Tumoren des Trigonum submandibulare
S. Riemann, A. Knopf
HNO.2023; 71(3): 164. CrossRef
Myoepithelial Carcinoma Ex Pleomorphic Adenoma of the Submandibular Gland: A Case Report
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Intraductal Carcinoma: The Carcinoma In Situ of the Salivary Gland
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Life.2022; 12(11): 1897. CrossRef
Utility of the Milan System for Reporting Salivary Gland Cytology, with focus on the incidence and histologic correlates of atypia of undetermined significance (AUS) and salivary gland neoplasm of uncertain malignant potential (SUMP): A 3‐year institution
Christopher M. Cormier, Shweta Agarwal
Cancer Cytopathology.2022; 130(4): 303. CrossRef
Percutaneous CT-Guided Core Needle Biopsies of Head and Neck Masses: Review of 184 Cases at a Single Academic Institution, Common and Special Techniques, Diagnostic Yield, and Safety
R.W. Jordan, D.P. Shlapak, J.C. Benson, F.E. Diehn, D.K. Kim, V.T. Lehman, G.B. Liebo, A.A. Madhavan, J.M. Morris, P.P. Morris, J.T. Verdoorn, C.M. Carr
American Journal of Neuroradiology.2022; 43(1): 117. CrossRef
Nodular fasciitis of the submandibular gland
Ting Suen Wong, Richard Wei Chern Gan, Laszlo Karsai, Bun Yin Winson Wong
BMJ Case Reports.2022; 15(4): e245584. CrossRef
Validation of the Milan system for reporting salivary gland cytopathology: a single institution’s 10-year experience
Christopher Felicelli, Joseph Reznicek, Yevgen Chornenkyy, Lucy Jager, Daniel Johnson
Journal of the American Society of Cytopathology.2022; 11(5): 264. CrossRef
Application of the Milan system for reporting salivary gland cytopathology using cell blocks
Grégoire B. Morand, Raihanah Alsayegh, Alex M. Mlynarek, Marianne Plourde, Tiffany Mach, Marco A. Mascarella, Michael P. Hier, Livia Florianova, Marc P. Pusztaszeri
Virchows Archiv.2022; 481(4): 575. CrossRef
Comparisons among the Ultrasonography Prediction Model, Real-Time and Shear Wave Elastography in the Evaluation of Major Salivary Gland Tumors
Ping-Chia Cheng, Wu-Chia Lo, Chih-Ming Chang, Ming-Hsun Wen, Po-Wen Cheng, Li-Jen Liao
Diagnostics.2022; 12(10): 2488. CrossRef
A Novel Sonographic Scoring Model in the Prediction of Major Salivary Gland Tumors
Wu‐Chia Lo, Chih‐Ming Chang, Chi‐Te Wang, Po‐Wen Cheng, Li‐Jen Liao
The Laryngoscope.2021;[Epub] CrossRef
Assessing the diagnostic accuracy for pleomorphic adenoma and Warthin tumor by employing the Milan System for Reporting Salivary Gland Cytopathology: An international, multi‐institutional study
Derek B. Allison, Alexander P. Smith, Daniel An, James Adam Miller, Khurram Shafique, Sharon Song, Kartik Viswanathan, Elizabeth Eykman, Rema A. Rao, Austin Wiles, Güliz A. Barkan, Ritu Nayar, Guido Fadda, Celeste N. Powers, Esther Diana Rossi, Momin T. S
Cancer Cytopathology.2021; 129(1): 43. CrossRef
Magnetic resonance imaging of salivary gland tumours: Key findings for imaging characterisation
Davide Maraghelli, Michele Pietragalla, Cesare Cordopatri, Cosimo Nardi, Anna Julie Peired, Giandomenico Maggiore, Stefano Colagrande
European Journal of Radiology.2021; 139: 109716. CrossRef
The Milan System, from Its Introduction to Its Current Adoption in the Diagnosis of Salivary Gland Cytology
Esther Diana Rossi
Journal of Molecular Pathology.2021; 2(2): 114. CrossRef
Utility of the Milan system for reporting salivary gland cytopathology during rapid on‐site evaluation (ROSE) of salivary gland aspirates
Aanchal Kakkar, Mukin Kumar, Priyadarsani Subramanian, Arshad Zubair, Rajeev Kumar, Alok Thakar, Deepali Jain, Sandeep R. Mathur, Venkateswaran K. Iyer
Cytopathology.2021; 32(6): 779. CrossRef
Contribution of small tissue biopsy and flow cytometry to preoperative cytological categorization of salivary gland fine needle aspirates according to the Milan System: Single center experience on 287 cases
Tolga Bağlan, Serpil Dizbay Sak, Cevriye Cansız Ersöz, Koray Ceyhan
Diagnostic Cytopathology.2021; 49(4): 509. CrossRef
Is Milan for kids?: The Milan System for Reporting Salivary Gland Cytology in pediatric patients at an academic children's hospital with cytologic‐histologic correlation
Swati P. Satturwar, Maren Y. Fuller, Sara E. Monaco
Cancer Cytopathology.2021; 129(11): 884. CrossRef
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Katherine France, Anwar A.A.Y. AlMuzaini, Mel Mupparapu
Dental Clinics of North America.2021; 65(3): 509. CrossRef
Carcinoma ex pleomorphic adenoma of major salivary glands: CT and MR imaging findings
