Follicular dendritic cell (FDC) sarcoma is rare and is classified either as conventional type or inflammatory pseudotumor (IPT)-like variant. Extranodal presentation is uncommon and nearly all gastrointestinal FDC tumors are of the conventional type. IPT-like variant tumors occur almost exclusively in the liver and spleen and are consistently associated with Epstein-Barr virus (EBV). Here we report the case of a 78-year-old woman with an IPT-like FDC sarcoma presenting as a pedunculated colonic polyp. Histologically, scanty atypical ovoid to spindle cells were mixed with a background of florid lymphoplasmacytic infiltrate, which led to an initial misdiagnosis of pseudolymphoma. These atypical cells expressed CD21, CD23, CD35, and D2-40, and were positive for EBV by in situ hybridization, confirming the diagnosis. The patient was free of disease five months after polypectomy without adjuvant therapy. Although extremely rare, the differential diagnosis for colonic polyp should include FDC sarcoma to avoid an erroneous diagnosis. A review of the 24 cases of IPT-like FDC sarcoma reported in the literature reveal that this tumor occurs predominantly in females with a predilection for liver and spleen, and has a strong association with EBV.

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• What is new in the 5th edition of the World Health Organization classification of mature B and T/NK cell tumors and stromal neoplasms?
  Ayoma D. Attygalle, John K. C. Chan, Sarah E. Coupland, Ming-Qing Du, Judith A. Ferry, Daphne de Jong, Dita Gratzinger, Megan S. Lim, Alina Nicolae, German Ott, Andreas Rosenwald, Anna Schuh, Reiner Siebert
  Journal of Hematopathology.2024; 17(2): 71.     CrossRef
• Pathologic characteristics of histiocytic and dendritic cell neoplasms
  Sun Och Yoon
  Blood Research.2024;[Epub]     CrossRef
• Epstein-barr virus (EBV)-positive inflammatory pseudotumor-like follicular dendritic cell sarcoma (IPT-like FDCS) presenting as thrombocytopenia: A case report and literature review
  Jiawei Jin, Xiaolong Zhu, Yi Wan, Yang Shi
  Heliyon.2024; 10(12): e32997.     CrossRef
• EBV-positive inflammatory follicular dendritic cell sarcoma of the colon with clonal immunoglobulin gene rearrangement: A case report and literature review
  Xia Xu, Xiuzhen Li, Qun Deng, Kaihang Yu, Jinfan Li
  Heliyon.2024; 10(11): e31947.     CrossRef
• Challenges in the Diagnosis of Epstein-Barr Virus-positive Inflammatory Follicular Dendritic Cell Sarcoma
  Yan Li, Xia Yang, Lili Tao, Weimei Zeng, Min Zuo, Shuo Li, Liyan Wu, Yanshong Lin, Ziying Zhang, Jingping Yun, Yuhua Huang
  American Journal of Surgical Pathology.2023; 47(4): 476.     CrossRef
• Epstein-Barr Virus-Positive Inflammatory Follicular Dendritic Cell Sarcoma Presenting as a Colonic Polyp: Report of a Case with a Literature Review
  Jiahui Hu, Dongdong Huang, Chengfu Xu, Yi Chen, Han Ma, Zhe Shen
  Medicina.2023; 59(7): 1341.     CrossRef
• A Clinicopathology Review and Update of Epstein–Barr Virus-Associated Mesenchymal Tumors
  Oswald Zhao Jian Lee, Noorjehan Omar, Joshua K. Tay, Victor Kwan Min Lee
  Cancers.2023; 15(23): 5563.     CrossRef
• Granulomatous splenic mass with necrosis revealing an EBV-positive inflammatory follicular dendritic cell sarcoma
  Irena Antonia Ungureanu, Renato Micelli Lupinacci, Marie Parrens, Jean-François Emile
  Journal of Surgical Case Reports.2022;[Epub]     CrossRef
• Case report: Hepatic inflammatory pseudotumor-like follicular dendritic cell sarcoma: A rare case and minireview of the literature
  Fan Ding, Chao Wang, Chi Xu, Hui Tang
  Frontiers in Medicine.2022;[Epub]     CrossRef
• Follicular dendritic cell sarcoma of gastrointestinal tract with two emerging distinct subtypes: a case report and systemic review
  Hongxing Gui, Jigisha Chaudhari, Rifat Mannan
  Diagnostic Pathology.2022;[Epub]     CrossRef
• Surgical treatment of liver inflammatory pseudotumor-like follicular dendritic cell sarcoma: A case report
  Li-Yue Fu, Jiu-Liang Jiang, Meng Liu, Jun-Jun Li, Kai-Ping Liu, Hai-Tao Zhu
  World Journal of Gastrointestinal Oncology.2022; 14(11): 2288.     CrossRef
• Inflammatory pseudotumor-like follicular/fibroblastic dendritic cell sarcoma: focus on immunohistochemical profile and association with Epstein-Barr virus
  Francesca Pagliuca, Andrea Ronchi, Annamaria Auricchio, Eva Lieto, Renato Franco
  Infectious Agents and Cancer.2022;[Epub]     CrossRef
• Recent Advances in Digestive Tract Tumors: Updates From the 5th Edition of the World Health Organization “Blue Book”
  Raul S. Gonzalez, Anwar Raza, Robert Propst, Oyedele Adeyi, Justin Bateman, Sabrina C. Sopha, Janet Shaw, Aaron Auerbach
