Journal of Pathology and Translational Medicine

Original Articles

A multicenter study of interobserver variability in pathologic diagnosis of papillary breast lesions on core needle biopsy with WHO classification: Hye Ju Kang, Sun Young Kwon, Ahrong Kim, Woo Gyeong Kim, Eun Kyung Kim, Ae Ree Kim, Chungyeul Kim, Soo Kee Min, So Young Park, Sun Hee Sung, Hye Kyoung Yoon, Ahwon Lee, Ji Shin Lee, Hyang Im Lee, Ho Chang Lee, Sung Chul Lim, Sun Young Jun, Min Jung Jung, Chang Won Jung, Soo Youn Cho, Eun Yoon Cho, Hye Jeong Choi, So Yeon Park, Jee Yeon Kim, In Ae Park, Youngmee Kwon; J Pathol Transl Med. 2021;55(6):380-387. Published online October 6, 2021; DOI: https://doi.org/10.4132/jptm.2021.07.29

4,467 View
205 Download
4 Web of Science
4 Crossref

Background
Papillary breast lesions (PBLs) comprise diverse entities from benign and atypical lesions to malignant tumors. Although PBLs are characterized by a papillary growth pattern, it is challenging to achieve high diagnostic accuracy and reproducibility. Thus, we investigated the diagnostic reproducibility of PBLs in core needle biopsy (CNB) specimens with World Health Organization (WHO) classification.
Methods
Diagnostic reproducibility was assessed using interobserver variability (kappa value, κ) and agreement rate in the pathologic diagnosis of 60 PBL cases on CNB among 20 breast pathologists affiliated with 20 medical institutions in Korea. This analysis was performed using hematoxylin and eosin (H&E) staining and immunohistochemical (IHC) staining for cytokeratin 5 (CK5) and p63. The pathologic diagnosis of PBLs was based on WHO classification, which was used to establish simple classifications (4-tier, 3-tier, and 2-tier).
Results
On WHO classification, H&E staining exhibited ‘fair agreement’ (κ = 0.21) with a 47.0% agreement rate. Simple classifications presented improvement in interobserver variability and agreement rate. IHC staining increased the kappa value and agreement rate in all the classifications. Despite IHC staining, the encapsulated/solid papillary carcinoma (EPC/SPC) subgroup (κ = 0.16) exhibited lower agreement compared to the non-EPC/SPC subgroup (κ = 0.35) with WHO classification, which was similar to the results of any other classification systems.
Conclusions
Although the use of IHC staining for CK5 and p63 increased the diagnostic agreement of PBLs in CNB specimens, WHO classification exhibited a higher discordance rate compared to any other classifications. Therefore, this result warrants further intensive consensus studies to improve the diagnostic reproducibility of PBLs with WHO classification.

Citations

Citations to this article as recorded by

Invasive papillary carcinoma of the breast
Shijing Wang, Qingfu Zhang, Xiaoyun Mao
Frontiers in Oncology.2024;[Epub] CrossRef
Recommendations for Performance Evaluation of Machine Learning in Pathology: A Concept Paper From the College of American Pathologists
Matthew G. Hanna, Niels H. Olson, Mark Zarella, Rajesh C. Dash, Markus D. Herrmann, Larissa V. Furtado, Michelle N. Stram, Patricia M. Raciti, Lewis Hassell, Alex Mays, Liron Pantanowitz, Joseph S. Sirintrapun, Savitri Krishnamurthy, Anil Parwani, Giovann
Archives of Pathology & Laboratory Medicine.2024; 148(10): e335. CrossRef
Encapsulated papillary carcinoma of the breast: A single institution experience
Liang Xu, Qixin Mao, Qiuming Liu, Yufeng Gao, Lihua Luo, Chungen Guo, Wei Qu, Ningning Yan, Yali Cao
Oncology Letters.2023;[Epub] CrossRef
High-risk and selected benign breast lesions diagnosed on core needle biopsy: Evidence for and against immediate surgical excision
Aparna Harbhajanka, Hannah L. Gilmore, Benjamin C. Calhoun
Modern Pathology.2022; 35(11): 1500. CrossRef

WHO Classification of Malignant Lymphomas in Korea: Report of the Third Nationwide Study.: Jin Man Kim, Young Hyeh Ko, Seung Sook Lee, Jooryung Huh, Chang Suk Kang, Chul Woo Kim, Yun Kyung Kang, Jai Hyang Go, Min Kyung Kim, Wan Seop Kim, Yoon Jung Kim, Hyun Jung Kim, Hee Kyung Kim, Jong Hee Nam, Hyung Bae Moon, Chan Kum Park, Tae In Park, Young Ha Oh, Dong Wha Lee, Jong Sil Lee, Juhie Lee, Hyekyung Lee, Sung Chul Lim, Kyu Yun Jang, Hee Kyung Chang, Yoon Kyung Jeon, Hye Ra Jung, Min Sun Cho, Hee Jeong Cha, Suk Jin Choi, Jae Ho Han, Sook Hee Hong, Insun Kim; Korean J Pathol. 2011;45(3):254-260.; DOI: https://doi.org/10.4132/KoreanJPathol.2011.45.3.254

6,275 View
134 Download
67 Crossref

Abstract PDF

BACKGROUND
The aim of study was to determine the relative frequency of malignant lymphoma according to World Health Organization (WHO) classification in Korea.
METHODS
A total of 3,998 cases diagnosed at 31 institutes between 2005 and 2006 were enrolled. Information including age, gender, pathologic diagnosis, site of involvement and immunophenotypes were obtained.
RESULTS
The relative frequency of non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) was 95.4% and 4.6%, respectively. B-cell lymphomas accounted for 77.6% of all NHL, while T/natural killer (T/NK)-cell lymphomas accounted for 22.4%. The most frequent subtypes of NHL were diffuse large B-cell lymphoma (42.7%), extranodal marginal zone B-cell lymphoma (MZBCL) of mucosa-associated lymphoid tissue (19.0%), NK/T-cell lymphoma (6.3%) and peripheral T-cell lymphoma (PTCL), unspecified (6.3%), in decreasing order. The relative frequency of HL was nodular sclerosis (47.4%), mixed cellularity (30.6%), and nodular lymphocyte predominant (12.1%) subtypes. Compared with a previous study in 1998, increase in gastric MZBCL and nodular sclerosis HL, and slight decrease of follicular lymphoma, PTCL, and NK/T-cell lymphoma were observed.
CONCLUSIONS
Korea had lower rates of HL and follicular lymphoma, and higher rates of extranodal NHL, extranodal MZBCL, and NK/T-cell lymphoma of nasal type compared with Western countries. Changes in the relative frequency of lymphoma subtypes are likely ascribed to refined diagnostic criteria and a change in national health care policy.