Can Wang, Qiang Yu, Siyi Li, Jingjing Sun, Ling Zhu, Pingzhong Wang
Dentomaxillofacial Radiology.2021; 50(7): 20200485. CrossRef
Salivary gland carcinoma in children and adolescents: The EXPeRT/PARTNER diagnosis and treatment recommendations
Aurore Surun, Dominik T. Schneider, Andrea Ferrari, Teresa Stachowicz‐Stencel, Jelena Rascon, Anna Synakiewicz, Abbas Agaimy, Kata Martinova, Denis Kachanov, Jelena Roganovic, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Frédéric Kolb, Juliette Thariat, Anto
Pediatric Blood & Cancer.2021;[Epub] CrossRef
A Call for Universal Acceptance of the Milan System for Reporting Salivary Gland Cytopathology
Eric Barbarite, Sidharth V. Puram, Adeeb Derakhshan, Esther D. Rossi, William C. Faquin, Mark A. Varvares
The Laryngoscope.2020; 130(1): 80. CrossRef
Preoperative biopsy in parotid malignancies: Variation in use and impact on surgical margins
Liliya Benchetrit, Sina J. Torabi, Elliot Morse, Saral Mehra, Rahmatullah Rahmati, Heather A. Osborn, Benjamin L. Judson
The Laryngoscope.2020; 130(6): 1450. CrossRef
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Sireesha Manne, Naveen Kondru, Huajun Jin, Vellareddy Anantharam, Xuemei Huang, Arthi Kanthasamy, Anumantha G. Kanthasamy
Movement Disorders.2020; 35(2): 268. CrossRef
The Accessory Parotid Gland and its Clinical Significance
Mateusz A. Rosa, Dominik P. Łazarz, Jakub R. Pękala, Bendik Skinningsrud, Sigurd S. Lauritzen, Bernard Solewski, Przemysław A. Pękala, Jerzy A. Walocha, Krzysztof A. Tomaszewski
Journal of Craniofacial Surgery.2020; 31(3): 856. CrossRef
Comparison of core needle biopsy and fine‐needle aspiration in diagnosis of ma lignant salivary gland neoplasm: Systematic review and meta‐analysis
Jungheum Cho, Junghoon Kim, Ji Sung Lee, Choong Guen Chee, Youngjune Kim, Sang Il Choi
Head & Neck.2020; 42(10): 3041. CrossRef
The Milan system for reporting salivary gland cytopathology: The clinical impact so far. Considerations from theory to practice
Esther Diana Rossi, William C. Faquin
Cytopathology.2020; 31(3): 181. CrossRef
The role of core needle biopsy in parotid glands lesions with inconclusive fine needle aspiration
Farrokh Heidari, Firouzeh Heidari, Benyamin Rahmaty, Neda Jafari, Kayvan Aghazadeh, Saeed Sohrabpour, Ebrahim Karimi
American Journal of Otolaryngology.2020; 41(6): 102718. CrossRef
Role of Fine Needle Aspiration Cytology in the Diagnosis of Parotid Gland Tumors: Analysis of 193 Cases
Rahim Dhanani, Haissan Iftikhar, Muhammad Sohail Awan, Nida Zahid, Sehrish Nizar Ali Momin
International Archives of Otorhinolaryngology.2020; 24(04): e508. CrossRef
Cytohistological correlation of salivary gland tumours with emphasis on Milan system for reporting: A novel step towards internal quality assurance
Anandraj Vaithy.K, ATM Venkat Raghava, E S Keerthika Sri, K R Umadevi
IP Archives of Cytology and Histopathology Research.2020; 5(4): 283. CrossRef
Diagnosing Recently Defined and Uncommon Salivary Gland Lesions in Limited Cellularity Specimens: Cytomorphology and Ancillary Studies
Esther Diana Rossi, Zubair Baloch, William Faquin, Liron Pantanowitz
AJSP: Reviews and Reports.2020; 25(5): 210. CrossRef
Peripheral T Cell Lymphoma of Parotid Gland: A Diagnostic Challenge
J. G. Aishwarya, Satish Nair, C. N. Patil, Swarna Shivakumar, N. Shrivalli, Ashish Shah
Indian Journal of Otolaryngology and Head & Neck Surgery.2019; 71(S1): 533. CrossRef
Potential utility of core needle biopsy in the diagnosis of IgG4-related dacryoadenitis and sialadenitis
Kenichi Takano, Tsuyoshi Okuni, Keisuke Yamamoto, Ryuta Kamekura, Ryoto Yajima, Motohisa Yamamoto, Hiroki Takahashi, Tetsuo Himi
Modern Rheumatology.2019; 29(2): 393. CrossRef
Retrospective assessment of the effectiveness of the Milan system for reporting salivary gland cytology: A systematic review and meta‐analysis of published literature
Sahar J Farahani, Zubair Baloch
Diagnostic Cytopathology.2019; 47(2): 67. CrossRef
Values of fine‐needle aspiration cytology of parotid gland tumors: A review of 996 cases at a single institution
Manabu Suzuki, Ryo Kawata, Masaaki Higashino, Shuji Nishikawa, Tetsuya Terada, Shin‐Ichi Haginomori, Yoshitaka Kurisu, Yoshinobu Hirose
Head & Neck.2019; 41(2): 358. CrossRef
Positive Surgical Margins in Submandibular Malignancies: Facility and Practice Variation
Liliya Benchetrit, Elliot Morse, Benjamin L. Judson, Saral Mehra
Otolaryngology–Head and Neck Surgery.2019; 161(4): 620. CrossRef
