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Case Study
Squamous Metaplasia in Pleomorphic Adenoma: A Diagnostic and Prognostic Enigma
Swati Sharma, Monica Mehendiratta, Nivedita Chaudhary, Vineet Gupta, Maulshree Kohli, Anjana Arora
J Pathol Transl Med. 2018;52(6):411-415.   Published online October 1, 2018
DOI: https://doi.org/10.4132/jptm.2018.07.15
  • 6,733 View
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  • 7 Web of Science
  • 14 Crossref
AbstractAbstract PDF
Pleomorphic adenoma (PA) is the most common benign salivary gland tumor. Histologically, squamous metaplasia has been reported in PA, but has rarely been documented as being extensive enough to cause significant misdiagnosis. Here, we present an unusual case of PA in a 50-year-old female patient presenting with swelling on the postero-lateral aspect of the palate for a week. Histopathologically, the tumor exhibited the features of conventional PA with extensive squamous metaplasia and giant keratotic lamellae in cyst-like areas. Such exuberant squamous metaplasia and keratin can be a diagnostic and prognostic pitfall and lead to overtreatment of the patient.

Citations

Citations to this article as recorded by  
  • Effective Management of a Giant Deforming Pleomorphic Adenoma With Airway Displacement in a 93-Year-Old Patient: A Case Report
    Julio A Palomino-Payan, Jessica Guillen-Valles, Daniel A Meza-Martinez, Fernanda Urias, Luis D Montes de Oca-Gordoa
    Cureus.2024;[Epub]     CrossRef
  • ECTOPIC PLEOMORPHIC ADENOMA OF BUCCAL SPACE: CASE REPORT WITH REVIEW OF LITERATURE
    SANCHIT BAJPAI
    UP STATE JOURNAL OF OTOLARYNGOLOGY AND HEAD AND NECK SURGERY.2024; VOLUME 12(ISSUE 1): 55.     CrossRef
  • Pleomorphic adenoma of the upper lip: A rare site for a common tumor- Case report
    Prasath Sathiah, Sujaya Mazumder, Santosh Tummidi, Vijay Kannaujiya
    SN Comprehensive Clinical Medicine.2023;[Epub]     CrossRef
  • Variable metaplastic entities in pleomorphic adenoma a review of a rare case report with a note on its significance
    N. Mahapatra, L. Bhuyan, Dash Chandra, P. Mishra
    Archive of Oncology.2023; 29(2): 18.     CrossRef
  • Pleomorphic adenoma with extensive oncocytic papillary cystic areas and trichilemmal keratinisation – A unique presentation
    CV Aiswarya, Raghunath Vandana, Kamal Firoz, Meda Samatha
    Journal of Oral and Maxillofacial Pathology.2023; 27(3): 562.     CrossRef
  • Pleomorphic Adenoma with Extensive Squamous and Adipocytic Metaplasia Mimicking as Low Grade Mucoepidermoid Carcinoma on FNAC
    Anu Singh, Ravi Hari Phulware, Arvind Ahuja, Ankur Gupta, Manju Kaushal
    Indian Journal of Otolaryngology and Head & Neck Surgery.2022; 74(S2): 2132.     CrossRef
  • Aspiration cytology of pleomorphic adenoma with squamous metaplasia: A case series and literature review illustrating diagnostic challenges
    Joshua J. X. Li, Joanna K. M. Ng, Eric H. L. Lau, Amy B. W. Chan
    Diagnostic Cytopathology.2022; 50(2): 64.     CrossRef
  • Pleomorphic adenoma with extensive squamous metaplasia: The first well-documented case involving the submandibular gland
    David A. Gaskin, Alain Reid, Pamela S. Gaskin
    Human Pathology Reports.2022; 27: 300600.     CrossRef
  • Salivary Gland Pleomorphic Adenomas Presenting With Extremely Varied Clinical Courses. A Single Institution Case-Control Study†
    Krzysztof Piwowarczyk, Ewelina Bartkowiak, Paweł Kosikowski, Jadzia Tin-Tsen Chou, Małgorzata Wierzbicka
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • A case report of pleomorphic adenoma squamous metaplasia resembling metastatic oral squamous cell carcinoma
    E. Donohoe, R. Courtney, S. Phelan, P.J. McCann
    Advances in Oral and Maxillofacial Surgery.2021; 2: 100074.     CrossRef
  • Extensive squamous metaplasia in minor salivary gland neoplasm mimicking squamous cell carcinoma: Diagnostic dilemma in aspiration cytology
    Renu Sukumaran, Nileena Nayak, RariP Mony
    Clinical Cancer Investigation Journal.2021; 10(5): 257.     CrossRef
  • Navigating small biopsies of salivary gland tumors: a pattern-based approach
    J. Stephen Nix, Lisa M. Rooper
    Journal of the American Society of Cytopathology.2020; 9(5): 369.     CrossRef
  • Giant Parotid Pleomorphic Adenoma with Atypical Histological Presentation and Long-Term Recurrence-Free Follow-Up after Surgery: A Case Report and Review of the Literature
    Mohammed AlKindi, Sundar Ramalingam, Lujain Abdulmajeed Hakeem, Manal A. AlSheddi
    Case Reports in Dentistry.2020; 2020: 1.     CrossRef
  • Pleomorphic adenoma of soft palate with extensive squamous metaplasia – A diagnostic enigma
    Rashmi Patnayak, Sandip Mohanty, AnjanKumar Sahoo, AdyaKinkara Panda, Amitabh Jena
    Journal of Dr. NTR University of Health Sciences.2019; 8(4): 268.     CrossRef

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