Remarkable developments in immuno-oncology have changed the landscape of gastric cancer (GC) treatment. Because immunotherapy intervenes with tumor immune response rather than directly targeting tumor cells, it is important to develop a greater understanding of tumor immunity. This review paper summarizes the tumor immune reaction and immune escape mechanisms while focusing on the role of T cells and their co-inhibitory signals, such as the immune checkpoint molecules programmed death-1 and programmed deathligand 1 (PD-L1). This paper also describes past clinical trials of immunotherapy for patients with GC and details their clinical implications. Strong predictive markers are essential to improve response to immunotherapy. Microsatellite instability, Epstein-Barr virus, PD-L1 expression, and tumor mutational burden are now regarded as potent predictive markers for immunotherapy in patients with GC. Novel immunotherapy and combination therapy targeting new immune checkpoint molecules such as lymphocyte-activation gene 3, T cell immunoglobulin, and mucin domain containing-3, and indoleamine 2,3-dioxygenase have been suggested, and trials are ongoing to evaluate their safety and efficacy. Immunotherapy is an important treatment option for patients with GC and has great potential for improving patient outcome, and further research in immuno-oncology should be carried out.
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Ubiquilin-4 induces immune escape in gastric cancer by activating the notch signaling pathway Quan Jiang, Hao Chen, Shixin Zhou, Tao Zhu, Wenshuai Liu, Hao Wu, Yong Zhang, Fenglin Liu, Yihong Sun Cellular Oncology.2024; 47(1): 303. CrossRef
Expression and prognostic value of APOBEC2 in gastric adenocarcinoma and its association with tumor-infiltrating immune cells Lipan Wei, Xiuqian Wu, Lan Wang, Ling Chen, Xuejun Wu, Tiantian Song, Yuanyuan Wang, Wenjun Chang, Aizhen Guo, Yongdong Niu, Haihua Huang BMC Cancer.2024;[Epub] CrossRef
Identification and characterization of CLEC11A and its derived immune signature in gastric cancer Qing Zheng, Zhenqi Gong, Baizhi Li, Runzi Cheng, Weican Luo, Cong Huang, Huaiming Wang Frontiers in Immunology.2024;[Epub] CrossRef
Cervical cancer subtype identification and model building based on lipid metabolism and post-infection microenvironment immune landscape Yongzhi Chen, Rongjie Cui, Dun Xiong, Yuan Zhao, Jianyu Pang, Samina Gul, Qi Qi, Yuheng Tang, Xuhong Zhou, Wenru Tang Heliyon.2024; 10(9): e30746. CrossRef
Systematic Analysis of Tumor Stem Cell-related Gene Characteristics
to Predict the PD-L1 Immunotherapy and Prognosis of Gastric
Cancer Chenchen Wang, Ying Chen, Ru Zhou, Ya’nan Yang, Yantian Fang Current Medicinal Chemistry.2024; 31(17): 2467. CrossRef
Comprehensive landscape of m6A regulator-related gene patterns and tumor microenvironment infiltration characterization in gastric cancer Bin Peng, Yinglin Lin, Gao Yi, Mingzhen Lin, Yao Xiao, Yezhenghong Qiu, Wenxia Yao, Xinke Zhou, Zhaoyu Liu Scientific Reports.2024;[Epub] CrossRef
Distinctive Phenotypic and Microenvironmental Characteristics of Neuroendocrine Carcinoma and Adenocarcinoma Components in Gastric Mixed Adenoneuroendocrine Carcinoma Yoonjin Kwak, Soo Kyung Nam, Yujun Park, Yun-Suhk Suh, Sang-Hoon Ahn, Seong-Ho Kong, Do Joong Park, Hyuk-Joon Lee, Hyung-Ho Kim, Han-Kwang Yang, Hye Seung Lee Modern Pathology.2024; 37(10): 100568. CrossRef