The growth rate and the positive prediction of needle biopsy of clinically diagnosed Warthin’s tumor
Jungirl Seok, Woo-Jin Jeong, Soon-Hyun Ahn, Young Ho Jung
European Archives of Oto-Rhino-Laryngology.2019; 276(7): 2091. CrossRef
The Difference in the Clinical Features Between Carcinoma ex Pleomorphic Adenoma and Pleomorphic Adenoma
Jungirl Seok, Se Jin Hyun, Woo-Jin Jeong, Soon-Hyun Ahn, Hyojin Kim, Young Ho Jung
Ear, Nose & Throat Journal.2019; 98(8): 504. CrossRef
Fine‐needle aspiration cytology and radiological imaging in parotid gland tumours: Our experience in 103 patients
Clare Perkins, Edward Toll, Philip Reece
Clinical Otolaryngology.2019; 44(6): 1124. CrossRef
Ultrasound‐guided core needle biopsy in salivary glands: A meta‐analysis
Hee Joon Kim, Jong Seung Kim
The Laryngoscope.2018; 128(1): 118. CrossRef
Accuracy and effectiveness of ultrasound-guided core-needle biopsy in the diagnosis of focal lesions in the salivary glands
Jose Luis del Cura, Gloria Coronado, Rosa Zabala, Igone Korta, Ignacio López
European Radiology.2018; 28(7): 2934. CrossRef
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Journal of the American Society of Cytopathology.2018; 7(3): 111. CrossRef
Routine and Advanced Ultrasound of Major Salivary Glands
Kunwar Suryaveer Singh Bhatia, Yuk-Ling Dai
Neuroimaging Clinics of North America.2018; 28(2): 273. CrossRef
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Esther Diana Rossi, Zubair W. Baloch, Marc Pusztaszeri, William C. Faquin
Acta Cytologica.2018; 62(3): 157. CrossRef
Evaluation and diagnosis of salivary gland neoplasms
Erica Jackson Mayland, Anna M. Pou
Operative Techniques in Otolaryngology-Head and Neck Surgery.2018; 29(3): 129. CrossRef
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Lana M. Chahine, Thomas G. Beach, Nicholas Seedorff, Chelsea Caspell-Garcia, Christopher S. Coffey, Michael Brumm, Charles H. Adler, Geidy E. Serrano, Carly Linder, Sherri Mosovsky, Tatiana Foroud, Holly Riss, Dixie Ecklund, John Seibyl, Danna Jennings, V
Journal of Parkinson's Disease.2018; 8(4): 517. CrossRef
Preoperative diagnostic of parotid gland neoplasms: fine-needle aspiration cytology or core needle biopsy?
Peter Zbären, Asterios Triantafyllou, Kenneth O. Devaney, Vincent Vander Poorten, Henrik Hellquist, Alessandra Rinaldo, Alfio Ferlito
European Archives of Oto-Rhino-Laryngology.2018; 275(11): 2609. CrossRef
A comparison study of the reporting systems for salivary gland fine needle aspirations: Are they really different?
Diana Montezuma, Sule Canberk, Ozlem Aydın, Mehmet Polat Dermirhas, André F. Vieira, Süha Goksel, Ümit İnce, Fernando Schmitt
Diagnostic Cytopathology.2018; 46(10): 859. CrossRef
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Céleste Rebours, Vincent Couloigner, Louise Galmiche, Odile Casiraghi, Cécile Badoual, Sabah Boudjemaa, Anthony Chauvin, Monique Elmaleh, Brice Fresneau, Sylvie Fasola, Erea‐Noël Garabédian, Thierry Van Den Abeele, Daniel Orbach
The Laryngoscope.2017; 127(1): 140. CrossRef
Agreement between rapid on‐site evaluation and the final cytological diagnosis of salivary gland specimens
S. Wangsiricharoen, S. Lekawanvijit, S. Rangdaeng
Cytopathology.2017; 28(4): 321. CrossRef
Mesenchymal neoplasms of the head and neck: a cytopathologic analysis on fine needle aspiration
James Lee, Samia Kazmi, Christopher J. VandenBussche, Syed Z. Ali
Journal of the American Society of Cytopathology.2017; 6(3): 105. CrossRef
Clinical Results of Surgical Treatment in Parotid Tumors
Ahmet Kara
Journal of Otolaryngology-ENT Research.2017;[Epub] CrossRef
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Achim M. Franzen, Thomas Günzel, Anja Lieder
Auris Nasus Larynx.2016; 43(2): 187. CrossRef
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Staging and follow-up of high-grade malignant salivary gland tumours: The role of traditional versus functional imaging approaches – A review
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Oral Oncology.2016; 60: 157. CrossRef
Biopsy of parotid masses: Review of current techniques
Sananda Haldar, Joseph D Sinnott, Kemal M Tekeli, Samuel S Turner, David C Howlett
World Journal of Radiology.2016; 8(5): 501. CrossRef
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Şehrazat Evirgen
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Seokhwi Kim, Jinah Chu, Hojoong Kim, Joungho Han
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Case Studies

