Childhood asymmetry labium majus enlargement (CALME) is a disctinctive clinicopathologic entity of pre- and early puberty first described in 2005. It is defined as an expansion of normal soft tissues of the vulva. Although CALME is not a rare lesion, it has been called lipoma, fibroma, hamartoma, and fibrous hyperplasia. CALME is not a true neoplasm and is a physiologic growth in response to hormone. It may tend to resolve spontaneously and recur after surgical resection. We report four cases of CALME with a review of the literature. To the best of the knowledge, this is the first Korean report.
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Keep CALME (childhood asymmetry labium majus enlargement) and follow up Andrea Sechi, Annalisa Patrizi, Giulio Vara, Rita Golfieri, Iria Neri JDDG: Journal der Deutschen Dermatologischen Gesellschaft.2021; 19(9): 1276. CrossRef
Bei CALME (childhood asymmetry labium majus enlargement): die Ruhe bewahren und nachverfolgen Andrea Sechi, Annalisa Patrizi, Giulio Vara, Rita Golfieri, Iria Neri JDDG: Journal der Deutschen Dermatologischen Gesellschaft.2021; 19(9): 1276. CrossRef
Childhood Asymmetry Labium Majus Enlargement (CALME): Description of Two Cases Cristina Salvatori, Ilaria Testa, Marco Prestipino, Maria Elena Laurenti, Sara Riccioni, Giuseppe Di Cara, Nicola Principi, Susanna Esposito, Mirko Bertozzi International Journal of Environmental Research and Public Health.2018; 15(7): 1525. CrossRef
Childhood asymmetrical labium majus enlargement sonographic and MR imaging appearances Ami Gokli, Jeremy Neuman, Ruby Lukse, June Koshy, Fanyi Kong, Tal Laor Pediatric Radiology.2016; 46(5): 674. CrossRef