FOXP3+/CD8+ ratio associated with aggressive behavior in RUNX3‐methylated diffuse esophagogastric junction tumor Suguru Maruyama, Yu Imamura, Tasuku Toihata, Ikumi Haraguchi, Manabu Takamatsu, Makiko Yamashita, Yuichiro Nakashima, Eiji Oki, Kenichi Taguchi, Manabu Yamamoto, Shinji Mine, Akihiko Okamura, Jun Kanamori, Souya Nunobe, Takeshi Sano, Shigehisa Kitano, Tet Cancer Science.2024;[Epub] CrossRef
Computed tomography-detected extramural venous invasion-related gene signature: a potential negative biomarker of immune checkpoint inhibitor treatment in patients with gastric cancer Hao Yang, Xinyi Gou, Caizhen Feng, Yinli Zhang, Fan Chai, Nan Hong, Yingjiang Ye, Yi Wang, Bo Gao, Jin Cheng Journal of Translational Medicine.2023;[Epub] CrossRef
A standardized pathology report for gastric cancer: 2nd edition Young Soo Park, Myeong-Cherl Kook, Baek-hui Kim, Hye Seung Lee, Dong-Wook Kang, Mi-Jin Gu, Ok Ran Shin, Younghee Choi, Wonae Lee, Hyunki Kim, In Hye Song, Kyoung-Mee Kim, Hee Sung Kim, Guhyun Kang, Do Youn Park, So-Young Jin, Joon Mee Kim, Yoon Jung Choi, Journal of Pathology and Translational Medicine.2023; 57(1): 1. CrossRef
A Standardized Pathology Report for Gastric Cancer: 2nd Edition Young Soo Park, Myeong-Cherl Kook, Baek-hui Kim, Hye Seung Lee, Dong-Wook Kang, Mi-Jin Gu, Ok Ran Shin, Younghee Choi, Wonae Lee, Hyunki Kim, In Hye Song, Kyoung-Mee Kim, Hee Sung Kim, Guhyun Kang, Do Youn Park, So-Young Jin, Joon Mee Kim, Yoon Jung Choi, Journal of Gastric Cancer.2023; 23(1): 107. CrossRef
Korean Practice Guidelines for Gastric Cancer 2022: An Evidence-based, Multidisciplinary Approach Tae-Han Kim, In-Ho Kim, Seung Joo Kang, Miyoung Choi, Baek-Hui Kim, Bang Wool Eom, Bum Jun Kim, Byung-Hoon Min, Chang In Choi, Cheol Min Shin, Chung Hyun Tae, Chung sik Gong, Dong Jin Kim, Arthur Eung-Hyuck Cho, Eun Jeong Gong, Geum Jong Song, Hyeon-Su Im Journal of Gastric Cancer.2023; 23(1): 3. CrossRef
Could Toll-like Receptor 2 Serve as Biomarker to Detect Advanced Gastric Cancer? Marek Majewski, Kamil Torres, Paulina Mertowska, Sebastian Mertowski, Izabela Korona-Głowniak, Jan Korulczyk, Witold Zgodziński, Ewelina Grywalska International Journal of Molecular Sciences.2023; 24(6): 5824. CrossRef
Research Progress of Immunotherapy for Gastric Cancer Zhipeng Zhang, Ningning Liu, Mingyu Sun Technology in Cancer Research & Treatment.2023;[Epub] CrossRef
Case Report: A rare synchronous multiple gastric carcinoma achieved progression-free disease through NGS-guided serial treatment Xinyi Shao, Jin Yin, Di Wang, Erjiong Huang, Yini Zhang, Jiani C. Yin, Chen Huang, Hao Wu, Xiaoli Wu Frontiers in Oncology.2023;[Epub] CrossRef
Artificial Intelligence-Enabled Gastric Cancer Interpretations Mustafa Yousif, Liron Pantanowitz Surgical Pathology Clinics.2023; 16(4): 673. CrossRef
The Optimal Tumor Mutational Burden Cutoff Value as a Novel Marker for Predicting the Efficacy of Programmed Cell Death-1 Checkpoint Inhibitors in Advanced Gastric Cancer Jae Yeon Jang, Youngkyung Jeon, Sun Young Jeong, Sung Hee Lim, Won Ki Kang, Jeeyun Lee, Seung Tae Kim Journal of Gastric Cancer.2023; 23(3): 476. CrossRef