Oncocytic Lipoadenoma: A Rare Case of Parotid Gland Tumor and Review of the Literature: Chen-lin Chi, Tseng-tong Kuo, Li-yu Lee; J Pathol Transl Med. 2015;49(2):144-147. Published online March 12, 2015; DOI: https://doi.org/10.4132/jptm.2014.02.10

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Abstract PDF

Oncocytic lipoadenoma is a rare tumor, with only 18 cases having been reported since the first in 1998. We encountered a case of oncocytic lipoadenoma presenting as a slowly growing parotid mass in a 71-year-old man. This tumor is characteristically comprised of a mixture of oncocytes and adipocytes. The present case is one of five reported cases of oncocytic lipoadenoma showing sebaceous differentiation. The results of immunohistochemical study with DOG1 antibody supported the origination of this tumor in the striated duct.

Citations

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Diffuse Large B-Cell Lymphoma Arising in Warthin's Tumor: Case Study and Review of the Literature: Güliz Özkök, Funda Taşlı, Nazan Özsan, Rafet Öztürk, Hakan Postacı; Korean J Pathol. 2013;47(6):579-582. Published online December 24, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.6.579

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Abstract PDF

Warthin's tumor is the second most common type of salivary gland tumor. Microscopically, Warthin's tumor displays a proliferative epithelial component and lymphoid stroma. Carcinomas arising from the epithelial component are well known, but malignant transformations of the lymphoid stroma are rare. When they do occur, they are most commonly B-cell type non-Hodgkin lymphomas. A 60-year-old male patient underwent surgical resection of a parotid mass. After superficial parotidectomy, microscopic examination indicated that the tumor was of epithelial components with basaloid and oncocytic columns of cells neighboring lymphoid components. In addition to the lymphoid follicles with distinct germinal centers, there were large, bizarre and extremely atypical neoplastic cells seen in the lymphoid component. Large neoplastic cells were diffusely CD20 and CD30 positive. The patient was diagnosed with "Warthin's tumor and diffuse large B-cell lymphoma with expression of CD30." The histopathologic and clinical features are discussed along with a review of the literature.