Citations

Citations to this article as recorded by

Pattern of Bone Marrow Involvement in B-cell Non-Hodgkin’s Lymphoma - Experience from a Tertiary Care Center in North India
Shareefa Akhter, Nusrat Bashir, Mohmad Hussain Mir, Fahim Manzoor, Maniza Ayub, Malik Tariq Rasool, Sheikh Bilal
Journal of Radiation and Cancer Research.2024; 15(2): 64. CrossRef
Novel clinical risk stratification and treatment strategies in relapsed/refractory peripheral T-cell lymphoma
Esther Wei Yin Chang, Ya Hwee Tan, Jason Yongsheng Chan
Journal of Hematology & Oncology.2024;[Epub] CrossRef
Primary extranodal lymphomas: Five-year experience from a tertiary care center of North India
Priyanka Mishra, Manoj Prashar, Nidhin Rehman, Anamika Sinha, Deep K. Raman
Indian Journal of Cancer.2024; 61(1): 16. CrossRef
Identification and overcoming rituximab resistance in diffuse large B-cell lymphoma using next-generation sequencing
Min Ji Jeon, Eun Sang Yu, Chul Won Choi, Dae Sik Kim
The Korean Journal of Internal Medicine.2023; 38(6): 893. CrossRef
Estimating the global burden of Epstein–Barr virus-related cancers
Yide Wong, Michael T. Meehan, Scott R. Burrows, Denise L. Doolan, John J. Miles
Journal of Cancer Research and Clinical Oncology.2022; 148(1): 31. CrossRef
Epidemiological Characteristics of Peripheral T-Cell Lymphoma: A Population-Based Study
Shuo Liu, Weiping Liu, Huichao Li, Lei Yang, Yuqin Song, Xi Zhang, Yangyang Cheng, Qingyu Li, Haoxin Li, Ning Wang, Jun Zhu, Jiafu Ji
Frontiers in Oncology.2022;[Epub] CrossRef
Structure and Function of Ligand CX3CL1 and its Receptor CX3CR1 in Cancer
Xinjie Lu
Current Medicinal Chemistry.2022; 29(41): 6228. CrossRef
Clinical course of duodenal mucosa‐associated lymphoid tissue lymphoma: Comparison with gastric mucosa‐associated lymphoid tissue lymphoma
Hee Kyong Na, Sung Hyun Won, Ji Yong Ahn, Ga Hee Kim, Kee Wook Jung, Jeong Hoon Lee, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon‐Yong Jung, Hwa Jung Kim
Journal of Gastroenterology and Hepatology.2021; 36(2): 406. CrossRef
Real-world data on the survival outcome of patients with newly diagnosed Waldenström macroglobulinemia
Jang Ho Cho, Joon-Ho Shim, Sang Eun Yoon, Hee-Jin Kim, Sun-Hee Kim, Young Hyeh Ko, Seung-Tae Lee, Kihyun Kim, Won Seog Kim, Seok Jin Kim
The Korean Journal of Internal Medicine.2021; 36(3): 668. CrossRef
Primary Gastrointestinal T/NK Cell Lymphoma
Eun Kyung Kim, Mi Jang, Woo Ick Yang, Sun Och Yoon
Cancers.2021; 13(11): 2679. CrossRef
Mucosa-Associated Lymphoid Tissue Lymphoma of the Cheek Mimicking Benign Entities: a Case Report
Hyun Hwang, Jae Ho Shin, Yon Kwon Ihn, Sungjun Han, Hong Sik Park
Investigative Magnetic Resonance Imaging.2021; 25(2): 129. CrossRef
Classification of non-Hodgkin lymphoma in the Middle Euphrates Region of Iraq according to the World Health Organization classification
Ahmed Mjali, AlyaaHadi Oudah, HaiderHasan Jaleel Al-Shammari, NareenTawfeeq Abbas
Iraqi Journal of Hematology.2021; 10(2): 170. CrossRef
Epstein-Barr virus NK and T cell lymphoproliferative disease: report of a 2018 international meeting
Jeffrey I. Cohen, Keiji Iwatsuki, Young-Hyeh Ko, Hiroshi Kimura, Irini Manoli, Koichi Ohshima, Stefania Pittaluga, Leticia Quintanilla-Martinez, Elaine S. Jaffe
Leukemia & Lymphoma.2020; 61(4): 808. CrossRef
Cutaneous lymphoma in Japan, 2012–2017: A nationwide study
Kazuyasu Fujii, Toshihisa Hamada, Takatoshi Shimauchi, Jun Asai, Yasuhiro Fujisawa, Hironobu Ihn, Norito Katoh
Journal of Dermatological Science.2020; 97(3): 187. CrossRef
Practical Approach to the Histologic Diagnosis of Gastrointestinal Lymphomas Through the First-line Marker Battery of CD20, CD3, CD30, and Epstein-Barr Virus–encoded RNAs
Eun Kyung Kim, Woo Ick Yang, Hyang Joo Ryu, Hee Lee Ji, Sun Och Yoon
Advances in Anatomic Pathology.2020; 27(2): 75. CrossRef
Treatment of mantle cell lymphoma in Asia: a consensus paper from the Asian Lymphoma Study Group
Dok Hyun Yoon, Junning Cao, Tsai-Yun Chen, Koji Izutsu, Seok Jin Kim, Yok Lam Kwong, Tong Yu Lin, Lim Soon Thye, Bing Xu, Deok Hwan Yang, Won Seog Kim
Journal of Hematology & Oncology.2020;[Epub] CrossRef
Morphologic variant of follicular lymphoma reminiscent of hyaline-vascular Castleman disease
Jiwon Koh, Yoon Kyung Jeon
Journal of Pathology and Translational Medicine.2020; 54(3): 253. CrossRef
Discovery of Novel Recurrent Mutations and Clinically Meaningful Subgroups in Nodal Marginal Zone Lymphoma
Jiwon Koh, Insoon Jang, Seongmin Choi, Sehui Kim, Ingeon Jang, Hyun Kyung Ahn, Cheol Lee, Jin Ho Paik, Chul Woo Kim, Megan S. Lim, Kwangsoo Kim, Yoon Kyung Jeon