Biomarkers for Predicting Response to Personalized Immunotherapy in Gastric Cancer Moonsik Kim, Ji Yun Jeong, An Na Seo Diagnostics.2023; 13(17): 2782. CrossRef
The Prognostic Value of the Prognostic Nutritional Index in Patients with Advanced or Metastatic Gastric Cancer Treated with Immunotherapy Yuting Pan, Yue Ma, Guanghai Dai Nutrients.2023; 15(19): 4290. CrossRef
Molecular classification of gastric cancer predicts survival in patients undergoing radical gastrectomy based on project HOPE Kenichiro Furukawa, Keiichi Hatakeyama, Masanori Terashima, Takeshi Nagashima, Kenichi Urakami, Keiichi Ohshima, Akifumi Notsu, Takashi Sugino, Taisuke Yagi, Keiichi Fujiya, Satoshi Kamiya, Makoto Hikage, Yutaka Tanizawa, Etsuro Bando, Yae Kanai, Yasuto A Gastric Cancer.2022; 25(1): 138. CrossRef
Immunotherapy for Gastric Cancer: A 2021 Update Christo Kole, Nikolaos Charalampakis, Sergios Tsakatikas, Nikolaos-Iasonas Kouris, George Papaxoinis, Michalis V Karamouzis, Anna Koumarianou, Dimitrios Schizas Immunotherapy.2022; 14(1): 41. CrossRef
The immune microenvironment in gastric adenocarcinoma Yana Zavros, Juanita L. Merchant Nature Reviews Gastroenterology & Hepatology.2022; 19(7): 451. CrossRef
Immunomodulation by Gut Microbiome on Gastrointestinal Cancers: Focusing on Colorectal Cancer Raghad Khalid AL-Ishaq, Lenka Koklesova, Peter Kubatka, Dietrich Büsselberg Cancers.2022; 14(9): 2140. CrossRef
An Immunity-Associated lncRNA Signature for Predicting Prognosis in Gastric Adenocarcinoma Xiaowen Zhao, Pingfan Wu, Dongling Liu, Changtian Li, Ling Xue, Zhe Liu, Meng Zhu, Jie Yang, Ziyi Chen, Yaling Li, Yali She, Kathiravan Srinivasan Journal of Healthcare Engineering.2022; 2022: 1. CrossRef
RNA modification writers influence tumor microenvironment in gastric cancer and prospects of targeted drug therapy Peng Song, Sheng Zhou, Xiaoyang Qi, Yuwen Jiao, Yu Gong, Jie Zhao, Haojun Yang, Zhifen Qian, Jun Qian, Liming Tang Journal of Bioinformatics and Computational Biology.2022;[Epub] CrossRef
Identification of the three subtypes and the prognostic characteristics of stomach adenocarcinoma: analysis of the hypoxia-related long non-coding RNAs Zehua Fan, Yanqun Wang, Rong Niu Functional & Integrative Genomics.2022; 22(5): 919. CrossRef
Complete Response of High Microsatellite Instability Gastric Cancer and Synchronous Microsatellite Stability Rectal Cancer Zachary E Hunzeker, Pooja Bhakta, Sindusha R Gudipally, Sri Bharathi Kavuri, Rohit Venkatesan, Chukwuyejulumafor Nwanze Cureus.2022;[Epub] CrossRef
Immune Profiling in Gastric Cancer Reveals the Dynamic Landscape of Immune Signature Underlying Tumor Progression Yuhan Wei, Jianwei Zhang, Xueke Fan, Zhi Zheng, Xiaoyue Jiang, Dexi Chen, Yuting Lu, Yingrui Li, Miao Wang, Min Hu, Qi Du, Liuting Yang, Hongzhong Li, Yi Xiao, Yongfu Li, Jiangtao Jin, Deying Wang, Xiangliang Yuan, Qin Li Frontiers in Immunology.2022;[Epub] CrossRef
Tumor vessel normalization and immunotherapy in gastric cancer Xianzhe Yu, Shan He, Jian Shen, Qiushi Huang, Peng Yang, Lin Huang, Dan Pu, Li Wang, Lu Li, Jinghua Liu, Zelong Liu, Lingling Zhu Therapeutic Advances in Medical Oncology.2022;[Epub] CrossRef
FN1 is a prognostic biomarker and correlated with immune infiltrates in gastric cancers Han Wang, Junchang Zhang, Huan Li, Hong Yu, Songyao Chen, Shuhao Liu, Changhua Zhang, Yulong He Frontiers in Oncology.2022;[Epub] CrossRef