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Diagnostic Pathology.2024;[Epub] CrossRef
Warthin’s Tumor of the Parotid Gland With Degeneration to Diffuse Large B-cell Lymphoma: A Case Report and Review of Literature
Mauricio Gutierrez-Alvarez, Cynthia Martinez, Ana Priscila Campollo Lopez, Kevin Fuentes, Jorge Alberto Robles Aviña
Cureus.2023;[Epub] CrossRef
Pathogenesis Analysis of Salivary Gland Tumors Through the Expression of Programmed Death-Ligand 1 (PD-L1)
Aisyah Izzatul Muna, Maria Evata Krismawati Surya, Meiske Margaretha, Jane Kosasih, Mei Syafriadi
Indian Journal of Otolaryngology and Head & Neck Surgery.2023; 75(4): 3098. CrossRef
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Dental Journal (Majalah Kedokteran Gigi).2022; 55(4): 194. CrossRef
Lymphoepithelial Carcinoma of Salivary Glands
Lester D.R. Thompson, Rumeal D. Whaley
Surgical Pathology Clinics.2021; 14(1): 75. CrossRef
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Fnu Alnoor, Jatin S. Gandhi, Matthew K. Stein, Joel F. Gradowski
Head and Neck Pathology.2020; 14(2): 386. CrossRef
Prevalence of Lymphoid Neoplasia in a Retrospective Analysis of Warthin Tumor: A Single Institution Experience
F. N. U. Alnoor, Jatin S. Gandhi, Matthew K. Stein, Jorge Solares, Joel F. Gradowski
Head and Neck Pathology.2020; 14(4): 944. CrossRef
A Case of Diffuse Large B Cell Lymphoma in Submandibular Gland
Sang Hoo Park, Min Gyoung Pak, Dong Kun Lee
Journal of Clinical Otolaryngology Head and Neck Surgery.2020; 31(1): 111. CrossRef
Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours
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Advances in Therapy.2019; 36(8): 1950. CrossRef
Diffuse large B-cell lymphoma arising from follicular lymphoma with warthin’s tumor of the parotid gland - immunophenotypic and genetic features: A case report
Chang-Song Wang, Xia Chu, Di Yang, Lei Ren, Nian-Long Meng, Xue-Xia Lv, Tian Yun, Yan-Sha Cao
World Journal of Clinical Cases.2019; 7(22): 3895. CrossRef
Presentation of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma in a Warthin Tumor: Case Report and Literature Review
Hadeel Jawad, Peter McCarthy, Gerard O’Leary, Cynthia C. Heffron
International Journal of Surgical Pathology.2018; 26(3): 256. CrossRef
Bilateral Warthin tumor in psoriatic patients in therapy with multiple immunosuppressive therapy
M Burlando, E Cozzani, C Chinazzo, M larosa, M Boggio, A Parodi
International Journal of Immunopathology and Pharmacology.2015; 28(1): 138. CrossRef
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International Journal of Surgical Pathology.2015; 23(5): 419. CrossRef

Case Reports

Osteoclast-like Giant Cell Tumor of the Parotid Gland Accompanied with Carcinoma ex Pleomorphic Adenoma.: Mi Jung Kwon, Eun Sook Nam, Seong Jin Cho, Hyung Sik Shin, Ji Hyun Kwon, Young Soo Rho; Korean J Pathol. 2011;45:S84-S88.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.S1.S84

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Abstract PDF

The origin of osteoclast-like giant cell tumor (OGCT) of the salivary gland has been debated because the prototypic cells of osteoclast-like cells and mononuclear stromal cells are largely unexplained in this gland. Bone marrow-derived CD14+ and CD45+ monocyte-derived multipotential cells (CD14+/CD45+ MOMC) may be one of the possible origins of OGCTs of salivary glands, which have never been explored in salivary OGCTs. We present a case of OGCT accompanied with carcinoma ex pleomorphic adenoma in the parotid gland of a 67-year-old Korean female. The tumor presented as a rapidly growing cervical mass comprising a central area of carcinoma ex pleomorphic adenoma and a peripheral circumferential area of OGCT. The immunohistochemical staining pattern was phenotypically consistent with bone marrow-derived CD14+/CD45+ MOMC. This case is the first report of a salivary OGCT in Korea.