Cancers.2020; 12(6): 1669. CrossRef
Clinicopathological and Immunophenotype Spectrum of Malignant Lymphoma in Eastern India Population – A Tertiary Care Hospital Study
Debahuti Mohapatra, Rajashree Tripathy, Prateek Das, Pallak Batalia
Journal of Evidence Based Medicine and Healthcare.2020; 7(38): 2120. CrossRef
Cost-utility analysis of pralatrexate for relapsed or refractory peripheral T-cell lymphoma based on a case-matched historical control study along with single arm clinical trial
Seonyoung Park, Ah-Young Kim, Hyeonseok Cho, Deborah Baik, Hankil Lee, Sunghwa Cho, Hye-Young Kang
BMC Cancer.2020;[Epub] CrossRef
Extranodal non-Hodgkin’s lymphoma: A case series at a tertiary care hospital
Pomilla Singh, Ravi Swami, Shashank Singh, N S Mani, M N Karandikar
IP Archives of Cytology and Histopathology Research.2020; 5(4): 302. CrossRef
Pediatric non‐Hodgkin lymphoma: Characteristics, stratification, and treatment at a single institute in Thailand
Worawut Choeyprasert, Usanarat Anurathapan, Samart Pakakasama, Nongnuch Sirachainan, Duantida Songdej, Surapong Lertthammakiat, Suradej Hongeng
Pediatrics International.2019; 61(1): 49. CrossRef
Epstein-Barr Virus-Associated T and NK-Cell Lymphoproliferative Diseases
Wook Youn Kim, Ivonne A. Montes-Mojarro, Falko Fend, Leticia Quintanilla-Martinez
Frontiers in Pediatrics.2019;[Epub] CrossRef
Chimeric Antigen Receptor T-Cell Therapy for Diffuse Large B-Cell Lymphoma
Heejung Chae, Dok Hyun Yoon
The Korean Journal of Medicine.2019; 94(2): 152. CrossRef
Classification of malignant lymphoma subtypes in Korean patients: a report of the 4th nationwide study
Hye-Ra Jung, Jooryung Huh, Young-Hyeh Ko, Yoon Kyung Jeon, Sun Och Yoon, Se Hoon Kim, Woo Ick Yang, Geongsin Park, Jo Heon Kim, Jin Ho Paik, Jae Ho Han, Hee Jung Cha, Kyu Yun Jang, Bong-Kyung Shin, Young-A Kim, Ji Eun Kim, Yoo Duk Choi, Min Gyoung Park, H
Journal of Hematopathology.2019; 12(4): 173. CrossRef
Phase II study of R–CVP followed by rituximab maintenance therapy for patients with advanced marginal zone lymphoma: consortium for improving survival of lymphoma (CISL) study
Sung Yong Oh, Won Seog Kim, Jin Seok Kim, Seok Jin Kim, Dok Hyun Yoon, Deok‐Hwan Yang, Won Sik Lee, Hyo Jung Kim, Ho‐Young Yhim, Seong Hyun Jeong, Jong Ho Won, Suee Lee, Jee Hyun Kong, Sung‐Nam Lim, Jun Ho Ji, Kyung A. Kwon, Gyeong‐Won Lee, Jae Hoon Lee,
Cancer Communications.2019; 39(1): 1. CrossRef
Changing trends in lymphoid neoplasm distribution in South Korea: analysis of 8615 cases from a single institute, 1997–2016
Jongmin Sim, Takuya Takayama, Junhun Cho, Seok Jin Kim, Won Seog Kim, Howe J. Ree, Young Hyeh Ko
Medicine.2019; 98(45): e17641. CrossRef
Non‐Hodgkin lymphoma in South East Asia: An analysis of the histopathology, clinical features, and survival from Thailand
Tanin Intragumtornchai, Udomsak Bunworasate, Kitsada Wudhikarn, Arnuparp Lekhakula, Jakrawadi Julamanee, Kanchana Chansung, Chittima Sirijerachai, Lalita Norasetthada, Weerasak Nawarawong, Archrob Khuhapinant, Noppadol Siritanaratanakul, Tontanai Numbenja
Hematological Oncology.2018; 36(1): 28. CrossRef
Prevalence and Implications of Bone Marrow Involvement in Patients with Gastric Mucosa-Associated Lymphoid Tissue Lymphoma
Sang Il Choi, Myeong-Cherl Kook, Sanghyun Hwang, Young-Il Kim, Jong Yeul Lee, Chan Gyoo Kim, Il Ju Choi, Hyewon Lee, Hyeon Seok Eom, Soo-Jeong Cho
Gut and Liver.2018; 12(3): 278. CrossRef
A Case of Synchronous Lung Squamous Cell Carcinoma and Diffuse Large B-cell Lymphoma
Seung Jae Lee, Si Young Lim, Tae Kyung Yoo, Seul Ki Kim, You Gyung Kim, Hyun Joo Lee, Jae Uk Song
The Korean Journal of Medicine.2018; 93(3): 300. CrossRef
A risk stratification model for nodal peripheral T-cell lymphomas based on the NCCN-IPI and posttreatment Deauville score
Ho-Young Yhim, Yong Park, Yeon-Hee Han, Sungeun Kim, Sae-Ryung Kang, Joon-Ho Moon, Ju Hye Jeong, Ho-Jin Shin, Keunyoung Kim, Yoon Seok Choi, Kunho Kim, Min Kyoung Kim, Eunjung Kong, Dae Sik Kim, Jae Seon Eo, Ji Hyun Lee, Do-Young Kang, Won Sik Lee, Seok M
European Journal of Nuclear Medicine and Molecular Imaging.2018; 45(13): 2274. CrossRef
Low-grade follicular lymphoma involvement of the bone marrow with a mixed paratrabecular, diffuse, and massive pattern expressing typical mantle cell lymphoma immunophenotype CD23−/FMC7+: a case report
Jaewook Kim, Ji-Hun Lim, Joseph Jeong, Seon-Ho Lee, Jae-Cheol Jo, Sang Hyuk Park
Blood Research.2018; 53(3): 261. CrossRef
Aspectos epidemiológicos, clínicos e anatomopatológicos do linfoma folicular em cães
Renata D. Mazaro, Isis P.J. Rizkallah, Flávia S. Luz, Douglas M. Lorensetti, Bruno Cogliati, Rafael A. Fighera