Molecular Pathology of Gastric Cancer Moonsik Kim, An Na Seo Journal of Gastric Cancer.2022; 22(4): 264. CrossRef
Bioinformatics Analysis and Structure of Gastric Cancer Prognosis Model Based on Lipid Metabolism and Immune Microenvironment Yongzhi Chen, Hongjun Yuan, Qian Yu, Jianyu Pang, Miaomiao Sheng, Wenru Tang Genes.2022; 13(9): 1581. CrossRef
Clinical implications of interleukins-31, 32, and 33 in gastric cancer Qing-Hua Liu, Ji-Wei Zhang, Lei Xia, Steven G Wise, Brett David Hambly, Kun Tao, Shi-San Bao World Journal of Gastrointestinal Oncology.2022; 14(9): 1808. CrossRef
Microbiota and the Immune System—Actors in the Gastric Cancer Story Marek Majewski, Paulina Mertowska, Sebastian Mertowski, Konrad Smolak, Ewelina Grywalska, Kamil Torres Cancers.2022; 14(15): 3832. CrossRef
Bioinformatics and Experimental Analyses Reveal MAP4K4 as a Potential Marker for Gastric Cancer Junping Zhang, Xiaoping Cai, Weifeng Cui, Zheng Wei Genes.2022; 13(10): 1786. CrossRef
Common strategies for effective immunotherapy of gastroesophageal cancers using immune checkpoint inhibitors Shuang Ma, Fei Chen Pathology - Research and Practice.2022; 238: 154110. CrossRef
High-level of intratumoral GITR+ CD4 T cells associate with poor prognosis in gastric cancer Shouyu Ke, Feng Xie, Yixian Guo, Jieqiong Chen, Zeyu Wang, Yimeng Yu, Haigang Geng, Danhua Xu, Xu Liu, Xiang Xia, Fengrong Yu, Chunchao Zhu, Zizhen Zhang, Gang Zhao, Bin Li, Wenyi Zhao iScience.2022; 25(12): 105529. CrossRef
Characteristics of Adenosine-to-Inosine RNA editing-based subtypes and novel risk score for the prognosis and drug sensitivity in stomach adenocarcinoma Jingjing Pan, Xinyuan Gu, Jing Luo, Xinye Qian, Qiang Gao, Tianjie Li, Longying Ye, Chenlu Li Frontiers in Cell and Developmental Biology.2022;[Epub] CrossRef
Inhibition of NF‐κB is required for oleanolic acid to downregulate PD‐L1 by promoting DNA demethylation in gastric cancer cells Xirong Lu, Yuyi Li, Wei Yang, Minghao Tao, Yanmiao Dai, Jinkang Xu, Qianfei Xu Journal of Biochemical and Molecular Toxicology.2021;[Epub] CrossRef
Prognostic Value of C-Reactive Protein to Albumin Ratio in Gastric Cancer: A Meta-Analysis Liang Yue, Yi Lu, Yulin Li, Yilin Wang Nutrition and Cancer.2021; 73(10): 1864. CrossRef
Immunogenic characteristics of microsatellite instability‐low esophagogastric junction adenocarcinoma based on clinicopathological, molecular, immunological and survival analyses Yu Imamura, Tasuku Toihata, Ikumi Haraguchi, Yoko Ogata, Manabu Takamatsu, Aya Kuchiba, Norio Tanaka, Osamu Gotoh, Seiichi Mori, Yuichiro Nakashima, Eiji Oki, Masaki Mori, Yoshinao Oda, Kenichi Taguchi, Manabu Yamamoto, Masaru Morita, Naoya Yoshida, Hideo International Journal of Cancer.2021; 148(5): 1260. CrossRef
Two Similar Signatures for Predicting the Prognosis and Immunotherapy Efficacy of Stomach Adenocarcinoma Patients Taohua Yue, Shuai Zuo, Jing Zhu, Shihao Guo, Zhihao Huang, Jichang Li, Xin Wang, Yucun Liu, Shanwen Chen, Pengyuan Wang Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef
Tumor microenvironment characterization in stage IV gastric cancer Feng Yang, Zhenbao Wang, Xianxue Zhang Bioscience Reports.2021;[Epub] CrossRef