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Tumeur à cellules géantes de type ostéoclastique de la parotide
S. Rammeh, I. Hergli, M.K. M’farrej, N. Znaidi, S. Nechi, R. Zermani
Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale.2014; 115(3): 185. CrossRef

Sclerosing Polycystic Adenosis of the Parotid Gland: A Case Report.: Byung Joo Jeong, Mi Ran Kim, Zhe Long Liang, Bon Seok Koo, Jin Man Kim; Korean J Pathol. 2011;45:S79-S83.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.S1.S79

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Sclerosing polycystic adenosis (SPA) of the salivary glands is a rare entity analogous to fibrocystic disease of the breast. Less than 50 cases of SPA have been published in the literature. We report the first Korean case of SPA of the right parotid gland. A 34-year-old man presented with a slowly growing right parotid mass. Computed tomography showed a relatively well-demarcated, heterogeneously enhancing mass with multiple small calcifications. Fine needle aspiration showed cohesive sheets of epithelial cells with granular oncocytic cytoplasm and scattered lymphocytes. The parotidectomy specimen showed a 3 cm-sized solid nodular lesion with small cysts. Microscopically, the lesion was an unencapsulated mass of sclerotic fibrous tissue with cystic ducts, multiple calcifications, and lymphoplasma cell infiltration. Sclerosing adenosis and cystic ducts with frequent apocrine-like cells were noted. Familiarity with the cytologic and histological features of SPA is very important making the correct diagnosis.

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Clinicopathological profile of sclerosing polycystic adenoma/adenosis: A systematic review
Talita de Carvalho Kimura, Reydson Alcides de Lima‐Souza, João Figueira Scarini, Luccas Lavareze, Erika Said Abu Egal, Albina Altemani, Fernanda Viviane Mariano
Head & Neck.2023; 45(9): 2449. CrossRef
Juvenile sclerosing polycystic adenosis cytologically mimicking Warthin tumor
Masataka Kawai, Tomohiro Inoue, Takaaki Yonaga, Kunio Mochizuki, Tadao Nakazawa, Keisuke Masuyama, Tetsuo Kondo
Diagnostic Cytopathology.2019; 47(11): 1208. CrossRef
A Case of Sclerosing Polycystic Adenosis of Parotid Gland
Young-Jun Kim, Jang-Won Choi, Young-Joong Kim, Soo-Kweon Koo
Korean Journal of Otorhinolaryngology-Head and Neck Surgery.2014; 57(8): 559. CrossRef

Parotid Gland Carcinosarcoma with Osteosarcoma as a Sarcomatous Component: A Case Report with Fine Needle Aspiration Cytologic Findings.: Se Min Jang, Young Jin Jun, Hulin Han, Ki Seok Jang, Seung Sam Paik; Korean J Pathol. 2011;45(4):412-416.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.4.412

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Carcinosarcoma of the salivary glands is a rare malignant tumor showing both malignant epithelial and mesenchymal components. Herein, we present a carcinosarcoma of the parotid gland in a 67-year-old man consisting of osteosarcoma and adenocarcinoma components with fine needle aspiration cytological findings. The tumor was composed predominantly of osteosarcoma and small areas of adenocarcinomatous components and a hyalinized nodule reminiscent of pleomorphic adenoma. The tumor showed infiltrative growth features with perineural, lymphatic, and vascular invasion. Despite postoperative adjuvant radiation therapy, multiple metastatic lesions occurred in the both lungs 5 months after surgery. As salivary gland carcinosarcoma has been known to demonstrate highly aggressive behavior, an accurate pathological diagnosis is prerequisite for appropriate treatment.

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Clinical and Morphological Aspects of Aggressive Salivary Gland Mixed Tumors: A Narrative Review
Alexandra Corina Faur, Alina Maria Șișu, Laura Andreea Ghenciu, Roxana Iacob, Emil Robert Stoicescu, Ovidiu Alin Hațegan, Mărioara Cornianu
Diagnostics.2024; 14(17): 1942. CrossRef
Carcinosarcoma of the parotid gland with abdominal metastasis: a case report and review of literature
Chang Gok Woo, Seung-Myoung Son
World Journal of Surgical Oncology.2018;[Epub] CrossRef

Benign Lymphoepithelial Cyst: A case report.: Jin Haeng Chung, Gyeong Hoon Kang, Je G Chi; Korean J Pathol. 1996;30(6):551-553.

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Abstract PDF: An intraparotid benign lymphoepithelial cyst is a rare disease characterized by unilateral painless swelling of parotid region. The histogenesis is controversial. Surgical excision is recommended for diagnosis and curative treatment. We present a case of benign lymphoepithelial cyst arising in a patient with neurofibromatosis. A 46-year-old woman presented with a slowly growing multilocular cystic mass in the left cheek. The cystic mass measured 4 cm in maximal outer diameter and the cystic wall was thick and yellowish pale to gray, soft with well circumscribed margin. Microscopically, the multilocular cyst was lined by stratified squamous epithelium for the most part and underlying lymphoid tissue aggregates with follicles and sharply demarcated from adjacent salivary parenchyma which is of normal appearance and without lymphoid aggregates. Since this lesion is absolutely benign, it is important to separate this benign cyst from cystic salivary gland tumors.