Pesquisa Veterinária Brasileira.2018; 38(9): 1772. CrossRef
Serious fungal infections in Korea
K. Huh, Y. E. Ha, D. W. Denning, K. R. Peck
European Journal of Clinical Microbiology & Infectious Diseases.2017; 36(6): 957. CrossRef
Epidural Lymphoma Mimicking Hematoma: A Case Report
Dong-Yeong Lee, Soon-Taek Jeong, Kun-Tae Kim, Jung-Wook Yang, Dong-Hee Kim
Journal of Korean Society of Spine Surgery.2017; 24(1): 49. CrossRef
Geographical Correlations between Indoor Radon Concentration and Risks of Lung Cancer, Non-Hodgkin’s Lymphoma, and Leukemia during 1999–2008 in Korea
Mina Ha, Seung-sik Hwang, Sungchan Kang, No-Wook Park, Byung-Uck Chang, Yongjae Kim
International Journal of Environmental Research and Public Health.2017; 14(4): 344. CrossRef
Platelet to lymphocyte ratio (PLR) retains independent prognostic significance in advanced stage marginal zone lymphoma patients treated with rituximab, cyclophosphamide, vincristine, and prednisone combination chemotherapy (R-CVP): Consortium for Improvi
Jeongkuk Seo, Won Seog Kim, Jin Seok Kim, Seok Jin Kim, Jae Hoon Lee, Jun Shik Hong, Gyeong-Won Lee, Sung Yong Oh, Ji-Hyun Lee, Dok Hyun Yoon, Won-Sik Lee, Hyo Jung Kim, Jae-Yong Kwak, Hye Jin Kang, Jae-Cheol Jo, Yong Park, Ho Sup Lee, Hyo-Jin Kim, Cheolw
Blood Research.2017; 52(3): 200. CrossRef
Treatment outcome and risk analysis for cataract after radiotherapy of localized ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma
Hee Hyun Park, Sea-Won Lee, Soo Yoon Sung, Byung Ock Choi
Radiation Oncology Journal.2017; 35(3): 249. CrossRef
The prognostic significance of CD11b+CX3CR1+ monocytes in patients with newly diagnosed diffuse large B-cell lymphoma
Ho-Young Yhim, Jeong-A Kim, Sun-Hye Ko, Youngrok Park, Eunjung Yim, Hee Sun Kim, Jae-Yong Kwak
Oncotarget.2017; 8(54): 92289. CrossRef
Epidural Lymphoma Mimicking Hematoma: A Case Report
Dong-Yeong Lee, Soon-Taek Jeong, Kun-Tae Kim, Jung-Wook Yang, Dong-Hee Kim
Journal of Korean Society of Spine Surgery.2017; 24(1): 49. CrossRef
A phase II study of oxaliplatin and prednisone for patients with relapsed or refractory marginal zone lymphoma: Consortium for Improving Survival of Lymphoma trial
Sung Yong Oh, Won Seog Kim, Jin Seok Kim, Yee Soo Chae, Gyeong-Won Lee, Hyeon Seok Eom, Hun Mo Ryoo, Suee Lee, Seok Jin Kim, Dok Hyun Yoon, Jong Ho Won, Junshik Hong, Jinny Park, Sang-Min Lee, Jung Yong Hong, Eunkyung Park, Hyo Jung Kim, Deok-Hwan Yang, H
Leukemia & Lymphoma.2016; 57(6): 1406. CrossRef
Diffuse Large B-Cell Lymphoma of the Peri-Implant Mucosa Mimicking Peri-Implantitis
Seong-Ho Jin, Gyeongsin Park, Youngkyung Ko, Jun-Beom Park
Journal of Oral Implantology.2016; 42(2): 220. CrossRef
The Roles of Radiotherapy and Chemotherapy in the Era of Multimodal Treatment for Early-Stage Nasal-Type Extranodal Natural Killer/T-Cell Lymphoma
Tae Hyung Kim, Jin Seok Kim, Yang-Gun Suh, Jaeho Cho, Woo-Ick Yang, Chang-Ok Suh
Yonsei Medical Journal.2016; 57(4): 846. CrossRef
Treatment outcomes of IMEP as a front-line chemotherapy for patients with peripheral T-cell lymphomas
Ji Young Lee, Sang Min Lee, Moon Young Choi, Ki Hyang Kim, Young Don Joo, Sung Nam Im, Won Sik Lee
Blood Research.2016; 51(3): 187. CrossRef
Immune reconstitution inflammatory syndrome versus non-immune reconstitution inflammatory syndrome lymphoma in HIV patients on antiretroviral therapy
Pyoeng Gyun Choe, Jinyong Park, Wan Beom Park, Tae Min Kim, Kyoung-Ho Song, Ji Hwan Bang, Eu Suk Kim, Sang Won Park, Hong Bin Kim, Nam Joong Kim, Myoung-don Oh, Kang Won Choe
International Journal of STD & AIDS.2016; 27(11): 1013. CrossRef
Clinical outcome and prognosis of patients with primary sinonasal tract diffuse large B-cell lymphoma treated with rituximab-cyclophosphamide, doxorubicin, vincristine and prednisone chemotherapy: a study by the Consortium for Improving Survival of Lympho
Gyeong-Won Lee, Se-Il Go, Seok-Hyun Kim, Junshik Hong, Yu Ri Kim, Sukjoong Oh, Sung-Yong Kim, Young Rok Do, Hyewon Lee, Soon Il Lee, Sung Hwa Bae, Sung Yong Oh, Moo Kon Song, Won-Sik Lee, Bohee Lee, Jin Seok Kim, Min Kyoung Kim, Hye Jin Kang, Jae-Sook Ahn
Leukemia & Lymphoma.2015; 56(4): 1020. CrossRef
Therapeutic comparison of Surgery combined with chemotherapy and chemotherapy alone for Primary Gastrointestinal Lymphoma: A single center study
Je Hun Kim, Ho Sup Lee, Jun Seop Lee, Jin Young Lee, Su Young Kim, Cheol Su Kim, Joung Wook Yang, Ga In You
Kosin Medical Journal.2015; 30(1): 29. CrossRef
A Case of Simultaneous Primary Gastric and Duodenal Mucosa-Associated Lymphoid Tissue Lymphoma after Therapeutic Endoscopy
