Pleomorphic adenoma (PA) is the most common benign salivary gland tumor. Histologically, squamous metaplasia has been reported in PA, but has rarely been documented as being extensive enough to cause significant misdiagnosis. Here, we present an unusual case of PA in a 50-year-old female patient presenting with swelling on the postero-lateral aspect of the palate for a week. Histopathologically, the tumor exhibited the features of conventional PA with extensive squamous metaplasia and giant keratotic lamellae in cyst-like areas. Such exuberant squamous metaplasia and keratin can be a diagnostic and prognostic pitfall and lead to overtreatment of the patient.
Citations
Citations to this article as recorded by
Effective Management of a Giant Deforming Pleomorphic Adenoma With Airway Displacement in a 93-Year-Old Patient: A Case Report Julio A Palomino-Payan, Jessica Guillen-Valles, Daniel A Meza-Martinez, Fernanda Urias, Luis D Montes de Oca-Gordoa Cureus.2024;[Epub] CrossRef
ECTOPIC PLEOMORPHIC ADENOMA OF BUCCAL SPACE: CASE REPORT WITH REVIEW OF LITERATURE SANCHIT BAJPAI UP STATE JOURNAL OF OTOLARYNGOLOGY AND HEAD AND NECK SURGERY.2024; VOLUME 12(ISSUE 1): 55. CrossRef
Pleomorphic adenoma of the upper lip: A rare site for a common tumor- Case report Prasath Sathiah, Sujaya Mazumder, Santosh Tummidi, Vijay Kannaujiya SN Comprehensive Clinical Medicine.2023;[Epub] CrossRef
Variable metaplastic entities in pleomorphic adenoma a review of a rare case report with a note on its significance N. Mahapatra, L. Bhuyan, Dash Chandra, P. Mishra Archive of Oncology.2023; 29(2): 18. CrossRef
Pleomorphic adenoma with extensive oncocytic papillary cystic areas and trichilemmal keratinisation – A unique presentation CV Aiswarya, Raghunath Vandana, Kamal Firoz, Meda Samatha Journal of Oral and Maxillofacial Pathology.2023; 27(3): 562. CrossRef
Pleomorphic Adenoma with Extensive Squamous and Adipocytic Metaplasia Mimicking as Low Grade Mucoepidermoid Carcinoma on FNAC Anu Singh, Ravi Hari Phulware, Arvind Ahuja, Ankur Gupta, Manju Kaushal Indian Journal of Otolaryngology and Head & Neck Surgery.2022; 74(S2): 2132. CrossRef
Aspiration cytology of pleomorphic adenoma with squamous metaplasia: A case series and literature review illustrating diagnostic challenges Joshua J. X. Li, Joanna K. M. Ng, Eric H. L. Lau, Amy B. W. Chan Diagnostic Cytopathology.2022; 50(2): 64. CrossRef
Pleomorphic adenoma with extensive squamous metaplasia: The first well-documented case involving the submandibular gland David A. Gaskin, Alain Reid, Pamela S. Gaskin Human Pathology Reports.2022; 27: 300600. CrossRef
Salivary Gland Pleomorphic Adenomas Presenting With Extremely Varied Clinical Courses. A Single Institution Case-Control Study† Krzysztof Piwowarczyk, Ewelina Bartkowiak, Paweł Kosikowski, Jadzia Tin-Tsen Chou, Małgorzata Wierzbicka Frontiers in Oncology.2021;[Epub] CrossRef
A case report of pleomorphic adenoma squamous metaplasia resembling metastatic oral squamous cell carcinoma E. Donohoe, R. Courtney, S. Phelan, P.J. McCann Advances in Oral and Maxillofacial Surgery.2021; 2: 100074. CrossRef
Extensive squamous metaplasia in minor salivary gland neoplasm mimicking squamous cell carcinoma: Diagnostic dilemma in aspiration cytology Renu Sukumaran, Nileena Nayak, RariP Mony Clinical Cancer Investigation Journal.2021; 10(5): 257. CrossRef
Navigating small biopsies of salivary gland tumors: a pattern-based approach J. Stephen Nix, Lisa M. Rooper Journal of the American Society of Cytopathology.2020; 9(5): 369. CrossRef
Giant Parotid Pleomorphic Adenoma with Atypical Histological Presentation and Long-Term Recurrence-Free Follow-Up after Surgery: A Case Report and Review of the Literature Mohammed AlKindi, Sundar Ramalingam, Lujain Abdulmajeed Hakeem, Manal A. AlSheddi Case Reports in Dentistry.2020; 2020: 1. CrossRef
Pleomorphic adenoma of soft palate with extensive squamous metaplasia – A diagnostic enigma Rashmi Patnayak, Sandip Mohanty, AnjanKumar Sahoo, AdyaKinkara Panda, Amitabh Jena Journal of Dr. NTR University of Health Sciences.2019; 8(4): 268. CrossRef