Congenital Sialoblastoma: A case report and review.: Jong In Yook, Hee Jeong Ahn, Jin Kim; Korean J Pathol. 1997;31(11):1227-1232.

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Abstract: A congenital salivary gland tumor, sialoblastoma, is extremely rare. A sialoblastoma of the parotid gland, occurring in a 28-week old fetus, is described. The histologic, immunohistochemical, and ultrastructural features of this tumor were studied. The tumor was characterized by solid nests or sheets of tumor cells intermingled with ductal structures lined by a columnar cells. Some of the tumor cells showed squamous differentiation. Immunohistochemically, these epidermoid cells reacted positively with anti-cytokeratin. But anti-S-100, anti- vimentin, anti-smooth muscle actin, anti-GFAP positive cells were not found. The ultrastructure was characterized by primitive epithelial cells. Although various names have been proposed, we favored the term "sialoblastoma". The histogenesis of this tumor is also discussed.

Malignant Myoepithelioma Arising in a Recurrent Pleomorphic Adenoma: A case report.: Jeong Yu Kyung, Yeon Lim Suh; Korean J Pathol. 1999;33(7):517-520.

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Abstract PDF: Malignant myoepithelioma is a rare neoplasm of salivary gland which may either arise de novo or develop in a pre-existing pleomorphic adenoma. The malignant myoepithelioma occurs in 0.45% of major salivary gland tumors. Malignant myoepitheliomas arising in the pleomorphic adenoma number less than 20 in English literature and 1 in Korea. We describe a case of malignant myoepithelioma arising in a recurrent pleomorphic adenoma of the left parotid gland of a 61-year-old man. The tumor was ill-defined and composed of polygonal or plasmacytoid myoepithelial cells. Infiltration to surrounding tissue, hemorrhage, necrosis, increased mitotic activity and vascular tumor emboli indicated its malignant nature. There were several satellite nodules with histologic features of typical pleomorphic adenoma. Immunohistochemically, tumor cells were reactive for S-100 protein, AE1/AE3, vimentin, smooth muscle actin and glial fibrillary acid protein.

Fibromatosis of the Parotid Gland: A Case Report.: Dae Su Kim, Chulhwan Kim, Insun Kim; Korean J Pathol. 2002;36(2):112-114.

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Abstract PDF: A 51-year-old woman was presented with a palpable mass in the infraauricular area that had existed for 4-months. The mass from the superficial lobe of the parotid gland was 2.7 cm in the greatest dimension and was ill-defined with rubbery, homogeneous, and fibrotic appearance. Histologically, the lesion was infiltrative into the lobules of the paratid gland, and was composed of a proliferation of spindle or stellate cells with cellular and sclerotic areas. On immunohistochemistry, the cells were only positive for vimentin and focally for smooth muscle actin. Differential diagnosis from nerve sheath tumors and solitary fibrous tumors involving the parotid gland was emphasized.

Fine Needle Aspiration Cytology of Small Cell Carcinoma of the Parotid Gland: A Case Report .: Chan Kwon Jung, Eun Sun Jung, Youn Soo Lee, Sun Moo Kim, Byung Kee Kim; Korean J Cytopathol. 1999;10(2):163-167.

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Abstract PDF: Primary small cell carcinoma of the salivary gland is a rare neoplasm that accounts for approximately 1.8% of all primary major salivary gland malignancies. Because of its rarity, it is difficult to diagnose small cell carcinoma of the parotid gland by fine needle aspiration cytology(FNAC). We experienced a case of primary small cell carcinoma of the parotid gland in a 72-year-old woman who presented with two palpable masses of the left infraauricular and ocular regions of two to three month's duration, respectively. Aspirate smears from the left infraauricular area were highly cellular on necrotic and lymphocytic background and showed individually dispersed cells or three-dimensional clusters of small cells. The tumor cells were round to oval with a very high nucleocytoplasmic ratio. Nuclei were about two times the size of lymphocytes and had uniformly dispersed but hyperchromatic to pyknotic chromatin. Nucleoli were occasionally visible but were generally inconspicuous. Numerous mitotic figures were detected. The clusters of these small tumor cells exhibited angular nuclear molding, irregular nuclear outlines, and occasionally rosette like arrangement. The tumor was confirmed by histology and immunohistochemistry.

Fine Needle Aspiration Cytology of Malignant Myoepithelioma of the Salivary Gland: A Case Report.: Jae Hwa Lee, Jean Kyung Park, Bang Hur; Korean J Cytopathol. 2002;13(1):28-32.

