Journal of Pathology and Translational Medicine

Case Studies

Gastric-Type Extremely Well-Differentiated Adenocarcinoma of the Stomach: A Challenge for Preoperative Diagnosis: Mee Joo, Song Hee Han; J Pathol Transl Med. 2016;50(1):71-74. Published online September 30, 2015; DOI: https://doi.org/10.4132/jptm.2015.07.14

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Gastric-type extremely well-differentiated adenocarcinoma (EWDA) is a rare type of gastric adenocarcinoma characterized by infiltration of well-formed mucinous glands with little or no nuclear atypia, which resemble foveolar epithelium or pyloric glands. Because of its high degree of differentiation, preoperative biopsy diagnosis of gastric-type EWDA is very difficult. We encountered a case of gastric-type EWDA, manifesting as a Borrmann type 4 lesion, in a 47-year-old man. Despite four repeated biopsies, the preoperative biopsy diagnosis was not conclusive due to the scarcity of diagnostic tumor cells and lack of knowledge regarding the unusual histologic findings of gastric-type EWDA. We herein describe the histologic findings of gastric-type EWDA in detail, with the aim of facilitating a preoperative biopsy diagnosis and understanding of this rare type of gastric adenocarcinoma.

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Gastric-type extremely well-differentiated adenocarcinoma of the stomach: A rare tumor with diagnostic difficulties and high inter-observer variation in endoscopic pinch biopsies
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Clinicopathological features of gastric adenocarcinoma of fundic gland type
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Characterization of pathological stomach tissue using polarization-sensitive second harmonic generation microscopy
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Extremely well-differentiated adenocarcinoma of the stomach: diagnostic pitfalls in endoscopic biopsy
Jongwon Lee, In-Seob Lee, Ji Yong Ahn, Young Soo Park, Jihun Kim
Journal of Pathology and Translational Medicine.2022; 56(2): 63. CrossRef
Helicobacter pylori-negative Gastric Cancer
Sun-Young Lee
The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2021; 21(1): 10. CrossRef
Preoperative diagnosis of a gastric extremely well-differentiated adenocarcinoma: A case report
Katsushi Suenaga, Shiro Matsumoto, Alan Kawarai Lefor, Yoshimasa Miura, Yoshinori Hosoya, Daigo Kuboki, Hidenori Haruta, Kentaro Kurashina, Atsushi Kihara, Daisuke Matsubara, Yasunari Sakuma, Joji Kitayama, Naohiro Sata
International Journal of Surgery Case Reports.2020; 73: 319. CrossRef
Gastric adenocarcinoma of the fundic gland type: clinicopathological features of eight patients treated with endoscopic submucosal dissection
Chengfang Li, Xinglong Wu, Shuang Yang, Xiaorong Yang, Jin Yao, Hong Zheng
Diagnostic Pathology.2020;[Epub] CrossRef
Gastric Adenocarcinoma of the Fundic Gland Type
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American Journal of Clinical Pathology.2018; 149(6): 461. CrossRef

Well-Differentiated Papillary Mesothelioma of the Tunica Vaginalis: A Case Study and Review of the Literature: Seyda Erdogan, Arbil Acikalin, Handan Zeren, Gulfılız Gonlusen, Suzan Zorludemir, Volkan Izol; Korean J Pathol. 2014;48(3):225-228. Published online June 26, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.3.225

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Abstract PDF

Well-differentiated papillary mesothelioma is an uncommon tumor of the testes that usually presents as a hydrocele. Here, we present the case of one patient who did not have a history of asbestos exposure. The tumor was localized in the tunica vaginalis and was composed of three pedunculated masses macroscopically. Microscopically, branching papillary structures with focal coagulative necrosis were present. In addition to immunohistochemistry, simian virus 40 DNA was also tested by polymerase chain reaction. This report presents one case of this rare entity, its clinical and macroscopic features, and follow-up results.