Sun Hee Park, Jae Young Jang, Min A Park, Hyuck Kim, Young Woon Chang
Korean Journal of Medicine.2015; 89(1): 64. CrossRef
Clinicopathologic Study of Chromosomal Aberrations in Ocular Adnexal Lymphomas of Korean Patients
Hokyung Choung, Young A Kim, Namju Kim, Min Joung Lee, Sang In Khwarg
Korean Journal of Ophthalmology.2015; 29(5): 285. CrossRef
A Rare Case of Malignant Lymphoma Occurred at Spinal Epidural Space: A Case Report
Hyun-Jun Cho, Jang-Bo Lee, Junseok W. Hur, Sung-Won Jin, Tai-Hyoung Cho, Jung-Yul Park
Korean Journal of Spine.2015; 12(3): 177. CrossRef
Radiotherapy as an effective treatment modality for follicular lymphoma: a single institution experience
Seo Hee Choi, Jaeho Cho, Jin Seok Kim, June-Won Cheong, Chang-Ok Suh
Radiation Oncology Journal.2015; 33(4): 310. CrossRef
Current therapy of choice for cutaneous lymphomas: Complementary to the Japanese Dermatological Association/Japanese Skin Cancer Society guidelines
Keiji Iwatsuki, Toshihisa Hamada
The Journal of Dermatology.2014; 41(1): 43. CrossRef
The Role of Radiotherapy in the Treatment of Gastric Mucosa-Associated Lymphoid Tissue Lymphoma
Taek-Keun Nam, Jae-Sook Ahn, Yoo-Duk Choi, Jae-Uk Jeong, Yong-Hyeob Kim, Mee Sun Yoon, Ju-Young Song, Sung-Ja Ahn, Woong-Ki Chung
Cancer Research and Treatment.2014; 46(1): 33. CrossRef
Current Concepts in Primary Effusion Lymphoma and Other Effusion-Based Lymphomas
Yoonjung Kim, Chan Jeong Park, Jin Roh, Jooryung Huh
Korean Journal of Pathology.2014; 48(2): 81. CrossRef
Benign Indolent CD56-Positive NK-Cell Lymphoproliferative Lesion Involving Gastrointestinal Tract in an Adolescent
Jaemoon Koh, Heounjeong Go, Won Ae Lee, Yoon Kyung Jeon
Korean Journal of Pathology.2014; 48(1): 73. CrossRef
Peripheral T cell lymphoma in Asia
Sanghui Park, Young Hyeh Ko
International Journal of Hematology.2014; 99(3): 227. CrossRef
Characteristics of Cutaneous Lymphomas in Korea According to the New WHO-EORTC Classification: Report of a Nationwide Study
Jae Ho Han, Young-Hyeh Ko, Yun Kyung Kang, Wan-Seop Kim, Yoon Jung Kim, Insun Kim, Hyun-Jung Kim, Soo Kee Min, Chan-Kum Park, Chan-Sik Park, Bong-Kyung Shin, Woo Ick Yang, Young-Ha Oh, Jong Sil Lee, Juhie Lee, Tae Hui Lee, Hyekyung Lee, Ho Jung Lee, Yoon
Korean Journal of Pathology.2014; 48(2): 126. CrossRef
Epstein–Barr virus‐associated T/natural killer‐cell lymphoproliferative disorders
Sanghui Park, Young H. Ko
The Journal of Dermatology.2014; 41(1): 29. CrossRef
Overexpression of sphingosine-1-phosphate receptor 1 and phospho-signal transducer and activator of transcription 3 is associated with poor prognosis in rituximab-treated diffuse large B-cell lymphomas
Jin Ho Paik, Soo Jeong Nam, Tae Min Kim, Dae Seog Heo, Chul-Woo Kim, Yoon Kyung Jeon
BMC Cancer.2014;[Epub] CrossRef
Clinicopathologic implication of A20/TNFAIP3 deletion in diffuse large B-cell lymphoma: an analysis according to immunohistochemical subgroups and rituximab treatment
Jin Ho Paik, Heounjeong Go, Soo Jeong Nam, Tae Min Kim, Dae Seog Heo, Chul-Woo Kim, Yoon Kyung Jeon
Leukemia & Lymphoma.2013; 54(9): 1934. CrossRef
Clinical features and survival outcomes of patients with diffuse large B-cell lymphoma: analysis of web-based data from the Korean Lymphoma Working Party Registry
Hyeon Gyu Yi, Jin Seok Kim, Cheolwon Suh, Won Seog Kim, Jae-Yong Kwak, Jong-Seok Lee, Yang Soo Kim, Young Don Joo, Yoo Hong Min, Hong Ghi Lee, Sung-Soo Yoon, Jong-Ho Won, Seonyang Park, Hugh Chul Kim, Chul Soo Kim
Blood Research.2013; 48(2): 115. CrossRef
Epidemiologic overview of malignant lymphoma
Jooryung Huh
The Korean Journal of Hematology.2012; 47(2): 92. CrossRef
Gastrointestinal Lymphoma
Yoon Jung Lee, Jun Haeng Lee
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2012; 12(3): 158. CrossRef
Transformation of CD5-Negative Follicular Lymphoma into CD5-Positive Diffuse Large B-Cell Lymphoma: A Case Report
Hyeong Kug Kim, In Sung Cho, Hye Kyung Lee, Yong Hun Choi, Seong Min Cho, Hyun Jin Moon, Jin A Lee
Korean Journal of Medicine.2012; 83(2): 263. CrossRef
The Role of Radiotherapy for the Treatment of Gastric MALT Lymphoma
Jae-Sook Ahn, Taek-Keun Nam
Korean Journal of Medicine.2012; 83(6): 712. CrossRef
Pathophysiology of Gastric MALT Lymphoma
Gyeongsin Park, Chang Suk Kang
Korean Journal of Medicine.2012; 83(6): 689. CrossRef
CD44s and CD44v6 Are Predominantly Expressed in the Non-germinal Center B-Cell-like Type of Diffuse Large B-Cell Lymphomas
Kyueng-Whan Min, Young-Ha Oh, Chan-Kum Park, So-Dug Lim, Wan-Seop Kim
The Korean Journal of Pathology.2011; 45(6): 589. CrossRef

