Journal of Pathology and Translational Medicine

Original Article

CD9 Expression in Colorectal Carcinomas and Its Prognostic Significance: Kyung-Ju Kim, Hee Jung Kwon, Min Chong Kim, Young Kyung Bae; J Pathol Transl Med. 2016;50(6):459-468. Published online October 25, 2016; DOI: https://doi.org/10.4132/jptm.2016.10.02

8,202 View
152 Download
15 Web of Science
12 Crossref

Background
CD9, a member of the tetraspanin superfamily, is a tumor suppressor in many malignancies. The aim of this study was to evaluate the immunohistochemical expression of CD9 in colorectal carcinomas (CRCs) and determine clinicopathological and prognostic significance of its expression.
Methods
The CD9 expression status of 305 CRCs was evaluated using a semi-quantitative scoring system in tumor cells (T-CD9) and immune cells (I-CD9) by classifying the results as high and low expression.
Results
High T-CD9 (T-CD9 [+]) expression was detected in 175 samples (57.6%) and high I-CD9 (I-CD9 [+]) expression was detected in 265 samples (86.9%). Using Kaplan- Meier survival analysis, the T-CD9 (+) group showed a tendency for better disease-free survival (DFS) (p = .057). In left-sided tumors, DFS was significantly longer in the T-CD9 (+) group (p = .021) but no statistical significance was observed with right-sided tumors (p = .453). I-CD9 (+) CRCs significantly correlated with well/moderately differentiation (p = .014). In Kaplan-Meier analysis, the I-CD9 (+) group had a tendency towards worse DFS compared to the I-CD9 (–) group (p = .156). In combined survival analysis of T-CD9 and I-CD9, we found that the longest DFS was among patients in the T-CD9 (+)/I-CD9 (–) group, whereas the T-CD9 (–)/I-CD9 (+) group showed the shortest DFS (p = .054).
Conclusions
High expression of T-CD9 was associated with a favorable DFS, especially in left-sided CRCs. Combined evaluation of T-CD9 and I-CD9 is required to determine the comprehensive prognostic effect of CD9 in CRCs.

Citations

Citations to this article as recorded by

Proteomic analysis of plasma exosomes in patients with metastatic colorectal cancer
Zhaoyue Zhong, Jiayin Ji, Hongxia Li, Ling Kang, Haipeng Zhu
Clinical Proteomics.2024;[Epub] CrossRef
Prognostic value and multifaceted roles of tetraspanin CD9 in cancer
Róbert Ondruššek, Barbora Kvokačková, Karolína Kryštofová, Světlana Brychtová, Karel Souček, Jan Bouchal
Frontiers in Oncology.2023;[Epub] CrossRef
Proteomic Signature of Extracellular Vesicles Associated with Colorectal Cancer
Natalia Soloveva, Svetlana Novikova, Tatiana Farafonova, Olga Tikhonova, Victor Zgoda
Molecules.2023; 28(10): 4227. CrossRef
Anti-Human CD9 Fab Fragment Antibody Blocks the Extracellular Vesicle-Mediated Increase in Malignancy of Colon Cancer Cells
Mark F. Santos, Germana Rappa, Simona Fontana, Jana Karbanová, Feryal Aalam, Derek Tai, Zhiyin Li, Marzia Pucci, Riccardo Alessandro, Chikao Morimoto, Denis Corbeil, Aurelio Lorico
Cells.2022; 11(16): 2474. CrossRef
The Study of the Extracellular Matrix in Chronic Inflammation: A Way to Prevent Cancer Initiation?
Asia Marangio, Andrea Biccari, Edoardo D’Angelo, Francesca Sensi, Gaya Spolverato, Salvatore Pucciarelli, Marco Agostini
Cancers.2022; 14(23): 5903. CrossRef
In vivo expansion of a CD9+ decidual-like NK cell subset following autologous hematopoietic stem cell transplantation
Ane Orrantia, Enrique Vázquez-De Luis, Gabirel Astarloa-Pando, Iñigo Terrén, Ainhoa Amarilla-Irusta, Diego Polanco-Alonso, Carmen González, Alasne Uranga, Tomás Carrascosa, Juan J. Mateos-Mazón, Juan C. García-Ruiz, Sergio Callejas, Ana Quintas, Ana Dopaz
iScience.2022; 25(10): 105235. CrossRef
Inhibition of cancer-cell migration by tetraspanin CD9-binding peptide
Thanawat Suwatthanarak, Masayoshi Tanaka, Yoshitaka Miyamoto, Kenji Miyado, Mina Okochi
Chemical Communications.2021; 57(40): 4906. CrossRef
High expression of tumor susceptibility gene 101 (TSG101) is associated with more aggressive behavior in colorectal carcinoma
Elmira Gheytanchi, Leili Saeednejad Zanjani, Roya Ghods, Maryam Abolhasani, Marzieh Shahin, Somayeh Vafaei, Marzieh Naseri, Fahimeh Fattahi, Zahra Madjd
Journal of Cancer Research and Clinical Oncology.2021; 147(6): 1631. CrossRef
Increased CD9 expression predicts favorable prognosis in human cancers: a systematic review and meta-analysis
Hyun Min Koh, Bo Gun Jang, Dong Hui Lee, Chang Lim Hyun
Cancer Cell International.2021;[Epub] CrossRef
Prognostic Value of CD9 in Solid Tumor: A Systematic Review and Meta-Analysis
Ping Zeng, Meng Si, Rui-xia Sun, Xu Cheng, Xiao-yang Li, Min-bin Chen
Frontiers in Oncology.2021;[Epub] CrossRef
Matrix Effect in the Isolation of Breast Cancer-Derived Nanovesicles by Immunomagnetic Separation and Electrochemical Immunosensing—A Comparative Study
Silio Lima Moura, Mercè Martì, María Isabel Pividori
Sensors.2020; 20(4): 965. CrossRef
CD9 expression indicates a poor outcome in acute lymphoblastic leukemia
Peiqi Liang, Miao Miao, Zhuogang Liu, Hongtao Wang, Wei Jiang, Shiyu Ma, Chuan Li, Rong Hu
Cancer Biomarkers.2018; 21(4): 781. CrossRef

First
Prev
Page of 1
Next
Last

Search