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Testicular/paratesticular mesothelial tumours: Uncommon histopathologic entities in a very complex anatomical site
Francesca Pagliuca, Stefano Lucà, Marco De Sio, Davide Arcaniolo, Gaetano Facchini, Marco De Martino, Francesco Esposito, Ferdinando DE Vita, Paolo Chieffi, Renato Franco
Pathology - Research and Practice.2024; 253: 155069. CrossRef
Well-differentiated Papillary Mesothelial Tumour of the Tunica Vaginalis Testis – A Rare Lesion, but one Pathologists Should Know About Two Patient Reports and a Review of the Literature
Johannes Kläger, Felicitas Oberndorfer, Cristophe Brunel, Julian Veser, Eva Compérat
International Journal of Surgical Pathology.2023; 31(6): 1126. CrossRef
A diagnostic approach to paratesticular lesions with tubulopapillary architecture: a series of 16 serous borderline tumors/low-grade serous carcinoma and 14 well-differentiated papillary mesothelial tumors and mesothelioma
Rabia Zafar, Lacey J. Schrader, John C. Cheville, J. Kenneth Schoolmeester, Anja C. Roden, Marie-Christine Aubry, Eunhee S. Yi, Aditya Raghunathan, Loren Herrera-Hernandez, R. Houston Thompson, Stephen A. Boorjian, Bradley C. Leibovich, Gary L. Keeney, Ra
Human Pathology.2022; 128: 31. CrossRef
Mesothelioma subtypes of the tunica vaginalis: a rare case report and review of histological criteria
Cutts Rebecca, Martin J Connor, Luxi Sun, Thomas Johnston, Rachel Gooch, John McLoughlin
Journal of Surgical Case Reports.2019;[Epub] CrossRef
Well‐differentiated papillary mesothelioma of tunica vaginalis testis of unknown malignant potential: Sonographic appearance
K.W.S. Ko, K.S. Tse, K.W. Shek, M.N. Hau, S.H. Ting
Journal of Clinical Ultrasound.2018; 46(5): 364. CrossRef
Tunica Vaginalis Thickening, Hemorrhagic Infiltration and Inflammatory Changes in 8 Children with Primary Hydrocele; Reactive Mesothelial Hyperplasia? A Prospective Clinical Study
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Two Case Reports of Benign Testicular Mesothelioma and Review of the Literature
Cristobal Ramirez Sevilla, Carme Admella Salvador, Josep Feliu Canaleta, Juan Llopis Manzanera, Miguel Angel Barranco Sanz, Juan Antoni Romero Martin, Sergi Bernal Salguero
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Well-differentiated Papillary Mesothelioma of the Tunica Vaginalis
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Urology.2016; 90: e7. CrossRef
Well-Differentiated Papillary Mesothelioma of the Tunica Vaginalis: Case Report and Systematic Review of Literature
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The legacy of the F344 rat as a cancer bioassay model (a retrospective summary of three common F344 rat neoplasms)
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Malignant Mesothelioma of the Tunica Vaginalis: A Rare Neoplasm—Case Report and Literature Review
Manuel Segura-González, Jorge Urias-Rocha, Jorge Castelán-Pedraza
Clinical Genitourinary Cancer.2015; 13(6): e401. CrossRef
In vivo Optical Coherence Tomography Imaging of the Mesothelium Using Developed Window Models
Yeh-Chan Ahn, Yu-Gyeong Chae, Sang Seok Hwang, Bong-Kwon Chun, Maan Hong Jung, Sung Jin Nam, Hae-Young Lee, Jae Min Chung, Chulho Oak, Eun-Kee Park
Journal of the Optical Society of Korea.2015; 19(1): 69. CrossRef

Case Reports

Fine Needle Aspiration Cytologic Features of Well-Differentiated Papillary Mesothelioma in the Pleura: A Case Report.: Han Suk Ryu, Min Sun Jin, Hee Seung Choi, HeeJong Baek, Jae Soo Koh; Korean J Pathol. 2009;43(6):583-588.; DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.6.583

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Abstract PDF

Well-differentiated papillary mesothelioma (WDPM) is a rare subtype of malignant mesothelioma, which is considered to have low malignant potential. Because of its rare occurrence in the pleura, cytopathologists are not familiar with the cytologic features of WDPM, and to date only one report regarding the cytomorphology of aspiration biopsies of WDPM in pleura has been released. The authors present the findings of fine needle aspiration cytology of WDPM in the pleura in a 53-year-old woman. Aspiration smears showed papillary clusters composed of one to three layers of surface tumor cells and a central hyalinized stromal core. Tumor cells were round, ovoid, and spindle like with minimally atypical nuclei and small conspicuous nucleoli. Mitotic activity was virtually absent. Excisional biopsy histologic and immunohistochemical findings were wholly compatible with WDPM findings. Knowledge of the specific cytologic findings of WDPM is crucial for accurate diagnosis and appropriate treatment.

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Well-Differentiated Papillary Mesothelioma of the Peritoneum
Jitendra G. Nasit, Gauravi Dhruva
American Journal of Clinical Pathology.2014; 142(2): 233. CrossRef

Well-Differentiated Papillary Mesothelioma of the Peritoneum: Report of a case.: Ji Eun Kim, So Duk Lim, Kyu Rae Kim, Han Young Choi; Korean J Pathol. 1996;30(7):646-648.

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Abstract PDF: We described a case of well differentiated papillary mesothelioma (WDPM) of the peritoneum in a 68-year-old man because of its rarity. It was incidentally found during operation for renal cell carcinoma. Grossly, the tumor appeared as multiple small granules or nodules on the entire peritoneal surface, including serosa of the intestine, omentum and mesentery. Microscopically, characteristic features are papillary, tubulopapillary or solid architecture lined by single layer of uniform, cytologically bland, cuboidal or polygonal mesothelial cells. The tumor cells were positive for EMA, cytokeratin and vimentin, but negative for CEA on immunohistochemical staining. Ultrastructural study showed characteristic long slender microvilli on the surface and intercellular junctions.

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