Korean Pediatric/Adolescent Lymphoma: Incidence and Pathologic Characteristics.: Seung Sook Lee, Jin Man Kim, Young Hyeh Ko, Jooryung Huh, Chang Suk Kang, Chul Woo Kim, Yun Kyung Kang, Jai Hyang Go, Min Kyung Kim, Wan Seop Kim, Yoon Jung Kim, Hyun Jung Kim, Hee Kyung Kim, Jong Hee Nam, Hyung Bae Moon, Chan Kum Park, Tae In Park, Young Ha Oh, Dong Wha Lee, Jong Sil Lee, Juhie Lee, Hyekyung Lee, Sung Chul Lim, Kyu Yun Jang, Hee Kyung Chang, Yoon Kyung Jeon, Hye Ra Jung, Min Sun Cho, Hee Jeong Cha, Suk Jin Choi, Jae Ho Han, Sook Hee Hong, Insun Kim; Korean J Pathol. 2010;44(2):117-124.; DOI: https://doi.org/10.4132/KoreanJPathol.2010.44.2.117

4,305 View
64 Download
1 Crossref

Abstract PDF

BACKGROUND
The Hematopathology Study Group of the Korean Society of Pathologists conducted a nation-wide retrospective analysis of Korean pediatric lymphoma, to provide pathologic data on pediatric/adolescent lymphoma subtypes and features.
METHODS
All lymphoma cases of all age groups were collected during a recent 2 year-period (2005-2006) from 32 institutes in Korea. Among 3,686 lymphoma patients, 142 who were age 18 or less were classified according to the World Health Organization (WHO) classification.
RESULTS
Among 142 pediatric/adolescent lymphoma patients, Hodgkin lymphoma accounted for 21 (14.8%) and non-Hodgkin lymphoma (NHL) for 121 (85.2%). Hodgkin lymphoma appears to be more common in the pediatric/adolescent age group than in the all-ages group (14.8% vs 4.4%). T- and natural killer cell-NHL was more common in the pediatric/adolescent age group than in the all ages group (46.3% vs 22%). The majority of Korean pediatric/adolescent NHL cases was composed of Burkitt lymphoma, T- or B-lymphoblastic lymphoma, anaplastic large-cell lymphoma, and diffuse large B-cell lymphoma. For lymphoma patients under the age of 6 years, most had B-lymphoblastic or Burkitt lymphoma, which commonly presented at extranodal sites.
CONCLUSIONS
The distribution of lymphoma subtypes in the pediatric/adolescent age group is quite different from the distribution of adults, but it was quite similar to distribution in Western countries.

Citations

Citations to this article as recorded by

A Case of Nasal Type Extranodal NK/T Cell Lymphoma Incidentally Detected in a Child
Ha Jin Oh, Sang Hyun Park, Hae In Jang, Dong Hoon Lee, Yoo Duk Choi, Hee Jo Baek, Hoon Kook
Clinical Pediatric Hematology-Oncology.2015; 22(1): 76. CrossRef

Case Report

Non-Hodgkin's Malignant Lymphoma Arising in the Appendix: A case report.: Yun Sin Kim, Mi Sook Lee, Kwang Seok Lee Lee, Sung Chul Lim, Ho Jong Jeon; Korean J Pathol. 1995;29(4):524-526.

1,653 View
19 Download

Abstract PDF: Primary malignant lymphoma of the appendix is an unconnnon neoplasm although the gastrointestinal tract is the most common extranodal site of malignant lymphoma. We report a case of primary malignant lymphoma of the appendix in a 54-year-old male, who presented with pain in the right lower abdomen. An appendectomy was performed. The appendix measured 9.5 cm in length and 5.5 cm in diameter. Cut sections showed a solitary circumferential mass in the appendiceal lumen. Light microscopic features were compatible with malignant lymphoma of diffuse large cell type(Working Formulation) and the immunophenotype was B cell type.

Original Article

Ultrastructural Changes in Human Gallbladder Epithelium in Acalculous and Calculous Cholecystitis.: Sung Chul Lim, Chae Hong Suh; Korean J Pathol. 1995;29(6):714-726.

1,587 View
12 Download

Abstract PDF: Cholelithiasis is defined as the presence of stones within the lumen of the gallbladder or in the extrahepatic biliary tree. Cholecystitis, secondary to gallstones, is a common surgical disorder in Korea. Detailed microscopic descriptions, particularly the ultrastructural changes, of these diseases were not available. The goal of this study was to identify the ultrastructural alterations of gallbladder epithelium in cholecystitis with and without a stone, according to the degree of severity of inflammation, and the nature of the stone. The gallbladders of the control group, and cholecystitis cases without stone and with stone were fixed and examined with routine stain, special stain, immunohistochemical stain and trans-mission electron microscopy. The number and the volume density of the mucin containing secretary granules were not significantly increased in the calculous cholecystitis cases compared with those of the acalculous cholecystitis cases. Major findings were that the calculous cholecystitis cases showed a markedly reduced total lysosome area and volume density of the lysosome compared with those of the acalculous chole-cystitis cases. The differences between the mucin secretary granules and lysosomes, according to the degree of severity of cholecystitis and the natures of gallstones, were statistically not significant.

Case Report

Paragonimiasis Involving the Female Genital Tract and Cul De Sac: A case report.: Mi Sook Lee, Yun Sin Kim, Sung Chul Lim, Keun Hong Kee, Ho Jong Jeo, Chae Hong Suh; Korean J Pathol. 1996;30(5):457-459.

1,655 View
14 Download

Abstract PDF: Paragonimiasis caused by Paragonimus westermani is essentially a pulmonary disorder, but it is also known to cause ectopic parasitism at various sites in human host such as the brain, muscle, liver, spinal cord and spleen. Ectopic parasitism of the female genital tract, especially the ovary is relatively rare. We have experienced a case of a 62-year-old Korean woman with asymptomatic ectopic paragonimiasis in the salpinx , ovary, and cul de sac.