  Archives of Pathology & Laboratory Medicine.2021; 145(5): 607.     CrossRef
• Hepatic inflammatory pseudotumor-like follicular dendritic cell tumor: a case report
  Ana Daniela Pascariu, Andreea Ioana Neagu, Andrei Valentin Neagu, Alexandru Băjenaru, Cezar Iulian Bețianu
  Journal of Medical Case Reports.2021;[Epub]     CrossRef
• Inflammatory pseudotumor-like follicular dendritic cell sarcoma: Literature review of 67 cases
  Hao Wu, Peng Liu, Xiao-Ran Xie, Jing-Shu Chi, Huan Li, Can-Xia Xu
  World Journal of Meta-Analysis.2021; 9(1): 1.     CrossRef
• New Clinicopathologic Scenarios of EBV+ Inflammatory Follicular Dendritic Cell Sarcoma
  Xiang-Nan Jiang, Yan Zhang, Tian Xue, Jie-Yu Chen, Alex C.L. Chan, Wah Cheuk, John K.C. Chan, Xiao-Qiu Li
  American Journal of Surgical Pathology.2021; 45(6): 765.     CrossRef
• Select Epstein-Barr Virus–Associated Digestive Tract Lesions for the Practicing Pathologist
  Zainab I. Alruwaii, Elizabeth A. Montgomery
  Archives of Pathology & Laboratory Medicine.2021; 145(5): 562.     CrossRef
• Overview of Gastrointestinal Lymphoproliferative disorders✰
  Aaron Auerbach, Nadine S. Aguilera
  Seminars in Diagnostic Pathology.2021; 38(4): 1.     CrossRef
• Follicular dendritic cell sarcoma
  Fabio Facchetti, Matteo Simbeni, Luisa Lorenzi
  Pathologica.2021; 113(5): 316.     CrossRef
• Hepatic inflammatory pseudotumor-like follicular dendritic cell tumor with hepatic lymphoma history
  Jiang Li, Hai-su Tao, Dong Chen, Zhi-yong Huang, Er-lei Zhang
  Medicine.2021; 100(39): e27392.     CrossRef
• Clinicopathological characteristics of extranodal follicular dendritic cell sarcoma: A report of two cases
  Xing Zhao, Dayong Sun, Gang Zhang
  Oncology Letters.2021;[Epub]     CrossRef
• Inflammatory pseudotumour-like follicular dendritic cell tumour of the colon with plasmacytosis mimicking EBV-positive lymphoproliferative disorder
  Ying-Ren Chen, Chi-Lin Lee, Yen-Chien Lee, Kung-Chao Chang
  Pathology.2020; 52(4): 484.     CrossRef
• Beware the inflammatory cell-rich colonic polyp: a rare case of EBV-positive inflammatory pseudotumour-like follicular dendritic cell sarcoma with increased IgG4-positive plasma cells
  Lynne Goh, Nan Zun Teo, Lai Mun Wang
  Pathology.2020; 52(6): 713.     CrossRef
• Epstein–Barr virus‐positive inflammatory follicular dendritic cell sarcoma presenting as a solitary colonic mass: two rare cases and a literature review
  Xiaokang Ke, Huihua He, Qingping Zhang, Jingping Yuan, Qilin Ao
  Histopathology.2020; 77(5): 832.     CrossRef
• Inflammatory pseudotumor-like follicular dendritic cell sarcoma: A brief report of two cases
  Bi-Xi Zhang, Zhi-Hong Chen, Yu Liu, Yuan-Jun Zeng, Yan-Chun Li
  World Journal of Gastrointestinal Oncology.2019; 11(12): 1231.     CrossRef
• Epstein-Barr virus (EBV)–associated lymphoid proliferations, a 2018 update
  Sherif A. Rezk, Xiaohui Zhao, Lawrence M. Weiss
  Human Pathology.2018; 79: 18.     CrossRef
• A Rare Case of Epstein-Barr Virus Negative Inflammatory Pseudotumor-like Follicular Dendritic Cell Sarcoma Presenting as a Solitary Colonic Mass in a 53-Year-Old Woman; Case Report and Review of Literature
  Rossana Kazemimood, Farid Saei Hamedani, Asma Sharif, Sujata Gaitonde, Elizabeth Wiley, Pier Cristoforo Giulianotti, John Vincent Groth
  Applied Immunohistochemistry & Molecular Morphology.2017; 25(5): e30.     CrossRef
• A Case of Inflammatory Pseudotumor-like Follicular Dendritic Cell Sarcoma of the Lymph Node in the Small Bowel Mesentery Accompanied by Myasthenia Gravis
  Daichi KITAGUCHI, Katsuji HISAKURA, Taiki SATO, Masanao KURATA, Tatsuya ODA, Nobuhiro OHKOHCHI
  Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association).2017; 78(3): 527.     CrossRef
• Clinicopathological features of inflammatory pseudotumour‐like follicular dendritic cell tumour of the abdomen
  Yanyang Chen, Huijuan Shi, Hui Li, Tiantian Zhen, Anjia Han
  Histopathology.2016; 68(6): 858.     CrossRef
• A Rare Case of Follicular Dendritic Cell Sarcoma with Pseudochylous Effusion and Review of Literature From India
  Kamal Kant Sahu, Gaurav Prakash, Sandeep Rao, Amanjit Bal, Pankaj Malhotra, Jasmina Ahluwalia, Rakesh K. Vashistha
  Indian Journal of Hematology and Blood Transfusion.2015; 31(2): 307.     CrossRef
• Epstein-Barr virus–associated inflammatory pseudotumor presenting as a colonic mass
  Shunyou Gong, Iwona Auer, Rajan Duggal, Stefania Pittaluga, Mark Raffeld, Elaine S. Jaffe
  Human Pathology.2015; 46(12): 1956.     CrossRef
• Response of follicular dendritic cell sarcoma to gemcitabine and docetaxel: report of two cases and literature review
  Robert M Conry
  Clinical Sarcoma Research.2014;[Epub]     CrossRef