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Abstract PDF: Malignant myoepithelioma (myoepithelial carcinoma), is a very rare malignant epithelial neoplasm accounting for less than 1% of all salivary gland tumors and has an intermediate malignant potential. We report a case of malignant myoepithelioma arising in the left parotid gland in a 54-year-old man, which was difficult to differentiate from pleomorphic adenoma and other malignant salivary gland neoplasms. Fine needle aspiration cytology of the parotid gland showed cellular smear, composed of overlapped sheets and clusters or individually scattered tumor cells without any acinic or ductal structures. The tumor cells were rather uniform, with distinct cell borders and moderate amount of cytoplasm. The eccentrically located nuclei were oval to round and pleomorphic and showed prominent nucleoli. A few clear cells were noted in the cellular aggregates. Metachromatic matrix was seen between individual tumor cells in a lacelike fashion, resembling pleomorphic adenoma. According to the immunohistochemical staining, we recognized that the component cells are myoepithelial in nature, showing reactivity for the S-100 protein, vimentin, and actin.

Epithelial-Myoepithelial Carcinoma of the Parotid Gland: Report of a Case Misinterpreted as Pleomorphic denoma on Fine Needle Aspiration Cytology.: Dong Chul Kim, Ahwon Lee, Kyo Young Lee, Cang Suk Kang, Sang In Shim; Korean J Cytopathol. 2002;13(1):42-46.

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Abstract PDF: Epithelial-myoepithelial carcinoma(EMC) is a rare, low grade malignant tumor of the salivary glands. The EMC has a distinctive histological appearance comprising ductal structures with an inner epithelial cell component and an outer layer of myoepithelial cells which show plump clear cytoplasm. The cytologic features of the EMC have been rarely described. A correct cytological diagnosis to this rare tumor is difficult with high false negative rate. We report a case of EMC in which fine needle aspiration cytologic findings were misinterpreted as a pleomorphic adenoma.

Fine Needle Aspiration Cytology of Lymphoepithelial Carcinoma of Parotid Gland: A Case Report.: Sung Jig Lim, Jung Yeon Kim, Kyeong Mee Park; Korean J Cytopathol. 2002;13(2):74-77.

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Abstract PDF: Lymphoepithelial carcinoma, also known as malignant lymphoepithelial lesion or lymphoepithelioma, is a rare tumor in salivary glands. Lymphoepithelial carcinoma has a characteristic histological findings comprising irregularly-shaped nests of malignant epithelial cells within a lymphocyte-rich stroma, occasionally forming lymphoid follicles. We recently experienced a case of fine needle aspiration cytology(FNAC) of lymphoepithelial carcinoma of parotid gland in a 61-year-old male. The FNAC yielded a hypercellular smear of many irregular clusters of malignant epithelial cells in the background of lymphoid stroma.

Fine Needle Aspiration Cytology of Kimura's Disease of Parotid Gland: Report of A Case Cytologically Failed to Diagnose as Kimura's Disease.: Se Hoon Kim, Haeryoung Kim, Sung Eun Kim, Woo Ick Yang, Soon Won Hong, Kwang Gil Lee; Korean J Cytopathol. 2003;14(2):86-90.

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Abstract PDF: Kimura's disease is a chronic inflammatory disorder of unknown cause and is most prevalent among Asians. The cytologic findings of Kimura's disease are significant numbers of eosinophils in a background of lymphoid cells, occasional fragments of collagenous tissue, proliferation of vessels, and Warthin-Finkeldey polykaryocytes. Among these features, the most important cytologic feature of Kimura's disease is a significant numbers of eosinophils. We experienced a case of Kimura's disease in the parotid gland which we failed to recognize on cytology due to the apparent paucity of eosinophils. On careful retrograde reviewing of the cytologic findings, a few scattered leukocytes, previously interpreted as polymorphous leukocytes, had bilobed nuclei and coarse green but granular cytoplasm on Papanicolaou preparation. These leukocytes showed obvious orange-red intracytoplasmic granules as in eosionophils on Giemsa stain. The paucity of eosinophils may be due to the thick fibrosis around lymphoid follicles or any technical error during aspiration. Whereas the Warthin-Finkeldey type giant cell is not a sensitive cytologic marker of Kimura's disease, it may be a helpful cytologic feature. To reach a correct cytologic diagnosis of Kimura's disease, it is important to keep in mind that searching for Warthin-Finkeldey type giant cells and evaluation of Giemsa stain for detection of eosinophils would be helpful.

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