Original Articles

Immunohistochemical Study of p53 Protein Expression in Colorectal Tumors.: Mi Sook Lee, Chae Hong Suh, Sung Chul Lim; Korean J Pathol. 1996;30(7):595-603.

1,490 View
16 Download

Abstract PDF: The aims of this study were to assess the role of p53 overexpression in colorectal tumorigenesis and the association with clinicopathological features. The immunohistochemical results were semiquantitatively assessed. Expression of aberrant p53, tumor-suppressor gene product, was studied immunohistochemically using a monoclonal antibody in 11 nonneoplastic polyps, 19 tubular adenomas, 9 villous adenomas, and 48 colorectal carcinomas. Five out of 11 nonneoplastic polyps, 14 out of 19 tubular adenomas and one out of 9 villous adenomas expressed p53 protein. Seven out of 24 colorectal carcinomas without lymph node metastasis and 14 out of 24 colorectal carcinomas with lymph node metastsis expressed p53 protein. The case of more than 75% positivity of p53 in colorectal carcinoma with lymph node metastasis was seven out of 24, but that in lymph node negative group was two out of 24. In the colorectal carcinoma with lymph node metastasis group; metastatic intranodal neoplastic cells were expressed positively for p53 in 10 out of 14 cases and zero out of 10 cases in group of positive and negative expression of primary lesions, respectively. p53 protein expression was not significantly correlated with variable clinicopathologic features such as age, sex, tumor location, tumor size, differentiation and Dukes' stage. It is suggested that p53 protein overexpression could be a early event in pathogenesis of colon cancer but is not involved in progression of villous adenoma to adenocarcinoma. p53 overexpression seems to be involved in metastatic ability of colorectal carcinomas.

A Study on the Tumor Angiogenesis and Expression of Cytokine and Growth Factors in the Prostatic Carcinoma.: Sung Chul Lim, Ho Jong Jeon; Korean J Pathol. 1996;30(8):671-679.

1,467 View
16 Download

Abstract PDF: There is considerable experimental evidence to indicate that tumor growth is dependent on angiogenesis. However, we do not understand how the angiogenic activity is initiated by a given tumor. There is a clear distinction between a stage without neovascularization, which correlates with a paucity of metastases, and a stage in which increasing neovascularization correlates with a rising rate of metastasis. The authors therefore asked whether the extent of angiogenesis in human prostatic carcinoma is correlated with the tumor grades or some growth factors. To investigate how tumor angiogenesis correlates with tumor aggressiveness, the authors counted microvessels within the various grades of invasive prostatic carcinomas of 44 patients and the nodular hyperplasias of 10 patients. Highlighting of the vessels by immunohistochemical staining for factor VIII-related antigen and assessment of the tumor aggressiveness by the degree of expression of some growth factors(transforming growth factor-alpha, and beta, epidermal growth factor), tumor necrosis factor-alpha and tumor grading(Gleason's score) were done. As a result, both microvessel counts and the expression of growth factors and tumor necrosis factor correlated with tumor grades. In conclusion, the number of microvessels per 200 X fields in the areas of most intense neovascularization in a prostatic carcinoma may be a predictor of the patient's prognosis. Therefore, assessment of tumor angiogenesis may prove valuable in selecting patients with prostatic carcinoma, especially small needle biopsy, for aggressive therapy.

Case Reports

Endothelial Cyst of the Adrenal Gland: Report of a case.: Sung Chul Lim, Mi Sook Lee, Yun Sin Kim, Keun Hong Kee, Yu Kyung Jeong, Mi Ja Lee, Soon Bong Chung; Korean J Pathol. 1996;30(8):742-745.

2,040 View
54 Download

Abstract PDF: Adrenal cysts are rare lesion that usually present themselves as an incidental finding during surgery, or at the time of autopsy. The cysts are usually small, seldom exceeding 10cm in diameter, and are generally asymptomatic. However, they present a difficult problem in differentiation between benign and malignant lesions of the adrenal gland. In the differential diagnosis, other cystic lesions of the upper abdomen must also be considered, including hepatic, splenic, renal and pancreatic cysts. Herein we report a case of endothelial cyst of lymphangiomatous type of the adrenal gland which was detected in a 44-year-old male patient during a routine health examination by ultrasonography as a pancreatic pseudocyst. Gross examination revealed multiple separate but continuous cysts, measuring 10.6x8x7cm in dimension. Within the wall, compressed adrenal cortex was noted. Microscopically, fibrous wall containing hypertrophied smooth muscle lined by endothelial cells was also noted. We reviewed literatures of the adrenal cyst and report a case.

Bilateral Elastofibroma: Report of a case.: Sung Chul Lim, Mi Sook Lee, You Kyung Jeong, Yun Shin Kim, Hyun Jong Park, Mi Ja Lee; Korean J Pathol. 1997;31(6):589-591.

1,604 View
14 Download

Abstract PDF: Elastofibroma is a rare benign tumor-like condition manifesting as firm and spherical mass with poorly circumscribed margins of fibroelastic tissue, occuring in the subscapular region or the chest wall of elderly persons. It is not a true neoplasm but rather a reactive or degenerative process causing abnormal elastogenesis. It is unilateral in the majority of cases and the right side is affected more commonly than the left. We report a case of bilateral elastofibromas removed from both subscapular regions of a 73-year-old female farmer. She was presented with tender masses on the bilateral subscapular areas for seven years. Microscopically, it consisted of a mixture of intertwining broad eosinophilic collagen bundles and elastic fibers associated with a few fibroblasts and mature fat cells. The elastic fibers had a degenerated beaded appearance or were fragmented into serrated globules in a linear arrangement.

Benign Cystic Mesothelioma.: Sung Chul Lim, You Kyung Jeong, Mi Sook Lee, Yun Shin Kim, Hyun Jong Park, Sang Joon Choi; Korean J Pathol. 1997;31(6):595-597.

1,637 View
16 Download

Abstract PDF: Benign cystic mesothelioma (BCM) is a rare mesothelial lesion that forms multicystic masses in the upper abdomen, pelvis and retroperitoneum. Although it is categorized as a benign lesion, it has a tendency to recur. It is uncertain whether the nature of this lesion is reactive or neoplastic, but many articles support the conclusion that it is reactive rather than neoplastic. The majority of cases were associated with a history of a previous abdominal or pelvic operation, or an evidence of endometriosis or a pelvic inflammatory disease, or a combination of these findings. In a 26-year-old woman we experienced a case of BCM which was incidentally discovered at cesarean delivery revealing multilocular thin and translucent walled cysts in the pelvic cavity. Microscopic examination revealed a thin cyst wall that was composed of fibrous connective tissue and lined by internal stratified and external nonstratified single cuboidal epithelia.