E2F2 inhibition induces autophagy via the PI3K/Akt/mTOR pathway in gastric cancer Hui Li, Shufen Zhao, Liwei Shen, Peige Wang, Shihai Liu, Yingji Ma, Zhiwei Liang, Gongjun Wang, Jing Lv, Wensheng Qiu Aging.2021; 13(10): 13626. CrossRef
Chemoradiation induces upregulation of immunogenic cell death-related molecules together with increased expression of PD-L1 and galectin-9 in gastric cancer S. H. Petersen, L. F. Kua, S. Nakajima, W. P. Yong, K. Kono Scientific Reports.2021;[Epub] CrossRef
Establishment of an Immune Cell Infiltration Score to Help Predict the Prognosis and Chemotherapy Responsiveness of Gastric Cancer Patients Quan Jiang, Jie Sun, Hao Chen, Chen Ding, Zhaoqing Tang, Yuanyuan Ruan, Fenglin Liu, Yihong Sun Frontiers in Oncology.2021;[Epub] CrossRef
Microsatellite instability in Gastric Cancer: Between lights and shadows Elisabetta Puliga, Simona Corso, Filippo Pietrantonio, Silvia Giordano Cancer Treatment Reviews.2021; 95: 102175. CrossRef
Survival-associated alternative splicing events interact with the immune microenvironment in stomach adenocarcinoma Zai-Sheng Ye, Miao Zheng, Qin-Ying Liu, Yi Zeng, Sheng-Hong Wei, Yi Wang, Zhi-Tao Lin, Chen Shu, Qiu-Hong Zheng, Lu-Chuan Chen World Journal of Gastroenterology.2021; 27(21): 2871. CrossRef
Immunotherapy of gastric cancer: Past, future perspective and challenges Jun Xie, Liping Fu, Li Jin Pathology - Research and Practice.2021; 218: 153322. CrossRef
Clinicopathologic and Prognostic Association of GRP94 Expression in Colorectal Cancer with Synchronous and Metachronous Metastases Sumi Yun, Sukmook Lee, Ho-Young Lee, Hyeon Jeong Oh, Yoonjin Kwak, Hye Seung Lee International Journal of Molecular Sciences.2021; 22(13): 7042. CrossRef
Injectable shear-thinning polylysine hydrogels for localized immunotherapy of gastric cancer through repolarization of tumor-associated macrophages Yan Yang, Yang Yang, Meili Chen, Jianquan Chen, Jinyan Wang, Yajun Ma, Hanqing Qian Biomaterials Science.2021; 9(19): 6597. CrossRef
Correlation between LRP1B Mutations and Tumor Mutation Burden in Gastric Cancer Sizhe Hu, Xiaokang Zhao, Feng Qian, Cancan Jin, Kaishun Hou, Tao Huang Computational and Mathematical Methods in Medicine.2021; 2021: 1. CrossRef
Comprehensive Analysis to Identify MAGEA3 Expression Correlated With Immune Infiltrates and Lymph Node Metastasis in Gastric Cancer Jinji Jin, Jianxin Tu, Jiahuan Ren, Yiqi Cai, Wenjing Chen, Lifang Zhang, Qiyu Zhang, Guanbao Zhu Frontiers in Oncology.2021;[Epub] CrossRef
Effect of P2X7 receptor on tumorigenesis and its pharmacological properties Wen-jun Zhang, Ce-gui Hu, Zheng-ming Zhu, Hong-liang Luo Biomedicine & Pharmacotherapy.2020; 125: 109844. CrossRef
Current status and future potential of predictive biomarkers for immune checkpoint inhibitors in gastric cancer Byung Woog Kang, Ian Chau ESMO Open.2020; 5(4): e000791. CrossRef
Is Ramucirumab Still the Only Second-Line Treatment in Metastatic Gastric Cancer? Khalil El Gharib, Hampig Raphael Kourie Pharmacogenomics.2020; 21(17): 1203. CrossRef
Deep Learning Predicts Underlying Features on Pathology Images with Therapeutic Relevance for Breast and Gastric Cancer Renan Valieris, Lucas Amaro, Cynthia Aparecida Bueno de Toledo Osório, Adriana Passos Bueno, Rafael Andres Rosales Mitrowsky, Dirce Maria Carraro, Diana Noronha Nunes, Emmanuel Dias-Neto, Israel Tojal da Silva Cancers.2020; 12(12): 3687. CrossRef