Original Articles

Overexpression of p53 Protein in Endometrial Hyperplasia and Adenocarcinoma.: Yun Sin Kim, Mi Sook Lee, Sung Chul Lim, Jang Shin Sohn, Chae Hong Suh; Korean J Pathol. 1997;31(7):655-661.

2,250 View
43 Download

Abstract PDF: Proliferations of the endometrial glands form a continuum from focal glandular crowding through simple hyperplasia, complex hyperplasia and atypical hyperplasia to frank adenocarcinoma. But objective criteria to distinguish these proliferative endometrial lesions are not clear-cut and terminology is confusing. The p53 protein is a nuclear phosphoprotein that can regulate cell proliferation and suppress tumor growth. Mutation in the p53 gene have been reported in a variety of human tumors, and in selected malignancies overexpression of p53 has been associated with poor prognosis. In this study we examined a series of endometrial proliferative lesion, including hyperplasia, adenocarcinoma, and adenomyosis to determine whether or not p53 is overexpressed in these lesions. In the result, p53 immunoreactivity was observed in 3 of 17 (17.6%) simple hyperplasia, one of 6 (16.6%) complex hyperplasia, none of 3 (O%) atypical hyperplasia, 6 of 13 (46.1%) adenocarcinoma and none of 10 (O%) adenomyosis. In conclusion, p53 mutation seems to play a role in oncogenesis of endometrial adenocarcinoma in early phase but there was no significant relationship between p53 overexpression and histologic grade of adenocarcinoma.

Immunohistochemical and Ultrastructural Observation on Small Round Cell Tumors.: Chae Hong Suh, Jeong Yeol Yang, Sung Chul Lim, Yong Lim Kim; Korean J Pathol. 1997;31(11):1200-1213.

1,615 View
10 Download

Abstract: Small round cell tumors such as neuroblastoma, rhabdomyosarcoma, Ewing's tumor, malignant lymphoma and small cell carcinoma are often confused clinically and histologically. To clarify the similarites and differences and to get more information on the histogenesis among the small round cell tumors, we examined histological, immunohistochemical and ultrastructural features of ten cases of neuroblastomas, twenty Ewing's tumors, ten embryonal rhabdomyosarcomas and twelve small cell carcinomas in children and young adults. Antibodies against desmin, vimentin, cytokeratin, neuron-specific enolase, synaptophysin, neurofilament, S-100 protein, chromogranin and HBA 71 were used in biotin streptavidin procedures. The results of the immunohistochemical and electron microscopical examinations yielded virtually identical findings in each group as followings. 1) Among the twenty cases of Ewing's tumors, eighteen cases were positive in staining for HBA-71. The staining for HBA-71 was negative in neuroblastoma, embryonal rhabdomyosarcoma and small cell carcinoma. 2) Neuroblastomas had marked interdigitating cytoplasmic processes containing many microtubules and dense-core secretory granules, however, they were sparse and rare in Ewing's tumor. 3) Embryonal rhabdomyosarcoma showed actin-myosin bundles. According to differentiation, well differentiated rhabdomyosarcoma exhibited Z-band materials and external lamina. 4) Neuroblastoma showed ultrastructural evidence of a neuronal differentiation, but neuronal differentration is a sparse and rare in Ewing's tumor. This ultrastructural feature strengthens the hypothesis that Ewing's tumor is derived not only from an undifferentiated neuroectodermal stem cell but from primitive cell of neuroectodermal origin.

Relationship between Vimentin Expression and Progression of Uterine Cervix Epithelial Neoplasms.: Sung Chul Lim, Keun Hong Kee, Hyun Jong Park; Korean J Pathol. 1998;32(9):663-669.

1,727 View
10 Download

Abstract: Vimentin is an intermediate filament protein normally expressed in mesenchymal cells, but the evidence of the aberrant expression of vimentin in epithelial cancer cells suggests that the vimentin expression might be related to local invasiveness and metastatic potential. There have been a few previous studies on the vimentin expression in human cervical carcinogenesis using in vivo and in vitro models. We examined the immunohistochemical vimentin expression in various squamous epithelial neoplasms of the uterine cervix, including the cervical intraepithelial neoplasia group (n=25), the microinvasive squamous cell carcinoma group (n=15), the invasive squamous cell carcinoma group (n=15) and the metastatic squamous cell carcinoma group (n=8). Vimentin positivity was significantly higher in the invasive than in the intraepithelial group, and in the cases with lymph node metastasis than in those without metastasis, suggesting a relationship between the vimentin expression and progression of the uterine cervical epithelial tumors.

Factors Influencing Regeneration of Calvarial Defects in Rats.: Sung Chul Lim, Young Sook Kim; Korean J Pathol. 1999;33(11):999-1008.

1,379 View
14 Download

Abstract PDF: An experimental study was done to evaluate factors influencing guided regeneration of bone in standardized calvarial bony defect. An 8 mm circular transosseous calvarial bony defect was made. Various material such as demineralized freeze-dried bone (DFDB), BioMesh , Millipore filter and its combination was placed in the bony defect. A sequential histopathologic, histochemical, immunohistochemical, and histomorphometric studies were done on the guided bone regeneration in the calvarial bony defect. Bone formation was sigificantly enhanced when the DFDB was retained within the bony defect with a protective bioabsorbable membrane. Inframembranous DFDB-filling was required to prevent collapse of the membrane and preserve spaces for bone regeneration. The bioabsorbable membrane should presumably remain intact for longer than at least 5 weeks to facilitate bone regeneration. The new bone formation was dependent on the barrier-effect (preserving secluded spaces) and inflammation-inducing property of membrane, and guiding bone regeneration of the grafts. Macrophages recruited by grafts were partly involved in decrease of bone regeneration via the sequential events of release of fibronectin, chemotactic effect of the fibronectin to fibroblasts, and collagen lay-down.

First
Prev
Page of 2
Next
Last

Search